{"id":"https://openalex.org/W2152017408","doi":"https://doi.org/10.1002/dvg.20734","title":"Generation of Osr1 conditional mutant mice","display_name":"Generation of Osr1 conditional mutant mice","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W2152017408","doi":"https://doi.org/10.1002/dvg.20734","mag":"2152017408","pmid":"https://pubmed.ncbi.nlm.nih.gov/21462293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3096694"},"language":"en","primary_location":{"id":"doi:10.1002/dvg.20734","doi":"https://doi.org/10.1002/dvg.20734","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dvg.20734","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvg.20734","source":{"id":"https://openalex.org/S124648948","display_name":"genesis","issn_l":"1526-954X","issn":["1526-954X","1526-968X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"genesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvg.20734","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019190546","display_name":"Yu Lan","orcid":"https://orcid.org/0000-0001-5611-3600","observed_orcids":["https://orcid.org/0000-0001-5611-3600"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Lan","raw_affiliation_strings":["Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA","Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100349032","display_name":"Han Liu","orcid":"https://orcid.org/0000-0002-0014-4675","observed_orcids":["https://orcid.org/0000-0002-0014-4675","https://orcid.org/0000-0002-4756-7149"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han Liu","raw_affiliation_strings":["Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074015682","display_name":"Catherine E. Ovitt","orcid":"https://orcid.org/0000-0002-8045-3119","observed_orcids":["https://orcid.org/0000-0002-8045-3119"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine E. Ovitt","raw_affiliation_strings":["Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050198479","display_name":"Rulang Jiang","orcid":"https://orcid.org/0000-0001-7842-4696","observed_orcids":["https://orcid.org/0000-0001-7842-4696"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rulang Jiang","raw_affiliation_strings":["Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050198479"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.427,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.80850381,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"49","issue":"5","first_page":"419","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osr1","display_name":"OSR1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/conditional-mutant-mice","display_name":"conditional mutant mice","score":0.8450000286102295},{"id":"https://openalex.org/keywords/exon-2-deletion","display_name":"exon 2 deletion","score":0.8700000047683716},{"id":"https://openalex.org/keywords/embryonic-lethality","display_name":"embryonic lethality","score":0.7279999852180481},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.7429999709129333},{"id":"https://openalex.org/keywords/kidney-development","display_name":"kidney development","score":0.9990000128746033},{"id":"https://openalex.org/keywords/zinc-finger-transcription-factor","display_name":"zinc finger transcription factor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/tissue-specific-gene-deletion","display_name":"tissue-specific gene deletion","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7553790807723999},{"id":"https://openalex.org/C125929170","wikidata":"https://www.wikidata.org/wiki/Q908966","display_name":"Cre recombinase","level":5,"score":0.6717141270637512},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6213715076446533},{"id":"https://openalex.org/C111829913","wikidata":"https://www.wikidata.org/wiki/Q211083","display_name":"Gene targeting","level":3,"score":0.6112976670265198},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.5584744215011597},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.5057015419006348},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4991624355316162},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4659688472747803},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.46367570757865906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.424194872379303},{"id":"https://openalex.org/C57708383","wikidata":"https://www.wikidata.org/wiki/Q260182","display_name":"Null allele","level":4,"score":0.42188718914985657},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40871113538742065},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4070419669151306},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3881511390209198}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004622","descriptor_name":"Embryo, Mammalian","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006720","descriptor_name":"Homozygote","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016335","descriptor_name":"Zinc Fingers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018390","descriptor_name":"Gene