{"id":"https://openalex.org/W2150776809","doi":"https://doi.org/10.1093/jnci/94.2.116","title":"Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients","display_name":"Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients","publication_year":2002,"publication_date":"2002-01-16","ids":{"openalex":"https://openalex.org/W2150776809","doi":"https://doi.org/10.1093/jnci/94.2.116","mag":"2150776809","pmid":"https://pubmed.ncbi.nlm.nih.gov/11792750"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/94.2.116","doi":"https://doi.org/10.1093/jnci/94.2.116","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnci/94.2.116","pdf_url":"https://academic.oup.com/jnci/article-pdf/94/2/116/9849235/116.pdf","source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/jnci/article-pdf/94/2/116/9849235/116.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110027208","display_name":"Maxime P. Look","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"M. P. Look","raw_affiliation_strings":["Department of Medical Oncology, University Hospital Rotterdam, The Netherlands. look@bidh.azr.nl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, University Hospital Rotterdam, The Netherlands. look@bidh.azr.nl","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108418848","display_name":"Wim L.J. van Putten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. L. J. van Putten","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067762018","display_name":"Michael Joe Duffy","orcid":"https://orcid.org/0000-0002-9259-6619","observed_orcids":["https://orcid.org/0000-0002-9259-6619"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. J. Duffy","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027231412","display_name":"Nadia Harbeck","orcid":"https://orcid.org/0000-0002-9744-7372","observed_orcids":["https://orcid.org/0000-0002-9744-7372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Harbeck","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063977962","display_name":"Ib Jarle Christensen","orcid":"https://orcid.org/0000-0002-3017-7195","observed_orcids":["https://orcid.org/0000-0002-3017-7195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"I. J. Christensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001617286","display_name":"Christoph Thomssen","orcid":"https://orcid.org/0000-0002-9324-2396","observed_orcids":["https://orcid.org/0000-0002-9324-2396"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. Thomssen","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022444628","display_name":"Ronald Ernest Kates","orcid":"https://orcid.org/0000-0003-3550-1051","observed_orcids":["https://orcid.org/0000-0003-3550-1051"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. Kates","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111463210","display_name":"Fr\u00e9d\u00e9rique Spyratos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Spyratos","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044494492","display_name":"M\u00e5rten Fern\u00f6","orcid":"https://orcid.org/0000-0003-2220-1236","observed_orcids":["https://orcid.org/0000-0003-2220-1236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ferno","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031592069","display_name":"Serenella Eppenberger\u2010Castori","orcid":"https://orcid.org/0000-0003-2194-2913","observed_orcids":["https://orcid.org/0000-0003-2194-2913"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"S. Eppenberger-Castori","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068183096","display_name":"Fred C.G.J. Sweep","orcid":"https://orcid.org/0000-0003-1103-3070","observed_orcids":["https://orcid.org/0000-0003-1103-3070"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C. G. J. F. Sweep","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057720144","display_name":"Kurt Ulm","orcid":"https://orcid.org/0000-0001-8540-9849","observed_orcids":["https://orcid.org/0000-0001-8540-9849"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K. Ulm","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108081545","display_name":"Jean\u2010Philippe Peyrat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J.-P. Peyrat","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109128780","display_name":"Pierre\u2010Marie Martin","orcid":"https://orcid.org/0009-0007-8111-2897","observed_orcids":["https://orcid.org/0009-0007-8111-2897"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P.-M. Martin","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045532","display_name":"H Magdel\u00e9nat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H. Magdelenat","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086607557","display_name":"Nils Br\u00fcnner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N. Brunner","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090808703","display_name":"Catherine R. Duggan","orcid":"https://orcid.org/0000-0001-7369-4021","observed_orcids":["https://orcid.org/0000-0001-7369-4021"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Duggan","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109213111","display_name":"B. Lisboa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. W. Lisboa","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061921179","display_name":"P\u00e4r\u2010Ola Bendahl","orcid":"https://orcid.org/0000-0001-8862-1845","observed_orcids":["https://orcid.org/0000-0001-8862-1845"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P.