{"id":"https://openalex.org/W2152115221","doi":"https://doi.org/10.1161/circoutcomes.108.830232","title":"Should Patient Characteristics Influence Target Anticoagulation Intensity for Stroke Prevention in Nonvalvular Atrial Fibrillation?","display_name":"Should Patient Characteristics Influence Target Anticoagulation Intensity for Stroke Prevention in Nonvalvular Atrial Fibrillation?","publication_year":2009,"publication_date":"2009-06-10","ids":{"openalex":"https://openalex.org/W2152115221","doi":"https://doi.org/10.1161/circoutcomes.108.830232","mag":"2152115221","pmid":"https://pubmed.ncbi.nlm.nih.gov/20031854","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2801892"},"language":"en","primary_location":{"id":"doi:10.1161/circoutcomes.108.830232","doi":"https://doi.org/10.1161/circoutcomes.108.830232","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circoutcomes.108.830232","pdf_url":null,"source":{"id":"https://openalex.org/S52278559","display_name":"Circulation Cardiovascular Quality and Outcomes","issn_l":"1941-7705","issn":["1941-7705","1941-7713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Cardiovascular Quality and Outcomes","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2801892","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020290782","display_name":"Daniel E. Singer","orcid":"https://orcid.org/0000-0001-6145-4848","observed_orcids":["https://orcid.org/0000-0001-6145-4848"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel E. Singer","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050981927","display_name":"Yuchiao Chang","orcid":"https://orcid.org/0000-0003-1093-3755","observed_orcids":["https://orcid.org/0000-0003-1093-3755"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuchiao Chang","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055666587","display_name":"Margaret C. Fang","orcid":"https://orcid.org/0000-0003-3362-1543","observed_orcids":["https://orcid.org/0000-0003-3362-1543"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret C. Fang","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024099354","display_name":"Leila H. Borowsky","orcid":"https://orcid.org/0000-0001-7498-4450","observed_orcids":["https://orcid.org/0000-0001-7498-4450"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leila H. Borowsky","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047189658","display_name":"Niela K. Pomernacki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niela K. Pomernacki","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045231333","display_name":"Natalia V. Udaltsova","orcid":"https://orcid.org/0000-0002-0679-4310","observed_orcids":["https://orcid.org/0000-0002-0679-4310"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natalia Udaltsova","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026846209","display_name":"Alan S. Go","orcid":"https://orcid.org/0000-0001-9109-0811","observed_orcids":["https://orcid.org/0000-0001-9109-0811","https://orcid.org/0000-0001-5671-0763"]},"institutions":[{"id":"https://openalex.org/I1343052199","display_name":"Kaiser Permanente","ror":"https://ror.org/00t60zh31","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1343052199"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4405284138","display_name":"Kaiser Permanente Northern California","ror":"https://ror.org/0302f6d89","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan S. Go","raw_affiliation_strings":["From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Clinical Epidemiology Unit, General Medicine Division (D.E.S., Y.C., L.H.B.), Massachusetts General Hospital, Boston, Mass; the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif; the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif; and the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I180670191","https://openalex.org/I4210087915","https://openalex.org/I4405284138"]},{"raw_affiliation_string":"the Department of Medicine (M.C.F., A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Departments of Epidemiology and Biostatistics (A.S.G.), University of California, San Francisco, Calif","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"the Division of Research (A.S.G., N.K.P., N.U.), Kaiser Permanente of Northern