{"id":"https://openalex.org/W2151552476","doi":"https://doi.org/10.1093/genetics/153.4.1655","title":"Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3","display_name":"Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3","publication_year":1999,"publication_date":"1999-12-01","ids":{"openalex":"https://openalex.org/W2151552476","doi":"https://doi.org/10.1093/genetics/153.4.1655","mag":"2151552476","pmid":"https://pubmed.ncbi.nlm.nih.gov/10581274","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1460877"},"language":"en","primary_location":{"id":"doi:10.1093/genetics/153.4.1655","doi":"https://doi.org/10.1093/genetics/153.4.1655","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/153.4.1655","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1460877/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009110539","display_name":"Shai Shaham","orcid":"https://orcid.org/0000-0002-3751-975X","observed_orcids":["https://orcid.org/0000-0002-3751-975X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shai Shaham","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA","Department of Biochemistry and Biophysics, Univer-ruption","Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9038","Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","Howard Hughes Medical Institute, Department of Biology, Room 68-425, Massachusetts Insti","sity of California, San Francisco, CA 94143-0448","tute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Univer-ruption","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9038","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Room 68-425, Massachusetts Insti","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"sity of California, San Francisco, CA 94143-0448","institution_ids":[]},{"raw_affiliation_string":"tute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011162507","display_name":"Peter W. Reddien","orcid":"https://orcid.org/0000-0002-5569-333X","observed_orcids":["https://orcid.org/0000-0002-5569-333X"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter W Reddien","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082420222","display_name":"Brian A. Davies","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Davies","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","Department of Biochemistry and Biophysics, Univer-ruption","Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9038","Howard Hughes Medical Institute, Department of Biology, Room 68-425, Massachusetts Insti","sity of California, San Francisco, CA 94143-0448","tute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Biochemistry and Biophysics, Univer-ruption","institution_ids":[]},{"raw_affiliation_string":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9038","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Room 68-425, Massachusetts Insti","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"sity of California, San Francisco, CA 94143-0448","institution_ids":[]},{"raw_affiliation_string":"tute of Technology, 77 Massachusetts Ave., Cambridge, MA 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075093223","display_name":"Howard Robert Horvitz","orcid":"https://orcid.org/0000-0002-9964-9613","observed_orcids":["https://orcid.org/0000-0002-9964-9613"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H Robert Horvitz","raw_affiliation_strings":["Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075093223"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I63966007"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":0.8622,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.67676913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"153","issue":"4","first_page":"1655","last_page":"1671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ced-3","display_name":"CED-3","score":0.9850000143051147},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"programmed cell death","score":0.9070000052452087},{"id":"https://openalex.org/keywords/caspases","display_name":"caspases","score":0.921999990940094},{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.9369999766349792},{"id":"https://openalex.org/keywords/active-site-cysteine","display_name":"active site cysteine","score":0.7680000066757202},{"id":"https://openalex.org/keywords/aspartate-residues","display_name":"aspartic acid residues","score":0.8040000200271606},{"id":"https://openalex.org/keywords/proprotein-processing","display_name":"proprotein processing","score":0.8140000104904175},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.8399999737739563},{"id":"https://openalex.org/keywords/protease-domain","display_name":"protease domain","score":0.8050000071525574},{"id":"https://openalex.org/keywords/interleukin-1-beta-converting-enzyme","display_name":"interleukin-1 beta converting