-O. Bendahl","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063276003","display_name":"V\u00e9ronique Quillien","orcid":"https://orcid.org/0000-0002-1465-3753","observed_orcids":["https://orcid.org/0000-0002-1465-3753"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"V. Quillien","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064828744","display_name":"Alain Daver","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. Daver","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030879081","display_name":"Gabriel Ricolleau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Ricolleau","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005328653","display_name":"Marion E. Meijer\u2010van Gelder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M. E. Meijer-van Gelder","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015314389","display_name":"Peggy Manders","orcid":"https://orcid.org/0000-0002-7066-6946","observed_orcids":["https://orcid.org/0000-0002-7066-6946"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. Manders","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060123408","display_name":"W. Edward Fiets","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. E. Fiets","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062035305","display_name":"Marinus A. Blankenstein","orcid":"https://orcid.org/0000-0003-1186-0770","observed_orcids":["https://orcid.org/0000-0003-1186-0770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. A. Blankenstein","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084980166","display_name":"Philippe Bro\u00ebt","orcid":"https://orcid.org/0000-0001-9122-2810","observed_orcids":["https://orcid.org/0000-0001-9122-2810"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"P. Broet","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111733093","display_name":"Sylvie Romain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"S. Romain","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109110371","display_name":"G\u00fcnter Daxenbichler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"G. Daxenbichler","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015887661","display_name":"Gudrun H. Windbichler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G. Windbichler","raw_affiliation_strings":["Department of Medical Oncology) , W"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology) , W","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059795069","display_name":"Tanja \u010cufer","orcid":"https://orcid.org/0000-0002-4417-7161","observed_orcids":["https://orcid.org/0000-0002-4417-7161"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. Cufer","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016700461","display_name":"Simona Bor\u0161tnar","orcid":"https://orcid.org/0000-0003-1980-4992","observed_orcids":["https://orcid.org/0000-0003-1980-4992"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"S. Borstnar","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045111218","display_name":"Willy Kueng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"W. Kueng","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108519251","display_name":"Louk V.A.M. Beex","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. V. A. M. Beex","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113593891","display_name":"Jan G.M. Klijn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267285","display_name":"Daniel den Hoed Kliniek","ror":"https://ror.org/020rz5h24","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908","https://openalex.org/I4405267285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. G. M. Klijn","raw_affiliation_strings":["( Depart- ment of Statistics) , Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"( Depart- ment of Statistics) , Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and","institution_ids":["https://openalex.org/I4405267285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028127660","display_name":"N. J. O\u2019Higgins","orcid":"https://orcid.org/0000-0003-3825-4498","observed_orcids":["https://orcid.org/0000-0003-3825-4498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. O'Higgins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071113287","display_name":"Urs Eppenberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137844","display_name":"Sk\u00e5ne University Hospital","ror":"https://ror.org/02z31g829","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I4210137844"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"U. Eppenberger","raw_affiliation_strings":["Department of Oncology , University Hospital , Lund , Sweden;","Laboratoire de Biologie Tissulaire , St. Cloud , France;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , University Hospital , Lund , Sweden;","institution_ids":["https://openalex.org/I4210137844"]},{"raw_affiliation_string":"Laboratoire de Biologie Tissulaire , St. Cloud , France;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047836442","display_name":"Fritz J\u00e4nicke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267285","display_name":"Daniel den Hoed Kliniek","ror":"https://ror.org/020rz5h24","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686","https://openalex.org/I4210149908","https://openalex.org/I4405267285"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"F. Janicke","raw_affiliation_strings":["( Depart- ment of Statistics) , Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"( Depart- ment of Statistics) , Rotterdam Cancer Institute (Daniel den Hoed Kliniek) and","institution_ids":["https://openalex.org/I4405267285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023638355","display_name":"Manfred