{"id":"https://openalex.org/W2152188773","doi":"https://doi.org/10.2174/1389201015666140909124310","title":"Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus","display_name":"Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus","publication_year":2014,"publication_date":"2014-09-30","ids":{"openalex":"https://openalex.org/W2152188773","doi":"https://doi.org/10.2174/1389201015666140909124310","mag":"2152188773","pmid":"https://pubmed.ncbi.nlm.nih.gov/25213310","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469273"},"language":"en","primary_location":{"id":"doi:10.2174/1389201015666140909124310","doi":"https://doi.org/10.2174/1389201015666140909124310","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389201015666140909124310","pdf_url":null,"source":{"id":"https://openalex.org/S6052435","display_name":"Current Pharmaceutical Biotechnology","issn_l":"1389-2010","issn":["1389-2010","1873-4316"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469273","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006741071","display_name":"Diana Cordero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diana Cordero","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021319925","display_name":"Christopher R. Fullenkamp","orcid":"https://orcid.org/0000-0002-9479-896X","observed_orcids":["https://orcid.org/0000-0002-9479-896X"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Fullenkamp","raw_affiliation_strings":["Department of Chemistry, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080031260","display_name":"Rachel M. Pelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Pelly","raw_affiliation_strings":["Department of Chemistry, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065614868","display_name":"Katie M Reed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katie Reed","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085099362","display_name":"Lindy Marie Caffo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindy Caffo","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043415001","display_name":"Ashley N. Zahrt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Zahrt","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110430575","display_name":"Micaleah Newman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Micaleah Newman","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058676801","display_name":"Sarah D. Komanapalli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Komanapalli","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060473733","display_name":"Evan M Niemeier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evan Niemeier","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073171838","display_name":"Derron L. Bishop","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derron Bishop","raw_affiliation_strings":["Indiana University School of Medicine - Muncie Campus, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine - Muncie Campus, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044448169","display_name":"Heather A. Bruns","orcid":"https://orcid.org/0000-0003-3168-3898","observed_orcids":["https://orcid.org/0000-0003-3168-3898"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heather Bruns","raw_affiliation_strings":["Department of Biology, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111761036","display_name":"Mark K. Haynes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Haynes","raw_affiliation_strings":["Center for Molecular Discovery, University of New Mexico, Albuquerque, NM, USA, 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Discovery, University of New Mexico, Albuquerque, NM, USA, 87131","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028187863","display_name":"Larry A. Sklar","orcid":"https://orcid.org/0000-0002-8196-5060","observed_orcids":["https://orcid.org/0000-0002-8196-5060"]},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry Sklar","raw_affiliation_strings":["Center for Molecular Discovery, University of New Mexico, Albuquerque, NM, USA, 87131"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Discovery, University of New Mexico, Albuquerque, NM, USA, 87131","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111542490","display_name":"Robert Erik Sammelson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Sammelson","raw_affiliation_strings":["Department of Chemistry, Ball State University, Muncie, IN, USA, 47306"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Ball State University, Muncie, IN, USA, 47306","institution_ids":["https://openalex.org/I198089087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109133066","display_name":"Susan A. McDowell","orcid":"https://orcid.org/0009-0005-5317-3591","observed_orcids":["https://orcid.org/0009-0005-5317-3591"]},"institutions":[{"id":"https://openalex.org/I198089087","display_name":"Ball State University","ror":"https://ror.org/00k6tx165","country_code":"US","type":"education","lineage":["https://openalex.org/I198089087"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan McDowell","raw_affiliation_strings":["Cooper Science Complex, CL 171C, 2111 Riverside Ave. Ball State University, Muncie, IN 47306, USA. samcdowell@bsu.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cooper Science Complex, CL 171C, 2111 Riverside Ave. Ball State University, Muncie, IN 47306, USA. samcdowell@bsu.edu","institution_ids":["https://openalex.org/I198089087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7005,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.74138486,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"8","first_page":"727","last_page":"737"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.9667999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":1.0},{"id":"https://openalex.org/keywords/endothelial-cell-invasion","display_name":"endothelial cell invasion","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cdc42","display_name":"Cdc42","score":0.8960000276565552},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9319999814033508},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.8220000267028809},{"id":"https://openalex.org/keywords/endocytic-uptake","display_name":"endocytic uptake","score":0.8880000114440918},{"id":"https://openalex.org/keywords/host-directed-therapy","display_name":"host-directed therapy","score":0.574999988079071},{"id":"https://openalex.org/keywords/intracellular-bacterial-infection","display_name":"intracellular bacterial infection","score":0.5569999814033508},{"id":"https://openalex.org/keywords/structural-analogs","display_name":"structural