{"id":"https://openalex.org/W2150681237","doi":"https://doi.org/10.1093/toxsci/kfq358","title":"Metabolomics in Toxicology: Preclinical and Clinical Applications","display_name":"Metabolomics in Toxicology: Preclinical and Clinical Applications","publication_year":2010,"publication_date":"2010-12-02","ids":{"openalex":"https://openalex.org/W2150681237","doi":"https://doi.org/10.1093/toxsci/kfq358","mag":"2150681237","pmid":"https://pubmed.ncbi.nlm.nih.gov/21127352"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfq358","doi":"https://doi.org/10.1093/toxsci/kfq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfq358","pdf_url":"https://academic.oup.com/toxsci/article-pdf/120/suppl_1/S146/4590282/kfq358.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/toxsci/article-pdf/120/suppl_1/S146/4590282/kfq358.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025198759","display_name":"D. G. Robertson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. G. Robertson","raw_affiliation_strings":["Applied and Investigative Metabolomics, Bristol-Myers Squibb Co., Princeton, New Jersey 08543, USA. don.robertson@bms.com","Applied and Investigative Metabolomics, Bristol-Myers Squibb Co. Princeton, New Jersey 08543"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied and Investigative Metabolomics, Bristol-Myers Squibb Co., Princeton, New Jersey 08543, USA. don.robertson@bms.com","institution_ids":["https://openalex.org/I4210091812"]},{"raw_affiliation_string":"Applied and Investigative Metabolomics, Bristol-Myers Squibb Co. Princeton, New Jersey 08543","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062878299","display_name":"Paul Brent Watkins","orcid":"https://orcid.org/0000-0001-9541-8917","observed_orcids":["https://orcid.org/0000-0001-9541-8917","https://orcid.org/0009-0008-3343-4418"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. B. Watkins","raw_affiliation_strings":["\u2020Hamner - University of North Carolina Institute for Drug Safety Sciences , Research Triangle Park , North Carolina , 27709 ; and \u2021Department of Medicine ,","Department of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599","Hamner-University of North Carolina Institute for Drug Safety Sciences, Research Triangle Park, North Carolina, 27709"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u2020Hamner - University of North Carolina Institute for Drug Safety Sciences , Research Triangle Park , North Carolina , 27709 ; and \u2021Department of Medicine ,","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Hamner-University of North Carolina Institute for Drug Safety Sciences, Research Triangle Park, North Carolina, 27709","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036472094","display_name":"Michael D. Reily","orcid":"https://orcid.org/0000-0003-1179-1525","observed_orcids":["https://orcid.org/0000-0003-1179-1525"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. D. Reily","raw_affiliation_strings":["Applied and Investigative Metabolomics, Bristol-Myers Squibb Co. Princeton, New Jersey 08543"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Applied and Investigative Metabolomics, Bristol-Myers Squibb Co. Princeton, New Jersey 08543","institution_ids":["https://openalex.org/I4210091812"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":6.6147,"has_fulltext":true,"cited_by_count":211,"citation_normalized_percentile":{"value":0.97882292,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"120","issue":"Supplement 1","first_page":"S146","last_page":"S170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolomics","display_name":"metabolomics","score":0.9539999961853027},{"id":"https://openalex.org/keywords/toxicology","display_name":"toxicology","score":0.9309999942779541},{"id":"https://openalex.org/keywords/metabolic-profiling","display_name":"metabolite profiling","score":0.9679999947547913},{"id":"https://openalex.org/keywords/xenobiotic-metabolism","display_name":"xenobiotic metabolism","score":0.5450000166893005},{"id":"https://openalex.org/keywords/preclinical-toxicology","display_name":"preclinical toxicology","score":0.5490000247955322},{"id":"https://openalex.org/keywords/medical-toxicology","display_name":"clinical