{"id":"https://openalex.org/W2151748280","doi":"https://doi.org/10.1073/pnas.1310230110","title":"Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers","display_name":"Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers","publication_year":2013,"publication_date":"2013-06-26","ids":{"openalex":"https://openalex.org/W2151748280","doi":"https://doi.org/10.1073/pnas.1310230110","mag":"2151748280","pmid":"https://pubmed.ncbi.nlm.nih.gov/23803853","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3718086"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1310230110","doi":"https://doi.org/10.1073/pnas.1310230110","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1310230110","pdf_url":"https://www.pnas.org/content/pnas/110/29/11988.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.pnas.org/content/pnas/110/29/11988.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014267088","display_name":"Michael Pourdehnad","orcid":"https://orcid.org/0000-0001-8701-930X","observed_orcids":["https://orcid.org/0000-0001-8701-930X"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Pourdehnad","raw_affiliation_strings":["Division of Hematology/Oncology and Department of Medicine, University of California, San Francisco, CA 94143;","School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology and Department of Medicine, University of California, San Francisco, CA 94143;","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014712960","display_name":"Morgan Truitt","orcid":"https://orcid.org/0000-0001-7012-1228","observed_orcids":["https://orcid.org/0000-0001-7012-1228"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan L. Truitt","raw_affiliation_strings":["School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030941347","display_name":"Imran N. Siddiqi","orcid":"https://orcid.org/0000-0001-8083-9639","observed_orcids":["https://orcid.org/0000-0001-8083-9639"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Imran N. Siddiqi","raw_affiliation_strings":["Department of Pathology, University of Southern California, Los Angeles, CA 90033;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Southern California, Los Angeles, CA 90033;","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081915409","display_name":"Gregory S. Ducker","orcid":"https://orcid.org/0000-0002-8651-6846","observed_orcids":["https://orcid.org/0000-0002-8651-6846"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory S. Ducker","raw_affiliation_strings":["Department of Chemistry, University of California, Berkeley, CA 94720; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of California, Berkeley, CA 94720; and","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079376363","display_name":"Kevan M. Shokat","orcid":"https://orcid.org/0000-0001-8590-7741","observed_orcids":["https://orcid.org/0000-0001-8590-7741"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevan M. Shokat","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023731504","display_name":"Davide Ruggero","orcid":"https://orcid.org/0000-0002-9444-5865","observed_orcids":["https://orcid.org/0000-0002-9444-5865"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210167126","display_name":"UCSF Helen Diller Family Comprehensive Cancer Center","ror":"https://ror.org/05yndxy10","country_code":"US","type":"facility","lineage":["https://openalex.org/I180670191","https://openalex.org/I4210110664","https://openalex.org/I4210167126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Davide Ruggero","raw_affiliation_strings":["School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine and Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94158;","institution_ids":["https://openalex.org/I180670191","https://openalex.org/I4210167126"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":10.5466,"has_fulltext":true,"cited_by_count":288,"citation_normalized_percentile":{"value":0.99142797,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"110","issue":"29","first_page":"11988","last_page":"11993"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.9940000176429749},{"id":"https://openalex.org/keywords/4e-bp1-phosphorylation","display_name":"4E-BP1 phosphorylation","score":0.9509999752044678},{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"synthetic lethality","score":0.8820000290870667},{"id":"https://openalex.org/keywords/myc-driven-cancer","display_name":"MYC-driven cancer","score":0.8069999814033508},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hematological-cancer","display_name":"hematologic cancer","score":0.8080000281333923},{"id":"https://openalex.org/keywords/lymphoma","display_name":"lymphoma","score":0.9459999799728394},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.7279999852180481},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7445823550224304},{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.706652045249939},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.595937192440033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5846371054649353},{"id":"https://openalex.org/C161295673","wikidata":"https://www.wikidata.org/wiki/Q5408696","display_name":"EIF4E","level":5,"score":0.5267007946968079},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5266706347465515},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.504339337348938},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.48513898253440857},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45967012643814087},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.4402102828025818},{"id":"https://openalex.org/C107846503","wikidata":"https://www.wikidata.org/wiki/Q14876061","display_name":"mTORC2","level":5,"score":0.4220660924911499},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.41550832986831665},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.4154323637485504},{"id":"https://openalex.org/C5122226","wikidata":"https://www.wikidata.org/wiki/Q17916086","display_name":"EIF4EBP1","level":5,"score":0.4126244783401489},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.31240731477737427},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26733386516571045},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.22992724180221558},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.22062337398529053},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.2047596275806427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19701498746871948},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16909411549568176}],"mesh":[{"descriptor_ui":"D000068338","descriptor_name":"Everolimus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001583","descriptor_name":"Benzoxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014176","descriptor_name":"Protein Biosynthesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020123","descriptor_name":"Sirolimus","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D039642","descriptor_name":"Eukaryotic Initiation Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1310230110","doi":"https://doi.org/10.1073/pnas.1310230110","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1310230110","pdf_url":"https://www.pnas.org/content/pnas/110/29/11988.