{"id":"https://openalex.org/W2152315871","doi":"https://doi.org/10.1146/annurev.neuro.23.1.417","title":"Guanylyl Cyclases as a Family of Putative Odorant Receptors","display_name":"Guanylyl Cyclases as a Family of Putative Odorant Receptors","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2152315871","doi":"https://doi.org/10.1146/annurev.neuro.23.1.417","mag":"2152315871","pmid":"https://pubmed.ncbi.nlm.nih.gov/10845070"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.neuro.23.1.417","doi":"https://doi.org/10.1146/annurev.neuro.23.1.417","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.neuro.23.1.417","pdf_url":null,"source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113689867","display_name":"Angelia D. Gibson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angelia D. Gibson","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073371787","display_name":"David L. Garbers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Garbers","raw_affiliation_strings":["Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, 75235;","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7976,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.71641791,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"23","issue":"1","first_page":"417","last_page":"439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guanylate-cyclase","display_name":"guanylate cyclase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/olfactory-receptors","display_name":"olfactory receptors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/olfaction","display_name":"olfaction","score":0.6729999780654907},{"id":"https://openalex.org/keywords/sensory-neurons","display_name":"sensory neurons","score":0.5849999785423279},{"id":"https://openalex.org/keywords/olfactory-bulb","display_name":"olfactory bulb","score":0.49399998784065247},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6320000290870667},{"id":"https://openalex.org/keywords/cgmp","display_name":"cyclic GMP","score":0.7609999775886536},{"id":"https://openalex.org/keywords/cyclic-nucleotide-gated-channels","display_name":"cyclic nucleotide-gated channels","score":0.8180000185966492},{"id":"https://openalex.org/keywords/gs-protein","display_name":"Gs protein","score":0.5839999914169312},{"id":"https://openalex.org/keywords/pheromone-receptors","display_name":"pheromone receptors","score":0.8939999938011169},{"id":"https://openalex.org/keywords/odor-discrimination","display_name":"odor discrimination","score":0.3709999918937683}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.750225841999054},{"id":"https://openalex.org/C2780187430","wikidata":"https://www.wikidata.org/wiki/Q3052544","display_name":"Olfactory epithelium","level":3,"score":0.64149409532547},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6033499836921692},{"id":"https://openalex.org/C2778827303","wikidata":"https://www.wikidata.org/wiki/Q7558945","display_name":"Soluble guanylyl cyclase","level":4,"score":0.5593704581260681},{"id":"https://openalex.org/C2779980732","wikidata":"https://www.wikidata.org/wiki/Q24774756","display_name":"Olfactory receptor","level":3,"score":0.5311174392700195},{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.5301578640937805},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5253412127494812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5228643417358398},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.5154712796211243},{"id":"https://openalex.org/C100094513","wikidata":"https://www.wikidata.org/wiki/Q180436","display_name":"Cilium","level":2,"score":0.5106819272041321},{"id":"https://openalex.org/C31519591","wikidata":"https://www.wikidata.org/wiki/Q18026719","display_name":"GUCY2D","level":5,"score":0.49408724904060364},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.4727671444416046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4159201979637146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3959726095199585},{"id":"https://openalex.org/C2780069284","wikidata":"https://www.wikidata.org/wiki/Q5198121","display_name":"Cyclase","level":3,"score":0.3354690372943878},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3292836546897888},{"id":"https://openalex.org/C13121076","wikidata":"https://www.wikidata.org/wiki/Q1552797","display_name":"Guanylate cyclase 2C","level":4,"score":0.1848333477973938},{"id":"https://openalex.org/C173803235","wikidata":"https://www.wikidata.org/wiki/Q419566","display_name":"Guanylate