{"id":"https://openalex.org/W2151985389","doi":"https://doi.org/10.1124/mol.109.062687","title":"Alcohol- and Alcohol Antagonist-Sensitive Human GABAA Receptors: Tracking \u03b4 Subunit Incorporation into Functional Receptors","display_name":"Alcohol- and Alcohol Antagonist-Sensitive Human GABAA Receptors: Tracking \u03b4 Subunit Incorporation into Functional Receptors","publication_year":2010,"publication_date":"2010-08-11","ids":{"openalex":"https://openalex.org/W2151985389","doi":"https://doi.org/10.1124/mol.109.062687","mag":"2151985389","pmid":"https://pubmed.ncbi.nlm.nih.gov/20699325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981361"},"language":"en","primary_location":{"id":"doi:10.1124/mol.109.062687","doi":"https://doi.org/10.1124/mol.109.062687","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.109.062687","pdf_url":"https://molpharm.aspetjournals.org/content/molpharm/78/5/918.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://molpharm.aspetjournals.org/content/molpharm/78/5/918.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043136568","display_name":"Pratap Meera","orcid":"https://orcid.org/0000-0001-9483-6690","observed_orcids":["https://orcid.org/0000-0001-9483-6690"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pratap Meera","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1735, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1735, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112027890","display_name":"Richard W. Olsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard W. Olsen","raw_affiliation_strings":["Department of Neurobiology (P..) and Molecular and Medical Pharmacology (R","Department of Neurobiology (P"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (P..) and Molecular and Medical Pharmacology (R","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology (P","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073764338","display_name":"Thomas S. Otis","orcid":"https://orcid.org/0000-0003-0383-8928","observed_orcids":["https://orcid.org/0000-0003-0383-8928"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas S. Otis","raw_affiliation_strings":["Department of Neurobiology (P..) and Molecular and Medical Pharmacology (R","Geffen School of Medicine , University of California , Los Angeles , California","Department of Neurobiology (P"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology (P..) and Molecular and Medical Pharmacology (R","institution_ids":[]},{"raw_affiliation_string":"Geffen School of Medicine , University of California , Los Angeles , California","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Neurobiology (P","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044070832","display_name":"Martin Wallner","orcid":"https://orcid.org/0000-0003-4134-8946","observed_orcids":["https://orcid.org/0000-0003-4134-8946"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin Wallner","raw_affiliation_strings":["Department of Molecular and Medical Pharmacology , 23-338 CHS , Los Angeles CA 90095-1735","Department of Neurobiology (P..) and Molecular and Medical Pharmacology (R","Department of Neurobiology (P"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Pharmacology , 23-338 CHS , Los Angeles CA 90095-1735","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology (P..) and Molecular and Medical Pharmacology (R","institution_ids":[]},{"raw_affiliation_string":"Department of Neurobiology (P","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.5616,"has_fulltext":true,"cited_by_count":35,"citation_normalized_percentile":{"value":0.80625477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"78","issue":"5","first_page":"918","last_page":"924"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11818","display_name":"Nicotinic Acetylcholine Receptors Study","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.925000011920929},{"id":"https://openalex.org/keywords/delta-subunit","display_name":"delta subunit","score":0.7760000228881836},{"id":"https://openalex.org/keywords/ethanol-sensitivity","display_name":"ethanol sensitivity","score":0.9049999713897705},{"id":"https://openalex.org/keywords/ro-15-4513","display_name":"Ro 15-4513","score":0.9559999704360962},{"id":"https://openalex.org/keywords/tonic-inhibition","display_name":"tonic inhibition","score":0.6230000257492065},{"id":"https://openalex.org/keywords/extrasynaptic-receptors","display_name":"extrasynaptic receptors","score":0.8669999837875366},{"id":"https://openalex.org/keywords/zinc-block","display_name":"zinc block","score":0.5759999752044678},{"id":"https://openalex.org/keywords/cell-to-cell-variability","display_name":"cell-to-cell variability","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.752837061882019},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7271090745925903},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.5583102703094482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5212476849555969},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.4107920527458191},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39662790298461914},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35306912660598755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2699284553527832}],"mesh":[{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000494","descriptor_name":"Allosteric Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001386","descriptor_name":"Azides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001569","descriptor_name":"Benzodiazepines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002243","descriptor_name":"Carbolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002413","descriptor_name":"Cations, Divalent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003975","descriptor_name":"Diazepam","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1124/mol.109.062687","doi":"https://doi.org/10.1124/mol.109.062687","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.109.062687","pdf_url":"https://molpharm.aspetjournals.org/content/molpharm/78/5/918.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2981361","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2981361","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Pharmacol","raw_type":"Text"},{"id":"pmid:20699325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20699325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.936.3905","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.936.3905","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molpharm.aspetjournals.org/content/early/2010/08/10/mol.109.062687.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.948.8077","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.948.8077","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://molpharm.aspetjournals.org/content/78/5/918.full.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10034739","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/10034739/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular Pharmacology , 78 (5) pp. 918-924. (2010)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1124/mol.109.062687","doi":"https://doi.org/10.1124/mol.109.062687","is_oa":true,"landing_page_url":"https://doi.org/10.1124/mol.109.062687","pdf_url":"https://molpharm.aspetjournals.org/content/molpharm/78/5/918.full.pdf","source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G554607850","display_name":"Plasticity of GABA-Mediated Inhibition","funder_award_id":"P01NS035985","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6999180065","display_name":"Ethanol sensitivity in delta subunit-containing GABA(A) receptors","funder_award_id":"R01AA017891","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320310207","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151985389.pdf","grobid_xml":"https://content.openalex.org/works/W2151985389.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1520068218","https://openalex.org/W1564393091","https://openalex.org/W1591864135","https://openalex.org/W1607092694","https://openalex.org/W1755149675","https://openalex.org/W1971627886","https://openalex.org/W1972816277","https://openalex.org/W1980471589","https://openalex.org/W1983967908","https://openalex.org/W1984312005","https://openalex.org/W1985881933","https://openalex.org/W1988635841","https://openalex.org/W1991847312","https://openalex.org/W1998719957","https://openalex.org/W2004166962","https://openalex.org/W2016321438","https://openalex.org/W2028650350","https://openalex.org/W2032093027","https://openalex.org/W2042507192","https://openalex.org/W2050252164","https://openalex.org/W2053928326","https://openalex.org/W2055872879","https://openalex.org/W2061947653","https://openalex.org/W2065692979","https://openalex.org/W2071709232","https://openalex.org/W2077225758","https://openalex.org/W2078116708","https://openalex.org/W2080338616","https://openalex.org/W2086581191","https://openalex.org/W2089911890","https://openalex.org/W2097812689","https://openalex.org/W2104021021","https://openalex.org/W2106607972","https://openalex.org/W2109471085","https://openalex.org/W2117770293","https://openalex.org/W2119109339","https://openalex.org/W2123595571","https://openalex.org/W2127385137","https://openalex.org/W2135663048","https://openalex.org/W2137471600","https://openalex.org/W2148975169","https://openalex.org/W2169019760","https://openalex.org/W2504438532"],"related_works":["https://openalex.org/W7099919054","https://openalex.org/W1978493649","https://openalex.org/W7098862862","https://openalex.org/W1971627886","https://openalex.org/W2077225758","https://openalex.org/W2127385137","https://openalex.org/W2025364532","https://openalex.org/W1966725378","https://openalex.org/W1972816277","https://openalex.org/W2032093027"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}