{"id":"https://openalex.org/W2151000863","doi":"https://doi.org/10.1002/eji.1830181224","title":"Comparison of interleukin 2 and 12\u2010O\u2010tetradecanoyl\u2010phorbol 13\u2010acetate as signals for protein kinase C activation in purified human T lymphocytes","display_name":"Comparison of interleukin 2 and 12\u2010O\u2010tetradecanoyl\u2010phorbol 13\u2010acetate as signals for protein kinase C activation in purified human T lymphocytes","publication_year":1988,"publication_date":"1988-12-01","ids":{"openalex":"https://openalex.org/W2151000863","doi":"https://doi.org/10.1002/eji.1830181224","mag":"2151000863","pmid":"https://pubmed.ncbi.nlm.nih.gov/2975602"},"language":"en","primary_location":{"id":"doi:10.1002/eji.1830181224","doi":"https://doi.org/10.1002/eji.1830181224","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830181224","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007116988","display_name":"Yann F. Mah\u00e9","orcid":"https://orcid.org/0000-0001-7403-4471","observed_orcids":["https://orcid.org/0000-0001-7403-4471"]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]},{"id":"https://openalex.org/I4405269973","display_name":"Fondation Gustave Roussy","ror":"https://ror.org/05rfnt234","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4405269973"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yann Mah\u00e9","raw_affiliation_strings":["Laboratoire d'Immuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif, France","Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","Recipient of a grant from the Ligue Nationale Fra\u00e7aise Contre le Cancer (LNFCC)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Immuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif, France","institution_ids":["https://openalex.org/I2801843802","https://openalex.org/I4405269973"]},{"raw_affiliation_string":"Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Recipient of a grant from the Ligue Nationale Fra\u00e7aise Contre le Cancer (LNFCC)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111546988","display_name":"Jean\u2010Pierre Piau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean\u2010Pierre Piau","raw_affiliation_strings":["Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059830328","display_name":"Naomi Wakasugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Naomi Wakasugi","raw_affiliation_strings":["Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044244232","display_name":"Thomas Tursz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Thomas Tursz","raw_affiliation_strings":["Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043847041","display_name":"G\u00e9rard G\u00e2con","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gerard Gacon","raw_affiliation_strings":["Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109001339","display_name":"Hiro Wakasugi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801843802","display_name":"Institut Gustave Roussy","ror":"https://ror.org/0321g0743","country_code":"FR","type":"facility","lineage":["https://openalex.org/I2801843802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Hiro Wakasugi","raw_affiliation_strings":["Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d\u030cImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]},{"raw_affiliation_string":"Laboratoire \u010fImmuno-Biologie des Tumeurs, Institut Gustave Roussy, Villejuif","institution_ids":["https://openalex.org/I2801843802"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044244232"],"corresponding_institution_ids":["https://openalex.org/I2801843802"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":1.1857,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.79407827,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"12","first_page":"2029","last_page":"2036"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8901000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.9259999990463257},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.9459999799728394},{"id":"https://openalex.org/keywords/protein-kinase-c","display_name":"protein kinase C","score":0.8420000076293945},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pkc-translocation","display_name":"PKC translocation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/anti-cd3-monoclonal-antibody","display_name":"anti-CD3 monoclonal antibody","score":0.9490000009536743},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.8339999914169312},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.5839999914169312}],"concepts":[{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.8738435506820679},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.6483985185623169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5981372594833374},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.5669993758201599},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.5669867396354675},{"id":"https://openalex.org/C2909761558","wikidata":"https://www.wikidata.org/wiki/Q416716","display_name":"Tetradecanoylphorbol Acetate","level":4,"score":0.557473361492157},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.5428214073181152},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5256316065788269},{"id":"https://openalex.org/C2992881475","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T