toxicology","score":0.953000009059906}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8570660352706909},{"id":"https://openalex.org/C2781140086","wikidata":"https://www.wikidata.org/wiki/Q557945","display_name":"Confusion","level":2,"score":0.598094642162323},{"id":"https://openalex.org/C2776224158","wikidata":"https://www.wikidata.org/wiki/Q187931","display_name":"Phrase","level":2,"score":0.47858214378356934},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4538690745830536},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44206884503364563},{"id":"https://openalex.org/C2994400308","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolite profiling","level":3,"score":0.4410162568092346},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4154011011123657},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.35535162687301636},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3026323914527893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2970302700996399},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.22659006714820862},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13388928771018982},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C11171543","wikidata":"https://www.wikidata.org/wiki/Q41630","display_name":"Psychoanalysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008658","descriptor_name":"Inactivation, Metabolic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014116","descriptor_name":"Toxicology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015262","descriptor_name":"Xenobiotics","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015706","descriptor_name":"Bibliometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015706","descriptor_name":"Bibliometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015706","descriptor_name":"Bibliometrics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/toxsci/kfq358","doi":"https://doi.org/10.1093/toxsci/kfq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfq358","pdf_url":"https://academic.oup.com/toxsci/article-pdf/120/suppl_1/S146/4590282/kfq358.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmid:21127352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21127352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/toxsci/kfq358","doi":"https://doi.org/10.1093/toxsci/kfq358","is_oa":true,"landing_page_url":"https://doi.org/10.1093/toxsci/kfq358","pdf_url":"https://academic.oup.com/toxsci/article-pdf/120/suppl_1/S146/4590282/kfq358.pdf","source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150681237.pdf","grobid_xml":"https://content.openalex.org/works/W2150681237.grobid-xml"},"referenced_works_count":299,"referenced_works":["https://openalex.org/W858887","https://openalex.org/W44319099","https://openalex.org/W78156908","https://openalex.org/W113358056","https://openalex.org/W587937822","https://openalex.org/W1495358463","https://openalex.org/W1498599153","https://openalex.org/W1528754792","https://openalex.org/W1533621372","https://openalex.org/W1536938526","https://openalex.org/W1540655326","https://openalex.org/W1558182028","https://openalex.org/W1583076619","https://openalex.org/W1606088617","https://openalex.org/W1611854178","https://openalex.org/W1738640266","https://openalex.org/W1875906722","https://openalex.org/W1899798983","https://openalex.org/W1942869306","https://openalex.org/W1963542257","https://openalex.org/W1964073233","https://openalex.org/W1964254621","https://openalex.org/W1964820180","https://openalex.org/W1965696568","https://openalex.org/W1966854042","https://openalex.org/W1966981724","https://openalex.org/W1967090815","https://openalex.org/W1968327516","https://openalex.org/W1968430975","https://openalex.org/W1968593126","https://openalex.org/W1968813633","https://openalex.org/W1969753425","https://openalex.org/W1969779341","https://openalex.org/W1969889522","https://openalex.org/W1970426869","https://openalex.org/W1972344619","https://openalex.org/W1973511738","https://openalex.org/W1973686253","https://openalex.org/W1973821892","https://openalex.org/W1973887423","https://openalex.org/W1974267906","https://openalex.org/W1974825668","https://openalex.org/W1975922633","https://openalex.org/W1976072307","https://openalex.org/W1976340581","https://openalex.org/W1977922773","https://openalex.org/W1978004240","https://openalex.org/W1978417221","https://openalex.org/W1978461542","https://openalex.org/W1979437648","https://openalex.org/W1980497766","https://openalex.org/W1980789957","https://openalex.org/W1981434053","https://openalex.org/W1982494061","https://openalex.org/W1982772252","https://openalex.org/W1983451