{"id":"https://openalex.org/W2151956271","doi":"https://doi.org/10.1517/14712598.6.1.55","title":"Adenovirus p53 gene therapy","display_name":"Adenovirus p53 gene therapy","publication_year":2005,"publication_date":"2005-12-22","ids":{"openalex":"https://openalex.org/W2151956271","doi":"https://doi.org/10.1517/14712598.6.1.55","mag":"2151956271","pmid":"https://pubmed.ncbi.nlm.nih.gov/16370914"},"language":"en","primary_location":{"id":"doi:10.1517/14712598.6.1.55","doi":"https://doi.org/10.1517/14712598.6.1.55","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.6.1.55","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027152610","display_name":"Jack A. Roth","orcid":"https://orcid.org/0000-0002-8955-1313","observed_orcids":["https://orcid.org/0000-0002-8955-1313"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jack A Roth","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, UT M. D. Anderson Cancer Center, P.O. Box 301402, Houston, TX 77230-1402, USA. jroth@mdanderson.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, UT M. D. Anderson Cancer Center, P.O. Box 301402, Houston, TX 77230-1402, USA. jroth@mdanderson.org","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5027152610"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":1.3267,"has_fulltext":false,"cited_by_count":131,"citation_normalized_percentile":{"value":0.77687444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"1","first_page":"55","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.06270000338554382,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6980000138282776},{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.859000027179718},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.8389999866485596},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.9919999837875366},{"id":"https://openalex.org/keywords/replication-deficient-adenovirus","display_name":"replication-defective adenovirus","score":0.8360000252723694},{"id":"https://openalex.org/keywords/intratumoral-injection","display_name":"intratumoral injection","score":0.878000020980835},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7139999866485596},{"id":"https://openalex.org/keywords/growth-arrest","display_name":"growth arrest","score":0.7160000205039978},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.8960000276565552},{"id":"https://openalex.org/keywords/radiation-therapy-resistance","display_name":"radiation therapy resistance","score":0.6299999952316284},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.949999988079071},{"id":"https://openalex.org/keywords/targeted-cancer-therapy","display_name":"targeted cancer therapy","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.7458891272544861},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6997770071029663},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6426948308944702},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6141653060913086},{"id":"https://openalex.org/C34981463","wikidata":"https://www.wikidata.org/wiki/Q3311663","display_name":"Suicide gene","level":4,"score":0.5750874876976013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5477383732795715},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5293517708778381},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4977138340473175},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4959634244441986},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45610740780830383},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.4445782005786896},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41011959314346313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.275877445936203},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16832515597343445},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.11208683252334595},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1105090081691742}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1517/14712598.6.1.55","doi":"https://doi.org/10.1517/14712598.6.1.55","is_oa":false,"landing_page_url":"https://doi.org/10.1517/14712598.6.1.55","pdf_url":null,"source":{"id":"https://openalex.org/S57380513","display_name":"Expert Opinion on Biological Therapy","issn_l":"1471-2598","issn":["1471-2598","1744-7682"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Biological Therapy","raw_type":"journal-article"},{"id":"pmid:16370914","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16370914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on biological therapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W96846446","https://openalex.org/W251134836","https://openalex.org/W1579336954","https://openalex.org/W1790220839","https://openalex.org/W1950719160","https://openalex.org/W1964617786","https://openalex.org/W1967986995","https://openalex.org/W1968450421","https://openalex.org/W1969785946","https://openalex.org/W1973478663","https://openalex.org/W1973886069","https://openalex.org/W1976816133","https://openalex.org/W1976936729","https://openalex.org/W1977686001","https://openalex.org/W1983386156","https://openalex.org/W1990406980","https://openalex.org/W1990614709","https://openalex.org/W2001571816","https://openalex.org/W2008420379","https://openalex.org/W2010781234","https://openalex.org/W2012322426","https://openalex.org/W2020850506","https://openalex.org/W2021875656","https://openalex.org/W2022790376","https://openalex.org/W2023917814","https://openalex.org/W2029533557","https://openalex.org/W2033791403","https://openalex.org/W2038096267","https://openalex.org/W2044217649","https://openalex.org/W2070051352","https://openalex.org/W2074114480","https://openalex.org/W2075447939","https://openalex.org/W2086532812","https://openalex.org/W2098287668","https://openalex.org/W2105327099","https://openalex.org/W2124052729","https://openalex.org/W2142058281","https://openalex.org/W2146763442","https://openalex.org/W2150732996","https://openalex.org/W2154589271","https://openalex.org/W2157472182","https://openalex.org/W2158446937","https://openalex.org/W2159127194","https://openalex.org/W2160176818","https://openalex.org/W2167597785","https://openalex.org/W2244995601","https://openalex.org/W2325667407","https://openalex.org/W2397072593","https://openalex.org/W2407896503","https://openalex.org/W2416102534","https://openalex.org/W2416306209","https://openalex.org/W2419086488","https://openalex.org/W2437300897"],"related_works":["https://openalex.org/W6980625810","https://openalex.org/W1970817857","https://openalex.org/W2411291807","https://openalex.org/W2308979567","https://openalex.org/W2159189771","https://openalex.org/W2054792292","https://openalex.org/W1542924271","https://openalex.org/W2419553077","https://openalex.org/W1989834582","https://openalex.org/W2066177052"],"abstract_inverted_index":{"To":[0],"date,":[1],"dysfunctional":[2],"tumour":[3,19,75,123],"suppressor":[4,20,124],"genes":[5,21,113],"are":[6],"the":[7,41,88,97,109,115],"most":[8],"common":[9],"genetic":[10],"lesions":[11],"identified":[12],"in":[13,40,57,114,132],"human":[14],"cancers.":[15],"Functional":[16],"copies":[17],"of":[18,46,55,90,96,111],"can":[22],"be":[23],"introduced":[24],"into":[25],"cancer":[26,58],"cells":[27,59],"by":[28],"gene":[29,125],"transfer":[30],"using":[31],"adenoviral":[32],"vectors.":[33],"This":[34],"approach":[35],"has":[36,100],"been":[37],"extensively":[38],"studied":[39],"clinic":[42],"with":[43,108],"intratumoural":[44],"injection":[45],"a":[47,129],"replication-defective":[48],"adenovirus":[49],"that":[50],"expresses":[51],"p53":[52,56,98,116],"(Ad-p53).":[53],"Overexpression":[54],"induces":[60],"growth":[61,78],"arrest":[62,79],"and":[63,72,77,93,105,127],"apoptosis.":[64],"Ad-p53":[65],"injections":[66],"have":[67,73,83],"an":[68],"excellent":[69],"safety":[70],"profile,":[71],"mediated":[74],"regression":[76],"as":[80],"monotherapy,":[81],"or":[82,86],"overcome":[84],"resistance":[85],"increased":[87],"effectiveness":[89],"radiation":[91],"therapy":[92,126],"chemotherapy.":[94],"Expression":[95],"transgene":[99],"occurred":[101],"at":[102],"high":[103],"levels":[104],"is":[106],"associated":[107],"activation":[110],"other":[112],"pathway.":[117],"These":[118],"studies":[119],"indicate":[120],"proof-of-principle":[121],"for":[122],"represent":[128],"new":[130],"paradigm":[131],"targeted":[133],"therapy.":[134]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