Schmitt","orcid":"https://orcid.org/0000-0002-9978-8357","observed_orcids":["https://orcid.org/0000-0002-9978-8357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Schmitt","raw_affiliation_strings":["Finsen Laboratory , Copenhagen , Denmark;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Finsen Laboratory , Copenhagen , Denmark;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108337708","display_name":"John A. Foekens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. A. Foekens","raw_affiliation_strings":["University Hospital Rotterdam , The Netherlands ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Hospital Rotterdam , The Netherlands ;","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110027208"],"corresponding_institution_ids":["https://openalex.org/I2801952686"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":15.5854,"has_fulltext":true,"cited_by_count":596,"citation_normalized_percentile":{"value":0.99592712,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"94","issue":"2","first_page":"116","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.3474000096321106,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9309999942779541},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9710000157356262},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.8740000128746033},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0},{"id":"https://openalex.org/keywords/lymph-node-status","display_name":"lymph node status","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tumor-invasion-and-metastasis","display_name":"tumor invasion and metastasis","score":0.8209999799728394},{"id":"https://openalex.org/keywords/pooled-analysis","display_name":"pooled analysis","score":0.5}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7852931022644043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7676998376846313},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.734713613986969},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.7059345245361328},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6880389451980591},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6867185235023499},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.6453670263290405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5365502834320068},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.5172348618507385},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4755111336708069},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4139830470085144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11941114068031311},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1093/jnci/94.2.116","doi":"https://doi.org/10.1093/jnci/94.2.116","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnci/94.2.116","pdf_url":"https://academic.oup.com/jnci/article-pdf/94/2/116/9849235/116.pdf","source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:11792750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11792750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/6074d712-ce46-4e85-9b97-990dd4286e8b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/6074d712-ce46-4e85-9b97-990dd4286e8b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doc.rero.ch:298721","doi":null,"is_oa":false,"landing_page_url":"http://doc.rero.ch/record/298721/files/0940116.pdf","pdf_url":"http://doc.rero.ch/record/298721/files/0940116.pdf","source":{"id":"https://openalex.org/S4306400148","display_name":"reroDoc Digital Library","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.335.2993","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.2993","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jnci.oxfordjournals.org/content/94/2/116.full.pdf","raw_type":"text"},{"id":"pmh:eur:oai:pure.eur.nl:publications/6074d712-ce46-4e85-9b97-990dd4286e8b","doi":null,"is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/6074d712-ce46-4e85-9b97-990dd4286e8b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the National Cancer Institute, 94(2), 116 - 128. Oxford University Press","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:9823","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/9823","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"National Cancer Institute. Journal (Print)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lup.lub.lu.se:3d865be1-5a19-40bc-b816-c9d1922c96f3","doi":null,"is_oa":false,"landing_page_url":"https://lup.lub.lu.se/record/345780","pdf_url":null,"source":{"id":"https://openalex.org/S4306400536","display_name":"Lund University Publications (Lund University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I187531555","host_organization_name":"Lund University","host_organization_lineage":["https://openalex.org/I187531555"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 1460-2105","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repository.ubn.ru.nl:2066/124510","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/2066/124510","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:repub.eur.nl:9823","doi":null,"is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/9823","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"National Cancer Institute. Journal (Print)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ru:oai:repository.ubn.ru.nl:2066/124510","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2066/124510","pdf_url":null,"source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the National Cancer Institute, 94, 116 - 28","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/jnci/94.2.116","doi":"https://doi.org/10.1093/jnci/94.2.116","is_oa":true,"landing_page_url":"https://doi.org/10.1093/jnci/94.2.116","pdf_url":"https://academic.oup.com/jnci/article-pdf/94/2/116/9849235/116.pdf","source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150776809.pdf","grobid_xml":"https://content.openalex.org/works/W2150776809.