enzyme","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.9224616885185242},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8876634836196899},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7907891869544983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6785414218902588},{"id":"https://openalex.org/C2776496032","wikidata":"https://www.wikidata.org/wiki/Q1904768","display_name":"Caenorhabditis","level":4,"score":0.5540371537208557},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.461894154548645}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015801","descriptor_name":"Helminth Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015801","descriptor_name":"Helminth Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/genetics/153.4.1655","doi":"https://doi.org/10.1093/genetics/153.4.1655","is_oa":false,"landing_page_url":"https://doi.org/10.1093/genetics/153.4.1655","pdf_url":null,"source":{"id":"https://openalex.org/S65932378","display_name":"Genetics","issn_l":"0016-6731","issn":["0016-6731","1943-2631"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"journal-article"},{"id":"pmid:10581274","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10581274","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1460877","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1460877/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1460877","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1460877/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genetics","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W91819719","https://openalex.org/W106780798","https://openalex.org/W1470758466","https://openalex.org/W1581412826","https://openalex.org/W1585201985","https://openalex.org/W1603342850","https://openalex.org/W1624001120","https://openalex.org/W1647075334","https://openalex.org/W1821435713","https://openalex.org/W1916777863","https://openalex.org/W1924646174","https://openalex.org/W1941848008","https://openalex.org/W1944127002","https://openalex.org/W1948927501","https://openalex.org/W1964977785","https://openalex.org/W1969331809","https://openalex.org/W1975670576","https://openalex.org/W1976133790","https://openalex.org/W1976312800","https://openalex.org/W1981106016","https://openalex.org/W1984338631","https://openalex.org/W1987785848","https://openalex.org/W1990917512","https://openalex.org/W1992637685","https://openalex.org/W1993336052","https://openalex.org/W1993864683","https://openalex.org/W1996180957","https://openalex.org/W2000352412","https://openalex.org/W2007755249","https://openalex.org/W2008348103","https://openalex.org/W2008448390","https://openalex.org/W2014808011","https://openalex.org/W2014988811","https://openalex.org/W2017708875","https://openalex.org/W2023813445","https://openalex.org/W2032417513","https://openalex.org/W2032446466","https://openalex.org/W2032579724","https://openalex.org/W2033107803","https://openalex.org/W2043481572","https://openalex.org/W2051658957","https://openalex.org/W2053937675","https://openalex.org/W2057241729","https://openalex.org/W2058773384","https://openalex.org/W2059666350","https://openalex.org/W2072502723","https://openalex.org/W2072894284","https://openalex.org/W2081145901","https://openalex.org/W2083560313","https://openalex.org/W2086493438","https://openalex.org/W2087092800","https://openalex.org/W2094334993","https://openalex.org/W2095159309","https://openalex.org/W2096285464","https://openalex.org/W2101699819","https://openalex.org/W2107237397","https://openalex.org/W2118509035","https://openalex.org/W2120473562","https://openalex.org/W2122163057","https://openalex.org/W2131901063","https://openalex.org/W2133287830","https://openalex.org/W2138144052","https://openalex.org/W2139360111","https://openalex.org/W2139587743","https://openalex.org/W2143772496","https://openalex.org/W2144634347","https://openalex.org/W2144701362","https://openalex.org/W2149755594","https://openalex.org/W2151680166","https://openalex.org/W2155815536","https://openalex.org/W2161020639","https://openalex.org/W2163636387","https://openalex.org/W2314225431","https://openalex.org/W4298405269","https://openalex.org/W4301119686","https://openalex.org/W6640526570","https://openalex.org/W6658669141"],"related_works":["https://openalex.org/W2083560313","https://openalex.org/W2151680166","https://openalex.org/W2048750043","https://openalex.org/W2149755594","https://openalex.org/W7101068356","https://openalex.org/W2943474274","https://openalex.org/W2089247952","https://openalex.org/W4230833239","https://openalex.org/W1969331809","https://openalex.org/W2323396556"],"abstract_inverted_index":{"Mutations":[0],"in":[1,23,62,83,147],"the":[2,24,36,41,45,53,66,71,89,116,124,131,134,139],"gene":[3,136],"ced-3,":[4],"which":[5,127],"encodes":[6,138],"a":[7,84],"protease":[8,43,140,162],"similar":[9],"to":[10,32,143],"interleukin-1beta":[11],"converting":[12],"enzyme":[13],"and":[14,44,70],"related":[15],"proteins":[16],"termed":[17],"caspases,":[18],"prevent":[19],"programmed":[20,59,148,154],"cell":[21,60,149,155],"death":[22,61,156],"nematode":[25],"Caenorhabditis":[26],"elegans.":[27],"We":[28,64],"used":[29],"site-directed":[30],"mutagenesis":[31],"demonstrate":[33],"that":[34,109,137,152],"both":[35],"presumptive":[37],"active-site":[38],"cysteine":[39],"of":[40,50,52,74,118,133,160],"CED-3":[42,54,161],"aspartate":[46],"residues":[47,111],"at":[48,103],"sites":[49,93,113],"processing":[51],"proprotein":[55],"are":[56,100],"required":[57],"for":[58,115,123,130],"vivo.":[63],"characterized":[65],"phenotypes":[67],"caused":[68],"by":[69,95],"molecular":[72],"lesions":[73],"52":[75],"ced-3":[76,96,135],"alleles.":[77],"These":[78],"alleles":[79],"can":[80,157],"be":[81,144],"ordered":[82],"graded":[85],"phenotypic":[86],"series.":[87],"Of":[88],"30":[90],"amino":[91],"acid":[92],"altered":[94],"missense":[97],"mutations,":[98],"29":[99],"conserved":[101],"with":[102],"least":[104],"one":[105],"other":[106],"caspase,":[107],"suggesting":[108,151],"these":[110],"define":[112],"important":[114],"functions":[117],"all":[119],"caspases.":[120],"Animals":[121],"homozygous":[122],"ced-3(n2452)":[125],"allele,":[126],"is":[128],"deleted":[129],"region":[132],"domain,":[141],"seemed":[142],"incompletely":[145],"blocked":[146],"death,":[150],"some":[153],"occur":[158],"independently":[159],"activity.":[163]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