Targeting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/dvg.20734","doi":"https://doi.org/10.1002/dvg.20734","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dvg.20734","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvg.20734","source":{"id":"https://openalex.org/S124648948","display_name":"genesis","issn_l":"1526-954X","issn":["1526-954X","1526-968X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"genesis","raw_type":"journal-article"},{"id":"pmid:21462293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21462293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genesis (New York, N.Y. : 2000)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3096694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3096694","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Genesis","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/dvg.20734","doi":"https://doi.org/10.1002/dvg.20734","is_oa":true,"landing_page_url":"https://doi.org/10.1002/dvg.20734","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/dvg.20734","source":{"id":"https://openalex.org/S124648948","display_name":"genesis","issn_l":"1526-954X","issn":["1526-954X","1526-968X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"genesis","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1934008728","display_name":"Molecular Genetic Analysis of Craniofacial Development","funder_award_id":"R01DE013681","funder_id":"https://openalex.org/F4320337365","funder_display_name":"National Institute of Dental and Craniofacial Research"}],"funders":[{"id":"https://openalex.org/F4320310246","display_name":"University of Rochester","ror":"https://ror.org/022kthw22"},{"id":"https://openalex.org/F4320337365","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2152017408.pdf"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1892628412","https://openalex.org/W1968963646","https://openalex.org/W1970638355","https://openalex.org/W1982787171","https://openalex.org/W1989534794","https://openalex.org/W1989677751","https://openalex.org/W1996984755","https://openalex.org/W2000572318","https://openalex.org/W2009238952","https://openalex.org/W2009487182","https://openalex.org/W2021298018","https://openalex.org/W2034349608","https://openalex.org/W2034717801","https://openalex.org/W2039248606","https://openalex.org/W2040118243","https://openalex.org/W2049377084","https://openalex.org/W2051843832","https://openalex.org/W2058172887","https://openalex.org/W2069704514","https://openalex.org/W2080782437","https://openalex.org/W2106598628","https://openalex.org/W2107648723","https://openalex.org/W2117432415","https://openalex.org/W2128323213","https://openalex.org/W2141810902","https://openalex.org/W2147304062","https://openalex.org/W2152111811","https://openalex.org/W2153726199","https://openalex.org/W2158021558","https://openalex.org/W2159943242","https://openalex.org/W2275175924"],"related_works":["https://openalex.org/W2011179743","https://openalex.org/W2021298018","https://openalex.org/W2034717801","https://openalex.org/W2049377084","https://openalex.org/W2056183549","https://openalex.org/W1778065828","https://openalex.org/W1996808043","https://openalex.org/W2060434989","https://openalex.org/W2974057972","https://openalex.org/W1989677751"],"abstract_inverted_index":{"The":[0,138],"Odd-skipped":[1,15],"related":[2],"1":[3],"(Osr1)":[4],"gene":[5],"encodes":[6],"a":[7],"zinc":[8],"finger":[9],"protein":[10],"homologous":[11],"to":[12],"the":[13,28,54,58,76,90,106,110,119,123,133,150],"Drosophila":[14],"transcription":[16],"factor.":[17],"During":[18],"mouse":[19],"embryogenesis,":[20],"Osr1":[21,48,59,91,134,153],"is":[22],"expressed":[23],"in":[24,49,68,115,122,154],"multiple":[25],"tissues,":[26],"including":[27],"developing":[29],"heart,":[30],"kidney,":[31],"limb,":[32],"lung,":[33],"and":[34,51,103,126,156],"craniofacial":[35],"structures.":[36],"Although":[37],"characterization":[38],"of":[39,57,65,78,89,118,149,152],"targeted":[40,97],"mutant":[41,80,136],"mice":[42,61,81,108,113,127,142],"has":[43,62],"revealed":[44],"essential":[45],"roles":[46,151],"for":[47,95,129,146],"heart":[50],"kidney":[52],"development,":[53],"embryonic":[55,155],"lethality":[56],"null":[60,135],"hindered":[63],"investigation":[64],"its":[66],"role":[67],"many":[69],"other":[70],"developmental":[71,158],"processes.":[72,159],"We":[73],"report":[74],"here":[75],"generation":[77],"conditional":[79,141],"containing":[82],"two":[83],"loxP":[84],"sites":[85],"flanking":[86],"exon":[87],"2":[88],"gene.":[92],"Mice":[93],"homozygous":[94,128],"this":[96,130],"Osr1(":[98,139],"fneo)":[99,140],"allele":[100],"are":[101],"normal":[102],"fertile.":[104],"Crossing":[105],"Osr1(fneo/fneo)":[107],"with":[109],"EIIa-Cre":[111],"transgenic":[112],"resulted":[114],"Cre-mediated":[116],"deletion":[117,131],"loxP-flanked":[120],"Exon2":[121],"germ":[124],"line":[125],"recapitulated":[132],"phenotypes.":[137],"will":[143],"be":[144],"valuable":[145],"tissue-specific":[147],"analysis":[148],"postnatal":[157],"genesis":[160],"49:419-422,":[161],"2011.":[162]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
