{"id":"https://openalex.org/W2151028899","doi":"https://doi.org/10.7554/elife.01462","title":"Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar","display_name":"Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar","publication_year":2013,"publication_date":"2013-12-31","ids":{"openalex":"https://openalex.org/W2151028899","doi":"https://doi.org/10.7554/elife.01462","mag":"2151028899","pmid":"https://pubmed.ncbi.nlm.nih.gov/24381247","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3875383"},"language":"en","primary_location":{"id":"doi:10.7554/elife.01462","doi":"https://doi.org/10.7554/elife.01462","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.01462","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.01462","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066819826","display_name":"Ana  Isabel Domingos","orcid":"https://orcid.org/0000-0002-7938-4814","observed_orcids":["https://orcid.org/0000-0002-7938-4814"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ana I Domingos","raw_affiliation_strings":["Laboratory of Molecular Genetics, The Rockefeller University, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, The Rockefeller University, New York, United States","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063710494","display_name":"Aylesse Sordillo","orcid":"https://orcid.org/0000-0002-6678-8748","observed_orcids":["https://orcid.org/0000-0002-6678-8748"]},"institutions":[{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aylesse Sordillo","raw_affiliation_strings":["Laboratory of Molecular Genetics, The Rockefeller University, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, The Rockefeller University, New York, United States","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003708330","display_name":"Marcelo O. Dietrich","orcid":"https://orcid.org/0000-0001-9781-2221","observed_orcids":["https://orcid.org/0000-0001-9781-2221"]},"institutions":[{"id":"https://openalex.org/I130442723","display_name":"Universidade Federal do Rio Grande do Sul","ror":"https://ror.org/041yk2d64","country_code":"BR","type":"education","lineage":["https://openalex.org/I130442723"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Marcelo O Dietrich","raw_affiliation_strings":["Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil","Section of Comparative Medicine, Yale University, New Haven, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil","institution_ids":["https://openalex.org/I130442723"]},{"raw_affiliation_string":"Section of Comparative Medicine, Yale University, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhong-Wu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhong-Wu Liu","raw_affiliation_strings":["Section of Comparative Medicine, Yale University, New Haven, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Comparative Medicine, Yale University, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044330754","display_name":"Luis A. T\u00e9llez","orcid":"https://orcid.org/0000-0002-3101-5817","observed_orcids":["https://orcid.org/0000-0002-3101-5817"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis A Tellez","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, United States","Feeding Laboratory, The JB Pierce Laboratory, New Haven, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Feeding Laboratory, The JB Pierce Laboratory, New Haven, United States","institution_ids":["https://openalex.org/I4210098204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051520147","display_name":"Jake Vaynshteyn","orcid":"https://orcid.org/0009-0005-5596-0871","observed_orcids":["https://orcid.org/0009-0005-5596-0871"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jake Vaynshteyn","raw_affiliation_strings":["Department of Neuroscience, Albert Einstein College of Medicine, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Albert Einstein College of Medicine, New York, United States","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054644265","display_name":"Joz\u00e9lia Gomes Pacheco Ferreira","orcid":"https://orcid.org/0000-0003-0097-3104","observed_orcids":["https://orcid.org/0000-0003-0097-3104"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jozelia G Ferreira","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, United States","Feeding Laboratory, The JB Pierce Laboratory, New Haven, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Feeding Laboratory, The JB Pierce Laboratory, New Haven, United States","institution_ids":["https://openalex.org/I4210098204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016842414","display_name":"Mats I. Ekstrand","orcid":"https://orcid.org/0000-0003-0019-9462","observed_orcids":["https://orcid.org/0000-0003-0019-9462"]},"institutions":[{"id":"https://openalex.org/I11385950","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49","country_code":"BR","type":"government","lineage":["https://openalex.org/I11385950","https://openalex.org/I4210151455"]},{"id":"https://openalex.org/I118636833","display_name":"Rockefeller Foundation","ror":"https://ror.org/03sfkwk85","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I118636833"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I48057805","display_name":"Instituto Gulbenkian de Ci\u00eancia","ror":"https://ror.org/04b08hq31","country_code":"PT","type":"education","lineage":["https://openalex.org/I4405252639","https://openalex.org/I48057805"]},{"id":"https://openalex.org/I7883018","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","ror":"https://ror.org/00snfqn58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210146676","https://openalex.org/I7883018"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["BR","PT","US"],"is_corresponding":false,"raw_author_name":"Mats I Ekstrand","raw_affiliation_strings":["Laboratory of Molecular Genetics, The Rockefeller University, New York, United States","CNPq-Brazil","National Institutes of Health DC009997, DK085579","National Institutes of Health DP1 DK006850","Obesity Laboratory, The Gulbenkian Science Institute, Oeiras, Portugal","Science and Technology Foundation-Portugal","The Rockefeller Foundation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, The Rockefeller University, New York, United States","institution_ids":["https://openalex.org/I83399316"]},{"raw_affiliation_string":"CNPq-Brazil","institution_ids":["https://openalex.org/I11385950"]},{"raw_affiliation_string":"National