{"id":"https://openalex.org/W2151417014","doi":"https://doi.org/10.1146/annurev.genom.9.081307.164437","title":"Transcriptional Control of Skeletogenesis","display_name":"Transcriptional Control of Skeletogenesis","publication_year":2008,"publication_date":"2008-09-01","ids":{"openalex":"https://openalex.org/W2151417014","doi":"https://doi.org/10.1146/annurev.genom.9.081307.164437","mag":"2151417014","pmid":"https://pubmed.ncbi.nlm.nih.gov/18767962"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.genom.9.081307.164437","doi":"https://doi.org/10.1146/annurev.genom.9.081307.164437","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev.genom.9.081307.164437","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.genom.9.081307.164437","source":{"id":"https://openalex.org/S8095556","display_name":"Annual Review of Genomics and Human Genetics","issn_l":"1527-8204","issn":["1527-8204","1545-293X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genomics and Human Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.genom.9.081307.164437","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086824931","display_name":"G\u00e9rard Karsenty","orcid":"https://orcid.org/0000-0002-9253-7627","observed_orcids":["https://orcid.org/0000-0002-9253-7627","https://orcid.org/0000-0002-9047-3332"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerard Karsenty","raw_affiliation_strings":["Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, New York 10032;","institution_ids":["https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086824931"],"corresponding_institution_ids":["https://openalex.org/I78577930"],"apc_list":null,"apc_paid":null,"fwci":2.5133,"has_fulltext":true,"cited_by_count":390,"citation_normalized_percentile":{"value":0.92051536,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"183","last_page":"196"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.14720000326633453,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.04410000145435333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/skeletogenesis","display_name":"skeletogenesis","score":0.9649999737739563},{"id":"https://openalex.org/keywords/transcription-factors","display_name":"transcription factors","score":0.8420000076293945},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.9070000052452087},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.996999979019165},{"id":"https://openalex.org/keywords/osteoclasts","display_name":"osteoclasts","score":1.0},{"id":"https://openalex.org/keywords/skeletal-dysplasia","display_name":"skeletal dysplasia","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7940000295639038},{"id":"https://openalex.org/keywords/skeletal-development","display_name":"skeletal development","score":0.5490000247955322},{"id":"https://openalex.org/keywords/chondrogenesis","display_name":"chondrogenesis","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6119240522384644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5711554288864136},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.571075975894928},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.5667181611061096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46592140197753906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3518754839897156},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3294844329357147},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25786542892456055},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18097862601280212}],"mesh":[{"descriptor_ui":"D000076182","descriptor_name":"Sp7 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001846","descriptor_name":"Bone Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001848","descriptor_name":"Bone Diseases, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010012","descriptor_name":"Osteogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050659","descriptor_name":"Core Binding Factor Alpha 1 Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051701","descriptor_name":"Activating Transcription Factor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1146/annurev.genom.9.081307.164437","doi":"https://doi.org/10.1146/annurev.genom.9.081307.164437","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev.genom.9.081307.164437","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.genom.9.081307.164437","source":{"id":"https://openalex.org/S8095556","display_name":"Annual Review of Genomics and Human Genetics","issn_l":"1527-8204","issn":["1527-8204","1545-293X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genomics and Human Genetics","raw_type":"journal-article"},{"id":"pmid:18767962","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18767962","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of genomics and human genetics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1146/annurev.genom.9.081307.164437","doi":"https://doi.org/10.1146/annurev.genom.9.081307.164437","is_oa":true,"landing_page_url":"https://doi.org/10.1146/annurev.genom.9.081307.164437","pdf_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.genom.9.081307.164437","source":{"id":"https://openalex.org/S8095556","display_name":"Annual Review of Genomics and Human Genetics","issn_l":"1527-8204","issn":["1527-8204","1545-293X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Genomics and Human Genetics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151417014.pdf","grobid_xml":"https://content.openalex.org/works/W2151417014.