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2877400","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3718086","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3718086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3718086","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:23803853","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23803853","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt7bz3n1wp","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/7bz3n1wp","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, vol 110, iss 29","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1073/pnas.1310230110","doi":"https://doi.org/10.1073/pnas.1310230110","is_oa":true,"landing_page_url":"https://doi.org/10.1073/pnas.1310230110","pdf_url":"https://www.pnas.org/content/pnas/110/29/11988.full.pdf","source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3553584197","display_name":"Delineating the Mechanisms Responsible for Synthetic Lethality in MYC-induced Tumorigenesis Driven by Control of Protein Synthesis","funder_award_id":"R01CA140456","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G981350091","display_name":"Deciphering the role of the translational oncogenic program in Prostate Cancer","funder_award_id":"R01CA154916","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320306091","display_name":"American Association for Cancer Research","ror":"https://ror.org/02fnpv153"},{"id":"https://openalex.org/F4320306548","display_name":"Samuel Waxman Cancer Research Foundation","ror":"https://ror.org/02qva2y28"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332622","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151748280.pdf","grobid_xml":"https://content.openalex.org/works/W2151748280.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1529982641","https://openalex.org/W1966826063","https://openalex.org/W1968075576","https://openalex.org/W1968919723","https://openalex.org/W1980396381","https://openalex.org/W1988817337","https://openalex.org/W1995431293","https://openalex.org/W1996092483","https://openalex.org/W1998762942","https://openalex.org/W1999999605","https://openalex.org/W2005056727","https://openalex.org/W2006559495","https://openalex.org/W2012182672","https://openalex.org/W2014031706","https://openalex.org/W2021764678","https://openalex.org/W2028744022","https://openalex.org/W2031980017","https://openalex.org/W2032058375","https://openalex.org/W2034060278","https://openalex.org/W2035521247","https://openalex.org/W2037313242","https://openalex.org/W2039171339","https://openalex.org/W2057239580","https://openalex.org/W2062348957","https://openalex.org/W2065825082","https://openalex.org/W2079537922","https://openalex.org/W2081777956","https://openalex.org/W2084839831","https://openalex.org/W2087122127","https://openalex.org/W2093199938","https://openalex.org/W2093431913","https://openalex.org/W2096797981","https://openalex.org/W2098912234","https://openalex.org/W2100572488","https://openalex.org/W2114492564","https://openalex.org/W2121030224","https://openalex.org/W2137216850","https://openalex.org/W2153607816","https://openalex.org/W2157230060","https://openalex.org/W2158389310","https://openalex.org/W2159862107","https://openalex.org/W2166412785","https://openalex.org/W7096186325"],"related_works":["https://openalex.org/W2093310008","https://openalex.org/W2948785548","https://openalex.org/W2059767477","https://openalex.org/W2564125894","https://openalex.org/W2093431913","https://openalex.org/W2179539353","https://openalex.org/W4210499131","https://openalex.org/W2804022490","https://openalex.org/W1966826063","https://openalex.org/W2954968846"],"abstract_inverted_index":{"Myc":[0,16,30,40,108,196,222,241],"is":[1,36,143,166,217],"one":[2],"of":[3,29,49,75,81,112,116,128,141,168,187,200,221],"the":[4,23,39,45,73,82,184,244],"most":[5],"commonly":[6],"deregulated":[7],"oncogenes":[8],"in":[9,22,31,149,177,205,243],"human":[10,77,206],"cancer,":[11],"yet":[12],"therapies":[13],"directly":[14,52],"targeting":[15],"hyperactivation":[17],"are":[18],"not":[19],"presently":[20],"available":[21],"clinic.":[24,245],"The":[25],"evolutionarily":[26],"conserved":[27],"function":[28],"modulating":[32],"protein":[33,46,64,129],"synthesis":[34,47,65,130],"control":[35],"critical":[37],"to":[38,54,225,239],"oncogenic":[41,223],"program.":[42],"Indeed,":[43],"enhancing":[44],"capacity":[48],"cancer":[50,146],"cells":[51],"contributes":[53],"their":[55],"survival,":[56],"proliferation,":[57],"and":[58,103,109,153,197,202,229],"genome":[59],"instability.":[60],"Therefore,":[61],"inhibiting":[62],"enhanced":[63],"may":[66],"represent":[67],"a":[68,101,125,133,159,192,235],"highly":[69],"relevant":[70],"strategy":[71],"for":[72,92,145],"treatment":[74],"Myc-dependent":[76,150],"cancers.":[78,180],"However,":[79],"components":[80],"translation":[83,118],"machinery":[84],"that":[85,138,158,212],"can":[86],"be":[87],"exploited":[88],"as":[89],"therapeutic":[90,175,203,237],"targets":[91],"Myc-driven":[93,178],"cancers":[94],"remain":[95],"poorly":[96],"defined.":[97],"Here,":[98],"we":[99,136,182],"uncover":[100],"surprising":[102],"important":[104,214],"functional":[105],"link":[106,194],"between":[107,195],"mammalian":[110],"target":[111],"rapamycin":[113],"(mTOR)-dependent":[114],"phosphorylation":[115,140,199],"eukaryotic":[117],"initiation":[119,152],"factor":[120],"4E":[121],"binding":[122],"protein-1":[123],"(4EBP1),":[124],"master":[126],"regulator":[127],"control.":[131],"Using":[132],"pharmacogenetic":[134],"approach,":[135],"find":[137],"mTOR-dependent":[139,170,198],"4EBP1":[142,171,201],"required":[144],"cell":[147],"survival":[148,228],"tumor":[151,227],"maintenance.":[154],"We":[155],"further":[156],"show":[157],"clinical":[160,185],"mTOR":[161,215],"active":[162],"site":[163],"inhibitor,":[164],"which":[165],"capable":[167],"blocking":[169],"phosphorylation,":[172],"has":[173],"remarkable":[174],"efficacy":[176],"hematological":[179],"Additionally,":[181],"demonstrate":[183],"implications":[186],"these":[188,209],"results":[189],"by":[190],"delineating":[191],"significant":[193],"response":[204],"lymphomas.":[207],"Together,":[208],"findings":[210],"reveal":[211],"an":[213],"substrate":[216],"found":[218],"hyperactivated":[219],"downstream":[220],"activity":[224],"promote":[226],"confers":[230],"synthetic":[231],"lethality,":[232],"thereby":[233],"revealing":[234],"unique":[236],"approach":[238],"render":[240],"druggable":[242]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":34},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}