lymphocyte","level":3,"score":0.49749496579170227},{"id":"https://openalex.org/C2780043322","wikidata":"https://www.wikidata.org/wiki/Q2705359","display_name":"Phorbol","level":4,"score":0.49465081095695496},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4700804054737091},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4490375220775604},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4424440562725067},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34249573945999146},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.29590165615081787},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28106576204299927},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2797577977180481},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.270549476146698},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2550086975097656},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2479511797428131},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21043601632118225},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.16635283827781677},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1402490735054016},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10640612244606018},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002451","descriptor_name":"Cell Compartmentation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015375","descriptor_name":"Receptors, Interleukin-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017252","descriptor_name":"CD3 Complex","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/eji.1830181224","doi":"https://doi.org/10.1002/eji.1830181224","is_oa":false,"landing_page_url":"https://doi.org/10.1002/eji.1830181224","pdf_url":null,"source":{"id":"https://openalex.org/S126191069","display_name":"European Journal of Immunology","issn_l":"0014-2980","issn":["0014-2980","1521-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:2975602","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2975602","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of immunology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1502994709","https://openalex.org/W1506157243","https://openalex.org/W1512275165","https://openalex.org/W1540536121","https://openalex.org/W1541216950","https://openalex.org/W1554575609","https://openalex.org/W1557498748","https://openalex.org/W1605135083","https://openalex.org/W1928575782","https://openalex.org/W1967979275","https://openalex.org/W1973005880","https://openalex.org/W1976038149","https://openalex.org/W1986924748","https://openalex.org/W1987722323","https://openalex.org/W1996917774","https://openalex.org/W2009856702","https://openalex.org/W2011060311","https://openalex.org/W2028826149","https://openalex.org/W2035304994","https://openalex.org/W2037385247","https://openalex.org/W2042298622","https://openalex.org/W2052643603","https://openalex.org/W2054800842","https://openalex.org/W2061628918","https://openalex.org/W2068877244","https://openalex.org/W2088910852","https://openalex.org/W2092359857","https://openalex.org/W2093505742","https://openalex.org/W2095905668","https://openalex.org/W2096579230","https://openalex.org/W2126544381","https://openalex.org/W2141410410","https://openalex.org/W2161798777","https://openalex.org/W2262549231","https://openalex.org/W2412102454","https://openalex.org/W2415627753"],"related_works":["https://openalex.org/W2115044816","https://openalex.org/W1982045946","https://openalex.org/W2042821597","https://openalex.org/W1967492923","https://openalex.org/W2061553573","https://openalex.org/W2418628393","https://openalex.org/W1987977660","https://openalex.org/W1488026585","https://openalex.org/W23548394","https://openalex.org/W1502994709"],"abstract_inverted_index":{"Interleukin":[0],"2":[1,195],"(IL2)":[2],"and":[3,162,184,245],"12-O-tetradecanoylphorbol":[4],"13-acetate":[5],"(TPA)":[6],"have":[7],"been":[8],"compared":[9],"for":[10,108,123],"their":[11],"ability":[12],"to":[13,51,93,139,170],"induce":[14,52],"translocation":[15,58],"of":[16,36,59,64,70,99,132,136,177,205,230,241,271],"protein":[17],"kinase":[18],"C":[19],"(PKC)":[20],"in":[21,31,129,146,153,158,213,217],"T":[22,44,72,95,111,126,143,173,272],"lymphocytes":[23,273],"prestimulated":[24],"with":[25,67,114,149,179,208],"anti-CD3":[26,83,115,141],"monoclonal":[27],"antibody":[28],"(mAb),":[29],"either":[30,81],"the":[32,68,71,82,86,94,109,130,134,140,154,160,171,175,180,185,193,198,203,209,238,256],"presence":[33],"or":[34,85,89,120],"absence":[35,131],"monocytes.":[37],"TPA":[38,75,103,244],"alone":[39,119],"did":[40,187],"not":[41,188],"promote":[42],"purified":[43,110,125],"cell":[45],"growth,":[46],"but":[47],"it":[48],"was":[49,105,168,182,211],"able":[50],"a":[53,150,190,247],"transient,":[54],"within":[55],"30":[56],"min,":[57],"PKC":[60,65,101,147,155,178,206,231,242],"activity.":[61],"The":[62,97],"profiles":[63],"association":[66,176],"membrane":[69,181,210],"cells":[73,112,144,215,219],"under":[74,102],"stimulation":[76,104,270],"were":[77,91],"quite":[78],"similar":[79],"when":[80],"mAb":[84],"fixed":[87,117],"monocytes,":[88,133],"both,":[90],"added":[92,169],"cells.":[96,127],"decrease":[98],"cytosolic":[100,163],"less":[106],"pronounced":[107],"stimulated":[113],"mAb,":[116],"monocytes":[118],"both":[121,159],"than":[122,216],"unstimulated":[124],"Even":[128],"addition":[135],"exogenous":[137,166],"IL2":[138,167,199,233,269,276],"mAb-treated":[142],"resulted":[145],"translocation,":[148],"transient":[151],"increase":[152],"activity":[156,186],"found":[157],"particulate":[161],"fractions.":[164],"When":[165],"proliferating":[172,214],"cells,":[174],"prolonged":[183],"reach":[189],"plateau":[191],"during":[192,268],"first":[194],"h":[196],"after":[197,223],"stimulation.":[200,224],"In":[201],"parallel,":[202],"level":[204],"associated":[207],"higher":[212],"resting":[218],"even":[220],"4":[221],"days":[222],"These":[225],"results":[226],"suggest":[227],"that":[228,246],"activation":[229,240,249],"by":[232,243,262],"might":[234,265],"be":[235,266],"different":[236],"from":[237,255],"direct":[239],"specific":[248],"pathway,":[250],"at":[251],"least":[252],"kinetically":[253],"distinct":[254],"classical":[257],"phosphatidyl":[258],"inositol":[259],"diphosphate":[260],"degradation":[261],"phospholipase":[263],"C,":[264],"involved":[267],"through":[274],"high-affinity":[275],"receptors.":[277]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}