{"id":"https://openalex.org/W2151982942","doi":null,"title":"Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.","display_name":"Photodynamic therapy with the phthalocyanine photosensitizer Pc 4 of SW480 human colon cancer xenografts in athymic mice.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2151982942","mag":"2151982942","pmid":"https://pubmed.ncbi.nlm.nih.gov/10815928"},"language":"en","primary_location":{"id":"pmid:10815928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045722540","display_name":"Cecilia M. Whitacre","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Whitacre","raw_affiliation_strings":["Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4937, USA. cxw34@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106-4937, USA. cxw34@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016335728","display_name":"Denise K. Feyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D K Feyes","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058524907","display_name":"Taroh Satoh","orcid":"https://orcid.org/0000-0002-4615-2638","observed_orcids":["https://orcid.org/0000-0002-4615-2638"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Satoh","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039447522","display_name":"Johannes Grossmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J Grossmann","raw_affiliation_strings":["University of Regensburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Regensburg","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111831300","display_name":"John W. Mulvihill","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J W Mulvihill","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082425428","display_name":"Hasan Mukhtar","orcid":"https://orcid.org/0000-0002-5358-077X","observed_orcids":["https://orcid.org/0000-0002-5358-077X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H Mukhtar","raw_affiliation_strings":["Case Western Reserve University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043087658","display_name":"Nancy L. Oleinick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N L Oleinick","raw_affiliation_strings":["Case Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4390039247"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.512,"has_fulltext":false,"cited_by_count":99,"citation_normalized_percentile":{"value":0.92519951,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"2021","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10903","display_name":"Porphyrin and Phthalocyanine Chemistry","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/photodynamic-therapy","display_name":"photodynamic therapy","score":1.0},{"id":"https://openalex.org/keywords/silicon-phthalocyanine","display_name":"silicon phthalocyanine","score":0.8489999771118164},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.8619999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.796999990940094},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9509999752044678},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":1.0},{"id":"https://openalex.org/keywords/parp-cleavage","display_name":"PARP cleavage","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8119999766349792},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tp53-status","display_name":"p53 status","score":0.7120000123977661},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.5809999704360962},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.818472146987915},{"id":"https://openalex.org/C2781469039","wikidata":"https://www.wikidata.org/wiki/Q18388377","display_name":"Photosensitizer","level":2,"score":0.7467650771141052},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7365303635597229},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6090769171714783},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.49051064252853394},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4806134104728699},{"id":"https://openalex.org/C182979987","wikidata":"https://www.wikidata.org/wiki/Q3907241","display_name":"Poly ADP ribose polymerase","level":4,"score":0.4638414978981018},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.43121129274368286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4053501486778259},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40210020542144775},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.39617085456848145},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3771008253097534},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3711646795272827},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.36580395698547363},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34785181283950806},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3144465684890747},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.2347213625907898},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2086663842201233},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16178447008132935},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1436644196510315},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.1176583468914032},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012821","descriptor_name":"Silanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012821","descriptor_name":"Silanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012821","descriptor_name":"Silanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016213","descriptor_name":"Cyclins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017319","descriptor_name":"Photosensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017646","descriptor_name":"Organosilicon Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017646","descriptor_name":"Organosilicon Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017646","descriptor_name":"Organosilicon Compounds","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10815928","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2151982942","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10815928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.7300000190734863,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2149005165","display_name":"DETACHMENT