{"id":"https://openalex.org/W2151937985","doi":null,"title":"Altered morphology, nuclear stability and adhesion of highly metastatic derivatives of osteoblast-like SAOS-2 osteosarcoma cells.","display_name":"Altered morphology, nuclear stability and adhesion of highly metastatic derivatives of osteoblast-like SAOS-2 osteosarcoma cells.","publication_year":2007,"publication_date":"2007-11-01","ids":{"openalex":"https://openalex.org/W2151937985","mag":"2151937985","pmid":"https://pubmed.ncbi.nlm.nih.gov/18225558"},"language":"en","primary_location":{"id":"pmid:18225558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052131590","display_name":"Roman Muff","orcid":"https://orcid.org/0000-0002-1534-6050","observed_orcids":["https://orcid.org/0000-0002-1534-6050"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210124057","display_name":"Universit\u00e4tsklinik Balgrist","ror":"https://ror.org/02yzaka98","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210124057"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roman Muff","raw_affiliation_strings":["Laboratory for Orthopaedic Research, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Orthopaedic Research, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210124057"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075606433","display_name":"Natalie Nigg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalie Nigg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078645258","display_name":"Philipp Gruber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philipp Gruber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014701529","display_name":"Denise K. Walters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Denise Walters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113769617","display_name":"Walter Born","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter Born","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017080008","display_name":"Bruno Fuchs","orcid":"https://orcid.org/0000-0001-6453-3947","observed_orcids":["https://orcid.org/0000-0001-6453-3947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Fuchs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"27","issue":"6B","first_page":"3973","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.023499999195337296,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/saos-2-cells","display_name":"Saos-2 cells","score":0.9679999947547913},{"id":"https://openalex.org/keywords/osteoblastic-phenotype","display_name":"osteoblastic phenotype","score":0.8450000286102295},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.753000020980835},{"id":"https://openalex.org/keywords/nuclear-instability","display_name":"nuclear instability","score":0.875},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.8460000157356262},{"id":"https://openalex.org/keywords/alkaline-phosphatase-activity","display_name":"alkaline phosphatase activity","score":0.7770000100135803},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.6370000243186951},{"id":"https://openalex.org/keywords/dedifferentiation","display_name":"dedifferentiation","score":0.8019999861717224},{"id":"https://openalex.org/keywords/cytoskeletal-rearrangement","display_name":"cytoskeletal rearrangement","score":0.9319999814033508},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.633604884147644},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5744539499282837},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5570303201675415},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.5466365218162537},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.43715721368789673},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.42412614822387695},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41324660181999207},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3893633186817169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3735863268375397},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35480064153671265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32505273818969727},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2581128180027008},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.18100333213806152},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09768363833427429},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005047","descriptor_name":"Etoposide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012516","descriptor_name":"Osteosarcoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:18225558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Journal Article"},{"id":"mag:2151937985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18225558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W186831022","https://openalex.org/W262921564","https://openalex.org/W326741768","https://openalex.org/W1975170728","https://openalex.org/W1978224575","https://openalex.org/W1983411073","https://openalex.org/W1985113469","https://openalex.org/W1987495895","https://openalex.org/W2011300566","https://openalex.org/W2032279152","https://openalex.org/W2043251287","https://openalex.org/W2044753978","https://openalex.org/W2046548272","https://openalex.org/W2052433404","https://openalex.org/W2058990823","https://openalex.org/W2062825083","https://openalex.org/W2078836207","https://openalex.org/W2078948299","https://openalex.org/W2088825115","https://openalex.org/W2097793253","https://openalex.org/W2098002569","https://openalex.org/W2103715841","https://openalex.org/W2107594885","https://openalex.org/W2115543187","https://openalex.org/W2130487088"],"related_works":["https://openalex.org/W2037396413","https://openalex.org/W271799375","https://openalex.org/W2385122087","https://openalex.org/W2073947367","https://openalex.org/W2808996835","https://openalex.org/W243705068","https://openalex.org/W1996957203","https://openalex.org/W3204325572","https://openalex.org/W1504043030","https://openalex.org/W7095998667"],"abstract_inverted_index":{"BACKGROUND:":[0],"Metastasis":[1],"is":[2,162],"the":[3,32,45,72,75,79,93,104,111,135,170,175,205,216,221,229],"leading":[4],"cause":[5],"of":[6,25,29,44,67,110,119,134,153,169,174,207,220],"death":[7],"in":[8,51,74,92,184,210],"patients":[9],"with":[10,165,195],"osteosarcoma":[11],"(OS).":[12],"High":[13],"alkaline":[14],"phosphatase":[15],"(ALP)":[16],"activity":[17,64],"and":[18,36,41,49,58,65,78,81,98,108,121,138,144,155,187,199,223],"resistance":[19,43],"to":[20,128,141,159,178,228],"chemotherapy":[21],"are":[22],"independent":[23],"predictors":[24],"poor":[26],"clinical":[27],"outcome":[28],"osteosarcoma.":[30],"Here,":[31],"osteoblastic":[33,171],"phenotype,":[34],"cell":[35,39,47,185,189],"nuclear":[37,197],"morphology,":[38],"adhesion":[40,118],"drug":[42],"SAOS-2":[46,77,106,129,160,231],"line":[48],"two":[50],"vivo":[52],"selected":[53],"highly":[54],"metastatic":[55,151,218],"derivatives,":[56],"LM5":[57,80,97,120,137,154,222],"LM7,":[59],"were":[60,71,101,146],"compared.":[61],"RESULTS:":[62],"ALP":[63],"deposition":[66],"mineralized":[68],"extracellular":[69],"matrix":[70],"same":[73],"parental":[76,105,230],"LM7":[82,94,99,112,122,139,156,211,224],"cells,":[83,107,212],"but":[84],"parathyroid":[85],"hormone":[86],"(PTH)-stimulated":[87],"cAMP":[88],"accumulation":[89],"was":[90,124],"lost":[91],"cells.":[95,130,232],"The":[96,117,131,149,182],"cells":[100,113,123,140,161],"smaller":[102],"than":[103],"10%":[109],"had":[114],"distorted":[115],"nuclei.":[116],"decreased":[125],"when":[126],"compared":[127,158,227],"cytotoxic":[132,176],"responses":[133],"SAOS-2,":[136],"Cisplatin,":[142],"Doxorubicin":[143],"Etoposide":[145],"indistinguishable.":[147],"CONCLUSION:":[148],"increased":[150,196],"potential":[152,219],"as":[157,202,226],"not":[163],"associated":[164],"a":[166],"substantial":[167],"change":[168],"phenotype":[172],"or":[173],"response":[177],"current":[179],"chemotherapeutic":[180],"drugs.":[181],"decrease":[183],"size":[186],"altered":[188],"adhesion,":[190],"reflecting":[191],"cytoskeletal":[192],"rearrangement,":[193],"together":[194],"instability":[198],"partial":[200],"dedifferentiation,":[201],"revealed":[203],"by":[204],"loss":[206],"PTH":[208],"responsiveness":[209],"may":[213],"account":[214],"for":[215],"higher":[217],"sublines":[225]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
