{"id":"https://openalex.org/W2151186972","doi":"https://doi.org/10.1124/jpet.109.156380","title":"Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders","display_name":"Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders","publication_year":2009,"publication_date":"2009-08-11","ids":{"openalex":"https://openalex.org/W2151186972","doi":"https://doi.org/10.1124/jpet.109.156380","mag":"2151186972","pmid":"https://pubmed.ncbi.nlm.nih.gov/19667132","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2775272"},"language":"en","primary_location":{"id":"doi:10.1124/jpet.109.156380","doi":"https://doi.org/10.1124/jpet.109.156380","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.109.156380","pdf_url":"https://jpet.aspetjournals.org/content/jpet/331/2/340.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jpet.aspetjournals.org/content/jpet/331/2/340.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100760592","display_name":"Liyun Wang","orcid":"https://orcid.org/0000-0002-3123-7727","observed_orcids":["https://orcid.org/0000-0002-3123-7727"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liyun Wang","raw_affiliation_strings":["Receptor Pharmacology Unit, and Metabolism Unit, the National Institutes of Health, National Institute on Aging, Baltimore, Maryland 21224, USA","Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","Receptor Pharmacology Unit (","University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Receptor Pharmacology Unit, and Metabolism Unit, the National Institutes of Health, National Institute on Aging, Baltimore, Maryland 21224, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Receptor Pharmacology Unit (","institution_ids":[]},{"raw_affiliation_string":"University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061101747","display_name":"Bronwen Martin","orcid":"https://orcid.org/0000-0002-9185-6925","observed_orcids":["https://orcid.org/0000-0002-9185-6925"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bronwen Martin","raw_affiliation_strings":["Metabolism Unit (B.M.) , the National Institutes of Health , National Institute on Aging , Baltimore , Maryland ; Cancer Biology Program ,","University of Miami , Miller School of Medicine , Miami , Florida","Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","Receptor Pharmacology Unit (","University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Metabolism Unit (B.M.) , the National Institutes of Health , National Institute on Aging , Baltimore , Maryland ; Cancer Biology Program ,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"raw_affiliation_string":"University of Miami , Miller School of Medicine , Miami , Florida","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Receptor Pharmacology Unit (","institution_ids":[]},{"raw_affiliation_string":"University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078065036","display_name":"Randall Brenneman","orcid":"https://orcid.org/0000-0001-6167-1746","observed_orcids":["https://orcid.org/0000-0001-6167-1746"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Randall Brenneman","raw_affiliation_strings":["Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","Receptor Pharmacology Unit (","University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Receptor Pharmacology Unit (","institution_ids":[]},{"raw_affiliation_string":"University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054100392","display_name":"Louis M. Luttrell","orcid":"https://orcid.org/0000-0003-2805-6949","observed_orcids":["https://orcid.org/0000-0003-2805-6949"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis M. Luttrell","raw_affiliation_strings":["Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","Receptor Pharmacology Unit (","University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Receptor Pharmacology Unit (","institution_ids":[]},{"raw_affiliation_string":"University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033862949","display_name":"Stuart R. Maudsley","orcid":"https://orcid.org/0000-0002-1868-184X","observed_orcids":["https://orcid.org/0000-0002-1868-184X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]},{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I4210132004","display_name":"Ralph H. Johnson VA Medical Center","ror":"https://ror.org/030ma0n95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210131075","https://openalex.org/I4210132004"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart Maudsley","raw_affiliation_strings":["Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","Receptor Pharmacology Unit (","University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical University of South Carolina, Department of Medicine, Division of Endocrinology, Diabetes and Medical Genetics, and the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, South Carolina (L.M","institution_ids":["https://openalex.org/I153297377","https://openalex.org/I4210132004"]},{"raw_affiliation_string":"National Institute on Aging, Biomedical Research Center, 251 Bayview Blvd., Balti-more, MD 21224","institution_ids":["https://openalex.org/I4210136897"]},{"raw_affiliation_string":"Receptor Pharmacology Unit (","institution_ids":[]},{"raw_affiliation_string":"University of Miami, Miller School of Medicine, Miami, Florida (R.B.); and","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"the National Institutes of Health, National Institute on Aging, Baltimore, Maryland; Cancer Biology Program,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5033862949"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I145608581","https://openalex.org/I153297377","https://openalex.org/I4210132004","https://openalex.org/I4210136897"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.1143,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.74520739,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":100},"biblio":{"volume":"331","issue":"2","first_page":"340","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.949999988079071},{"id":"https://openalex.org/keywords/allosteric-modulators","display_name":"allosteric modulators","score":0.9829999804496765},{"id":"https://openalex.org/keywords/allosteric-site","display_name":"allosteric site","score":0.9259999990463257},{"id":"https://openalex.org/keywords/signal-bias","display_name":"signal bias","score":0.6700000166893005},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.6830000281333923},{"id":"https://openalex.org/keywords/age-related-cognitive-impairment","display_name":"age-related cognitive impairment","score":0.9860000014305115},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"drug discovery","score":0.6520000100135803}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.9648397564888},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.8283240795135498},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6544546484947205},{"id":"https://openalex.org/C2776038425","wikidata":"https://www.wikidata.org/wiki/Q2649417","display_name":"Allosteric modulator","level":4,"score":0.6147100329399109},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5575811266899109},{"id":"https://openalex.org/C43587935","wikidata":"https://www.wikidata.org/wiki/Q1258877","display_name":"Functional