{"id":"https://openalex.org/W2152124063","doi":"https://doi.org/10.1126/science.1077771","title":"KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation","display_name":"KCNQ1 Gain-of-Function Mutation in Familial Atrial Fibrillation","publication_year":2003,"publication_date":"2003-01-09","ids":{"openalex":"https://openalex.org/W2152124063","doi":"https://doi.org/10.1126/science.1077771","mag":"2152124063","pmid":"https://pubmed.ncbi.nlm.nih.gov/12522251"},"language":"en","primary_location":{"id":"doi:10.1126/science.1077771","doi":"https://doi.org/10.1126/science.1077771","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1077771","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2152124063"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109242934","display_name":"Yi-Han Chen","orcid":"https://orcid.org/0000-0003-1000-1835","observed_orcids":["https://orcid.org/0000-0003-1000-1835"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Han Chen","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101754699","display_name":"Shi-Jie Xu","orcid":"https://orcid.org/0000-0003-4974-3940","observed_orcids":["https://orcid.org/0000-0003-4974-3940"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shi-Jie Xu","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","Health Science Center, Institute for Biological Sciences\u2013Chinese Academy of Sciences and Shanghai Second Medical University, Shanghai 200025, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]},{"raw_affiliation_string":"Health Science Center, Institute for Biological Sciences\u2013Chinese Academy of Sciences and Shanghai Second Medical University, Shanghai 200025, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065231556","display_name":"Sa\u00efd Bendahhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sa\u0131\u0308d Bendahhou","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS, 660 Route des lucioles, 06560 Sophia Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS, 660 Route des lucioles, 06560 Sophia Antipolis, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044220733","display_name":"Xiao-Liang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Liang Wang","raw_affiliation_strings":["Institute of Materia Media, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Media, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ying Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Wang","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Wen-Yuan Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Yuan Xu","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073496574","display_name":"Hongwei Jin","orcid":"https://orcid.org/0000-0002-7509-2697","observed_orcids":["https://orcid.org/0000-0002-7509-2697"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Wei Jin","raw_affiliation_strings":["Institute of Materia Media, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Materia Media, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050, People's Republic of China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100649912","display_name":"Hao Sun","orcid":"https://orcid.org/0000-0002-4329-3910","observed_orcids":["https://orcid.org/0000-0002-4329-3910"]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Sun","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103570503","display_name":"Xiao-Yan Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Yan Su","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108228397","display_name":"Qi-Nan Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi-Nan Zhuang","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101573559","display_name":"Yiqing Yang","orcid":"https://orcid.org/0000-0001-6090-1378","observed_orcids":["https://orcid.org/0000-0001-6090-1378"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Qing Yang","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077198564","display_name":"Yue-Bin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue-Bin Li","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101977698","display_name":"Yi Liu","orcid":"https://orcid.org/0000-0002-3315-3447","observed_orcids":["https://orcid.org/0000-0002-3315-3447"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109242935","display_name":"Hong-Ju Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Ju Xu","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100358281","display_name":"Xiaofei Li","orcid":"https://orcid.org/0000-0001-6707-1274","observed_orcids":["https://orcid.org/0000-0001-6707-1274"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao-Fei Li","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070158905","display_name":"Ning Ma","orcid":"https://orcid.org/0000-0001-7315-8835","observed_orcids":["https://orcid.org/0000-0001-7315-8835"]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning Ma","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113689779","display_name":"Chun-Ping Mou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Ping Mou","raw_affiliation_strings":["Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Tongji Hospital, and Institute of Medical Genetics, Tongji University, 399 Xin Cun Road, Shanghai 200065, People's Republic of China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100449751","display_name":"Zhu