{"id":"https://openalex.org/W2152345083","doi":"https://doi.org/10.1016/s8756-3282(01)00486-0","title":"Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice","display_name":"Bone biomechanical properties in prostaglandin EP1 and EP2 knockout mice","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W2152345083","doi":"https://doi.org/10.1016/s8756-3282(01)00486-0","mag":"2152345083","pmid":"https://pubmed.ncbi.nlm.nih.gov/11502472"},"language":"en","primary_location":{"id":"doi:10.1016/s8756-3282(01)00486-0","doi":"https://doi.org/10.1016/s8756-3282(01)00486-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s8756-3282(01)00486-0","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111963596","display_name":"M. P. Akhter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.P Akhter","raw_affiliation_strings":["Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA","Osteoporosis Research Center, Creighton University, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center, Creighton University, Omaha, NE 68131, USA","institution_ids":["https://openalex.org/I114493937"]},{"raw_affiliation_string":"Osteoporosis Research Center, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030639482","display_name":"Diane M. Cullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.M Cullen","raw_affiliation_strings":["Osteoporosis Research Center, Creighton University, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029020512","display_name":"G. Gong","orcid":"https://orcid.org/0000-0002-0781-9591","observed_orcids":["https://orcid.org/0000-0002-0781-9591"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Gong","raw_affiliation_strings":["Osteoporosis Research Center, Creighton University, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052478195","display_name":"Robert R. Recker","orcid":"https://orcid.org/0000-0002-8774-1404","observed_orcids":["https://orcid.org/0000-0002-8774-1404"]},"institutions":[{"id":"https://openalex.org/I114493937","display_name":"Creighton University","ror":"https://ror.org/05wf30g94","country_code":"US","type":"education","lineage":["https://openalex.org/I114493937"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.R Recker","raw_affiliation_strings":["Osteoporosis Research Center, Creighton University, Omaha, NE, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Osteoporosis Research Center, Creighton University, Omaha, NE, USA","institution_ids":["https://openalex.org/I114493937"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111963596"],"corresponding_institution_ids":["https://openalex.org/I114493937"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":0.931,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.72707539,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"29","issue":"2","first_page":"121","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.1818999946117401,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.07199999690055847,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9440000057220459},{"id":"https://openalex.org/keywords/ep1-receptor","display_name":"EP1 receptor","score":0.8629999756813049},{"id":"https://openalex.org/keywords/ep2-receptor","display_name":"EP2 receptor","score":1.0},{"id":"https://openalex.org/keywords/prostaglandin-e-receptors","display_name":"prostaglandin E receptors","score":0.6589999794960022},{"id":"https://openalex.org/keywords/mechanical-properties-of-bone","display_name":"bone mechanical properties","score":0.8999999761581421},{"id":"https://openalex.org/keywords/bone-strength","display_name":"bone strength","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bone-mass","display_name":"bone mass","score":0.6759999990463257},{"id":"https://openalex.org/keywords/knockout-mice","display_name":"knockout mice","score":0.609000027179718},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.734000027179718},{"id":"https://openalex.org/keywords/bone-adaptation","display_name":"bone adaptation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.6320000290870667},{"id":"https://openalex.org/keywords/three-point-bending","display_name":"three-point bending","score":0.781000018119812},{"id":"https://openalex.org/keywords/compression-test","display_name":"compression testing","score":0.7059999704360962},{"id":"https://openalex.org/keywords/ulna","display_name":"ulna","score":0.6890000104904175},{"id":"https://openalex.org/keywords/femur","display_name":"femur","score":0.9589999914169312},{"id":"https://openalex.org/keywords/vertebral-body","display_name":"vertebral body","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C178592051","wikidata":"https://www.wikidata.org/wiki/Q28208812","display_name":"Prostaglandin E2 receptor","level":4,"score":0.9168484210968018},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.6721255779266357},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6563884019851685},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6446553468704224},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.6399757862091064},{"id":"https://openalex.org/C2777956040","wikidata":"https://www.wikidata.org/wiki/Q416554","display_name":"Prostaglandin E2","level":2,"score":0.6322025656700134},{"id":"https://openalex.org/C2776350087","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cancellous bone","level":2,"score":0.6002995371818542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5950107574462891},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5918155908584595},{"id":"https://openalex.org/C2777198256","wikidata":"https://www.wikidata.org/wiki/Q4860325","display_name":"Prostaglandin E","level":2,"score":0.5548287630081177},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.5010566711425781},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.44087332487106323},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.4101078510284424},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40177834033966064},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.30181968212127686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21086087822914124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19464212656021118},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.17357996106147766}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058306","descriptor_name":"Receptors, Prostaglandin E, EP1 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058307","descriptor_name":"Receptors, Prostaglandin E, EP2 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s8756-3282(01)00486-0","doi":"https://doi.org/10.1016/s8756-3282(01)00486-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s8756-3282(01)00486-0","pdf_url":null,"source":{"id":"https://openalex.org/S121725775","display_name":"Bone","issn_l":"1873-2763","issn":["1873-2763","8756-3282"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"journal-article"},{"id":"pmid:11502472","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11502472","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1995341583","display_name":null,"funder_award_id":"12556","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1489071669","https://openalex.org/W1523969239","https://openalex.org/W1546944401","https://openalex.org/W1557741015","https://openalex.org/W1963655248","https://openalex.org/W1970955782","https://openalex.org/W1971690617","https://openalex.org/W1975593412","https://openalex.org/W1983443682","https://openalex.org/W1987458789","https://openalex.org/W1988296112","https://openalex.org/W1992536251","https://openalex.org/W1996138805","https://openalex.org/W1998572033","https://openalex.org/W2000317189","https://openalex.org/W2001451877","https://openalex.org/W2006880764","https://openalex.org/W2007362470","https://openalex.org/W2017472612","https://openalex.org/W2019673607","https://openalex.org/W2024191310","https://openalex.org/W2027506256","https://openalex.org/W2032633863","https://openalex.org/W2045981686","https://openalex.org/W2049787159","https://openalex.org/W2056625902","https://openalex.org/W2075355171","https://openalex.org/W2077040449","https://openalex.org/W2086005052","https://openalex.org/W2093224917","https://openalex.org/W2103739359","https://openalex.org/W2115293226","https://openalex.org/W2131512996","https://openalex.org/W2133686946","https://openalex.org/W2148437430","https://openalex.org/W2156409625","https://openalex.org/W2157630878","https://openalex.org/W2167859431","https://openalex.org/W2169485692","https://openalex.org/W2395814502","https://openalex.org/W2396783344","https://openalex.org/W2415762206","https://openalex.org/W4248634331"],"related_works":["https://openalex.org/W2053619019","https://openalex.org/W2187945025","https://openalex.org/W2055401422","https://openalex.org/W1991231518","https://openalex.org/W1846149196","https://openalex.org/W7097903608","https://openalex.org/W2065445418","https://openalex.org/W2122427056","https://openalex.org/W7100292830","https://openalex.org/W2115293226"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}