{"id":"https://openalex.org/W2152296355","doi":"https://doi.org/10.1007/s00441-007-0469-4","title":"Telomeres, senescence, and hematopoietic stem cells","display_name":"Telomeres, senescence, and hematopoietic stem cells","publication_year":2007,"publication_date":"2007-10-24","ids":{"openalex":"https://openalex.org/W2152296355","doi":"https://doi.org/10.1007/s00441-007-0469-4","mag":"2152296355","pmid":"https://pubmed.ncbi.nlm.nih.gov/17960423"},"language":"en","primary_location":{"id":"doi:10.1007/s00441-007-0469-4","doi":"https://doi.org/10.1007/s00441-007-0469-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00441-007-0469-4","pdf_url":null,"source":{"id":"https://openalex.org/S139399906","display_name":"Cell and Tissue Research","issn_l":"0302-766X","issn":["0302-766X","1432-0878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and Tissue Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040353760","display_name":"Stefan Zimmermann","orcid":"https://orcid.org/0000-0003-0715-3184","observed_orcids":["https://orcid.org/0000-0003-0715-3184"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Stefan Zimmermann","raw_affiliation_strings":["Department of Hematology/Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany. stefan.zimmermann@uniklinik-freiburg.de","Department of Hematology/Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany. stefan.zimmermann@uniklinik-freiburg.de","institution_ids":["https://openalex.org/I2801240073"]},{"raw_affiliation_string":"Department of Hematology/Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017172335","display_name":"Uwe M. Martens","orcid":"https://orcid.org/0000-0001-7999-4359","observed_orcids":["https://orcid.org/0000-0001-7999-4359"]},"institutions":[{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe M. Martens","raw_affiliation_strings":["Department of Hematology/Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology/Oncology, Freiburg University Medical Center, Hugstetterstrasse 55, 79106, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5040353760"],"corresponding_institution_ids":["https://openalex.org/I2801240073"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":0.3092,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.29434447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"331","issue":"1","first_page":"79","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cellular-senescence","display_name":"cellular senescence","score":0.9819999933242798},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/telomere-maintenance","display_name":"telomere maintenance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/replicative-lifespan","display_name":"replicative lifespan","score":0.9330000281333923},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4449999928474426},{"id":"https://openalex.org/keywords/telomere-shortening","display_name":"telomere shortening","score":0.7559999823570251},{"id":"https://openalex.org/keywords/hematopoietic-regeneration","display_name":"hematopoietic regeneration","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.9382935166358948},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.8682622909545898},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.8250218629837036},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7519917488098145},{"id":"https://openalex.org/C14218858","wikidata":"https://www.wikidata.org/wiki/Q7607301","display_name":"Stem cell theory of aging","level":5,"score":0.7498158812522888},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7101746797561646},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6666086912155151},{"id":"https://openalex.org/C522857546","wikidata":"https://www.wikidata.org/wiki/Q2070979","display_name":"Senescence","level":2,"score":0.6440016627311707},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.5621605515480042},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.5275900959968567},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.5037378668785095},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.49441075325012207},{"id":"https://openalex.org/C125593758","wikidata":"https://www.wikidata.org/wiki/Q15315135","display_name":"Telomerase reverse transcriptase","level":4,"score":0.42008376121520996},{"id":"https://openalex.org/C2022786","wikidata":"https://www.wikidata.org/wiki/Q909331","display_name":"Stem cell factor","level":4,"score":0.3927004635334015},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.24903467297554016},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.21336323022842407},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.08007121086120605},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.06944409012794495},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019098","descriptor_name":"Telomerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s00441-007-0469-4","doi":"https://doi.org/10.1007/s00441-007-0469-4","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00441-007-0469-4","pdf_url":null,"source":{"id":"https://openalex.org/S139399906","display_name":"Cell and Tissue Research","issn_l":"0302-766X","issn":["0302-766X","1432-0878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and Tissue Research","raw_type":"journal-article"},{"id":"pmid:17960423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17960423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell and tissue research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.392.4317","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.392.4317","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.lib.gdpu.edu.cn/cyzy/tssjk/lbeyxjzt/2009lbejzt/yjjz/sl/200912/P020091207326015463352.