167","https://openalex.org/W1983498359","https://openalex.org/W1983997746","https://openalex.org/W1986674928","https://openalex.org/W1986876160","https://openalex.org/W1988369570","https://openalex.org/W1988808786","https://openalex.org/W1989108204","https://openalex.org/W1989755866","https://openalex.org/W1992615825","https://openalex.org/W1993554093","https://openalex.org/W1993832260","https://openalex.org/W1995192295","https://openalex.org/W1995392322","https://openalex.org/W1996584337","https://openalex.org/W1997862861","https://openalex.org/W2000066364","https://openalex.org/W2000066924","https://openalex.org/W2001378242","https://openalex.org/W2001630726","https://openalex.org/W2002310949","https://openalex.org/W2002799523","https://openalex.org/W2003414488","https://openalex.org/W2003418600","https://openalex.org/W2004349331","https://openalex.org/W2004842676","https://openalex.org/W2005105145","https://openalex.org/W2005521037","https://openalex.org/W2006860157","https://openalex.org/W2007412933","https://openalex.org/W2008756377","https://openalex.org/W2009291602","https://openalex.org/W2009945101","https://openalex.org/W2010520132","https://openalex.org/W2011072368","https://openalex.org/W2013036395","https://openalex.org/W2013358394","https://openalex.org/W2014438278","https://openalex.org/W2014671368","https://openalex.org/W2015054158","https://openalex.org/W2015301575","https://openalex.org/W2016235232","https://openalex.org/W2018351118","https://openalex.org/W2018507034","https://openalex.org/W2019402080","https://openalex.org/W2020171653","https://openalex.org/W2022831017","https://openalex.org/W2023002358","https://openalex.org/W2023224944","https://openalex.org/W2024938665","https://openalex.org/W2026250639","https://openalex.org/W2026448882","https://openalex.org/W2027505155","https://openalex.org/W2027578754","https://openalex.org/W2027762699","https://openalex.org/W2027774666","https://openalex.org/W2028240481","https://openalex.org/W2029532166","https://openalex.org/W2030535474","https://openalex.org/W2030587698","https://openalex.org/W2030616135","https://openalex.org/W2034487622","https://openalex.org/W2034771348","https://openalex.org/W2035313776","https://openalex.org/W2035607496","https://openalex.org/W2035765701","https://openalex.org/W2036006402","https://openalex.org/W2036583236","https://openalex.org/W2036720248","https://openalex.org/W2037199469","https://openalex.org/W2038181377","https://openalex.org/W2038325414","https://openalex.org/W2038405427","https://openalex.org/W2040643627","https://openalex.org/W2042475696","https://openalex.org/W2042516638","https://openalex.org/W2043717441","https://openalex.org/W2044276318","https://openalex.org/W2044680278","https://openalex.org/W2045546001","https://openalex.org/W2045781044","https://openalex.org/W2046964618","https://openalex.org/W2047255681","https://openalex.org/W2047370287","https://openalex.org/W2047536337","https://openalex.org/W2050062639","https://openalex.org/W2051091267","https://openalex.org/W2051148933","https://openalex.org/W2051180998","https://openalex.org/W2051533263","https://openalex.org/W2052134101","https://openalex.org/W2052214707","https://openalex.org/W2053385401","https://openalex.org/W2053690403","https://openalex.org/W2054120770","https://openalex.org/W2054442254","https://openalex.org/W2054507410","https://openalex.org/W2055261499","https://openalex.org/W2055861670","https://openalex.org/W2060220140","https://openalex.org/W2061156796","https://openalex.org/W2062312530","https://openalex.org/W2062661728","https://openalex.org/W2062881631","https://openalex.org/W2062936856","https://openalex.org/W2063097993","https://openalex.org/W2065096976","https://openalex.org/W2066268415","https://openalex.org/W2066324459","https://openalex.org/W2067544564","https://openalex.org/W2068256216","https://openalex.org/W2069470844","https://openalex.org/W2070646473","https://openalex.org/W2071259051","https://openalex.org/W2071288609","https://openalex.org/W2074023722","https://openalex.org/W2075109094","https://openalex.org/W2075373098","https://openalex.org/W2075397364","https://openalex.org/W2077126840","https://openalex.org/W2077249034","https://openalex.org/W2078489012","https://openalex.org/W2078878055","https://openalex.org/W2078918165","https://openalex.org/W2079212574","https://openalex.org/W2079664351","https://openalex.org/W2081285201","https://openalex