California, Oakland, Calif","institution_ids":["https://openalex.org/I1343052199","https://openalex.org/I4405284138"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.1554,"has_fulltext":false,"cited_by_count":106,"citation_normalized_percentile":{"value":0.9771544,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"2","issue":"4","first_page":"297","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-valvular-atrial-fibrillation","display_name":"non-valvular atrial fibrillation","score":0.9409999847412109},{"id":"https://openalex.org/keywords/anticoagulation-intensity","display_name":"anticoagulation intensity","score":0.796999990940094},{"id":"https://openalex.org/keywords/inr-target-range","display_name":"INR target range","score":0.8199999928474426},{"id":"https://openalex.org/keywords/warfarin","display_name":"warfarin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/ischemic-stroke-prevention","display_name":"ischemic stroke prevention","score":0.8949999809265137},{"id":"https://openalex.org/keywords/thromboembolism","display_name":"thromboembolism","score":0.9300000071525574},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.9959999918937683},{"id":"https://openalex.org/keywords/chads2-score","display_name":"CHADS2 score","score":0.8889999985694885},{"id":"https://openalex.org/keywords/history-of-stroke","display_name":"stroke history","score":0.7200000286102295},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9559530019760132},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.8906603455543518},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6940704584121704},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48549917340278625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.475286602973938},{"id":"https://openalex.org/C2776301958","wikidata":"https://www.wikidata.org/wiki/Q407431","display_name":"Warfarin","level":3,"score":0.4449041485786438},{"id":"https://openalex.org/C93038891","wikidata":"https://www.wikidata.org/wiki/Q1061524","display_name":"Intensity (physics)","level":2,"score":0.41861242055892944},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.41691094636917114},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3451443016529083},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001281","descriptor_name":"Atrial Fibrillation","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D013923","descriptor_name":"Thromboembolism","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014859","descriptor_name":"Warfarin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020300","descriptor_name":"Intracranial Hemorrhages","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1161/circoutcomes.108.830232","doi":"https://doi.org/10.1161/circoutcomes.108.830232","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circoutcomes.108.830232","pdf_url":null,"source":{"id":"https://openalex.org/S52278559","display_name":"Circulation Cardiovascular Quality and Outcomes","issn_l":"1941-7705","issn":["1941-7705","1941-7713"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation: Cardiovascular Quality and Outcomes","raw_type":"journal-article"},{"id":"pmid:20031854","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20031854","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation. Cardiovascular quality and outcomes","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2801892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2801892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Cardiovasc Qual Outcomes","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2801892","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2801892","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Circ Cardiovasc Qual Outcomes","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G3411204215","display_name":"Risks of Warfarin for Elders with Atrial Fibrillation","funder_award_id":"K23AG028978","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5414572495","display_name":"Epidemiology of Anticoagulation in Atrial Fibrillation","funder_award_id":"R01AG015478","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8464679669","display_name":"HMO Research Network Cardiovascular Research