Institutes of Health DC009997, DK085579","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"National Institutes of Health DP1 DK006850","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"Obesity Laboratory, The Gulbenkian Science Institute, Oeiras, Portugal","institution_ids":["https://openalex.org/I48057805"]},{"raw_affiliation_string":"Science and Technology Foundation-Portugal","institution_ids":["https://openalex.org/I7883018"]},{"raw_affiliation_string":"The Rockefeller Foundation","institution_ids":["https://openalex.org/I118636833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003734252","display_name":"Tam\u00e1s L. Horv\u00e1th","orcid":"https://orcid.org/0000-0002-7522-4602","observed_orcids":["https://orcid.org/0000-0002-7522-4602"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamas L Horvath","raw_affiliation_strings":["Section of Comparative Medicine, Yale University, New Haven, United States","Laboratory of Molecular Genetics, The Rockefeller University, New York, United States;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Comparative Medicine, Yale University, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Laboratory of Molecular Genetics, The Rockefeller University, New York, United States;","institution_ids":["https://openalex.org/I83399316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081487798","display_name":"Ivan E. de Ara\u00fajo","orcid":"https://orcid.org/0000-0003-3081-3339","observed_orcids":["https://orcid.org/0000-0003-3081-3339"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan E de Araujo","raw_affiliation_strings":["Department of Psychiatry, Yale University School of Medicine, New Haven, United States","Feeding Laboratory, The JB Pierce Laboratory, New Haven, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Yale University School of Medicine, New Haven, United States","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Feeding Laboratory, The JB Pierce Laboratory, New Haven, United States","institution_ids":["https://openalex.org/I4210098204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065622211","display_name":"Jeffrey M. Friedman","orcid":"https://orcid.org/0000-0003-2152-0868","observed_orcids":["https://orcid.org/0000-0003-2152-0868"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I83399316","display_name":"Rockefeller University","ror":"https://ror.org/0420db125","country_code":"US","type":"education","lineage":["https://openalex.org/I83399316"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey M Friedman","raw_affiliation_strings":["Howard Hughes Medical Institute, The Rockefeller University, New York, United States","Laboratory of Molecular Genetics, The Rockefeller University, New York, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute, The Rockefeller University, New York, United States","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"]},{"raw_affiliation_string":"Laboratory of Molecular Genetics, The Rockefeller University, New York, United States","institution_ids":["https://openalex.org/I83399316"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5065622211","https://openalex.org/A5066819826"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I83399316"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":5.7818,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.97336422,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"2","issue":null,"first_page":"e01462","last_page":"e01462"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.6679999828338623,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.18549999594688416,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11584","display_name":"Biochemical Analysis and Sensing Techniques","score":0.1371999979019165,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanin-concentrating-hormone-neurons","display_name":"melanin-concentrating hormone neurons","score":0.9430000185966492},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9369999766349792},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.7139999866485596},{"id":"https://openalex.org/keywords/sucralose","display_name":"sucralose","score":0.8600000143051147},{"id":"https://openalex.org/keywords/artificial-sweeteners","display_name":"artificial sweeteners","score":0.9950000047683716},{"id":"https://openalex.org/keywords/striatal-dopamine-release","display_name":"striatal dopamine release","score":0.906000018119812},{"id":"https://openalex.org/keywords/food-reward","display_name":"food reward","score":0.7369999885559082},{"id":"https://openalex.org/keywords/trpm5","display_name":"TRPM5","score":0.8539999723434448},{"id":"https://openalex.org/keywords/food-preferences","display_name":"food preferences","score":0.6549999713897705},{"id":"https://openalex.org/keywords/optogenetic-stimulation","display_name":"optogenetic stimulation","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2776480571","wikidata":"https://www.wikidata.org/wiki/Q410209","display_name":"Sucralose","level":2,"score":0.9443456530570984},{"id":"https://openalex.org/C2776632733","wikidata":"https://www.wikidata.org/wiki/Q3324438","display_name":"Melanin-concentrating hormone","level":4,"score":0.7814177870750427},{"id":"https://openalex.org/C2911055575","wikidata":"https://www.wikidata.org/wiki/Q626292","display_name":"Artificial Sweetener","level":3,"score":0.7580844759941101},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.6905969977378845},{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.6109298467636108},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6046121120452881},{"id":"https://openalex.org/C2776030549","wikidata":"https://www.wikidata.org/wiki/Q7829395","display_name":"Nutrient