{"id":"https://openalex.org/W2151988692","doi":"https://doi.org/10.3109/00498258609050251","title":"The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation","display_name":"The molecular mechanisms of two common polymorphisms of drug oxidation-evidence for functional changes in cytochrome P-450 isozymes catalysing bufuralol and mephenytoin oxidation","publication_year":1986,"publication_date":"1986-01-01","ids":{"openalex":"https://openalex.org/W2151988692","doi":"https://doi.org/10.3109/00498258609050251","mag":"2151988692","pmid":"https://pubmed.ncbi.nlm.nih.gov/2874666"},"language":"en","primary_location":{"id":"doi:10.3109/00498258609050251","doi":"https://doi.org/10.3109/00498258609050251","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00498258609050251","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053870539","display_name":"Urs Meyer","orcid":"https://orcid.org/0000-0001-7244-0345","observed_orcids":["https://orcid.org/0000-0001-7244-0345"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"U. A. Meyer","raw_affiliation_strings":["Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113228924","display_name":"Josef Gut","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J. Gut","raw_affiliation_strings":["Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036729172","display_name":"Thomas Kronbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"T. Kronbach","raw_affiliation_strings":["Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042667638","display_name":"C. Skoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"C. Skoda","raw_affiliation_strings":["Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004333869","display_name":"U. Thomas Meier","orcid":"https://orcid.org/0000-0001-6677-2677","observed_orcids":["https://orcid.org/0000-0001-6677-2677"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"U. T. Meier","raw_affiliation_strings":["Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080512427","display_name":"Therese Catin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"T. Catin","raw_affiliation_strings":["Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Biocenter of the University of Basel, CH-4056, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019857762","display_name":"Pierre Dayer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106256","display_name":"University Hospital of Geneva","ror":"https://ror.org/01m1pv723","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210106256"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P. Dayer","raw_affiliation_strings":["Clinical Pharmacology Unit, University of Geneva Hospital, CH-1211, Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Unit, University of Geneva Hospital, CH-1211, Geneva 4, Switzerland","institution_ids":["https://openalex.org/I4210106256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.7666,"has_fulltext":false,"cited_by_count":130,"citation_normalized_percentile":{"value":0.98976204,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"16","issue":"5","first_page":"449","last_page":"464"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyp2c9-polymorphism","display_name":"CYP2C9 polymorphism","score":0.5989999771118164},{"id":"https://openalex.org/keywords/cyp2c19-polymorphism","display_name":"CYP2C19 polymorphism","score":0.8190000057220459},{"id":"https://openalex.org/keywords/debrisoquine","display_name":"debrisoquine","score":0.6460000276565552},{"id":"https://openalex.org/keywords/sparteine","display_name":"sparteine","score":0.9760000109672546},{"id":"https://openalex.org/keywords/stereospecific-metabolism","display_name":"stereospecific metabolism","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cytochrome-p450-isozymes","display_name":"cytochrome P450 isozymes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cyp2c9-2","display_name":"CYP2C9*2","score":0.5429999828338623},{"id":"https://openalex.org/keywords/cyp2c19-2","display_name":"CYP2C19*2","score":0.8669999837875366},{"id":"https://openalex.org/keywords/quinidine-inhibition","display_name":"quinidine inhibition","score":0.9049999713897705},{"id":"https://openalex.org/keywords/enzyme-deficiency","display_name":"enzyme deficiency","score":0.40299999713897705},{"id":"https://openalex.org/keywords/poor-metabolizers","display_name":"poor metabolizers","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.8376673460006714},{"id":"https://openalex.org/C2778694420","wikidata":"https://www.wikidata.org/wiki/Q419552","display_name":"Sparteine","level":2,"score":0.8103999495506287},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.7997044324874878},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.7847967147827148},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.6837189793586731},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6834369897842407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6027995944023132},{"id":"https://openalex.org/C2776838488","wikidata":"https://www.wikidata.org/wiki/Q1175385","display_name":"Mephenytoin","level":5,"score":0.5440099239349365},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5223713517189026},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5030490756034851},{"id":"https://openalex.org/C187921627","wikidata":"https://www.wikidata.org/wiki/Q2469470","display_name":"Stereospecificity","level":3,"score":0.5009503364562988},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.4815266728401184},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45769554376602173},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45183759927749634},{"id":"https://openalex.org/C89311334","wikidata":"https://www.wikidata.org/wiki/Q1124842","display_name":"Drug