{"id":"https://openalex.org/W2152564604","doi":"https://doi.org/10.1016/j.bbrc.2010.06.009","title":"Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials","display_name":"Hydrogen gas treatment prolongs replicative lifespan of bone marrow multipotential stromal cells in vitro while preserving differentiation and paracrine potentials","publication_year":2010,"publication_date":"2010-06-05","ids":{"openalex":"https://openalex.org/W2152564604","doi":"https://doi.org/10.1016/j.bbrc.2010.06.009","mag":"2152564604","pmid":"https://pubmed.ncbi.nlm.nih.gov/20570654"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2010.06.009","doi":"https://doi.org/10.1016/j.bbrc.2010.06.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2010.06.009","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Haruhisa Kawasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haruhisa Kawasaki","raw_affiliation_strings":["Department of Pathology, The Ohio State University, Columbus, OH 43210, United States","Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, The Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090064010","display_name":"Jianjun Guan","orcid":"https://orcid.org/0000-0002-1040-3386","observed_orcids":["https://orcid.org/0000-0002-1040-3386"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianjun Guan","raw_affiliation_strings":["Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Materials Science and Engineering, The Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085041729","display_name":"Kenichi Tamama","orcid":"https://orcid.org/0000-0002-9627-9442","observed_orcids":["https://orcid.org/0000-0002-9627-9442"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenichi Tamama","raw_affiliation_strings":["Center for Stem Cell and Regenerative Medicine, The Ohio State University, Columbus, OH 43210, United States","Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States","Department of Pathology, The Ohio State University, Columbus, OH 43210, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Stem Cell and Regenerative Medicine, The Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Pathology, The Ohio State University, Columbus, OH 43210, United States","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085041729"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":3.0356,"has_fulltext":false,"cited_by_count":58,"citation_normalized_percentile":{"value":0.90776655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"397","issue":"3","first_page":"608","last_page":"613"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13775","display_name":"Hydrogen's biological and therapeutic effects","score":0.9429000020027161,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/molecular-hydrogen","display_name":"molecular hydrogen","score":0.8920000195503235},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9629999995231628},{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.8429999947547913},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.8539999723434448},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8560000061988831},{"id":"https://openalex.org/keywords/hydroxyl-radical-scavenging","display_name":"hydroxyl radical scavenging","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-carbonyls","display_name":"protein carbonyls","score":0.6840000152587891},{"id":"https://openalex.org/keywords/8-hydroxy-2-deoxyguanosine","display_name":"8-hydroxy-2'-deoxyguanosine","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7994339466094971},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.724575936794281},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6157040596008301},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6137797236442566},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5627970099449158},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5474869608879089},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5263592004776001},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4842047691345215},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4767875671386719},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.4452454447746277},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.38309866189956665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30108022689819336},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.29628485441207886},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2526196837425232},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.234523743391037},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.04517820477485657},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005740","descriptor_name":"Gases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006859","descriptor_name":"Hydrogen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017665","descriptor_name":"Hydroxyl Radical","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2010.06.009","doi":"https://doi.org/10.1016/j.bbrc.2010.06.009","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2010.06.009","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:20570654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20570654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1975982131","display_name":"Preparation and Distribution of Adult Stem Cells","funder_award_id":"P40RR017447","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W280054117","https://openalex.org/W1493043296","https://openalex.org/W1502442150","https://openalex.org/W1963789809","https://openalex.org/W1965953554","https://openalex.org/W1967636663","https://openalex.org/W1967824323","https://openalex.org/W1977950302","https://openalex.org/W1978702852","https://openalex.org/W1979043688","https://openalex.org/W1979274462","https://openalex.org/W1987603976","https://openalex.org/W1988237668","https://openalex.org/W1989485116","https://openalex.org/W1994924724","https://openalex.org/W1996803044","https://openalex.org/W2002320509","https://openalex.org/W2005943573","https://openalex.org/W2015055389","https://openalex.org/W2015356704","https://openalex.org/W2019495971","https://openalex.org/W2020358784","https://openalex.org/W2024950877","https://openalex.org/W2034004034","https://openalex.org/W2039751388","https://openalex.org/W2041360667","https://openalex.org/W2044992203","https://openalex.org/W2045018966","https://openalex.org/W2048870371","https://openalex.org/W2049584490","https://openalex.org/W2056884098","https://openalex.org/W2068888599","https://openalex.org/W2072949048","https://openalex.org/W2080416062","https://openalex.org/W2088764218","https://openalex.org/W2088773865","https://openalex.org/W2095132685","https://openalex.org/W2104908670","https://openalex.org/W2154502936","https://openalex.org/W2159999899","https://openalex.org/W2169657429"],"related_works":["https://openalex.org/W2321014873","https://openalex.org/W4389442024","https://openalex.org/W7204436650","https://openalex.org/W3046348326","https://openalex.org/W2799851324","https://openalex.org/W7163214444","https://openalex.org/W4368362499","https://openalex.org/W4401590755","https://openalex.org/W4405699538","https://openalex.org/W2143451025"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
