{"id":"https://openalex.org/W2152089409","doi":"https://doi.org/10.1186/1742-4690-7-11","title":"sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates","display_name":"sCD4-17b bifunctional protein: Extremely broad and potent neutralization of HIV-1 Env pseudotyped viruses from genetically diverse primary isolates","publication_year":2010,"publication_date":"2010-02-16","ids":{"openalex":"https://openalex.org/W2152089409","doi":"https://doi.org/10.1186/1742-4690-7-11","mag":"2152089409","pmid":"https://pubmed.ncbi.nlm.nih.gov/20158904","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2843639"},"language":"en","primary_location":{"id":"doi:10.1186/1742-4690-7-11","doi":"https://doi.org/10.1186/1742-4690-7-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-7-11","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-7-11","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-7-11","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112732156","display_name":"Laurel A. Lagenaur","orcid":"https://orcid.org/0000-0001-6640-839X","observed_orcids":["https://orcid.org/0000-0001-6640-839X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laurel A Lagenaur","raw_affiliation_strings":["Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031361479","display_name":"Vadim A. Villarroel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vadim A Villarroel","raw_affiliation_strings":["Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036761878","display_name":"Virgilio Bundoc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Virgilio Bundoc","raw_affiliation_strings":["Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027739582","display_name":"Barna Dey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barna Dey","raw_affiliation_strings":["Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058743104","display_name":"Edward A. Berger","orcid":"https://orcid.org/0000-0001-8457-3997","observed_orcids":["https://orcid.org/0000-0001-8457-3997"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edward A Berger","raw_affiliation_strings":["Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, 20892, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058743104"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210134534"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":2.026,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.86287776,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"1","first_page":"11","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-neutralizing-antibodies","display_name":"HIV-1 neutralizing antibodies","score":0.7870000004768372},{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.7889999747276306},{"id":"https://openalex.org/keywords/soluble-cd4","display_name":"soluble CD4","score":0.847000002861023},{"id":"https://openalex.org/keywords/hiv-1-subtypes","display_name":"HIV-1 subtypes","score":0.6489999890327454},{"id":"https://openalex.org/keywords/circulating-recombinant-forms","display_name":"circulating recombinant forms","score":0.796999990940094},{"id":"https://openalex.org/keywords/hiv-1-entry-inhibition","display_name":"HIV-1 entry inhibition","score":0.5989999771118164},{"id":"https://openalex.org/keywords/hiv-1-vaccine","display_name":"HIV-1 vaccine","score":0.5699999928474426}],"concepts":[{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.8205872774124146},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.6618829369544983},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.6360259652137756},{"id":"https://openalex.org/C2780443040","wikidata":"https://www.wikidata.org/wiki/Q3737863","display_name":"Bifunctional","level":3,"score":0.5757741332054138},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5497314929962158},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5176680088043213},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48660194873809814},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.4798312187194824},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4539879858493805},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.44677355885505676},{"id":"https://openalex.org/C2776997796","wikidata":"https://www.wikidata.org/wiki/Q1345259","display_name":"Entry