{"id":"https://openalex.org/W2151000645","doi":"https://doi.org/10.1186/1756-9966-33-6","title":"Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1","display_name":"Characterization of the biological activity of a potent small molecule Hec1 inhibitor TAI-1","publication_year":2014,"publication_date":"2014-01-09","ids":{"openalex":"https://openalex.org/W2151000645","doi":"https://doi.org/10.1186/1756-9966-33-6","mag":"2151000645","pmid":"https://pubmed.ncbi.nlm.nih.gov/24401611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3895848"},"language":"en","primary_location":{"id":"doi:10.1186/1756-9966-33-6","doi":"https://doi.org/10.1186/1756-9966-33-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-9966-33-6","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/1756-9966-33-6","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2151000645"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/1756-9966-33-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110244413","display_name":"Lynn Y.L. Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lynn YL Huang","raw_affiliation_strings":["Taivex Therapeutics Corporation, 17th Floor, No, 3, Yuanqu Street, Nangang District, Taipei City 115, Taiwan. lynnhuang.lh245@gmail.com","Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taivex Therapeutics Corporation, 17th Floor, No, 3, Yuanqu Street, Nangang District, Taipei City 115, Taiwan. lynnhuang.lh245@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002247713","display_name":"Ying-Shuan Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ying-Shuan Lee","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732580","display_name":"Jiann\u2010Jyh Huang","orcid":"https://orcid.org/0000-0003-4336-7913","observed_orcids":["https://orcid.org/0000-0003-4336-7913"]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jiann-Jyh Huang","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078475971","display_name":"Chia\u2010Chi Chang","orcid":"https://orcid.org/0000-0003-0050-1705","observed_orcids":["https://orcid.org/0000-0003-0050-1705","https://orcid.org/0000-0001-5370-9433"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chia-chi Chang","raw_affiliation_strings":["Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101448167","display_name":"Jia\u2010Ming Chang","orcid":"https://orcid.org/0000-0002-2111-0829","observed_orcids":["https://orcid.org/0000-0002-2111-0829"]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jia-Ming Chang","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103397349","display_name":"Shih\u2010Hsien Chuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Shih-Hsien Chuang","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032449888","display_name":"Kuo-Jang Kao","orcid":"https://orcid.org/0000-0001-6501-7987","observed_orcids":["https://orcid.org/0000-0001-6501-7987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kuo-Jang Kao","raw_affiliation_strings":["Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110101541","display_name":"Yung-Jen Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yung-Jen Tsai","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102086930","display_name":"Pei\u2010Yi Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Pei-Yi Tsai","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115749209","display_name":"Chia-Wei Liu","orcid":"https://orcid.org/0000-0003-2031-1976","observed_orcids":["https://orcid.org/0000-0003-2031-1976"]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chia-Wei Liu","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067395853","display_name":"Her-Sheng Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128122","display_name":"Development Center for Biotechnology","ror":"https://ror.org/02ys1c285","country_code":"TW","type":"nonprofit","lineage":["https://openalex.org/I4210128122"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Her-Sheng Lin","raw_affiliation_strings":["Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Development Center for Biotechnology, 101, Lane 169, Kangning Street, Xizhi District, New Taipei City, 22180, Taiwan","institution_ids":["https://openalex.org/I4210128122"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109851920","display_name":"Johnson Y. N. Lau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johnson YN Lau","raw_affiliation_strings":["Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Taivex Therapeutics Corporation, 17th Floor, No. 3, Yuanqu Street, Nangang District, Taipei City, 115, Taiwan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110244413"],"corresponding_institution_ids":[],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":{"value":4190,"currency":"USD","value_usd":4190},"fwci":1.1877,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.72331755,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"1","first_page":"6","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hec1","display_name":"HEC-1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nek2","display_name":"NEK2","score":0.8330000042915344},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.6259999871253967},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7639999985694885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.902999997138977},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/liver-cancer","display_name":"liver cancer","score":0.9399999976158142},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.675000011920929},{"id":"https://openalex.org/keywords/rb1","display_name":"RB1","score":0.5690000057220459},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8399999737739563},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.7820000052452087},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7789999842643738},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.5342985987663269},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46151280403137207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3203396201133728},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2678874731063843},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2064034342765808}],"mesh":[{"descriptor_ui":"D000072379","descriptor_name":"NIMA-Related Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016160","descriptor_name":"Retinoblastoma Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059748","descriptor_name":"Proteolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061605","descriptor_name":"Administration, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/1756-9966-33-6","doi":"https://doi.org/10.1186/1756-9966-33-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-9966-33-6","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/1756-9966-33-6","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2887884","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3895848","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24401611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24401611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of