sensing","level":3,"score":0.5657216906547546},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4468051493167877},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.44621944427490234},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38081473112106323},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3792012333869934},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3371826410293579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33664897084236145},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30886346101760864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2255755364894867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10630053281784058},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.10356828570365906},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08529800176620483},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08272814750671387}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008543","descriptor_name":"Melanins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009753","descriptor_name":"Nutritive Value","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.7554/elife.01462","doi":"https://doi.org/10.7554/elife.01462","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.01462","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3875383","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3875383","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmid:24381247","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24381247","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:arca.gimm.pt:10400.7/597","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10400.7/597","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:2e2c255927d44e7290c9d1cd1cba0781","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/2e2c255927d44e7290c9d1cd1cba0781","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 2 (2013)","raw_type":"article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:d3de13aa-cea4-4395-b6b3-2a160eaffa1e","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:d3de13aa-cea4-4395-b6b3-2a160eaffa1e","pdf_url":null,"source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements at Oxford","raw_type":"Journal article"},{"id":"pmh:oai:pure.mpg.de:item_3710070","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/21.11116/0000-0013-144E-E","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.7554/elife.01462","doi":"https://doi.org/10.7554/elife.01462","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.01462","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G375240210","display_name":"The role of the amygdala in weight gain susceptibility","funder_award_id":"R01DK085579","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3836001252","display_name":null,"funder_award_id":"DP1 DK006850","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6671232148","display_name":"The role of taste in amino acid appetite","funder_award_id":"R01DC009997","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G6966244776","display_name":"Hypothalamic AgRP neurons are determinants of healthy lifespan and higher brain f","funder_award_id":"DP1OD006850","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8385243446","display_name":null,"funder_award_id":"DP1 DK006850","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306149","display_name":"Rockefeller Foundation","ror":"https://ror.org/03sfkwk85"},{"id":"https://openalex.org/F4320309814","display_name":"JPB Foundation","ror":"https://ror.org/05nzwyq50"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1481893565","https://openalex.org/W1970250202","https://openalex.org/W1975983146","https://openalex.org/W1981256051","https://openalex.org/W1984390450","https://openalex.org/W1986357169","https://openalex.org/W1993442928","https://openalex.org/W1997098169","https://openalex.org/W2002287622","https://openalex.org/W2017984010","https://openalex.org/W2022366514","https://openalex.org/W2030928971","https://openalex.org/W2032014096","https://openalex.org/W2046460103","https://openalex.org/W2049903091","https://openalex.org/W2060275713","https://openalex.org/W2069129402","https://openalex.org/W2089408029","https://openalex.org/W2100438097","https://openalex.org/W2122112567","https://openalex.org/W2141830087","https://openalex.org/W2146237811","https://openalex.org/W2148894764","https://openalex.org/W2151795265","https://openalex.org/W2154864066","https://openalex.org/W2163470859","https://openalex.org/W2171223091","https://openalex.org/W2171374386","https://openalex.org/W4229838574","https://openalex.org/W4249590403"],"related_works":["https://openalex.org/W2321597090","https://openalex.org/W7162917182","https://openalex.org/W2109400326","https://openalex.org/W2265431861","https://openalex.org/W6940378373","https://openalex.org/W2338776047","https://openalex.org/W1997098169","https://openalex.org/W2948899114","https://openalex.org/W2046460103","https://openalex.org/W2087173041"],"abstract_inverted_index":{"Sugars":[0],"that":[1,49,63,116],"contain":[2],"glucose,":[3],"such":[4],"as":[5],"sucrose,":[6],"are":[7,124],"generally":[8],"preferred":[9],"to":[10,14,102,120],"artificial":[11,31,75],"sweeteners":[12,32],"owing":[13],"their":[15],"post-ingestive":[16,27,128],"rewarding":[17,28,52,129],"effect,":[18,29],"which":[19,30],"elevates":[20],"striatal":[21,79,107],"dopamine":[22,80],"(DA)":[23],"release.":[24],"While":[25],"the":[26,37,46,51,74,84,127,144],"do":[33],"not":[34],"have,":[35],"signals":[36],"nutrient":[38,148],"value":[39],"of":[40,54,66,73,95,131,143],"sugar":[41],"and":[42,82,104,123,150],"influences":[43],"food":[44,151],"preference,":[45],"neural":[47,145],"circuitry":[48],"mediates":[50],"effect":[53,130],"glucose":[55],"is":[56],"unknown.":[57],"In":[58],"this":[59],"study,":[60],"we":[61],"show":[62,105,115],"optogenetic":[64],"activation":[65],"melanin-concentrating":[67],"hormone":[68],"(MCH)":[69],"neurons":[70,97,118],"during":[71],"intake":[72],"sweetener":[76],"sucralose":[77,103],"increases":[78],"levels":[81],"inverts":[83],"normal":[85],"preference":[86],"for":[87,126],"sucrose":[88,101,111,132],"vs":[89],"sucralose.":[90],"Conversely,":[91],"animals":[92],"with":[93],"ablation":[94],"MCH":[96,117],"no":[98],"longer":[99],"prefer":[100],"reduced":[106],"DA":[108],"release":[109],"upon":[110],"ingestion.":[112],"We":[113],"further":[114],"project":[119],"reward":[121],"areas":[122],"required":[125],"in":[133],"sweet-blind":[134],"Trpm5(-/-)":[135],"mice.":[136],"These":[137],"studies":[138],"identify":[139],"an":[140],"essential":[141],"component":[142],"pathways":[146],"linking":[147],"sensing":[149],"reward.":[152],"DOI:":[153],"http://dx.doi.org/10.7554/eLife.01462.001.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":8}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}