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W206480088","https://openalex.org/W1498982535","https://openalex.org/W1531559622","https://openalex.org/W1564977527","https://openalex.org/W1573701740","https://openalex.org/W1775749144","https://openalex.org/W1926488772","https://openalex.org/W1953981819","https://openalex.org/W1955500014","https://openalex.org/W1961620949","https://openalex.org/W1963671524","https://openalex.org/W1971538947","https://openalex.org/W1991962266","https://openalex.org/W1996881264","https://openalex.org/W2005113904","https://openalex.org/W2006860708","https://openalex.org/W2013336992","https://openalex.org/W2018264126","https://openalex.org/W2020612457","https://openalex.org/W2031575410","https://openalex.org/W2034350621","https://openalex.org/W2042487706","https://openalex.org/W2071328106","https://openalex.org/W2079293485","https://openalex.org/W2085628794","https://openalex.org/W2101379758","https://openalex.org/W2102577298","https://openalex.org/W2105346716","https://openalex.org/W2107328434","https://openalex.org/W2111924468","https://openalex.org/W2115581335","https://openalex.org/W2127182052","https://openalex.org/W2129925362","https://openalex.org/W2133812056","https://openalex.org/W2136359746","https://openalex.org/W2143071116","https://openalex.org/W2148291626","https://openalex.org/W2155498341","https://openalex.org/W2159330791","https://openalex.org/W2323421875","https://openalex.org/W2405442768","https://openalex.org/W4238806036"],"related_works":["https://openalex.org/W2026789741","https://openalex.org/W6884756511","https://openalex.org/W2148291626","https://openalex.org/W2076243133","https://openalex.org/W2150268988","https://openalex.org/W7095284201","https://openalex.org/W1995406904","https://openalex.org/W4230620075","https://openalex.org/W2037844444","https://openalex.org/W2121519964"],"abstract_inverted_index":{"BACKGROUND:":[0],"Urokinase-type":[1],"plasminogen":[2],"activator":[3],"(uPA)":[4],"and":[5,15,22,40,60,64,89,95,112,138,145,175,194,204,218,224,233,244,265,271,285],"its":[6],"inhibitor":[7],"(PAI-1)":[8],"play":[9],"essential":[10],"roles":[11],"in":[12,29,42,97,119,207,214,241,273,288],"tumor":[13,98,171],"invasion":[14],"metastasis.":[16],"High":[17],"levels":[18,140,191],"of":[19,38,54,62,85,93,117,134,136,192,200,210,258,269],"both":[20,201,215],"uPA":[21,39,94,137,193,223,243,270,284],"PAI-1":[23,41,96,139,195,225,245,272,286],"are":[24],"associated":[25,229],"with":[26,141,230,279],"poor":[27,202,205,231,234],"prognosis":[28],"breast":[30,44,76,275,282],"cancer":[31,77],"patients.":[32,78,212],"To":[33],"confirm":[34],"the":[35,55,86,115,160,197,208,259,263],"prognostic":[36,163,250,267],"value":[37,268],"primary":[43,274,289],"cancer,":[45,283],"we":[46],"reanalyzed":[47],"individual":[48],"patient":[49],"data":[50],"provided":[51],"by":[52,103,114,151,157],"members":[53],"European":[56],"Organization":[57],"for":[58,295],"Research":[59],"Treatment":[61],"Cancer-Receptor":[63],"Biomarker":[65],"Group":[66],"(EORTC-RBG).":[67],"METHODS:":[68],"The":[69],"study":[70],"included":[71,246],"18":[72],"datasets":[73,261],"involving":[74],"8377":[75],"During":[79],"follow-up":[80],"(median":[81],"79":[82],"months),":[83],"35%":[84],"patients":[87,118,240,278],"relapsed":[88],"27%":[90],"died.":[91],"Levels":[92],"tissue":[99],"extracts":[100],"were":[101,107,149,182,196,227],"determined":[102],"different":[104],"immunoassays;":[105],"values":[106,181,226],"ranked":[108],"within":[109],"each":[110],"dataset":[111,121],"divided":[113],"number":[116],"that":[120,126],"to":[122],"produce":[123],"fractional":[124],"ranks":[125,135],"could":[127],"be":[128,292],"compared":[129],"directly":[130],"across":[131],"datasets.":[132],"Associations":[133],"relapse-free":[142],"survival":[143,147],"(RFS)":[144],"overall":[146],"(OS)":[148],"analyzed":[150],"Cox":[152],"multivariable":[153],"regression":[154],"analysis":[155,257],"stratified":[156],"dataset,":[158],"including":[159],"following":[161],"traditional":[162],"variables:":[164],"age,":[165],"menopausal":[166],"status,":[167,170,189],"lymph":[168,187,216,219,238,280],"node":[169,188],"size,":[172],"histologic":[173],"grade,":[174],"steroid":[176],"hormone-receptor":[177],"status.":[178],"All":[179],"P":[180],"two-sided.":[183],"RESULTS:":[184],"Apart":[185],"from":[186],"high":[190],"strongest":[198],"predictors":[199],"RFS":[203,232],"OS":[206],"analyses":[209],"all":[211],"Moreover,":[213],"node-positive":[217],"node-negative":[220,239,281],"patients,":[221],"higher":[222],"independently":[228],"OS.":[235],"For":[236,277],"(untreated)":[237],"particular,":[242],"together":[247],"showed":[248],"strong":[249,264],"ability":[251],"(all":[252],"P<.001).":[253],"CONCLUSIONS:":[254],"This":[255],"pooled":[256],"EORTC-RBG":[260],"confirmed":[262],"independent":[266],"cancer.":[276],"measurements":[287],"tumors":[290],"may":[291],"especially":[293],"useful":[294],"designing":[296],"individualized":[297],"treatment":[298],"strategies.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":17},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":19},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":38}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}