{"id":"https://openalex.org/W2152169393","doi":"https://doi.org/10.1152/jappl.1997.82.3.913","title":"Endogenous nitric oxide decreases xanthine oxidase-mediated neutrophil adherence: role of P-selectin","display_name":"Endogenous nitric oxide decreases xanthine oxidase-mediated neutrophil adherence: role of P-selectin","publication_year":1997,"publication_date":"1997-03-01","ids":{"openalex":"https://openalex.org/W2152169393","doi":"https://doi.org/10.1152/jappl.1997.82.3.913","mag":"2152169393","pmid":"https://pubmed.ncbi.nlm.nih.gov/9074982"},"language":"en","primary_location":{"id":"doi:10.1152/jappl.1997.82.3.913","doi":"https://doi.org/10.1152/jappl.1997.82.3.913","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1997.82.3.913","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031228447","display_name":"Lance S. Terada","orcid":"https://orcid.org/0000-0001-7441-9734","observed_orcids":["https://orcid.org/0000-0001-7441-9734"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance S. Terada","raw_affiliation_strings":["Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057139432","display_name":"John E. Repine","orcid":"https://orcid.org/0000-0003-0203-0257","observed_orcids":["https://orcid.org/0000-0003-0203-0257"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Repine","raw_affiliation_strings":["Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042452714","display_name":"Dale Piermattei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dale Piermattei","raw_affiliation_strings":["Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":["https://openalex.org/I4210087413"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052406548","display_name":"Brooks M. Hybertson","orcid":"https://orcid.org/0000-0002-9851-3554","observed_orcids":["https://orcid.org/0000-0002-9851-3554"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brooks M. Hybertson","raw_affiliation_strings":["Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Webb-Waring Institute for Biomedical Research, University of Colorado Health Sciences Center, Denver, Colorado 80262","institution_ids":["https://openalex.org/I4210087413"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210087413"],"apc_list":null,"apc_paid":null,"fwci":0.2034,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.59758497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"82","issue":"3","first_page":"913","last_page":"917"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.8554999828338623,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.10350000113248825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.968999981880188},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/neutrophil-adhesion","display_name":"neutrophil adhesion","score":0.8889999985694885},{"id":"https://openalex.org/keywords/neutrophil-rolling","display_name":"neutrophil rolling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/pulmonary-artery-endothelial-cells","display_name":"pulmonary artery endothelial cells","score":0.8009999990463257},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8149999976158142},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.6079999804496765},{"id":"https://openalex.org/keywords/ng-nitro-l-arginine","display_name":"L-NNA","score":0.8270000219345093},{"id":"https://openalex.org/keywords/sodium-nitroprusside","display_name":"sodium nitroprusside","score":0.8709999918937683},{"id":"https://openalex.org/keywords/negative-feedback-regulation","display_name":"negative feedback regulation","score":0.47999998927116394},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.8176709413528442},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.761114776134491},{"id":"https://openalex.org/C2779610285","wikidata":"https://www.wikidata.org/wiki/Q27108300","display_name":"Sodium nitroprusside","level":3,"score":0.6625540256500244},{"id":"https://openalex.org/C2776179834","wikidata":"https://www.wikidata.org/wiki/Q72158415","display_name":"Nitrite","level":3,"score":0.6261895895004272},{"id":"https://openalex.org/C16613235","wikidata":"https://www.wikidata.org/wiki/Q285982","display_name":"Endogeny","level":2,"score":0.5973161458969116},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5967618227005005},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5405662655830383},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.42565420269966125},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.4245876669883728},{"id":"https://openalex.org/C155619193","wikidata":"https://www.wikidata.org/wiki/Q415915","display_name":"Selectin","level":3,"score":0.4220374822616577},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3707674741744995},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34849464893341064},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33207643032073975},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3207651972770691},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.2807161211967468},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.239732563495636},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21985739469528198},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.14380958676338196},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C2776384668","wikidata":"https://www.wikidata.org/wiki/Q182168","display_name":"Nitrate","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014969","descriptor_name":"Xanthine Oxidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1152/jappl.1997.82.3.913","doi":"https://doi.org/10.1152/jappl.1997.82.3.913","is_oa":false,"landing_page_url":"https://doi.org/10.1152/jappl.1997.82.3.913","pdf_url":null,"source":{"id":"https://openalex.org/S140889577","display_name":"Journal of Applied Physiology","issn_l":"0161-7567","issn":["0161-7567","1522-1601","8750-7587"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320155","host_organization_name":"American Physiological Society","host_organization_lineage":["https://openalex.org/P4310320155"],"host_organization_lineage_names":["American Physiological Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Applied Physiology","raw_type":"journal-article"},{"id":"pmid:9074982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9074982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of applied physiology (Bethesda, Md. : 1985)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.590.5119","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.590.5119","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jap.physiology.org/content/82/3/913.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.4099999964237213,"display_name":"Clean water and sanitation","id":"https://metadata.un.org/sdg/6"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2559388516","display_name":null,"funder_award_id":"R29-HL52591","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4616769921","display_name":"SCOR IN ACUTE LUNG INJURY","funder_award_id":"5p50hl040784-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G49134201","display_name":null,"funder_award_id":"P50 HL 40784","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6283849928","display_name":"Respiratory Endothelial Injury by Xanthine Oxidase","funder_award_id":"R01HL045582","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G652413998","display_name":"OXIDANT PRODUCTION BY ENDOTHELIAL CELL XANTHINE OXIDASE","funder_award_id":"5r29hl052591-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000895966","display_name":"Colorado Summer Research Training for Undergraduate Diversity","funder_award_id":"R25HL108823","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W183295734","https://openalex.org/W1501106246","https://openalex.org/W1570412320","https://openalex.org/W1924909341","https://openalex.org/W1965874741","https://openalex.org/W1987823842","https://openalex.org/W1999063996","https://openalex.org/W2020186228","https://openalex.org/W2021117769","https://openalex.org/W2029491963","https://openalex.org/W2047751005","https://openalex.org/W2048020333","https://openalex.org/W2051977813","https://openalex.org/W2095411825","https://openalex.org/W2125076307","https://openalex.org/W2129241682","https://openalex.org/W2130014701","https://openalex.org/W2138127893","https://openalex.org/W2152922547","https://openalex.org/W2174238176","https://openalex.org/W2193143775","https://openalex.org/W2214682247","https://openalex.org/W2402244402","https://openalex.org/W2414113211"],"related_works":["https://openalex.org/W2152922547","https://openalex.org/W2284760100","https://openalex.org/W4236014977","https://openalex.org/W7118404","https://openalex.org/W2157524361","https://openalex.org/W2048020333","https://openalex.org/W2013933357","https://openalex.org/W2189016226","https://openalex.org/W85814666","https://openalex.org/W2226728325"],"abstract_inverted_index":{"The":[0],"oxygen":[1],"radical-producing":[2],"enzyme":[3],"xanthine":[4],"oxidase":[5],"(XO)":[6],"can":[7],"promote":[8],"neutrophil":[9,78,83,139,158],"adherence":[10,84],"to":[11,24,41,63,85,149,174],"endothelium.":[12],"Recognizing":[13],"that":[14,33,145,153],"a":[15],"balance":[16],"often":[17],"exists":[18],"in":[19,87,165],"inflammatory":[20],"processes,":[21],"we":[22],"sought":[23],"determine":[25],"whether":[26],"XO":[27,42,68,110,146],"initiates":[28],"antiadherent":[29],"pathways.":[30],"We":[31,143],"found":[32],"bovine":[34],"pulmonary":[35],"arterial":[36],"endothelial":[37],"cells":[38],"(EC)":[39],"exposed":[40],"released":[43],"increased":[44,53,77,113],"amounts":[45],"of":[46,55,107,117,121,129,179],"nitrite":[47],"into":[48,125],"the":[49,70,132,156,175],"media,":[50],"reflecting":[51],"an":[52,88,170],"production":[54],"nitric":[56],"oxide":[57],"(NO).":[58],"When":[59],"EC":[60,86,108,130,148],"were":[61,96],"subjected":[62],"shear":[64],"stress,":[65],"treatment":[66,106,128],"with":[67,109,131],"and/or":[69,111],"NO":[71,133,151,154,167],"synthase":[72],"inhibitor":[73],"N":[74],"omega-nitro-L-arginine":[75],"(L-NNA)":[76],"rolling":[79,92,140],"behavior":[80],"and":[81,93,119,141,152],"firm":[82],"additive":[89],"fashion.":[90],"Both":[91],"adherent":[94],"interactions":[95],"abolished":[97],"by":[98,161],"monoclonal":[99],"antibodies":[100],"directed":[101],"against":[102],"P-selectin.":[103],"In":[104],"addition,":[105],"L-NNA":[112],"both":[114],"surface":[115],"expression":[116],"P-selectin":[118],"release":[120],"von":[122],"Willebrand":[123],"factor":[124],"media.":[126],"Finally,":[127],"donor":[134],"sodium":[135],"nitroprusside":[136],"decreased":[137],"XO-mediated":[138],"adherence.":[142],"conclude":[144],"stimulates":[147],"produce":[150],"decreases":[155],"P-selectin-dependent":[157],"adhesion":[159],"initiated":[160],"XO.":[162,180],"Such":[163],"increases":[164],"endogenous":[166],"may":[168],"constitute":[169],"important":[171],"negative-feedback":[172],"response":[173],"acute":[176],"proadhesive":[177],"effects":[178]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}