{"id":"https://openalex.org/W2151284087","doi":"https://doi.org/10.1021/bi990684r","title":"Escherichia coli Methionine Aminopeptidase: Implications of Crystallographic Analyses of the Native, Mutant, and Inhibited Enzymes for the Mechanism of Catalysis ,","display_name":"Escherichia coli Methionine Aminopeptidase: Implications of Crystallographic Analyses of the Native, Mutant, and Inhibited Enzymes for the Mechanism of Catalysis ,","publication_year":1999,"publication_date":"1999-05-26","ids":{"openalex":"https://openalex.org/W2151284087","doi":"https://doi.org/10.1021/bi990684r","mag":"2151284087","pmid":"https://pubmed.ncbi.nlm.nih.gov/10387007"},"language":"en","primary_location":{"id":"doi:10.1021/bi990684r","doi":"https://doi.org/10.1021/bi990684r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi990684r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090966947","display_name":"W. Todd Lowther","orcid":"https://orcid.org/0000-0002-0246-1295","observed_orcids":["https://orcid.org/0000-0002-0246-1295"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Todd Lowther","raw_affiliation_strings":["Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016562586","display_name":"Allen Milster Orville","orcid":"https://orcid.org/0000-0002-7803-1777","observed_orcids":["https://orcid.org/0000-0002-7803-1777"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen M. Orville","raw_affiliation_strings":["Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034084898","display_name":"David T. Madden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Madden","raw_affiliation_strings":["Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069025071","display_name":"Sejin Lim","orcid":"https://orcid.org/0000-0002-0465-1666","observed_orcids":["https://orcid.org/0000-0002-0465-1666"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sejin Lim","raw_affiliation_strings":["Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I181233156"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069015659","display_name":"Daniel H. Rich","orcid":"https://orcid.org/0000-0001-5662-6529","observed_orcids":["https://orcid.org/0000-0001-5662-6529"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel H. Rich","raw_affiliation_strings":["Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112526839","display_name":"Brian W. Matthews","orcid":"https://orcid.org/0000-0002-3342-3160","observed_orcids":["https://orcid.org/0000-0002-3342-3160"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian W. Matthews","raw_affiliation_strings":["Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, Howard Hughes Medical Institute and Department of Physics, 1229 University of Oregon, Eugene, Oregon 97403, and Department of Chemistry and School of Pharmacy, University of WisconsinMadison, 425 North Charter Street, Madison Wisconsin 53706","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I135310074","https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.7592,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.94123457,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"24","first_page":"7678","last_page":"7688"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methionine-aminopeptidase","display_name":"methionine aminopeptidase","score":0.9480000138282776},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9559999704360962},{"id":"https://openalex.org/keywords/substrate-analog-inhibitors","display_name":"substrate analog inhibitors","score":0.6119999885559082},{"id":"https://openalex.org/keywords/enzyme-inhibition-mechanism","display_name":"enzyme inhibition mechanism","score":0.42800000309944153},{"id":"https://openalex.org/keywords/catalytic-mechanism","display_name":"catalytic mechanism","score":0.7429999709129333},{"id":"https://openalex.org/keywords/apo-enzyme-structure","display_name":"apoenzyme structure","score":0.7009999752044678},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.4830000102519989},{"id":"https://openalex.org/keywords/angiogenesis-inhibitors","display_name":"angiogenesis inhibitors","score":0.6010000109672546},{"id":"https://openalex.org/keywords/fungal-infection-treatment","display_name":"fungal infection treatment","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7480939626693726},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.6786701679229736},{"id":"https://openalex.org/C11111787","wikidata":"https://www.wikidata.org/wiki/Q675972","display_name":"Coordination sphere","level":3,"score":0.6203768253326416},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5668935179710388},{"id":"https://openalex.org/C2778074193","wikidata":"https://www.wikidata.org/wiki/Q3498942","display_name":"Carboxylate","level":2,"score":0.5378730297088623},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.5246391892433167},{"id":"https://openalex.org/C158842870","wikidata":"https://www.wikidata.org/wiki/Q6125309","display_name":"Pentagonal bipyramidal molecular geometry","level":3,"score":0.49434447288513184},{"id":"https://openalex.org/C179506582","wikidata":"https://www.wikidata.org/wiki/Q7115108","display_name":"Oxyanion hole","level":4,"score":0.47691866755485535},{"id":"https://openalex.org/C111592845","wikidata":"https://www.wikidata.org/wiki/Q2867924","display_name":"Trigonal bipyramidal molecular geometry","level":3,"score":0.4741501212120056},{"id":"https://openalex.org/C194196696","wikidata":"https://www.wikidata.org/wiki/Q1753378","display_name":"Coordination geometry","level":4,"score":0.42026498913764954},{"id":"https://openalex.org/C112887158","wikidata":"https://www.wikidata.org/wiki/Q169324","display_name":"Hydrogen