{"id":"https://openalex.org/W2151866005","doi":"https://doi.org/10.1093/infdis/166.2.260","title":"Varicella-Zoster Virus (VZV)-Specific Cytotoxicity after Immunization of Nonimmune Adults with Oka Strain Attenuated VZV Vaccine","display_name":"Varicella-Zoster Virus (VZV)-Specific Cytotoxicity after Immunization of Nonimmune Adults with Oka Strain Attenuated VZV Vaccine","publication_year":1992,"publication_date":"1992-08-01","ids":{"openalex":"https://openalex.org/W2151866005","doi":"https://doi.org/10.1093/infdis/166.2.260","mag":"2151866005","pmid":"https://pubmed.ncbi.nlm.nih.gov/1321860"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/166.2.260","doi":"https://doi.org/10.1093/infdis/166.2.260","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/166.2.260","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047782310","display_name":"Anthony R Hayward","orcid":"https://orcid.org/0000-0003-3123-2894","observed_orcids":["https://orcid.org/0000-0003-3123-2894"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. Hayward","raw_affiliation_strings":["Department of Pediatrics, Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver","Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413"]},{"raw_affiliation_string":"Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089458839","display_name":"Eileen Villanueba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Villanueba","raw_affiliation_strings":["Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070268501","display_name":"Mary Cosyns","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Cosyns","raw_affiliation_strings":["Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051264386","display_name":"Myron J. Levin","orcid":"https://orcid.org/0000-0002-7468-106X","observed_orcids":["https://orcid.org/0000-0002-7468-106X"]},"institutions":[{"id":"https://openalex.org/I4210087413","display_name":"University of Colorado Health","ror":"https://ror.org/0107w4315","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087413"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Levin","raw_affiliation_strings":["Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pediatrics, Microbiology, and Medicine and the Barbara Davis Childhood Diabetes Center, University of Colorado Health Sciences Center, Denver","institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5047782310"],"corresponding_institution_ids":["https://openalex.org/I4210087413","https://openalex.org/I921990950"],"apc_list":{"value":4763,"currency":"USD","value_usd":4763},"apc_paid":null,"fwci":0.3551,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.63674949,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"166","issue":"2","first_page":"260","last_page":"264"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/varicella-vaccine","display_name":"varicella vaccine","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cell-mediated-immunity","display_name":"cell-mediated immunity","score":0.8289999961853027},{"id":"https://openalex.org/keywords/humoral-immune-response","display_name":"humoral immune response","score":0.7289999723434448},{"id":"https://openalex.org/keywords/igg-response","display_name":"IgG antibody response","score":0.7839999794960022},{"id":"https://openalex.org/keywords/lymphocyte-proliferation","display_name":"lymphocyte proliferation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/vaccine-immunogenicity","display_name":"vaccine immunogenicity","score":0.7379999756813049}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7985970973968506},{"id":"https://openalex.org/C2776159415","wikidata":"https://www.wikidata.org/wiki/Q6868","display_name":"Varicella zoster virus","level":3,"score":0.7194919586181641},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.7131133079528809},{"id":"https://openalex.org/C2780473352","wikidata":"https://www.wikidata.org/wiki/Q2721987","display_name":"Varicella vaccine","level":4,"score":0.6271478533744812},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5331233143806458},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5198112726211548},{"id":"https://openalex.org/C2908772859","wikidata":"https://www.wikidata.org/wiki/Q2721987","display_name":"Chickenpox Vaccine","level":5,"score":0.5134128332138062},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.47962674498558044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4714463949203491},{"id":"https://openalex.org/C2991898273","wikidata":"https://www.wikidata.org/wiki/Q855769","display_name":"Virus strain","level":3,"score":0.4244159460067749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32072532176971436},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31789469718933105},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.18293854594230652},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12162020802497864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003601","descriptor_name":"Cytotoxicity Tests, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014613","descriptor_name":"Vaccines, Attenuated","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014645","descriptor_name":"Herpesvirus 3, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019433","descriptor_name":"Chickenpox Vaccine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/infdis/166.2.260","doi":"https://doi.org/10.1093/infdis/166.2.260","is_oa":false,"landing_page_url":"https://doi.org/10.1093/infdis/166.2.260","pdf_url":null,"source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:1321860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1321860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1792482854","display_name":"CHRONIC NEUROLOGIC DISEASE--NEUROTROPIC VIRUS","funder_award_id":"5p01ag007347-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4162986956","display_name":null,"funder_award_id":"AG 07347","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1495829907","https://openalex.org/W1500989809","https://openalex.org/W1674375323","https://openalex.org/W1822812702","https://openalex.org/W1866001421","https://openalex.org/W1907848682","https://openalex.org/W1961797414","https://openalex.org/W1984149448","https://openalex.org/W2061739175","https://openalex.org/W2082443813","https://openalex.org/W2111772189","https://openalex.org/W2118664562","https://openalex.org/W2123116316","https://openalex.org/W2134727595"],"related_works":["https://openalex.org/W2437845558","https://openalex.org/W1997241297","https://openalex.org/W2150538593","https://openalex.org/W7096236288","https://openalex.org/W7099895414","https://openalex.org/W2016881992","https://openalex.org/W1972855962","https://openalex.org/W1976135993","https://openalex.org/W583048926","https://openalex.org/W2105887133"],"abstract_inverted_index":{"Cytotoxic,":[0],"proliferative,":[1,83],"and":[2,69,77,84,104,116],"serum":[3],"IgG":[4],"antibody":[5,85,115],"responses":[6,65,86,119],"to":[7,36,120],"varicella-zoster":[8],"virus":[9],"(VZV)":[10],"were":[11,74,87],"measured":[12],"monthly":[13],"in":[14,89,124],"29":[15],"young":[16],"adults":[17],"for":[18],"3":[19,70,136],"months":[20,71,137],"following":[21],"primary":[22],"immunization":[23,73,122],"with":[24,57],"the":[25,90,101,108],"Oka":[26],"strain":[27],"attenuated":[28],"VZV":[29,51,121],"vaccine.":[30],"No":[31],"subjects":[32,46,56],"had":[33],"lymphocytes":[34,43],"stimulated":[35,49],"VZV-specific":[37],"cytotoxicity":[38],"at":[39,66],"study":[40],"entry":[41],"although":[42],"from":[44],"2":[45],"proliferated":[47],"when":[48],"by":[50,107,135],"antigen.":[52],"The":[53,111],"percentages":[54],"of":[55],"positive":[58],"major":[59],"histocompatibility":[60],"complex":[61],"class":[62],"II-restricted":[63],"cytotoxic":[64],"1,":[67],"2,":[68],"after":[72,93,100,126,138],"54%,":[75],"69%,":[76],"66%,":[78],"respectively.":[79],"Correlations":[80],"between":[81],"cytotoxic,":[82],"highest":[88],"first":[91],"month":[92],"immunization;":[94],"lower":[95],"but":[96,128],"still":[97],"statistically":[98],"significant":[99],"second":[102],"month;":[103],"not":[105],"apparent":[106],"third":[109],"month.":[110],"data":[112],"suggest":[113],"that":[114],"cell-mediated":[117],"immune":[118],"develop":[123],"parallel":[125],"immunization,":[127],"these":[129],"effector":[130],"mechanisms":[131],"are":[132],"independently":[133],"regulated":[134],"immunization.":[139]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}