inhibitor","level":5,"score":0.42691439390182495},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.41905486583709717},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39748039841651917},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.376677542924881},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.2875964641571045},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.273553729057312},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2191556692123413},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.2137914001941681},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.18999147415161133},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.16500401496887207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1282828450202942},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001688","descriptor_name":"Biological Products","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015483","descriptor_name":"HIV Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1742-4690-7-11","doi":"https://doi.org/10.1186/1742-4690-7-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-7-11","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-7-11","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2843639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2843639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Text"},{"id":"pmid:20158904","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20158904","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2c5273d07fec48cb94e692107da82b20","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2c5273d07fec48cb94e692107da82b20","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Retrovirology, Vol 7, Iss 1, p 11 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-4690-7-11","doi":"https://doi.org/10.1186/1742-4690-7-11","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-4690-7-11","pdf_url":"https://retrovirology.biomedcentral.com/counter/pdf/10.1186/1742-4690-7-11","source":{"id":"https://openalex.org/S54115554","display_name":"Retrovirology","issn_l":"1742-4690","issn":["1742-4690"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Retrovirology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152089409.pdf","grobid_xml":"https://content.openalex.org/works/W2152089409.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W72329031","https://openalex.org/W150399887","https://openalex.org/W1479910554","https://openalex.org/W1480555318","https://openalex.org/W1587830797","https://openalex.org/W1607434342","https://openalex.org/W1628484047","https://openalex.org/W1631767963","https://openalex.org/W1971777539","https://openalex.org/W1980965429","https://openalex.org/W1981726195","https://openalex.org/W1982525636","https://openalex.org/W1982846458","https://openalex.org/W1984609370","https://openalex.org/W1993366615","https://openalex.org/W1995355944","https://openalex.org/W1997677784","https://openalex.org/W1997989849","https://openalex.org/W2000361373","https://openalex.org/W2002944156","https://openalex.org/W2007300056","https://openalex.org/W2010521915","https://openalex.org/W2012451048","https://openalex.org/W2017551575","https://openalex.org/W2018444971","https://openalex.org/W2023989211","https://openalex.org/W2029804942","https://openalex.org/W2031420717","https://openalex.org/W2032104932","https://openalex.org/W2038114373","https://openalex.org/W2038504202","https://openalex.org/W2055253070","https://openalex.org/W2059441263","https://openalex.org/W2079028174","https://openalex.org/W2081291921","https://openalex.org/W2083726777","https://openalex.org/W2083803997","https://openalex.org/W2091180436","https://openalex.org/W2097480342","https://openalex.org/W2098781795","https://openalex.org/W2101722262","https://openalex.org/W2105118712","https://openalex.org/W2110499527","https://openalex.org/W2113645094","https://openalex.org/W2115906128","https://openalex.org/W2124935744","https://openalex.org/W2126977955","https://openalex.org/W2128461524","https://openalex.org/W2131903471","https://openalex.org/W2140927222","https://openalex.org/W2143036112","https://openalex.org/W2143649821","https://openalex.org/W2146704167","https://openalex.org/W2147009832","https://openalex.org/W2147907754","https://openalex.org/W2147947123","https://openalex.org/W2150412330","https://openalex.org/W2157615131","https://openalex.org/W2157616888","https://openalex.org/W2172063653","https://openalex.org/W4245781185"],"related_works":["https://openalex.org/W1968798652","https://openalex.org/W2012451048","https://openalex.org/W1982887925","https://openalex.org/W1991539551","https://openalex.org/W2150412330","https://openalex.org/W2005099669","https://openalex.org/W2102670802","https://openalex.org/W7100338990","https://openalex.org/W2156997818","https://openalex.org/W1988781661"],"abstract_inverted_index":{"BACKGROUND:":[0],"We":[1,168,184],"previously":[2,199],"described":[3],"a":[4,17,147,152,218,221,235,238,340],"potent":[5,259,354,365],"recombinant":[6,283],"HIV-1":[7,158,192,197,268,375],"neutralizing":[8,139,260,303,368],"protein,":[9],"sCD4-17b,":[10],"composed":[11],"of":[12,24,38,47,115,130,141,155,174,246,264,314,370],"soluble":[13],"CD4":[14,120],"attached":[15],"via":[16],"flexible":[18],"polypeptide":[19],"linker":[20,134,239],"to":[21,52,63,201,242,295,318,387],"an":[22],"SCFv":[23,61,251],"the":[25,32,48,59,67,77,102,113,138,142,162,171,206,214,247,301,333,348,356,363],"17b":[26,60,250],"human":[27],"monoclonal":[28,304,349],"antibody":[29],"directed":[30],"against":[31,108,151,262,321,355,372],"highly":[33],"conserved":[34],"CD4-induced":[35],"bridging":[36],"sheet":[37],"gp120":[39,53],"involved":[40],"in":[41,205],"coreceptor":[42],"binding.":[43],"The":[44,73,209,288,312,360,378],"sCD4":[45,248],"moiety":[46,62],"bifunctional":[49,379],"protein":[50,380],"binds":[51],"on":[54],"free":[55],"virions,":[56],"thereby":[57],"enabling":[58],"bind":[64],"and":[65,121,136,217,230,249,281,286,291,310,366],"block":[66],"gp120/coreceptor":[68],"interaction":[69],"required":[70],"for":[71,118,213,300,384],"entry.":[72],"previous":[74],"studies":[75],"using":[76,161],"MAGI-CCR5":[78,207],"assay":[79,166],"system":[80],"indicated":[81],"that":[82,186],"sCD4-17b":[83,131,172,189,257,315,371],"(in":[84],"concentrated":[85],"cell":[86,181,336],"culture":[87],"medium,":[88],"or":[89,338],"partially":[90],"purified)":[91],"potently":[92],"neutralized":[93,191],"several":[94,109],"genetically":[95,156,373],"diverse":[96,157,272,374],"HIIV-1":[97],"primary":[98,159,269,376],"isolates;":[99],"however,":[100],"at":[101],"concentrations":[103],"tested":[104,137],"it":[105],"was":[106,253,316],"ineffective":[107],"other":[110],"strains":[111],"despite":[112],"conservation":[114],"binding":[116,245],"sites":[117],"both":[119,227],"17b.":[122],"To":[123],"address":[124],"this":[125,345],"puzzle,":[126],"we":[127],"designed":[128],"variants":[129],"with":[132,220,226,237,347],"different":[133,179],"lengths,":[135],"activities":[140],"immunoaffinity":[143,187],"purified":[144,188],"proteins":[145],"over":[146],"broader":[148],"concentration":[149],"range":[150],"large":[153],"number":[154],"isolates,":[160],"TZM-bl":[163],"Env":[164],"pseudotype":[165,228],"system.":[167],"also":[169],"examined":[170],"sensitivities":[173],"isogenic":[175,322],"viruses":[176],"generated":[177],"from":[178,196,271,325,332],"producer":[180,335],"types.":[182],"RESULTS:":[183],"observed":[185,225],"effectively":[190],"pseudotypes,":[193],"including":[194],"those":[195],"isolates":[198,270],"found":[200,317],"be":[202,319],"relatively":[203],"insensitive":[204],"assay.":[208],"potencies":[210],"were":[211,293,352],"equivalent":[212],"original":[215],"construct":[216,236],"variant":[219],"longer":[222],"linker,":[223],"as":[224],"particles":[229,324],"infectious":[231,326],"virions;":[232],"by":[233],"contrast,":[234],"too":[240],"short":[241],"enable":[243],"simultaneous":[244],"moieties":[252],"much":[254],"less":[255,353],"effective.":[256],"displayed":[258],"activity":[261,313,369],"100%":[263],"nearly":[265],"4":[266],"dozen":[267],"genetic":[273],"subtypes":[274],"(clades":[275],"A,":[276],"B,":[277],"C,":[278],"D,":[279],"F,":[280],"circulating":[282],"forms":[284],"AE":[285],"AG).":[287],"neutralization":[289],"breadth":[290],"potency":[292],"superior":[294],"what":[296],"have":[297],"been":[298],"reported":[299],"broadly":[302],"antibodies":[305],"IgG":[306],"b12,":[307],"2G12,":[308],"2F5,":[309],"4E10.":[311],"similar":[320],"virus":[323],"molecular":[327],"clones":[328],"derived":[329],"either":[330],"directly":[331],"transfected":[334],"line":[337],"after":[339],"single":[341],"passage":[342],"through":[343],"PBMCs;":[344],"contrasted":[346],"antibodies,":[350],"which":[351],"PMBC-passaged":[357],"viruses.":[358],"CONCLUSIONS:":[359],"results":[361],"highlight":[362],"extremely":[364],"broad":[367],"isolates.":[377],"has":[381],"potential":[382],"applications":[383],"antiviral":[385],"approaches":[386],"combat":[388],"HIV":[389],"infection.":[390]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