metabolism","level":3,"score":0.44771990180015564},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.442231148481369},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2676883041858673},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.12798452377319336},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09485173225402832},{"id":"https://openalex.org/C140840227","wikidata":"https://www.wikidata.org/wiki/Q3737532","display_name":"CYP2C19","level":4,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004983","descriptor_name":"Ethanolamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006827","descriptor_name":"Hydantoins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008617","descriptor_name":"Mephenytoin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008790","descriptor_name":"Metoprolol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014019","descriptor_name":"Tissue Donors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/00498258609050251","doi":"https://doi.org/10.3109/00498258609050251","is_oa":false,"landing_page_url":"https://doi.org/10.3109/00498258609050251","pdf_url":null,"source":{"id":"https://openalex.org/S48760969","display_name":"Xenobiotica","issn_l":"0049-8254","issn":["0049-8254","1366-5928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica","raw_type":"journal-article"},{"id":"pmid:2874666","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2874666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Xenobiotica; the fate of foreign compounds in biological systems","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1971027234","https://openalex.org/W1972269897","https://openalex.org/W1982671241","https://openalex.org/W1984850614","https://openalex.org/W1992700556","https://openalex.org/W2002009588","https://openalex.org/W2006778720","https://openalex.org/W2031889281","https://openalex.org/W2049008689","https://openalex.org/W2066094532","https://openalex.org/W2084449553","https://openalex.org/W2084931114","https://openalex.org/W2092116907","https://openalex.org/W2125889771","https://openalex.org/W2155324370","https://openalex.org/W2169514401","https://openalex.org/W2171589895","https://openalex.org/W2178350164","https://openalex.org/W2470723664"],"related_works":["https://openalex.org/W1524323459","https://openalex.org/W2084931114","https://openalex.org/W1540726821","https://openalex.org/W1972269897","https://openalex.org/W2010281912","https://openalex.org/W1987593275","https://openalex.org/W2052367691","https://openalex.org/W1969215912","https://openalex.org/W2049008689","https://openalex.org/W2125889771"],"abstract_inverted_index":{"Using":[0],"the":[1,18,22,85,88,94,104,145,219,249,256,283,338,366],"stereospecific":[2,112,291],"metabolism":[3,52,113,214,285,292],"of":[4,21,29,43,53,58,64,84,87,96,103,107,114,147,233,237,273,293,300,305,311,335,340,371],"(+)-":[5,9],"and":[6,8,10,39,80,116,130,177,208,217,229,239,265,302,320,332],"(-)-bufuralol":[7],"(-)-metoprolol":[11],"as":[12,169,327],"model":[13,102],"reactions,":[14],"we":[15],"have":[16],"characterized":[17,69,194,315],"enzymic":[19],"deficiency":[20],"debrisoquine/sparteine-type":[23],"polymorphism":[24],"by":[25,70,188,195,201,316],"comparing":[26],"kinetic":[27],"data":[28],"subjects":[30],"in":[31,37,55,59,74,78,98,161,215,231,248,286,297,308,368],"vivo":[32,60],"with":[33,40,135,218,224,227,346,359],"their":[34,148],"microsomal":[35],"activities":[36,42],"vitro":[38,232],"reconstituted":[41,220],"cytochrome":[44,109,124,344],"P-450":[45,110,125,127,131,156,172,189,205,209,262,266,274,345],"isozymes":[46],"purified":[47,140,353],"from":[48,141,235,354],"human":[49,142,355],"liver.":[50,356],"The":[51,288],"bufuralol":[54,115,152,160,186,213],"liver":[56,143,298],"microsomes":[57,97,216,228,299,370],"phenotyped":[61,307],"'poor":[62],"metabolizers'":[63],"debrisoquine":[65],"and/or":[66],"sparteine":[67],"is":[68],"a":[71,76,81,108,162,179,246,270,321,333,372],"marked":[72],"increase":[73],"Km,":[75],"decrease":[77,247],"Vmax":[79,323],"virtual":[82],"loss":[83,334],"stereoselectivity":[86],"reaction.":[89],"These":[90],"parameters":[91],"apparently":[92],"allow":[93],"'phenotyping'":[95],"vitro.":[99],"A":[100,343],"structural":[101],"active":[105],"site":[106],"for":[111,183,245,324,337,349],"other":[117],"polymorphically":[118],"metabolized":[119,159],"substrates":[120],"was":[121,192,295,352],"constructed.":[122],"Two":[123],"isozymes,":[126],"buf":[128,132,157,173,190,206,210,263,267,275],"I":[129,158,191,207,264,276],"II,":[133,268],"both":[134,269],"MW":[136],"50,000":[137],"Da,":[138],"were":[139,314],"on":[144],"basis":[146],"ability":[149],"to":[150,153,171,199,329],"metabolize":[151],"1'-hydroxy-bufuralol.":[154],"However,":[155],"highly":[163],"stereoselective":[164],"fashion":[165],"((-)/(+)":[166],"ratio":[167],"0.16)":[168],"compared":[170,328],"II":[174,211],"(ratio":[175],"0.99)":[176],"had":[178],"markedly":[180],"lower":[181],"Km":[182,319],"bufuralol.":[184],"Moreover,":[185],"1'-hydroxylation":[187],"uniquely":[193],"its":[196,253,278],"extreme":[197],"sensitivity":[198],"inhibition":[200],"quinidine.":[202],"Antibodies":[203],"against":[204,362],"inhibited":[212],"enzymes.":[221],"Immunochemical":[222,357],"studies":[223,358],"these":[225],"antibodies":[226,257,361],"translations":[230],"RNA":[234],"livers":[236],"extensive":[238,301,330],"poor":[240,303,312],"metabolizers":[241,304,313,331],"showed":[242],"no":[243],"evidence":[244],"recognized":[250],"protein":[251],"or":[252,277],"mRNA.":[254],"Because":[255],"do":[258],"not":[259],"discriminate":[260],"between":[261],"decreased":[271,322],"content":[272],"functional":[279],"alteration":[280],"could":[281],"explain":[282],"polymorphic":[284],"microsomes.":[287],"genetically":[289],"defective":[290],"mephenytoin":[294,306,350],"determined":[296],"vivo.":[309],"Microsomes":[310],"an":[317],"increased":[318],"S-mephenytoin":[325],"hydroxylation":[326,339],"stereospecificity":[336],"S-versus":[341],"R-mephenytoin.":[342],"high":[347],"activity":[348],"4-hydroxylation":[351],"inhibitory":[360],"this":[363],"isozyme":[364],"suggest":[365],"presence":[367],"poor-metabolizer":[369],"functionally":[373],"altered":[374],"enzyme.":[375]},"counts_by_year":[{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