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":162,"referenced_works":["https://openalex.org/W36278818","https://openalex.org/W97711432","https://openalex.org/W176973267","https://openalex.org/W1486872926","https://openalex.org/W1496772673","https://openalex.org/W1496836853","https://openalex.org/W1516272650","https://openalex.org/W1521209045","https://openalex.org/W1525804167","https://openalex.org/W1549738127","https://openalex.org/W1551544315","https://openalex.org/W1553072335","https://openalex.org/W1571651130","https://openalex.org/W1576947953","https://openalex.org/W1587107897","https://openalex.org/W1927581912","https://openalex.org/W1965671668","https://openalex.org/W1970748081","https://openalex.org/W1970878541","https://openalex.org/W1973577066","https://openalex.org/W1976273464","https://openalex.org/W1980235738","https://openalex.org/W1981730769","https://openalex.org/W1983673827","https://openalex.org/W1983851163","https://openalex.org/W1984187829","https://openalex.org/W1984280207","https://openalex.org/W1985398394","https://openalex.org/W1991827974","https://openalex.org/W1992044148","https://openalex.org/W1992996777","https://openalex.org/W1994924724","https://openalex.org/W1995552443","https://openalex.org/W1998663807","https://openalex.org/W1999872096","https://openalex.org/W2000971601","https://openalex.org/W2001627351","https://openalex.org/W2002632740","https://openalex.org/W2004247546","https://openalex.org/W2006446079","https://openalex.org/W2007419319","https://openalex.org/W2008814693","https://openalex.org/W2010006194","https://openalex.org/W2010706760","https://openalex.org/W2011059381","https://openalex.org/W2011221227","https://openalex.org/W2011734959","https://openalex.org/W2014460292","https://openalex.org/W2015591824","https://openalex.org/W2016146452","https://openalex.org/W2018369441","https://openalex.org/W2019317570","https://openalex.org/W2020545711","https://openalex.org/W2021050536","https://openalex.org/W2021489383","https://openalex.org/W2021758398","https://openalex.org/W2024209230","https://openalex.org/W2025535815","https://openalex.org/W2025843494","https://openalex.org/W2027190304","https://openalex.org/W2027434466","https://openalex.org/W2030809859","https://openalex.org/W2031716275","https://openalex.org/W2032407757","https://openalex.org/W2033514910","https://openalex.org/W2034899445","https://openalex.org/W2036478371","https://openalex.org/W2037236933","https://openalex.org/W2041897873","https://openalex.org/W2042000503","https://openalex.org/W2042377388","https://openalex.org/W2043204829","https://openalex.org/W2044493529","https://openalex.org/W2044758458","https://openalex.org/W2045121825","https://openalex.org/W2045702252","https://openalex.org/W2046204996","https://openalex.org/W2046739831","https://openalex.org/W2047561456","https://openalex.org/W2047604240","https://openalex.org/W2048182519","https://openalex.org/W2049462421","https://openalex.org/W2049602391","https://openalex.org/W2052066518","https://openalex.org/W2052260390","https://openalex.org/W2052468427","https://openalex.org/W2057392346","https://openalex.org/W2063914679","https://openalex.org/W2064208421","https://openalex.org/W2064651531","https://openalex.org/W2066058593","https://openalex.org/W2068409711","https://openalex.org/W2075933572","https://openalex.org/W2076825355","https://openalex.org/W2076942739","https://openalex.org/W2078281194","https://openalex.org/W2080045652","https://openalex.org/W2080370285","https://openalex.org/W2080503635","https://openalex.org/W2083141185","https://openalex.org/W2084289371","https://openalex.org/W2084994494","https://openalex.org/W2086089050","https://openalex.org/W2086943348","https://openalex.org/W2088193327","https://openalex.org/W2088438660","https://openalex.org/W2090300056","https://openalex.org/W2090355482","https://openalex.org/W2091428457","https://openalex.org/W2091920930","https://openalex.org/W2092015913","https://openalex.org/W2092476508","https://openalex.org/W2093184953","https://openalex.org/W2095210083","https://openalex.org/W2095252752","https://openalex.org/W2096996955","https://openalex.org/W2097142631","https://openalex.org/W2097857054","https://openalex.org/W2098898118","https://openalex.org/W2099180608","https://openalex.org/W2100550233","https://openalex.org/W2108482850","https://openalex.org/W2110286112","https://openalex.org/W2110603381","https://openalex.org/W2113300169","https://openalex.org/W2113343307","https://openalex.org/W2117154423","https://openalex.org/W2118228848","https://openalex.org/W2118453722","https://openalex.org/W2119739306","https://openalex.org/W2120634098","https://openalex.org/W2122030982","https://openalex.org/W2123111989","https://openalex.org/W2125343208","https://openalex.org/W2125741853","https://openalex.org/W2132882668","https://openalex.org/W2134724878","https://openalex.org/W2137236379","https://openalex.org/W2139137777","https://openalex.org/W2139485932","https://openalex.org/W2143384363","https://openalex.org/W2143983456","https://openalex.org/W2144059985","https://openalex.org/W2145099626","https://openalex.org/W2145344158","https://openalex.org/W2147654197","https://openalex.org/W2148013194","https://openalex.org/W2148531499","https://openalex.org/W2152006444","https://openalex.org/W2158048826","https://openalex.org/W2159231148","https://openalex.org/W2160276170","https://openalex.org/W2160829100","https://openalex.org/W2194123211","https://openalex.org/W2220472138","https://openalex.org/W2264796473","https://openalex.org/W2275293408","https://openalex.org/W2323139758","https://openalex.org/W2330794279","https://openalex.org/W2464740083","https://openalex.org/W4234890809","https://openalex.org/W4239942220"],"related_works":["https://openalex.org/W7096054456","https://openalex.org/W80419790","https://openalex.org/W2056452059","https://openalex.org/W1995148922","https://openalex.org/W2080876205","https://openalex.org/W2185699367","https://openalex.org/W2054901022","https://openalex.org/W2392889325","https://openalex.org/W1971846400","https://openalex.org/W3023977076"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