cyclase","level":3,"score":0.18044164776802063},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.11737698316574097}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006162","descriptor_name":"Guanylate Cyclase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009833","descriptor_name":"Olfactory Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012903","descriptor_name":"Smell","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018035","descriptor_name":"Receptors, Odorant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.neuro.23.1.417","doi":"https://doi.org/10.1146/annurev.neuro.23.1.417","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.neuro.23.1.417","pdf_url":null,"source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},{"id":"pmid:10845070","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10845070","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of neuroscience","raw_type":"Journal Article"},{"id":"mag:2184862351","doi":null,"is_oa":false,"landing_page_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.neuro.23.1.417","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W20397492","https://openalex.org/W130682363","https://openalex.org/W304581165","https://openalex.org/W1480593564","https://openalex.org/W1487066117","https://openalex.org/W1488433029","https://openalex.org/W1491886695","https://openalex.org/W1493349568","https://openalex.org/W1508362079","https://openalex.org/W1514240524","https://openalex.org/W1522192042","https://openalex.org/W1576752839","https://openalex.org/W1579903794","https://openalex.org/W1589508442","https://openalex.org/W1595603700","https://openalex.org/W1604714563","https://openalex.org/W1639758740","https://openalex.org/W1640889105","https://openalex.org/W1895908349","https://openalex.org/W1914786390","https://openalex.org/W1942540978","https://openalex.org/W1950894243","https://openalex.org/W1964942190","https://openalex.org/W1966609546","https://openalex.org/W1966631841","https://openalex.org/W1967915017","https://openalex.org/W1970256374","https://openalex.org/W1970467033","https://openalex.org/W1970706920","https://openalex.org/W1971401377","https://openalex.org/W1971633294","https://openalex.org/W1972201383","https://openalex.org/W1972334416","https://openalex.org/W1973042031","https://openalex.org/W1974162074","https://openalex.org/W1978331009","https://openalex.org/W1981165639","https://openalex.org/W1982602809","https://openalex.org/W1983094993","https://openalex.org/W1983486478","https://openalex.org/W1983765302","https://openalex.org/W1984092953","https://openalex.org/W1984147203","https://openalex.org/W1984170777","https://openalex.org/W1985602726","https://openalex.org/W1986377109","https://openalex.org/W1987029335","https://openalex.org/W1988182516","https://openalex.org/W1989352995","https://openalex.org/W1989566939","https://openalex.org/W1989678684","https://openalex.org/W1990185310","https://openalex.org/W1992328142","https://openalex.org/W1993917985","https://openalex.org/W1995246129","https://openalex.org/W1998904527","https://openalex.org/W1999852582","https://openalex.org/W2000754576","https://openalex.org/W2000941559","https://openalex.org/W2004026630","https://openalex.org/W2004365090","https://openalex.org/W2004660422","https://openalex.org/W2006448839","https://openalex.org/W2007839214","https://openalex.org/W2008118471","https://openalex.org/W2008485465","https://openalex.org/W2009540683","https://openalex.org/W2010730039","https://openalex.org/W2011120951","https://openalex.org/W2013083006","https://openalex.org/W2013326794","https://openalex.org/W2013348596","https://openalex.org/W2013496322","https://openalex.org/W2015455079","https://openalex.org/W2018348038","https://openalex.org/W2020791858","https://openalex.org/W2021586559","https://openalex.org/W2021640673","https://openalex.org/W2022298701","https://openalex.org/W2023071085","https://openalex.org/W2023631751","https://openalex.org/W2023882000","https://openalex.org/W2025364863","https://openalex.org/W2027903939","https://openalex.org/W2030703617","https://openalex.org/W2031893537","https://openalex.org/W2032368609","https://openalex.org/W2033434600","https://openalex.org/W2034176125","https://openalex.org/W2035375570","https://openalex.org/W2036564332","https://openalex.org/W2037815198","https://openalex.org/W2037854344","https://openalex.org/W2038416383","https://openalex.org/W2039686608","https://openalex.org/W2042343877","https://openalex.org/W2045477387","https://openalex.org/W2048772732","https://openalex.org/W2048877959","https://openalex.org/W2050203483