SENSITIZES CELLS TO TOPOISOMERASE INHIBITORS","funder_award_id":"7k01ca077065-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4323490007","display_name":"PHTHALOCYANINE PHOTODYNAMIC THERAPY--MECHANISTIC STUDIES","funder_award_id":"P01CA048735","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6579298273","display_name":"PHTHALOCYANINE PHOTODYNAMIC THERAPY OF SKIN TUMORS","funder_award_id":"5r01ca051802-09","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1505158644","https://openalex.org/W1555002034","https://openalex.org/W1578932070","https://openalex.org/W1601779735","https://openalex.org/W1772341276","https://openalex.org/W1969172805","https://openalex.org/W1973766879","https://openalex.org/W1976462601","https://openalex.org/W1978293661","https://openalex.org/W1979995768","https://openalex.org/W1986254790","https://openalex.org/W1990397750","https://openalex.org/W1992572186","https://openalex.org/W1995281577","https://openalex.org/W1998424046","https://openalex.org/W1998887606","https://openalex.org/W2001399809","https://openalex.org/W2007030237","https://openalex.org/W2007986629","https://openalex.org/W2010298858","https://openalex.org/W2011206688","https://openalex.org/W2022259405","https://openalex.org/W2028305534","https://openalex.org/W2032063521","https://openalex.org/W2032731042","https://openalex.org/W2034824476","https://openalex.org/W2035920818","https://openalex.org/W2044505588","https://openalex.org/W2048620835","https://openalex.org/W2050843442","https://openalex.org/W2053569846","https://openalex.org/W2058452428","https://openalex.org/W2060048383","https://openalex.org/W2067896742","https://openalex.org/W2072502723","https://openalex.org/W2079162542","https://openalex.org/W2080853992","https://openalex.org/W2081145901","https://openalex.org/W2083440657","https://openalex.org/W2086405807","https://openalex.org/W2090202756","https://openalex.org/W2091012624","https://openalex.org/W2091210609","https://openalex.org/W2098662084","https://openalex.org/W2099572184","https://openalex.org/W2100837269","https://openalex.org/W2106509469","https://openalex.org/W2109344294","https://openalex.org/W2124378074","https://openalex.org/W2126798834","https://openalex.org/W2128016549","https://openalex.org/W2130477771","https://openalex.org/W2130866079","https://openalex.org/W2148061274","https://openalex.org/W2164733112","https://openalex.org/W2315250335","https://openalex.org/W2315953643","https://openalex.org/W2331874435","https://openalex.org/W2470518962"],"related_works":["https://openalex.org/W2020232556","https://openalex.org/W2022259405","https://openalex.org/W2380692669","https://openalex.org/W2079162542","https://openalex.org/W1601779735","https://openalex.org/W3029779596","https://openalex.org/W3211764250","https://openalex.org/W2343082737","https://openalex.org/W3127630761","https://openalex.org/W2049195473"],"abstract_inverted_index":{"Photodynamic":[0],"therapy":[1],"(PDT)":[2],"using":[3],"the":[4,26,104,124,127,140,204,214,219,252,276],"silicon":[5],"phthalocyanine":[6],"photosensitizer":[7],"Pc":[8,29,51,88,152,170,197,247,277],"4":[9,52],"[HOSiPcOSi(CH3)2(CH2)3N-(CH3)2]":[10],"is":[11,249],"an":[12],"oxidative":[13],"stress":[14],"associated":[15,168],"with":[16,46,59,169,218],"induction":[17],"of":[18,28,115,126,136,139,189,203,208,221,228,239,254,261,288],"apoptosis":[19,110,172,289],"in":[20,37,76,100,123,173,187,201,213,216,224,251,275,290,294,296],"various":[21,80],"cell":[22],"types.":[23],"We":[24],"assessed":[25],"effectiveness":[27],"4-PDT":[30,89,198,248],"on":[31],"SW480":[32,225,255],"colon":[33,257],"cancer":[34,258],"xenografts":[35,43,77,215,259],"grown":[36],"athymic":[38],"nude":[39],"mice.":[40],"Animals":[41],"bearing":[42],"were":[44,57,74,182,210],"treated":[45],"1":[47,194],"mg/kg":[48],"body":[49],"weight":[50],"and":[53,117,119,180,272,280],"48":[54],"h":[55,86,195],"later":[56],"irradiated":[58],"150":[60,70],"J/cm2":[61],"672-nm":[62],"light":[63],"from":[64],"a":[65,97,120,134,237,286],"diode":[66],"laser":[67],"delivered":[68],"at":[69,79,144],"mW/cm2.":[71],"Biochemical":[72],"studies":[73],"performed":[75],"resected":[78,106],"time":[81,150],"points":[82],"up":[83],"to":[84,133,166,292],"26":[85,146],"after":[87,196,236],"treatment,":[90],"whereas":[91],"tumor":[92,229,233,298],"size":[93,230],"was":[94,111,191],"evaluated":[95],"over":[96],"4-week":[98],"period":[99],"parallel":[101],"experiments.":[102],"In":[103],"tumors":[105,154],"for":[107],"biochemical":[108],"studies,":[109],"visualized":[112],"by":[113,270],"activation":[114,274],"caspase-9":[116,271],"caspase-3":[118,273],"gradual":[121],"increase":[122,186],"cleavage":[125,266],"nuclear":[128],"enzyme":[129],"poly(ADP-ribose)":[130],"polymerase":[131],"(PARP)":[132],"maximum":[135],"approximately":[137,145],"60%":[138],"total":[141],"PARP":[142,265],"present":[143],"h.":[147],"At":[148],"that":[149,161,232],"all":[151],"4-PDT-treated":[153,278],"had":[155],"regressed":[156],"significantly.":[157],"Two":[158],"signaling":[159],"responses":[160],"have":[162],"previously":[163],"been":[164],"shown":[165],"be":[167,268,285],"4-PDT-induced":[171],"cultured":[174],"cells,":[175],"p38":[176,190,205,282],"mitogen-activated":[177],"protein":[178],"kinase":[179],"p21/WAF1/Cip1,":[181],"examined.":[183],"A":[184],"marked":[185],"phosphorylation":[188,283],"observed":[192],"within":[193],"without":[199],"changes":[200],"levels":[202],"protein.":[206],"Levels":[207],"p21":[209],"not":[211],"altered":[212],"correspondence":[217],"presence":[220],"mutant":[222],"p53":[223,262],"cells.":[226],"Evaluation":[227],"showed":[231],"growth":[234],"resumed":[235],"delay":[238],"9-15":[240],"days.":[241],"Our":[242],"results":[243],"suggest":[244],"that:":[245],"(a)":[246],"effective":[250],"treatment":[253],"human":[256],"independent":[260],"status;":[263],"(b)":[264],"may":[267,284],"mediated":[269],"tumors;":[279],"(c)":[281],"trigger":[287],"response":[291],"PDT":[293],"vivo":[295],"this":[297],"model.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}