Chen","orcid":"https://orcid.org/0000-0002-9974-0716","observed_orcids":["https://orcid.org/0000-0002-9974-0716","https://orcid.org/0000-0001-8827-3342"]},"institutions":[{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]},{"id":"https://openalex.org/I4210147369","display_name":"Shanghai Institute of Hematology","ror":"https://ror.org/03fz4ce66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210147369"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhu Chen","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Second Medical University, Shanghai 200025, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]},{"raw_affiliation_string":"State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Second Medical University, Shanghai 200025, People's Republic of China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I4210147369","https://openalex.org/I4392021104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013230246","display_name":"Jacques Barhanin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210160500","display_name":"Institut de Pharmacologie Mol\u00e9culaire et Cellulaire","ror":"https://ror.org/05k4ema52","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I201841394","https://openalex.org/I4210096427","https://openalex.org/I4210160500"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Barhanin","raw_affiliation_strings":["Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS, 660 Route des lucioles, 06560 Sophia Antipolis, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Pharmacologie Mole\u0301culaire et Cellulaire, CNRS, 660 Route des lucioles, 06560 Sophia Antipolis, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210160500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010345121","display_name":"Wei Huang","orcid":"https://orcid.org/0000-0001-9561-5099","observed_orcids":["https://orcid.org/0000-0001-9561-5099"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]},{"id":"https://openalex.org/I4210099308","display_name":"Chinese National Human Genome Center at Shanghai","ror":"https://ror.org/017xz5989","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210099308"]},{"id":"https://openalex.org/I4210106477","display_name":"Shanghai Institutes for Biological Sciences","ror":"https://ror.org/011rf9d86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"id":"https://openalex.org/I4210147369","display_name":"Shanghai Institute of Hematology","ror":"https://ror.org/03fz4ce66","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210147369"]},{"id":"https://openalex.org/I4392021104","display_name":"State Key Laboratory of Medical Genomics","ror":"https://ror.org/04m0qde81","country_code":"CN","type":"facility","lineage":["https://openalex.org/I183067930","https://openalex.org/I4392021104"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Huang","raw_affiliation_strings":["Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","Health Science Center, Institute for Biological Sciences\u2013Chinese Academy of Sciences and Shanghai Second Medical University, Shanghai 200025, People's Republic of China","State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Second Medical University, Shanghai 200025, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, People's Republic of China","institution_ids":["https://openalex.org/I4210099308"]},{"raw_affiliation_string":"Health Science Center, Institute for Biological Sciences\u2013Chinese Academy of Sciences and Shanghai Second Medical University, Shanghai 200025, People's Republic of China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106477"]},{"raw_affiliation_string":"State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital affiliated to Shanghai Second Medical University, Shanghai 200025, People's Republic of China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I4210147369","https://openalex.org/I4392021104"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5101754699","https://openalex.org/A5109242934"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I19820366","https://openalex.org/I4210099308","https://openalex.org/I4210106477"],"apc_list":null,"apc_paid":null,"fwci":32.9472,"has_fulltext":false,"cited_by_count":1007,"citation_normalized_percentile":{"value":0.99805254,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"299","issue":"5604","first_page":"251","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kcnq1","display_name":"KCNQ1","score":0.906000018119812},{"id":"https://openalex.org/keywords/gain-of-function-mutations","display_name":"gain-of-function mutations","score":0.8159999847412109},{"id":"https://openalex.org/keywords/familial-atrial-fibrillation","display_name":"familial atrial fibrillation","score":0.9879999756813049},{"id":"https://openalex.org/keywords/potassium-channels","display_name":"potassium channels","score":0.39399999380111694},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.8180000185966492},{"id":"https://openalex.org/keywords/effective-refractory-period","display_name":"effective refractory period","score":0.9879999756813049},{"id":"https://openalex.org/keywords/atrial-myocytes","display_name":"atrial myocytes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/long-qt-syndrome","display_name":"long QT syndrome","score":0.6639999747276306},{"id":"https://openalex.org/keywords/chromosome-11p15-5","display_name":"chromosome 