selectivity","level":4,"score":0.5326221585273743},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.515984833240509},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47433891892433167},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4490049481391907},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44137296080589294},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32829028367996216},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.258754700422287},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.23812153935432434},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1976557970046997}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004358","descriptor_name":"Drug Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1124/jpet.109.156380","doi":"https://doi.org/10.1124/jpet.109.156380","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.109.156380","pdf_url":"https://jpet.aspetjournals.org/content/jpet/331/2/340.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2775272","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2775272","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Pharmacol Exp Ther","raw_type":"Text"},{"id":"pmid:19667132","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19667132","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacology and experimental therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.971.680","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.971.680","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jpet.aspetjournals.org/content/331/2/340.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1124/jpet.109.156380","doi":"https://doi.org/10.1124/jpet.109.156380","is_oa":true,"landing_page_url":"https://doi.org/10.1124/jpet.109.156380","pdf_url":"https://jpet.aspetjournals.org/content/jpet/331/2/340.full.pdf","source":{"id":"https://openalex.org/S102125482","display_name":"Journal of Pharmacology and Experimental Therapeutics","issn_l":"0022-3565","issn":["0022-3565","1521-0103"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pharmacology and Experimental Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G599612762","display_name":null,"funder_award_id":"DK055524","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G728020513","display_name":"Tyrosine Kinases in G Protein Mediated Signaling","funder_award_id":"R01DK055524","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8357898320","display_name":"Age and pathology-induced alteration of G protein-coupled receptor signaling","funder_award_id":"ZIAAG000318","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151186972.pdf","grobid_xml":"https://content.openalex.org/works/W2151186972.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W72465559","https://openalex.org/W1483932465","https://openalex.org/W1513722678","https://openalex.org/W1515745795","https://openalex.org/W1654156243","https://openalex.org/W1718009280","https://openalex.org/W1825353903","https://openalex.org/W1852077611","https://openalex.org/W1911458131","https://openalex.org/W1921401956","https://openalex.org/W1958218436","https://openalex.org/W1963693349","https://openalex.org/W1970410358","https://openalex.org/W1972722155","https://openalex.org/W1976266427","https://openalex.org/W1979010452","https://openalex.org/W1983534052","https://openalex.org/W1985423204","https://openalex.org/W1991426892","https://openalex.org/W1992090445","https://openalex.org/W1992388910","https://openalex.org/W1996774458","https://openalex.org/W1997085676","https://openalex.org/W1999799735","https://openalex.org/W2000147356","https://openalex.org/W2002717737","https://openalex.org/W2003736358","https://openalex.org/W2004791695","https://openalex.org/W2011964198","https://openalex.org/W2016278859","https://openalex.org/W2017255942","https://openalex.org/W2019168768","https://openalex.org/W2020696885","https://openalex.org/W2021294213","https://openalex.org/W2022576341","https://openalex.org/W2023291722","https://openalex.org/W2025434157","https://openalex.org/W2027591014","https://openalex.org/W2032790231","https://openalex.org/W2041160041","https://openalex.org/W2041662510","https://openalex.org/W2042239308","https://openalex.org/W2043612148","https://openalex.org/W2048264021","https://openalex.org/W2050899637","https://openalex.org/W2053911700","https://openalex.org/W2057496996","https://openalex.org/W2060372151","https://openalex.org/W2060765599","https://openalex.org/W2062485176","https://openalex.org/W2069602349","https://openalex.org/W2070624363","https://openalex.org/W2071935671","https://openalex.org/W2074446534","https://openalex.org/W2074753958","https://openalex.org/W2075320283","https://openalex.org/W2076439922","https://openalex.org/W2078789579","https://openalex.org/W2084093310","https://openalex.org/W2095775529","https://openalex.org/W2096686163","https://openalex.org/W2098273077","https://openalex.org/W2101769320","https://openalex.org/W2101896923","https://openalex.org/W2102679378","https://openalex.org/W2109068089","https://openalex.org/W2110469184","https://openalex.org/W2111112233","https://openalex.org/W2116719688","https://openalex.org/W2116803443","https://openalex.org/W2118338007","https://openalex.org/W2118770079","https://openalex.org/W2121895272","https://openalex.org/W2124091258","https://openalex.org/W2125662993","https://openalex.org/W2126210332","https://openalex.org/W2129134595","https://openalex.org/W2134289201","https://openalex.org/W2136629503","https://openalex.org/W2137092708","https://openalex.org/W2138677261","https://openalex.org/W2138779981","https://openalex.org/W2139129258","https://openalex.org/W2140783531","https://openalex.org/W2142789746","https://openalex.org/W2143594596","https://openalex.org/W2147984948","https://openalex.org/W2150063046","https://openalex.org/W2150501463","https://openalex.org/W2151312020","https://openalex.org/W2155547273","https://openalex.org/W2158066978","https://openalex.org/W2160475276","https://openalex.org/W2162312300","https://openalex.org/W2162348868","https://openalex.org/W2162384842","https://openalex.org/W2162714394","https://openalex.org/W2164339448","https://openalex.org/W2165902043","https://openalex.org/W2170692825","https://openalex.org/W2180638588","https://openalex.org/W2188184596","https://openalex.org/W2267294796","https://openalex.org/W2336542886","https://openalex.org/W2340702450","https://openalex.org/W2344060459","https://openalex.org/W2397485333","https://openalex.org/W2803643185","https://openalex.org/W4230060112","https://openalex.org/W4285719527","https://openalex.org/W4406499657"],"related_works":["https://openalex.org/W7095256830","https://openalex.org/W2091471302","https://openalex.org/W3022499436","https://openalex.org/W4321088347","https://openalex.org/W2414984505","https://openalex.org/W2187134967","https://openalex.org/W1976266427","https://openalex.org/W2095775529","https://openalex.org/W2066514887","https://openalex.org/W2094080855"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
