{"id":"https://openalex.org/W2151897602","doi":"https://doi.org/10.1681/asn.v51102","title":"Differential effects of ureteral obstruction on rat kininogen gene family.","display_name":"Differential effects of ureteral obstruction on rat kininogen gene family.","publication_year":1994,"publication_date":"1994-07-01","ids":{"openalex":"https://openalex.org/W2151897602","doi":"https://doi.org/10.1681/asn.v51102","mag":"2151897602","pmid":"https://pubmed.ncbi.nlm.nih.gov/7948776"},"language":"en","primary_location":{"id":"doi:10.1681/asn.v51102","doi":"https://doi.org/10.1681/asn.v51102","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v51102","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044765791","display_name":"Samir Sayem El-Dahr","orcid":"https://orcid.org/0000-0001-7571-4292","observed_orcids":["https://orcid.org/0000-0001-7571-4292"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S S el-Dahr","raw_affiliation_strings":["Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089950604","display_name":"Susana Dipp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Dipp","raw_affiliation_strings":["Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tulane University School of Medicine, New Orleans, LA 70112","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":null,"apc_paid":null,"fwci":1.1769,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77674992,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":"102","last_page":"109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-kininogen","display_name":"T-kininogen","score":0.996999979019165},{"id":"https://openalex.org/keywords/ureteral-obstruction","display_name":"ureteral obstruction","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.5019999742507935},{"id":"https://openalex.org/keywords/kallikrein-kinin-system","display_name":"kallikrein-kinin system","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mrna-splicing","display_name":"mRNA splicing","score":0.5759999752044678},{"id":"https://openalex.org/keywords/liver","display_name":"liver","score":0.42399999499320984},{"id":"https://openalex.org/keywords/kidney","display_name":"kidney","score":0.734000027179718},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.7630000114440918},{"id":"https://openalex.org/keywords/thiol-protease-inhibitors","display_name":"thiol protease inhibitors","score":0.777999997138977},{"id":"https://openalex.org/keywords/renal-hemodynamics","display_name":"renal hemodynamics","score":0.609000027179718}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6538600325584412},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6408876180648804},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.6156122088432312},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5624098181724548},{"id":"https://openalex.org/C2779591629","wikidata":"https://www.wikidata.org/wiki/Q24745328","display_name":"Bradykinin","level":3,"score":0.5407642126083374},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.524951696395874},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5221174955368042},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5007519721984863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44780245423316956},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4368010461330414},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.413699209690094},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32325807213783264},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21349644660949707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1528140902519226},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07914388179779053}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D007704","descriptor_name":"Kininogens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018123","descriptor_name":"Receptors, Interleukin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1681/asn.v51102","doi":"https://doi.org/10.1681/asn.v51102","is_oa":false,"landing_page_url":"https://doi.org/10.1681/asn.v51102","pdf_url":null,"source":{"id":"https://openalex.org/S115693375","display_name":"Journal of the American Society of Nephrology","issn_l":"1046-6673","issn":["1046-6673","1533-3450"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315620","host_organization_name":"American Society of