11p15.5","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6347613334655762},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5648185014724731},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.5199924111366272},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.49422767758369446},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49040985107421875},{"id":"https://openalex.org/C2988455589","wikidata":"https://www.wikidata.org/wiki/Q189331","display_name":"Cardiac arrhythmia","level":3,"score":0.45186880230903625},{"id":"https://openalex.org/C3020204279","wikidata":"https://www.wikidata.org/wiki/Q105590653","display_name":"Gain of function","level":4,"score":0.44189268350601196},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4357416033744812},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41335827112197876},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4013424515724182},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3791116774082184},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.35176652669906616},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.2678695321083069}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002681","descriptor_name":"China","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002880","descriptor_name":"Chromosomes, Human, Pair 11","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004562","descriptor_name":"Electrocardiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006239","descriptor_name":"Haplotypes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006325","descriptor_name":"Heart Atria","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008126","descriptor_name":"Lod Score","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008133","descriptor_name":"Long QT Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010375","descriptor_name":"Pedigree","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015221","descriptor_name":"Potassium Channels","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024642","descriptor_name":"Potassium Channels, Voltage-Gated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051656","descriptor_name":"KCNQ Potassium Channels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051657","descriptor_name":"KCNQ1 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.1077771","doi":"https://doi.org/10.1126/science.1077771","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.1077771","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:12522251","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12522251","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1491803208","https://openalex.org/W1668163968","https://openalex.org/W1983137097","https://openalex.org/W1988911499","https://openalex.org/W1991662012","https://openalex.org/W1994983075","https://openalex.org/W2002422701","https://openalex.org/W2018409817","https://openalex.org/W2039155026","https://openalex.org/W2052976216","https://openalex.org/W2062206620","https://openalex.org/W2077110754","https://openalex.org/W2082497857","https://openalex.org/W2093214695","https://openalex.org/W2096981079","https://openalex.org/W2101310027","https://openalex.org/W2116051448","https://openalex.org/W2121677695","https://openalex.org/W2125741862","https://openalex.org/W2337236768","https://openalex.org/W2593137870","https://openalex.org/W4251984461"],"related_works":["https://openalex.org/W2126590887","https://openalex.org/W4250181896","https://openalex.org/W2061393468","https://openalex.org/W1754996786","https://openalex.org/W118576942","https://openalex.org/W2075826861","https://openalex.org/W2112815773","https://openalex.org/W1554621827","https://openalex.org/W1990087395","https://openalex.org/W81917683"],"abstract_inverted_index":{"Atrial":[0],"fibrillation":[1],"(AF)":[2],"is":[3,11,99],"a":[4,16,64],"common":[5],"cardiac":[6,46],"arrhythmia":[7],"whose":[8],"molecular":[9],"etiology":[10],"poorly":[12],"understood.":[13],"We":[14],"studied":[15],"family":[17],"with":[18,76,91],"hereditary":[19],"persistent":[20],"AF":[21,105],"and":[22,52,70,103,111],"identified":[23,88],"the":[24,29,40,45,50,53,60,68,71,77,84,96],"causative":[25],"mutation":[26,98],"(S140G)":[27],"in":[28,89,115],"KCNQ1":[30,37,85],"(KvLQT1)":[31],"gene":[32,38],"on":[33,67],"chromosome":[34],"11p15.5.":[35],"The":[36],"encodes":[39],"pore-forming":[41],"alpha":[42],"subunit":[43],"of":[44,59,83],"I(Ks)":[47],"channel":[48],"(KCNQ1/KCNE1),":[49],"KCNQ1/KCNE2":[51,72],"KCNQ1/KCNE3":[54],"potassium":[55],"channels.":[56],"Functional":[57],"analysis":[58],"S140G":[61,97],"mutant":[62],"revealed":[63],"gain-of-function":[65],"effect":[66],"KCNQ1/KCNE1":[69],"currents,":[73],"which":[74],"contrasts":[75],"dominant":[78],"negative":[79],"or":[80],"loss-of-function":[81],"effects":[82],"mutations":[86],"previously":[87],"patients":[90],"long":[92],"QT":[93],"syndrome.":[94],"Thus,":[95],"likely":[100],"to":[101],"initiate":[102],"maintain":[104],"by":[106],"reducing":[107],"action":[108],"potential":[109],"duration":[110],"effective":[112],"refractory":[113],"period":[114],"atrial":[116],"myocytes.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":24},{"year":2025,"cited_by_count":23},{"year":2024,"cited_by_count":39},{"year":2023,"cited_by_count":25},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":43},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":44},{"year":2014,"cited_by_count":44},{"year":2013,"cited_by_count":62},{"year":2012,"cited_by_count":62}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}