{"id":"https://openalex.org/W2151046347","doi":"https://doi.org/10.1210/jc.2003-030249","title":"Combined Thyroxine/Liothyronine Treatment Does Not Improve Well-Being, Quality of Life, or Cognitive Function Compared to Thyroxine Alone: A Randomized Controlled Trial in Patients with Primary Hypothyroidism","display_name":"Combined Thyroxine/Liothyronine Treatment Does Not Improve Well-Being, Quality of Life, or Cognitive Function Compared to Thyroxine Alone: A Randomized Controlled Trial in Patients with Primary Hypothyroidism","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2151046347","doi":"https://doi.org/10.1210/jc.2003-030249","mag":"2151046347","pmid":"https://pubmed.ncbi.nlm.nih.gov/14557419"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2003-030249","doi":"https://doi.org/10.1210/jc.2003-030249","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-030249","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071773047","display_name":"John P. Walsh","orcid":"https://orcid.org/0000-0002-1766-2612","observed_orcids":["https://orcid.org/0000-0002-1766-2612"]},"institutions":[{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"John P. Walsh","raw_affiliation_strings":["Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. john.walsh@health.wa.gov.au","Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia. john.walsh@health.wa.gov.au","institution_ids":["https://openalex.org/I2802220196"]},{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085074057","display_name":"Lauren Shiels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Lauren Shiels","raw_affiliation_strings":["Psychiatry and Behavioural Science (L.S.), Sir Charles Gairdner Hospital, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Psychiatry and Behavioural Science (L.S.), Sir Charles Gairdner Hospital, Australia","institution_ids":["https://openalex.org/I2802220196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004347826","display_name":"Ee Mun Lim","orcid":"https://orcid.org/0000-0001-5879-5553","observed_orcids":["https://orcid.org/0000-0001-5879-5553"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ee Mun Lim","raw_affiliation_strings":["Western Australian Center for Pathology and Medical Research (PathCentre) (E.M.L., C.I.B.), Nedlands, Western Australia 6009, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Australian Center for Pathology and Medical Research (PathCentre) (E.M.L., C.I.B.), Nedlands, Western Australia 6009, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110326718","display_name":"Chotoo I. Bhagat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chotoo I. Bhagat","raw_affiliation_strings":["Western Australian Center for Pathology and Medical Research (PathCentre) (E.M.L., C.I.B.), Nedlands, Western Australia 6009, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Western Australian Center for Pathology and Medical Research (PathCentre) (E.M.L., C.I.B.), Nedlands, Western Australia 6009, Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106182735","display_name":"Lynley Ward","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lynley C. Ward","raw_affiliation_strings":["Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000902840","display_name":"Bronwyn G. A. Stuckey","orcid":"https://orcid.org/0000-0002-9109-9864","observed_orcids":["https://orcid.org/0000-0002-9109-9864"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bronwyn G. A. Stuckey","raw_affiliation_strings":["Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035139059","display_name":"Satvinder Singh Dhaliwal","orcid":"https://orcid.org/0000-0002-4476-1042","observed_orcids":["https://orcid.org/0000-0002-4476-1042"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satvinder S. Dhaliwal","raw_affiliation_strings":["Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108380080","display_name":"Gerard T. Chew","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerard T. Chew","raw_affiliation_strings":["Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040533156","display_name":"Minoti C. Bhagat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minoti C. Bhagat","raw_affiliation_strings":["Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110475765","display_name":"Andrea J. Cussons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea J. Cussons","raw_affiliation_strings":["Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Diabetes (J.P.W., L.C.W., B.G.A.S., S.S.D., G.T.C., M.C.B., A.J.C.), Australia","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071773047"],"corresponding_institution_ids":["https://openalex.org/I2802220196"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":7.0003,"has_fulltext":true,"cited_by_count":210,"citation_normalized_percentile":{"value":0.97763131,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"88","issue":"10","first_page":"4543","last_page":"4550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-hypothyroidism","display_name":"primary hypothyroidism","score":0.9940000176429749},{"id":"https://openalex.org/keywords/liothyronine","display_name":"liothyronine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/thyroxine","display_name":"thyroxine","score":0.9160000085830688},{"id":"https://openalex.org/keywords/thyroid-hormone-replacement-therapy","display_name":"thyroid hormone replacement","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.8669999837875366},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.9589999914169312},{"id":"https://openalex.org/keywords/well-being","display_name":"well-being","score":0.9829999804496765},{"id":"https://openalex.org/keywords/thyroid-symptoms","display_name":"thyroid symptoms","score":0.6010000109672546},{"id":"https://openalex.org/keywords/serum-tsh","display_name":"serum TSH","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.7089999914169312},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.6190000176429749},{"id":"https://openalex.org/keywords/treatment-satisfaction","display_name":"treatment satisfaction","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2779951463","wikidata":"https://www.wikidata.org/wiki/Q7268788","display_name":"Quality of life (healthcare)","level":2,"score":0.696532130241394},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.677234947681427},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5791930556297302},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.5315769910812378},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5312117338180542},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5238202214241028},{"id":"https://openalex.org/C558461103","wikidata":"https://www.wikidata.org/wiki/Q154430","display_name":"Anxiety","level":2,"score":0.5035356879234314},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.48581361770629883},{"id":"https://openalex.org/C2993291352","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid function","level":3,"score":0.4253010153770447},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.42134159803390503},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.3629806637763977},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34789207577705383},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.33950120210647583},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1308455765247345},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003071","descriptor_name":"Cognition","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010349","descriptor_name":"Patient Compliance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012018","descriptor_name":"Reflex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013974","descriptor_name":"Thyroxine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1210/jc.2003-030249","doi":"https://doi.org/10.1210/jc.2003-030249","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-030249","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:14557419","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14557419","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Clinical Trial"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.616.7251","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.616.7251","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://ds.dial.pipex.com/town/estate/aquc35/book/walsh.pdf","raw_type":"text"},{"id":"pmh:oai:pure.atira.dk:publications/91721aec-98d6-49ce-b443-73df0344e44f","doi":null,"is_oa":false,"landing_page_url":"https://admin.research-repository.uwa.edu.au/en/publications/91721aec-98d6-49ce-b443-73df0344e44f","pdf_url":null,"source":{"id":"https://openalex.org/S4306402492","display_name":"UWA Profiles and Research Repository (UWA)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I177877127","host_organization_name":"The University of Western Australia","host_organization_lineage":["https://openalex.org/I177877127"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Walsh, J, Shiels, L, Lim, E M, Bhagat, C I, Ward, L C, Stuckey, B G A, Dhaliwal, S S, Chew, G T, Bhagat, M C & Cussons, A J 2003, 'Combined Throxine/Liothyronine Treatment Does Not Impove Well-Being, Quality of Life, or Cognitive Function Compared to Thyroxine Alone: A Randomized Controlled Trial in Patients with Primary Hypothyroidism', The Journal of Clinical Endocrinology & Metabolism, vol. 88, no. 10, pp. 4543-4550. https://doi.org/10.1210/jc.2003-030249","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W64574869","https://openalex.org/W1493773294","https://openalex.org/W1596333373","https://openalex.org/W1657562951","https://openalex.org/W1830481607","https://openalex.org/W1835291741","https://openalex.org/W1888479777","https://openalex.org/W1930142341","https://openalex.org/W1966602367","https://openalex.org/W1969897771","https://openalex.org/W1999060428","https://openalex.org/W2001045706","https://openalex.org/W2018603419","https://openalex.org/W2021314292","https://openalex.org/W2022350011","https://openalex.org/W2023075542","https://openalex.org/W2032962339","https://openalex.org/W2036844510","https://openalex.org/W2040251978","https://openalex.org/W2047148845","https://openalex.org/W2048245477","https://openalex.org/W2054161925","https://openalex.org/W2057348494","https://openalex.org/W2067276001","https://openalex.org/W2086367569","https://openalex.org/W2097165278","https://openalex.org/W2104878795","https://openalex.org/W2165735056","https://openalex.org/W2168250407","https://openalex.org/W2315033586","https://openalex.org/W2324164337","https://openalex.org/W2346035769"],"related_works":["https://openalex.org/W2120786909","https://openalex.org/W2140933987","https://openalex.org/W3015406762","https://openalex.org/W2165188459","https://openalex.org/W2137548260","https://openalex.org/W2085495215","https://openalex.org/W2563973474","https://openalex.org/W2054867435","https://openalex.org/W2127290117","https://openalex.org/W2806754702"],"abstract_inverted_index":{"T(4)":[0,22,59,68,124,131,177,204],"is":[1],"standard":[2],"treatment":[3,14,72,121,132,137,168,174,191],"for":[4,51,119,123],"hypothyroidism.":[5],"A":[6],"recent":[7],"study":[8],"reported":[9],"that":[10,181],"combined":[11,70,120,135,173,189],"T(4)/liothyronine":[12],"(T(3))":[13],"improved":[15],"well-being":[16],"and":[17,69,104,110],"cognitive":[18,76,196],"function":[19],"compared":[20,175,202],"with":[21,31,40,88,161,176,203],"alone.":[23,125,178,205],"We":[24,179],"conducted":[25],"a":[26,32,152],"double-blind,":[27],"randomized,":[28],"controlled":[29],"trial":[30],"crossover":[33],"design":[34],"in":[35,43,182,186],"110":[36],"patients":[37],"(101":[38],"completers)":[39],"primary":[41],"hypothyroidism":[42],"which":[44],"liothyronine":[45],"10":[46,93],"micro":[47,53],"g":[48,54],"was":[49,73,128],"substituted":[50],"50":[52],"of":[55,79,92,159,200],"the":[56,100,183],"patients'":[57],"usual":[58],"dose.":[60],"No":[61],"significant":[62],"(P":[63,115],"<":[64,116,150],"0.05)":[65,117],"difference":[66],"between":[67],"T(4)/T(3)":[71,136,190],"demonstrated":[74],"on":[75],"function,":[77,197],"quality":[78,199],"life":[80,201],"scores,":[81,85],"Thyroid":[82],"Symptom":[83],"Questionnaire":[84],"subjective":[86],"satisfaction":[87],"treatment,":[89],"or":[90,198],"eight":[91],"visual":[94,105],"analog":[95,106],"scales":[96,107],"assessing":[97,108],"symptoms.":[98],"For":[99],"General":[101],"Health":[102],"Questionnaire-28":[103],"anxiety":[109],"nausea,":[111],"scores":[112],"were":[113],"significantly":[114],"worse":[118],"than":[122,133],"Serum":[126],"TSH":[127,164],"lower":[129],"during":[130,134,166],"(mean":[138],"+/-":[139,142,146],"SEM,":[140],"1.5":[141],"0.2":[143,147],"vs.":[144],"3.1":[145],"mU/liter;":[148],"P":[149],"0.001),":[151],"potentially":[153],"confounding":[154],"factor;":[155],"however,":[156],"subgroup":[157],"analysis":[158],"subjects":[160],"comparable":[162],"serum":[163],"concentrations":[165],"each":[167],"showed":[169],"no":[170],"benefit":[171],"from":[172],"conclude":[180],"doses":[184],"used":[185],"this":[187],"study,":[188],"does":[192],"not":[193],"improve":[194],"well-being,":[195]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