","https://openalex.org/W2051342213","https://openalex.org/W2052823089","https://openalex.org/W2053204895","https://openalex.org/W2059313753","https://openalex.org/W2060691910","https://openalex.org/W2062264003","https://openalex.org/W2062569150","https://openalex.org/W2062972107","https://openalex.org/W2064469698","https://openalex.org/W2067240295","https://openalex.org/W2067545717","https://openalex.org/W2069186336","https://openalex.org/W2071230525","https://openalex.org/W2072430528","https://openalex.org/W2076399829","https://openalex.org/W2077928814","https://openalex.org/W2079690597","https://openalex.org/W2081423963","https://openalex.org/W2082471884","https://openalex.org/W2084519533","https://openalex.org/W2084994296","https://openalex.org/W2085673544","https://openalex.org/W2087131888","https://openalex.org/W2087179850","https://openalex.org/W2087280841","https://openalex.org/W2087405091","https://openalex.org/W2089193539","https://openalex.org/W2089227897","https://openalex.org/W2089340953","https://openalex.org/W2093446143","https://openalex.org/W2093695309","https://openalex.org/W2095353164","https://openalex.org/W2097186487","https://openalex.org/W2097823677","https://openalex.org/W2098493367","https://openalex.org/W2106097207","https://openalex.org/W2110614029","https://openalex.org/W2111872480","https://openalex.org/W2113470722","https://openalex.org/W2124063036","https://openalex.org/W2132800912","https://openalex.org/W2133831748","https://openalex.org/W2133950013","https://openalex.org/W2135798485","https://openalex.org/W2140718203","https://openalex.org/W2144529674","https://openalex.org/W2148109871","https://openalex.org/W2148211715","https://openalex.org/W2150284538","https://openalex.org/W2152887599","https://openalex.org/W2156122316","https://openalex.org/W2159609666","https://openalex.org/W2161390302","https://openalex.org/W2161659751","https://openalex.org/W2165170253","https://openalex.org/W2165186547","https://openalex.org/W2167689408","https://openalex.org/W2167897610","https://openalex.org/W2173367747","https://openalex.org/W2182214361","https://openalex.org/W2288125743","https://openalex.org/W2465412761"],"related_works":["https://openalex.org/W2184862351","https://openalex.org/W2062569150","https://openalex.org/W1984474897","https://openalex.org/W1985602726","https://openalex.org/W2128631557","https://openalex.org/W1986377109","https://openalex.org/W2087179850","https://openalex.org/W2129936331","https://openalex.org/W1966631841","https://openalex.org/W2077672285"],"abstract_inverted_index":{"Mammals":[0],"can":[1,94],"discriminate":[2],"among":[3],"a":[4,25,49,64,70,87,112,166],"large":[5,26,113],"number":[6,27],"(>":[7],"10,000)":[8],"of":[9,28,40,80,86,115,133,144,149,169],"unique":[10],"odorants.":[11],"The":[12,56,91],"most":[13],"highly":[14],"supported":[15],"explanation":[16],"for":[17,156],"this":[18],"ability":[19],"is":[20],"that":[21,32,68,141],"olfactory":[22,42,54,61,102],"neurons":[23,62],"express":[24],"seven":[29],"transmembrane":[30],"receptors":[31,155],"are":[33,127],"not":[34],"spatially":[35],"organized":[36],"at":[37],"the":[38,41,53,130,134,145,160],"level":[39],"epithelium,":[43],"but":[44],"whose":[45],"axonal":[46],"projections":[47],"form":[48],"distinct":[50],"pattern":[51],"within":[52],"bulb.":[55],"odor-induced":[57],"signaling":[58],"pathway":[59],"in":[60,78,108,122,129],"includes":[63],"Gs-like":[65],"protein":[66],"(G(olf))":[67],"activates":[69],"specific":[71],"adenylyl":[72],"cyclase":[73,105],"(type":[74],"III)":[75],"isoform,":[76],"resulting":[77],"elevations":[79],"cyclic":[81,88,98],"AMP":[82],"and":[83,110,137],"subsequent":[84],"activation":[85],"nucleotide-gated":[89],"channel.":[90],"channel":[92],"also":[93],"be":[95,154],"regulated":[96],"by":[97],"GMP.":[99],"Recently,":[100],"an":[101],"neuron-specific":[103],"guanylyl":[104,118,125,150,161],"was":[106,120],"discovered":[107],"rodents,":[109],"subsequently":[111],"family":[114,168],"sensory":[116],"neuronal":[117],"cyclases":[119,126,151,162],"identified":[121],"nematodes.":[123],"These":[124],"concentrated":[128],"plasma":[131],"membrane":[132],"dendritic":[135],"cilia":[136],"contain":[138],"extracellular":[139],"domains":[140],"retain":[142],"many":[143],"primary":[146],"sequence":[147],"characteristics":[148],"known":[152],"to":[153,164],"various":[157],"peptides.":[158],"Thus,":[159],"appear":[163],"represent":[165],"second":[167],"odorant/pheromone":[170],"receptors.":[171]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}