analogues","score":0.699999988079071}],"concepts":[{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.7870041728019714},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6965081691741943},{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.6382719874382019},{"id":"https://openalex.org/C2780040266","wikidata":"https://www.wikidata.org/wiki/Q15311701","display_name":"CDC42","level":3,"score":0.5469940900802612},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.5325115323066711},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.47630059719085693},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4533396065235138},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.35993343591690063},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34856265783309937},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30228206515312195},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19393253326416016},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.15560966730117798},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1495659351348877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001422","descriptor_name":"Bacterial Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013211","descriptor_name":"Staphylococcus aureus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D065636","descriptor_name":"Myotonin-Protein Kinase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.2174/1389201015666140909124310","doi":"https://doi.org/10.2174/1389201015666140909124310","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1389201015666140909124310","pdf_url":null,"source":{"id":"https://openalex.org/S6052435","display_name":"Current Pharmaceutical Biotechnology","issn_l":"1389-2010","issn":["1389-2010","1873-4316"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Pharmaceutical Biotechnology","raw_type":"journal-article"},{"id":"pmid:25213310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25213310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current pharmaceutical biotechnology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3431831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4469273","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469273","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Curr Pharm Biotechnol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3431831","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4469273","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5600000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2101135766","display_name":"Statins as Inhibitors of Bacterial Host Cell Invasion","funder_award_id":"R15HL092504","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8187984429","display_name":"University of New Mexico Center for Molecular Discovery","funder_award_id":"U54MH084690","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1950875084","https://openalex.org/W1973675012","https://openalex.org/W1981310409","https://openalex.org/W1986702514","https://openalex.org/W1990771347","https://openalex.org/W1990953109","https://openalex.org/W1997176414","https://openalex.org/W1998032673","https://openalex.org/W1998221324","https://openalex.org/W2026938753","https://openalex.org/W2027810531","https://openalex.org/W2033775944","https://openalex.org/W2036103344","https://openalex.org/W2046282834","https://openalex.org/W2048960219","https://openalex.org/W2055411163","https://openalex.org/W2061977049","https://openalex.org/W2065612201","https://openalex.org/W2066651120","https://openalex.org/W2069372950","https://openalex.org/W2069434111","https://openalex.org/W2086731907","https://openalex.org/W2116187189","https://openalex.org/W2137893923","https://openalex.org/W2139360044","https://openalex.org/W2139863514","https://openalex.org/W2144584054","https://openalex.org/W2153593459","https://openalex.org/W2153660769","https://openalex.org/W2167809238","https://openalex.org/W2176744910","https://openalex.org/W2314649741","https://openalex.org/W2950075056","https://openalex.org/W2993222596","https://openalex.org/W3032238784"],"related_works":["https://openalex.org/W2980839232","https://openalex.org/W1141277479","https://openalex.org/W7066722108","https://openalex.org/W2067683753","https://openalex.org/W7030005967","https://openalex.org/W2003553780","https://openalex.org/W196484795","https://openalex.org/W2163434681","https://openalex.org/W3136958976","https://openalex.org/W812024126"],"abstract_inverted_index":{"Staphylococcus":[0],"aureus":[1,23,128],"is":[2,15],"a":[3,55,74,84,121,144],"leading":[4],"causative":[5],"agent":[6],"in":[7,83,95],"sepsis,":[8],"endocarditis,":[9],"and":[10,42,80,86,143,152],"pneumonia.":[11],"An":[12],"emerging":[13],"concept":[14],"that":[16,71,102,147],"prognosis":[17],"worsens":[18],"when":[19],"the":[20,26,66,140,158,171,174],"infecting":[21],"S.":[22,63,127],"strain":[24],"has":[25],"capacity":[27],"to":[28,38,92,97,114,129],"not":[29],"only":[30],"colonize":[31],"tissue":[32],"as":[33,54,139],"an":[34],"extracellular":[35],"pathogen,":[36],"but":[37],"invade":[39],"host":[40,52,164],"cells":[41],"establish":[43],"intracellular":[44],"bacterial":[45],"populations.":[46],"In":[47,65],"previous":[48],"work,":[49,68],"we":[50,69],"identified":[51,146],"CDC42":[53,76,165],"central":[56],"regulator":[57],"of":[58,100,107,133,160,173],"endothelial":[59],"cell":[60],"invasion":[61,79,149],"by":[62,126],"aureus.":[64],"current":[67],"report":[70],"ML":[72,110,134],"141,":[73],"first-in-class":[75],"inhibitor,":[77],"decreases":[78],"resultant":[81],"pathogenesis":[82],"dose-dependent":[85],"reversible":[87],"manner.":[88],"Inhibition":[89],"was":[90],"found":[91],"be":[93],"due":[94],"part":[96],"decreased":[98,112],"remodeling":[99],"actin":[101],"potentially":[103],"drives":[104],"endocytic":[105],"uptake":[106],"bacteria/fibronectin/integrin":[108],"complexes.":[109],"141":[111,135],"binding":[113],"fibronectin":[115],"at":[116,170],"these":[117],"complexes,":[118],"thereby":[119],"limiting":[120],"key":[122],"pathogenic":[123],"mechanism":[124],"used":[125],"invade.":[130],"Structural":[131],"analogs":[132],"were":[136],"synthesized":[137],"(designated":[138],"RSM":[141],"series)":[142],"subset":[145],"inhibit":[148],"through":[150],"non-cytotoxic":[151],"non-bactericidal":[153],"mechanisms.":[154],"Our":[155],"results":[156],"support":[157],"development":[159],"adjunctive":[161],"therapeutics":[162],"targeting":[163],"for":[166],"mitigating":[167],"invasive":[168],"infection":[169],"level":[172],"host.":[175]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}