bond","level":3,"score":0.4172346293926239},{"id":"https://openalex.org/C2780985610","wikidata":"https://www.wikidata.org/wiki/Q419527","display_name":"Aminopeptidase","level":4,"score":0.41605108976364136},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.4015175402164459},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.36052072048187256},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.3101568818092346},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.22876334190368652},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16178101301193237},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13301965594291687},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.09398260712623596}],"mesh":[{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002414","descriptor_name":"Cations, Monovalent","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003035","descriptor_name":"Cobalt","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006639","descriptor_name":"Histidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020035","descriptor_name":"Holoenzymes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020035","descriptor_name":"Holoenzymes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D063208","descriptor_name":"Methionyl Aminopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi990684r","doi":"https://doi.org/10.1021/bi990684r","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi990684r","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:10387007","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10387007","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3370562123","display_name":"STRUCTURE-FUNCTION ANALYSIS OF METHIONINE AMINOPEPTIDASE","funder_award_id":"F32GM017536","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G4740068639","display_name":null,"funder_award_id":"GM20066","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1512554230","https://openalex.org/W1891265320","https://openalex.org/W1968185653","https://openalex.org/W1975055907","https://openalex.org/W1978928219","https://openalex.org/W2000000541","https://openalex.org/W2003107936","https://openalex.org/W2009009411","https://openalex.org/W2011268373","https://openalex.org/W2027297527","https://openalex.org/W2080476827","https://openalex.org/W2082835240","https://openalex.org/W2155894308","https://openalex.org/W2158965678","https://openalex.org/W2322589625","https://openalex.org/W2324677651","https://openalex.org/W4249231186"],"related_works":["https://openalex.org/W1985880865","https://openalex.org/W2121733516","https://openalex.org/W2088580576","https://openalex.org/W1531835467","https://openalex.org/W1996643987","https://openalex.org/W2151833855","https://openalex.org/W1979619881","https://openalex.org/W1971762245","https://openalex.org/W2057676790","https://openalex.org/W1964348848"],"abstract_inverted_index":{"By":[0],"improving":[1],"the":[2,18,21,37,44,56,90,97,101,123,134,144,154,158,165,172,175,183,188,202,233,237,249,300],"expression":[3],"and":[4,12,40,60,147,171,196,215,236,271,298,304],"purification":[5],"of":[6,20,36,43,100,106,133,143,157,167,174,178,205,226,232,239,276,302],"Escherichia":[7],"coli":[8],"methionine":[9,114],"aminopeptidase":[10],"(eMetAP)":[11],"using":[13],"slightly":[14],"different":[15,266],"crystallization":[16],"conditions,":[17],"resolution":[19],"parent":[22],"structure":[23,42,105,231],"was":[24,82],"extended":[25],"from":[26,89],"2.4":[27],"to":[28,75,112,137,151,182,256,274,286],"1.9":[29],"A":[30,65,77,87],"resolution.":[31],"This":[32,120],"has":[33,116],"permitted":[34],"visualization":[35],"coordination":[38,142,176],"geometry":[39],"solvent":[41,50,67,169],"active-site":[45],"dinuclear":[46],"metal":[47,91,124,186,263],"center.":[48,264],"One":[49],"molecule":[51],"(likely":[52],"a":[53,69,107,113,257,261],"mu-hydroxide)":[54],"bridges":[55],"trigonal":[57],"bipyramidal":[58],"(Co1)":[59],"octahedral":[61],"(Co2)":[62],"cobalt":[63],"ions.":[64],"second":[66],"(possibly":[68],"hydroxide":[70],"ion)":[71],"is":[72,253],"bound":[73,111],"terminally":[74],"Co2.":[76],"monovalent":[78],"cation":[79],"binding":[80,162],"site":[81,204],"also":[83,117,281],"identified":[84],"about":[85],"13":[86],"away":[88],"center":[92,125],"at":[93],"an":[94],"interface":[95],"between":[96],"two":[98,168,198],"subdomains":[99],"protein.":[102],"The":[103,230],"first":[104],"substrate-like":[108],"inhibitor,":[109],"(3R)-amino-(2S)-hydroxyheptanoyl-L-Ala-L-Leu-L-Val-L-Phe-OMe,":[110],"aminopeptidase,":[115],"been":[118],"determined.":[119],"inhibitor":[121],"coordinates":[122],"through":[126],"four":[127],"interactions":[128],"as":[129],"follows:":[130],"(i)":[131],"ligation":[132,150],"N-terminal":[135],"(3R)-nitrogen":[136],"Co2,":[138],"(ii,":[139],"iii)":[140],"bridging":[141],"(2S)-hydroxyl":[145],"group,":[146],"(iv)":[148],"terminal":[149],"Co1":[152],"by":[153],"keto":[155],"oxygen":[156],"pseudo-peptide":[159],"linkage.":[160],"Inhibitor":[161],"occurs":[163],"with":[164,194,219,244],"displacement":[166],"ligands":[170],"expansion":[173],"sphere":[177],"Co1.":[179],"In":[180],"addition":[181],"tetradentate,":[184],"bis-chelate":[185],"coordination,":[187],"substrate":[189],"analogue":[190],"forms":[191],"hydrogen":[192],"bonds":[193],"His79":[195,214],"His178,":[197],"conserved":[199],"residues":[200],"within":[201],"active":[203],"all":[206],"MetAPs.":[207],"To":[208],"evaluate":[209],"their":[210],"importance":[211],"in":[212,251,293,296,299],"catalysis":[213],"His178":[216],"were":[217],"replaced":[218],"alanine.":[220],"Both":[221],"substitutions,":[222],"but":[223],"especially":[224],"that":[225,248,283,287],"His79,":[227],"reduce":[228],"activity.":[229],"His79Ala":[234],"apoenzyme":[235],"comparison":[238],"its":[240],"electronic":[241],"absorption":[242],"spectra":[243],"other":[245],"variants":[246],"suggest":[247,282],"loss":[250],"activity":[252],"not":[254],"due":[255],"conformational":[258],"change":[259],"or":[260],"defective":[262],"Two":[265],"reaction":[267],"mechanisms":[268],"are":[269,272],"proposed":[270],"compared":[273],"those":[275],"related":[277],"enzymes.":[278],"These":[279],"results":[280],"inhibitors":[284],"analogous":[285],"reported":[288],"here":[289],"may":[290],"be":[291],"useful":[292],"preventing":[294],"angiogenesis":[295],"cancer":[297],"treatment":[301],"microbial":[303],"fungal":[305],"infections.":[306]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