.org/W2081655850","https://openalex.org/W2083113920","https://openalex.org/W2083340629","https://openalex.org/W2083729297","https://openalex.org/W2084375915","https://openalex.org/W2085637379","https://openalex.org/W2086257496","https://openalex.org/W2087082980","https://openalex.org/W2087568855","https://openalex.org/W2088351705","https://openalex.org/W2089995468","https://openalex.org/W2090871922","https://openalex.org/W2091078375","https://openalex.org/W2092155681","https://openalex.org/W2092302841","https://openalex.org/W2093893564","https://openalex.org/W2094223456","https://openalex.org/W2097333015","https://openalex.org/W2097834427","https://openalex.org/W2098203054","https://openalex.org/W2099026924","https://openalex.org/W2100240421","https://openalex.org/W2100463095","https://openalex.org/W2102788947","https://openalex.org/W2105479208","https://openalex.org/W2106224719","https://openalex.org/W2106576546","https://openalex.org/W2107363389","https://openalex.org/W2107568445","https://openalex.org/W2108842111","https://openalex.org/W2109329073","https://openalex.org/W2109628662","https://openalex.org/W2111115065","https://openalex.org/W2111396590","https://openalex.org/W2111630085","https://openalex.org/W2113132494","https://openalex.org/W2114390083","https://openalex.org/W2114431588","https://openalex.org/W2114872517","https://openalex.org/W2115532189","https://openalex.org/W2115831778","https://openalex.org/W2116303839","https://openalex.org/W2119167116","https://openalex.org/W2119351324","https://openalex.org/W2119919478","https://openalex.org/W2120117490","https://openalex.org/W2120680392","https://openalex.org/W2120714068","https://openalex.org/W2121046408","https://openalex.org/W2122259188","https://openalex.org/W2122367003","https://openalex.org/W2123934362","https://openalex.org/W2124132939","https://openalex.org/W2124686901","https://openalex.org/W2124850376","https://openalex.org/W2127332827","https://openalex.org/W2129314769","https://openalex.org/W2130784515","https://openalex.org/W2132282482","https://openalex.org/W2133279956","https://openalex.org/W2134483262","https://openalex.org/W2135842485","https://openalex.org/W2137380457","https://openalex.org/W2138330140","https://openalex.org/W2139464173","https://openalex.org/W2139782977","https://openalex.org/W2141518585","https://openalex.org/W2141979695","https://openalex.org/W2142923621","https://openalex.org/W2145196491","https://openalex.org/W2145829756","https://openalex.org/W2145999389","https://openalex.org/W2146560286","https://openalex.org/W2146779833","https://openalex.org/W2147443546","https://openalex.org/W2149212516","https://openalex.org/W2149633201","https://openalex.org/W2150488988","https://openalex.org/W2150907966","https://openalex.org/W2151346683","https://openalex.org/W2152943013","https://openalex.org/W2155297127","https://openalex.org/W2155680682","https://openalex.org/W2155897723","https://openalex.org/W2158646266","https://openalex.org/W2159314121","https://openalex.org/W2160890270","https://openalex.org/W2162079485","https://openalex.org/W2162397015","https://openalex.org/W2163388517","https://openalex.org/W2163617578","https://openalex.org/W2164619177","https://openalex.org/W2165429738","https://openalex.org/W2166086031","https://openalex.org/W2168590651","https://openalex.org/W2168815462","https://openalex.org/W2169128690","https://openalex.org/W2170191475","https://openalex.org/W2171975860","https://openalex.org/W2389161923","https://openalex.org/W2406321977","https://openalex.org/W2411841238","https://openalex.org/W2438329614","https://openalex.org/W2484916838","https://openalex.org/W2494562525","https://openalex.org/W2612016156","https://openalex.org/W2620687372","https://openalex.org/W2950694274","https://openalex.org/W3139387189","https://openalex.org/W4205098749","https://openalex.org/W4211085285","https://openalex.org/W4230154705","https://openalex.org/W4231113577","https://openalex.org/W4238868733","https://openalex.org/W4245721008","https://openalex.org/W4285719527","https://openalex.org/W4294326454"],"related_works":["https://openalex.org/W599564969","https://openalex.org/W2068338028","https://openalex.org/W2904830650","https://openalex.org/W2008066743","https://openalex.org/W1982494061","https://openalex.org/W4234330887","https://openalex.org/W2980667428","https://openalex.org/W2114039589","https://openalex.org/W1484003115","https://openalex.org/W2142