experimental & clinical cancer research : CR","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3895848","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3895848/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Exp Clin Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/1756-9966-33-6","doi":"https://doi.org/10.1186/1756-9966-33-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1756-9966-33-6","pdf_url":"https://jeccr.biomedcentral.com/counter/pdf/10.1186/1756-9966-33-6","source":{"id":"https://openalex.org/S33781645","display_name":"Journal of Experimental & Clinical Cancer Research","issn_l":"0392-9078","issn":["0392-9078","1756-9966"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Clinical Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2151000645.pdf","grobid_xml":"https://content.openalex.org/works/W2151000645.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W46661231","https://openalex.org/W1555236883","https://openalex.org/W1650906623","https://openalex.org/W1927337580","https://openalex.org/W1964609486","https://openalex.org/W1977219013","https://openalex.org/W1987788840","https://openalex.org/W1999123701","https://openalex.org/W2011069301","https://openalex.org/W2018884388","https://openalex.org/W2019149932","https://openalex.org/W2043591733","https://openalex.org/W2055786275","https://openalex.org/W2071166181","https://openalex.org/W2071906362","https://openalex.org/W2084917180","https://openalex.org/W2088121612","https://openalex.org/W2095440598","https://openalex.org/W2106888057","https://openalex.org/W2133973186","https://openalex.org/W2141615852","https://openalex.org/W2146376756","https://openalex.org/W2150972506","https://openalex.org/W2159058669","https://openalex.org/W2162136844","https://openalex.org/W2324952193","https://openalex.org/W2350275910","https://openalex.org/W2384066113","https://openalex.org/W2861650616"],"related_works":["https://openalex.org/W1987195921","https://openalex.org/W2125097758","https://openalex.org/W3004517097","https://openalex.org/W2141615852","https://openalex.org/W2046333895","https://openalex.org/W1987294960","https://openalex.org/W2330627702","https://openalex.org/W2026159896","https://openalex.org/W2155205362","https://openalex.org/W4281650459"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hec1":[1],"(NDC80)":[2],"is":[3,11,43,224],"an":[4,21,53],"integral":[5],"part":[6],"of":[7,16,28,73,81,95,145,177,246,252,266,280],"the":[8,26,113,193,219,244],"kinetochore":[9],"and":[10,42,69,88,163,184,198,211,214,229,234,248,254,277],"overexpressed":[12],"in":[13,45,61,92,99,103,109,161,172,173,231,256,294],"a":[14,118,142],"variety":[15],"human":[17,133,267],"cancers,":[18],"making":[19],"it":[20],"attractive":[22],"molecular":[23,264],"target":[24,114,213],"for":[25,56,71,291],"design":[27],"novel":[29],"anticancer":[30,54],"therapeutics.":[31],"A":[32],"highly":[33],"potent":[34,282],"first-in-class":[35,283],"compound":[36],"targeting":[37],"Hec1,":[38],"TAI-1,":[39],"was":[40,83,97,107,115,123,130,169,241],"identified":[41],"characterized":[44],"this":[46,281],"study":[47],"to":[48,112,154,208,212,239,261],"determine":[49],"its":[50,289],"potential":[51,290],"as":[52],"agent":[55],"clinical":[57],"utility.":[58],"METHODS:":[59],"The":[60,91,273],"vitro":[62],"potency,":[63,275],"cancer":[64,183,209,236,257,269],"cell":[65,78,166],"specificity,":[66],"synergy":[67],"activity,":[68],"markers":[70],"response":[72],"TAI-1":[74,96,137,148,168,204,223,240,287],"were":[75,270],"evaluated":[76,98,108,124],"with":[77,85,117,125,132,226,243],"lines.":[79],"Mechanism":[80],"action":[82],"confirmed":[84],"western":[86],"blotting":[87],"immunofluorescent":[89],"staining.":[90],"vivo":[93,174],"potency":[94,140],"three":[100],"xenograft":[101],"models":[102,176],"mice.":[104,110],"Preliminary":[105,187],"toxicity":[106,188],"Specificity":[111],"tested":[116],"kinase":[119],"panel.":[120],"Cardiac":[121],"safety":[122,276],"hERG":[126],"assay.":[127],"Clinical":[128],"correlation":[129],"performed":[131],"gene":[134],"database.":[135],"RESULTS:":[136],"showed":[138],"strong":[139],"across":[141],"broad":[143],"spectrum":[144],"tumor":[146],"cells.":[147,237],"disrupted":[149],"Hec1-Nek2":[150],"protein":[151],"interaction,":[152],"led":[153],"Nek2":[155],"degradation,":[156],"induced":[157,164],"significant":[158],"chromosomal":[159],"misalignment":[160],"metaphase,":[162],"apoptotic":[165],"death.":[167],"effective":[170],"orally":[171],"animal":[175],"triple":[178],"negative":[179],"breast":[180,233],"cancer,":[181],"colon":[182],"liver":[185,235],"cancer.":[186],"shows":[189,205],"no":[190,216],"effect":[191,217],"on":[192,218],"body":[194],"weights,":[195,197],"organ":[196],"blood":[199],"indices":[200],"at":[201],"efficacious":[202],"doses.":[203],"high":[206],"specificity":[207],"cells":[210,258],"had":[215],"cardiac":[220],"channel":[221],"hERG.":[222],"synergistic":[225,278],"doxorubicin,":[227],"topotecan":[228],"paclitaxel":[230],"leukemia,":[232],"Sensitivity":[238],"associated":[242],"status":[245],"RB":[247,253],"P53":[249,255],"gene.":[250],"Knockdown":[251],"increased":[259],"sensitivity":[260],"TAI-1.":[262],"Hec1-overexpressing":[263],"subtypes":[265],"lung":[268],"identified.":[271],"CONCLUSIONS:":[272],"excellent":[274],"profiles":[279],"Hec1-targeted":[284],"small":[285],"molecule":[286],"show":[288],"clinically":[292],"utility":[293],"anti-cancer":[295],"treatment":[296],"regimens.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}