Network","funder_award_id":"U19HL091179","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W44202489","https://openalex.org/W1522894564","https://openalex.org/W1585955360","https://openalex.org/W1586488555","https://openalex.org/W1975855508","https://openalex.org/W1986506316","https://openalex.org/W1999085701","https://openalex.org/W2001411232","https://openalex.org/W2004337162","https://openalex.org/W2040859034","https://openalex.org/W2062786076","https://openalex.org/W2063455447","https://openalex.org/W2064836413","https://openalex.org/W2071126330","https://openalex.org/W2078414845","https://openalex.org/W2082378560","https://openalex.org/W2089534375","https://openalex.org/W2103053426","https://openalex.org/W2110167268","https://openalex.org/W2116489124","https://openalex.org/W2119221555","https://openalex.org/W2126789285","https://openalex.org/W2130047524","https://openalex.org/W2132505348","https://openalex.org/W2136065216","https://openalex.org/W2141889414","https://openalex.org/W2143681591","https://openalex.org/W2146243367","https://openalex.org/W2150612389","https://openalex.org/W2150666115","https://openalex.org/W2159193915","https://openalex.org/W2159730165","https://openalex.org/W2160781070","https://openalex.org/W2163012396","https://openalex.org/W2166503147","https://openalex.org/W2166866093","https://openalex.org/W2172245650","https://openalex.org/W2283740320","https://openalex.org/W2340635798","https://openalex.org/W2548706052","https://openalex.org/W3145760233","https://openalex.org/W4206535002","https://openalex.org/W4233664165"],"related_works":["https://openalex.org/W2120064023","https://openalex.org/W2340635798","https://openalex.org/W2126789285","https://openalex.org/W323873945","https://openalex.org/W1971637176","https://openalex.org/W2081205482","https://openalex.org/W2531175253","https://openalex.org/W2999552157","https://openalex.org/W2163012396","https://openalex.org/W2809513293"],"abstract_inverted_index":{"BACKGROUND:":[0],"Randomized":[1],"trials":[2],"and":[3,65,73,89,108,116,136,147],"observational":[4],"studies":[5],"support":[6,272],"using":[7,112],"an":[8],"international":[9],"normalized":[10],"ratio":[11],"(INR)":[12],"target":[13,30],"of":[14,68,74,123,143,161,184,209,221,231,239,254,274],"2.0":[15,81,155,256],"to":[16,58,79,82,156,175,180,199,204,257,278],"3.0":[17,258],"for":[18,259],"preventing":[19],"ischemic":[20],"stroke":[21,109,130,281],"in":[22,263],"atrial":[23,53,260],"fibrillation.":[24],"We":[25,42,84,120],"assessed":[26],"whether":[27],"the":[28,49,60,66,124,128,141,158,251,264],"INR":[29,63,80,150,154,166,178,189,202,215,226,255,266,275],"should":[31],"be":[32],"adjusted":[33],"based":[34],"on":[35,105],"selected":[36,102],"patient":[37],"characteristics.":[38],"METHODS":[39],"AND":[40],"RESULTS:":[41],"conducted":[43],"a":[44],"case-control":[45],"study":[46],"nested":[47],"within":[48],"ATRIA":[50],"cohort's":[51],"9217":[52],"fibrillation":[54,261],"patients":[55],"taking":[56],"warfarin":[57],"define":[59],"relationship":[61],"between":[62],"level":[64],"odds":[67,142,160,169,183,193,208],"thromboembolism":[69],"(TE;":[70],"mainly":[71],"stroke)":[72],"intracranial":[75],"hemorrhage":[76],"(ICH)":[77],"relative":[78,159,207],"2.5.":[83],"identified":[85],"396":[86],"TE":[87,144,162],"cases":[88,92],"164":[90],"ICH":[91,185,210,223],"during":[93],"follow-up.":[94],"Each":[95],"case":[96],"was":[97,218],"compared":[98],"with":[99,153],"4":[100],"randomly":[101],"controls":[103],"matched":[104,113],"calendar":[106],"date":[107],"risk":[110,131,138,224,232,244,282],"factors":[111],"univariable":[114],"analyses":[115],"conditional":[117],"logistic":[118],"regression.":[119],"explored":[121],"modification":[122],"INR-outcome":[125],"relationships":[126],"by":[127,237],"following":[129],"factors:":[132],"prior":[133],"stroke,":[134,240],"age,":[135,241],"CHADS(2)":[137,243],"score.":[139,245],"Overall,":[140],"were":[145,211],"low":[146,213],"stable":[148],"above":[149],"1.8.":[151],"Compared":[152],"2.5,":[157],"increased":[163,186],"strikingly":[164],"at":[165,177,188,201,214,225],"<1.8":[167],"(eg,":[168,192],"ratio,":[170,194],"3.72;":[171],"95%":[172,196],"CI,":[173],"2.67":[174],"5.19,":[176],"1.4":[179],"1.7).":[181],"The":[182,206],"markedly":[187],"values":[190],">3.5":[191],"3.56;":[195],"CI:":[197],"1.70":[198],"7.46,":[200],"3.6":[203],"4.5).":[205],"consistently":[212],"<3.6.":[216],"There":[217],"no":[219],"evidence":[220],"lower":[222],"levels":[227],"<2.0.":[228],"These":[229],"patterns":[230],"did":[233],"not":[234,271],"differ":[235],"substantially":[236],"history":[238],"or":[242],"CONCLUSIONS:":[246],"Our":[247,268],"results":[248],"confirm":[249],"that":[250],"current":[252],"standard":[253],"falls":[262],"optimal":[265],"range.":[267],"findings":[269],"do":[270],"adjustment":[273],"targets":[276],"according":[277],"previously":[279],"defined":[280],"factors.":[283]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}