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W147299052","https://openalex.org/W1489648704","https://openalex.org/W1524345526","https://openalex.org/W1541819796","https://openalex.org/W1574722884","https://openalex.org/W1599501164","https://openalex.org/W1963690512","https://openalex.org/W1967485093","https://openalex.org/W1970728706","https://openalex.org/W1971955679","https://openalex.org/W1973295687","https://openalex.org/W1980740451","https://openalex.org/W1981856729","https://openalex.org/W1982581668","https://openalex.org/W1984754431","https://openalex.org/W1986208864","https://openalex.org/W1986515287","https://openalex.org/W1986671812","https://openalex.org/W1988151099","https://openalex.org/W1993064864","https://openalex.org/W1994596418","https://openalex.org/W1996461969","https://openalex.org/W1997508587","https://openalex.org/W1997812904","https://openalex.org/W2002345411","https://openalex.org/W2004583463","https://openalex.org/W2004895813","https://openalex.org/W2008949718","https://openalex.org/W2013176040","https://openalex.org/W2013714561","https://openalex.org/W2014164632","https://openalex.org/W2014316105","https://openalex.org/W2019460013","https://openalex.org/W2025046506","https://openalex.org/W2025404099","https://openalex.org/W2026201824","https://openalex.org/W2036224418","https://openalex.org/W2036287488","https://openalex.org/W2036851890","https://openalex.org/W2049157134","https://openalex.org/W2049254268","https://openalex.org/W2065584680","https://openalex.org/W2067427748","https://openalex.org/W2075328770","https://openalex.org/W2076974856","https://openalex.org/W2079475603","https://openalex.org/W2082575625","https://openalex.org/W2085907524","https://openalex.org/W2088120545","https://openalex.org/W2098326006","https://openalex.org/W2099397203","https://openalex.org/W2101469591","https://openalex.org/W2102047286","https://openalex.org/W2102070943","https://openalex.org/W2105244370","https://openalex.org/W2105723130","https://openalex.org/W2108698814","https://openalex.org/W2109540605","https://openalex.org/W2109587624","https://openalex.org/W2122367477","https://openalex.org/W2122433264","https://openalex.org/W2126853193","https://openalex.org/W2129735760","https://openalex.org/W2131632095","https://openalex.org/W2133014215","https://openalex.org/W2136163260","https://openalex.org/W2136358316","https://openalex.org/W2142256883","https://openalex.org/W2147510409","https://openalex.org/W2147803180","https://openalex.org/W2151497881","https://openalex.org/W2151708616","https://openalex.org/W2154967508","https://openalex.org/W2159231404","https://openalex.org/W2166913542","https://openalex.org/W2167625289","https://openalex.org/W2170516128","https://openalex.org/W2171628252","https://openalex.org/W2183023031","https://openalex.org/W2329404090"],"related_works":["https://openalex.org/W2075526364","https://openalex.org/W1989580334","https://openalex.org/W2164448282","https://openalex.org/W2037499635","https://openalex.org/W2087250138","https://openalex.org/W2326293806","https://openalex.org/W2533324812","https://openalex.org/W2353578725","https://openalex.org/W947162997","https://openalex.org/W2017467803"],"abstract_inverted_index":{"The":[0],"skeleton":[1],"contains":[2],"three":[3,29],"specific":[4],"cell":[5,25],"types:":[6],"chondrocytes":[7,43],"in":[8,14,34],"cartilage":[9],"and":[10,12,44,70,77],"osteoblasts":[11,45],"osteoclasts":[13],"bone.":[15],"Our":[16],"understanding":[17],"of":[18,42,56,75],"the":[19,35,40,53,63],"transcriptional":[20],"mechanisms":[21],"that":[22,67],"lead":[23],"to":[24,92],"differentiation":[26],"along":[27],"these":[28],"lineages":[30],"has":[31,90],"increased":[32],"considerably":[33],"past":[36],"ten":[37],"years.":[38],"In":[39],"case":[41],"advances":[46],"have":[47],"been":[48],"made":[49],"possible":[50],"largely":[51],"through":[52],"molecular":[54],"elucidation":[55],"human":[57,88],"skeletal":[58],"dysplasias.":[59],"This":[60],"review":[61],"discusses":[62],"key":[64],"transcription":[65],"factors":[66],"regulate":[68],"skeletogenesis":[69],"highlights":[71],"their":[72],"function,":[73],"mode":[74],"action,":[76],"regulation":[78],"by":[79],"other":[80],"factors,":[81],"with":[82],"a":[83],"special":[84],"emphasis":[85],"on":[86],"how":[87],"genetics":[89],"contributed":[91],"this":[93],"knowledge.":[94]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":21},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":36},{"year":2015,"cited_by_count":32},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":31},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}