{"id":"https://openalex.org/W2151295847","doi":"https://doi.org/10.1136/thx.2007.086454","title":"Cost-effectiveness of using continuous positive airway pressure in the treatment of severe obstructive sleep apnoea/hypopnoea syndrome in the UK","display_name":"Cost-effectiveness of using continuous positive airway pressure in the treatment of severe obstructive sleep apnoea/hypopnoea syndrome in the UK","publication_year":2008,"publication_date":"2008-04-17","ids":{"openalex":"https://openalex.org/W2151295847","doi":"https://doi.org/10.1136/thx.2007.086454","mag":"2151295847","pmid":"https://pubmed.ncbi.nlm.nih.gov/18408048"},"language":"en","primary_location":{"id":"doi:10.1136/thx.2007.086454","doi":"https://doi.org/10.1136/thx.2007.086454","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2007.086454","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/63/10/860.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/63/10/860.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003866278","display_name":"Julian F. Guest","orcid":"https://orcid.org/0000-0003-0162-2007","observed_orcids":["https://orcid.org/0000-0003-0162-2007"]},"institutions":[{"id":"https://openalex.org/I4210110111","display_name":"Catalyst Health Economics Consultants Ltd","ror":"https://ror.org/01yft1b10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210110111"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"J F Guest","raw_affiliation_strings":["Catalyst Health Economics Consultants, 34b High Street, Northwood, Middlesex HA6 1BN, UK. julian.guest@catalyst-health.co.uk","Catalyst Health Economics Consultants, 34b High Street, Northwood, Middlesex HA6 1BN, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalyst Health Economics Consultants, 34b High Street, Northwood, Middlesex HA6 1BN, UK. julian.guest@catalyst-health.co.uk","institution_ids":["https://openalex.org/I4210110111"]},{"raw_affiliation_string":"Catalyst Health Economics Consultants, 34b High Street, Northwood, Middlesex HA6 1BN, UK","institution_ids":["https://openalex.org/I4210110111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002426412","display_name":"T\u00edmea Mariann Helter","orcid":"https://orcid.org/0000-0002-2696-2553","observed_orcids":["https://orcid.org/0000-0002-2696-2553"]},"institutions":[{"id":"https://openalex.org/I4210110111","display_name":"Catalyst Health Economics Consultants Ltd","ror":"https://ror.org/01yft1b10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210110111"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M T Helter","raw_affiliation_strings":["Catalyst Health Economics Consultants, Northwood, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalyst Health Economics Consultants, Northwood, Middlesex, UK","institution_ids":["https://openalex.org/I4210110111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020226716","display_name":"A Morga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210110111","display_name":"Catalyst Health Economics Consultants Ltd","ror":"https://ror.org/01yft1b10","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210110111"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A Morga","raw_affiliation_strings":["Catalyst Health Economics Consultants, Northwood, Middlesex, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Catalyst Health Economics Consultants, Northwood, Middlesex, UK","institution_ids":["https://openalex.org/I4210110111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018887395","display_name":"John R. Stradling","orcid":"https://orcid.org/0000-0003-4971-5018","observed_orcids":["https://orcid.org/0000-0003-4971-5018"]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J R Stradling","raw_affiliation_strings":["Respiratory Sleep Unit, Churchill Hospital, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Sleep Unit, Churchill Hospital, Oxford, UK","institution_ids":["https://openalex.org/I2801179840"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003866278"],"corresponding_institution_ids":["https://openalex.org/I4210110111"],"apc_list":null,"apc_paid":null,"fwci":4.0572,"has_fulltext":true,"cited_by_count":118,"citation_normalized_percentile":{"value":0.93750697,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"63","issue":"10","first_page":"860","last_page":"865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10234","display_name":"Obstructive Sleep Apnea Research","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10316","display_name":"Sleep and related disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/continuous-positive-airway-pressure","display_name":"continuous positive airway pressure","score":0.9589999914169312},{"id":"https://openalex.org/keywords/obstructive-sleep-apnea","display_name":"obstructive sleep apnea","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9490000009536743},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cost-per-quality-adjusted-life-year","display_name":"cost per quality-adjusted life year","score":0.8059999942779541},{"id":"https://openalex.org/keywords/national-health-service","display_name":"National Health Service","score":0.6800000071525574},{"id":"https://openalex.org/keywords/apnea-hypopnea-index","display_name":"apnea-hypopnea index","score":0.8640000224113464},{"id":"https://openalex.org/keywords/daytime-sleepiness","display_name":"daytime sleepiness","score":0.8529999852180481},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.5619999766349792}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9414539933204651},{"id":"https://openalex.org/C2779547634","wikidata":"https://www.wikidata.org/wiki/Q5165502","display_name":"Continuous positive airway pressure","level":3,"score":0.8552227020263672},{"id":"https://openalex.org/C3019080777","wikidata":"https://www.wikidata.org/wiki/Q1754768","display_name":"Cost effectiveness","level":2,"score":0.6227132081985474},{"id":"https://openalex.org/C2778664715","wikidata":"https://www.wikidata.org/wiki/Q1347756","display_name":"Epworth Sleepiness Scale","level":4,"score":0.5961025357246399},{"id":"https://openalex.org/C64332521","wikidata":"https://www.wikidata.org/wiki/Q614165","display_name":"Quality-adjusted