Nephrology","host_organization_lineage":["https://openalex.org/P4310315620"],"host_organization_lineage_names":["American Society of Nephrology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology","raw_type":"journal-article"},{"id":"pmid:7948776","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7948776","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Society of Nephrology : JASN","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W67432497","https://openalex.org/W1488573278","https://openalex.org/W1491892821","https://openalex.org/W1541720947","https://openalex.org/W1552052595","https://openalex.org/W1577674296","https://openalex.org/W1673630983","https://openalex.org/W1764686129","https://openalex.org/W1775749144","https://openalex.org/W1781443963","https://openalex.org/W1979428032","https://openalex.org/W1983224547","https://openalex.org/W1988018295","https://openalex.org/W2008921324","https://openalex.org/W2013215719","https://openalex.org/W2018068445","https://openalex.org/W2030077469","https://openalex.org/W2050514240","https://openalex.org/W2055732220","https://openalex.org/W2063930484","https://openalex.org/W2071196043","https://openalex.org/W2080928368","https://openalex.org/W2088805142","https://openalex.org/W2102542092","https://openalex.org/W2115798976","https://openalex.org/W2134812217","https://openalex.org/W2178615409","https://openalex.org/W2318594036","https://openalex.org/W2412867428","https://openalex.org/W2441237787"],"related_works":["https://openalex.org/W1988018295","https://openalex.org/W2398618431","https://openalex.org/W2006833979","https://openalex.org/W2305362710","https://openalex.org/W2089186634","https://openalex.org/W2022901857","https://openalex.org/W2183945091","https://openalex.org/W2588791465","https://openalex.org/W2286829789","https://openalex.org/W2099083215"],"abstract_inverted_index":{"The":[0,29],"precursors":[1,42],"of":[2,43,70,110,119,141,182,193,201],"kinins,":[3],"K-kininogens":[4],"and":[5,23,35,38,55,75,80,84,116,122,157,196],"T-kininogens":[6],"(KG),":[7],"are":[8,26],"encoded":[9],"by":[10],"separate":[11],"genes":[12,25],"that":[13,103,169],"display":[14],"90%":[15],"nucleotide":[16],"sequence":[17],"homology.":[18],"Despite":[19],"their":[20,64],"homology,":[21],"K-KG":[22,30,83,134],"T-KG":[24,51,85,132,143,172],"differentially":[27],"regulated.":[28],"gene":[31,52,86],"is":[32,53,58],"expressed":[33],"constitutively":[34],"encodes":[36],"high-":[37],"low-molecular-weight":[39],"KG,":[40],"the":[41,44,50,68,76,148,170,180,191],"vasoactive":[45],"nonapeptide":[46],"bradykinin.":[47],"In":[48,188],"contrast,":[49,190],"inducible,":[54],"its":[56],"protein":[57,173],"a":[59,101],"potent":[60],"thiol-protease":[61],"inhibitor.":[62],"Given":[63],"potential":[65],"role":[66],"in":[67,88,147,179],"regulation":[69],"blood":[71],"pressure,":[72],"renal":[73,105],"hemodynamics,":[74],"response":[77],"to":[78,91,108,130,177],"inflammation":[79],"tissue":[81],"injury,":[82],"expression":[87],"rats":[89,184],"subjected":[90],"chronic":[92],"(1":[93],"or":[94,133],"5":[95,160],"wk)":[96],"unilateral":[97],"ureteral":[98],"obstruction":[99],"(UUO),":[100],"maneuver":[102],"suppresses":[104],"kallikrein":[106],"synthesis":[107],"25%":[109],"controls,":[111],"has":[112],"been":[113],"examined.":[114],"Northern":[115],"slot":[117],"blots":[118],"total":[120],"liver":[121,181],"kidney":[123],"RNA":[124],"were":[125,145],"probed":[126],"with":[127,151],"oligonucleotides":[128],"complementary":[129],"either":[131,209],"mRNA":[135,144,204],"under":[136],"high-stringency":[137],"conditions.":[138],"Steady-state":[139],"levels":[140],"hepatic":[142,202],"increased":[146],"UUO":[149,183],"compared":[150],"sham-operated":[152],"rats--2.7-fold":[153],"at":[154,159,208],"1":[155],"wk":[156,161],"4.1-fold":[158],"(P":[162,185],"<":[163,186],"0.05).":[164,187],"Western":[165],"blot":[166],"analysis":[167],"revealed":[168],"68-kd":[171],"was":[174,205],"up-regulated":[175],"2.5-":[176],"3-fold":[178],"marked":[189],"abundance":[192],"high":[194],"(2.3-kb)-":[195],"low":[197],"(1.6-kb)-molecular-weight":[198],"splicing":[199],"transcripts":[200],"pre-K-KG":[203],"not":[206],"altered":[207],"time":[210],"after":[211],"UUO.(ABSTRACT":[212],"TRUNCATED":[213],"AT":[214],"250":[215],"WORDS)":[216]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}