life year","level":3,"score":0.42923521995544434},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4085463583469391},{"id":"https://openalex.org/C2778205975","wikidata":"https://www.wikidata.org/wiki/Q1754874","display_name":"Polysomnography","level":3,"score":0.29002323746681213},{"id":"https://openalex.org/C2776006263","wikidata":"https://www.wikidata.org/wiki/Q16606552","display_name":"Obstructive sleep apnea","level":2,"score":0.27865326404571533},{"id":"https://openalex.org/C2781326671","wikidata":"https://www.wikidata.org/wiki/Q754424","display_name":"Apnea","level":2,"score":0.2593580484390259},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.24869167804718018},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000063","descriptor_name":"Accidents, Traffic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017048","descriptor_name":"Health Care Costs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D020181","descriptor_name":"Sleep Apnea, Obstructive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D045422","descriptor_name":"Continuous Positive Airway Pressure","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1136/thx.2007.086454","doi":"https://doi.org/10.1136/thx.2007.086454","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2007.086454","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/63/10/860.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmid:18408048","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18408048","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.837.5645","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.837.5645","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://thorax.bmj.com/content/63/10/860.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:thoraxjnl:thx.2007.086454v1","doi":null,"is_oa":false,"landing_page_url":"http://thorax.bmj.com/cgi/content/short/thx.2007.086454v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"doi:10.1136/thx.2007.086454","doi":"https://doi.org/10.1136/thx.2007.086454","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.2007.086454","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/63/10/860.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320317536","display_name":"ResMed","ror":"https://ror.org/01j0jk666"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151295847.pdf","grobid_xml":"https://content.openalex.org/works/W2151295847.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W108214990","https://openalex.org/W145364333","https://openalex.org/W205434250","https://openalex.org/W1714259827","https://openalex.org/W1980732575","https://openalex.org/W2031374244","https://openalex.org/W2034556696","https://openalex.org/W2041291206","https://openalex.org/W2055802019","https://openalex.org/W2057914080","https://openalex.org/W2097864917","https://openalex.org/W2108207174","https://openalex.org/W2112312437","https://openalex.org/W2117225632","https://openalex.org/W2132653208","https://openalex.org/W2136167986","https://openalex.org/W2139227400","https://openalex.org/W2143132974","https://openalex.org/W2159142517","https://openalex.org/W3162256417","https://openalex.org/W4302367392","https://openalex.org/W4321508254"],"related_works":["https://openalex.org/W2098383566","https://openalex.org/W2117700583","https://openalex.org/W2300362070","https://openalex.org/W2139227400","https://openalex.org/W2073968141","https://openalex.org/W7095089392","https://openalex.org/W44727445","https://openalex.org/W4402246331","https://openalex.org/W2118983774","https://openalex.org/W2128155584"],"abstract_inverted_index":{"OBJECTIVE:":[0],"A":[1,43],"study":[2],"was":[3,46,162,231],"undertaken":[4],"to":[5,48,96,105,126,135,148,165,181,198,233],"estimate":[6],"the":[7,17,33,36,50,61,97,109,128,171,191,225,228,243,246],"cost-effectiveness":[8,51],"of":[9,19,35,52,63,91,100,111,117,159,189,207,227,245,255,258],"using":[10],"continuous":[11],"positive":[12],"airway":[13],"pressure":[14],"(CPAP)":[15],"in":[16],"management":[18,62],"patients":[20,102,118,123],"with":[21,29,55,67,115,120,143,154],"severe":[22,68],"obstructive":[23],"sleep":[24],"apnoea/hypopnoea":[25],"syndrome":[26],"(OSAHS)":[27],"compared":[28,54,114,142],"no":[30,56,218,239],"treatment":[31,190,213,219,240],"from":[32,242],"perspective":[34,244],"UK's":[37,247],"National":[38],"Health":[39],"Service":[40],"(NHS).":[41],"METHODS:":[42],"Markov":[44],"model":[45,59,87],"constructed":[47],"assess":[49],"CPAP":[53,155,209,230],"treatment.":[57,259],"The":[58,86],"depicted":[60],"a":[64,89,157,167,211,249,253],"55-year-old":[65],"patient":[66,138],"OSAHS":[69],"as":[70],"defined":[71],"by":[72],"an":[73],"apnoea-hypopnoea":[74],"index":[75],"(AHI)":[76],">30":[77],"and":[78],"daytime":[79],"sleepiness":[80],"(Epworth":[81],"Sleepiness":[82],"Scale":[83],"score":[84],">or=12).":[85],"spans":[88],"period":[90,158],"14":[92,112,140],"years.":[93],"RESULTS:":[94],"According":[95],"model,":[98,229],"57%":[99],"untreated":[101],"are":[103,124],"expected":[104,125,180,197],"be":[106,166,182,199,234],"alive":[107],"at":[108],"end":[110],"years":[113,141,188,206,257],"72%":[116],"treated":[119],"CPAP.":[121],"Untreated":[122],"cost":[127,172,192],"NHS":[129],"pound10":[130],"645":[131],"(95%":[132,145],"CI":[133,146],"pound7988":[134],"pound14,098)":[136],"per":[137,150,173,193],"over":[139],"pound9672":[144],"pound8057":[147],"pound12,860)":[149],"CPAP-treated":[151],"patient.":[152],"Treatment":[153],"for":[156,220],"1":[160],"year":[161,176],"found":[163,232],"not":[164],"cost-effective":[168,250],"option":[169],"since":[170],"quality-adjusted":[174],"life":[175],"(QALY)":[177],"gained":[178,195],"is":[179,196],">":[183],"pound20,000,":[184],"but":[185],"after":[186,204,252],"2":[187,256],"QALY":[194],"pound10,000":[200],"or":[201],"less":[202,221],"and,":[203,241],"13":[205],"treatment,":[208],"becomes":[210],"dominant":[212],"(ie,":[214],"more":[215,236],"effective":[216,237],"than":[217,238],"cost).":[222],"CONCLUSION:":[223],"Within":[224],"limitations":[226],"clinically":[235],"NHS,":[248],"strategy":[251],"minimum":[254]},"counts_by_year":[{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