478210"],"abstract_inverted_index":{"Metabolomics":[0],"first":[1,74],"burst":[2],"into":[3,86,284],"the":[4,18,27,40,46,51,63,73,82,106,119,136,139,148,165,176,183,221,293,304,306,315,340,343,361,371,385,394,399,432,449],"toxicology":[5],"arena":[6],"approximately":[7],"10\u201312":[8],"years":[9],"ago,":[10],"experiencing":[11],"rapid":[12],"growth":[13],"as":[14,98,257,269,298],"a":[15,99,270,311,405],"science":[16],"in":[17,42,161,249,384],"intervening":[19],"period":[20],"(Fig.":[21,154],"1).":[22,155],"Though":[23],"metabolomics":[24,84,146,157,235,297,312,374],"still":[25,186,225],"trails":[26],"publication":[28],"rates":[29],"of":[30,44,48,53,59,105,123,242,322,333,335,363,373,393,407,420,435,448],"its":[31,130],"sister":[32],"technologies,":[33],"genomics":[34],"and":[35,50,67,231,239,265,331,390,445],"proteomics,":[36],"it":[37,126,141,168,211,291],"is":[38,61,94,127,142,147,185,215,233,236,309,402],"closing":[39],"gap":[41],"terms":[43,64,192],"both":[45],"numbers":[47],"publications":[49],"quality":[52],"those":[54,417,452],"publications.":[55],"One":[56],"continuing":[57],"source":[58],"confusion":[60,104],"differentiating":[62],"metabolomics,":[65],"metabonomics,":[66],"metabolic":[68],"profiling.":[69],"Although":[70,387],"metabonomics":[71],"was":[72],"term":[75,83,101,149],"formally":[76],"defined":[77],"(Nicholson":[78],"et":[79],"al.,":[80],"1999),":[81],"came":[85],"usage":[87],"shortly":[88],"thereafter":[89],"(Fiehn,":[90,245],"2002).":[91],"Metabolic":[92],"profiling":[93],"used":[95,160,180],"by":[96,151],"some":[97,425],"generic":[100],"to":[102,135,188,203,208,227,255,292,295,317,328,345,351,375,415,455],"avoid":[103],"two":[107],"aforementioned":[108],"\u2018\u2018omic\u2019\u2019":[109],"terms,":[110],"but":[111,182,220,378],"that":[112,145,167,198,232,234,250,310,325],"phrase":[113,251],"itself":[114],"can":[115,178,261,326],"be":[116,159,179,228,253,413],"confused":[117],"with":[118,164,217,358,398,438],"comprehensive":[120,238],"metabolite":[121],"analysis":[122,241],"xenobiotics,":[124],"so":[125],"debatable":[128],"whether":[129],"use":[131],"adds":[132],"any":[133,376],"clarity":[134],"situation.":[137],"Whatever":[138],"case,":[140],"now":[143,403],"clear":[144],"preferred":[150],"most":[152,174,222,229],"practitioners":[153],"Therefore,":[156],"will":[158,289,368,379,411],"this":[162,285,366,409,428],"review":[163,367,410,429],"understanding":[166],"represents":[169],"all":[170,190,243],"three":[171,191],"terms.":[172],"For":[173,303],"people,":[175],"names":[177],"interchangeably,":[181],"reader":[184,294],"advised":[187],"utilize":[189],"when":[193],"performing":[194],"literature":[195,214,408],"searches.":[196],"Now":[197],"we":[199,206,288],"have":[200,396],"determined":[201],"what":[202,210,266,276],"call":[204],"it,":[205],"need":[207],"define":[209,296],"is.":[212],"The":[213],"replete":[216],"fine-tuned":[218],"definitions,":[219],"succinct":[223],"definition":[224],"appears":[226],"appropriate,":[230],"\u2018\u2018the":[237],"quantitative":[240],"metabolites\u2019\u2019":[244],"2001).":[246],"Every":[247],"word":[248],"could":[252],"subject":[254],"debate":[256],"no":[258],"analytical":[259,442],"technique":[260],"measure":[262],"\u2018\u2018all\u2019\u2019":[263],"metabolites":[264,274],"exactly":[267],"qualifies":[268],"metabolite?":[271],"Do":[272],"dietaryderived":[273],"qualify,":[275],"about":[277],"gut":[278],"flora\u2013derived":[279],"metabolites?":[280],"Rather":[281],"than":[282],"wade":[283],"academic":[286],"argument,":[287],"leave":[290],"he":[299],"or":[300,348],"she":[301],"chooses.":[302],"toxicologist,":[305],"important":[307],"point":[308],"approach":[313],"has":[314,342],"potential":[316,344],"reveal":[318],"novel":[319],"biochemical":[320,353],"sequelae":[321],"toxicant":[323],"administration":[324],"lead":[327],"mechanistic":[329],"insights":[330],"identification":[332],"biomarkers":[334],"cause":[336],"and/or":[337],"effect.":[338],"Furthermore,":[339],"technology":[341,395,437],"characterize":[346],"models":[347],"disease":[349],"states":[350],"provide":[352],"bases":[354],"for":[355],"observed":[356],"interactions":[357],"xenobiotics.":[359],"Given":[360],"explosion":[362],"recent":[364,382],"literature,":[365],"not":[369,412],"revisit":[370],"origins":[372],"extent":[377],"focus":[380],"on":[381,431,440],"advances":[383],"field.":[386],"botanical,":[388],"environmental,":[389],"nutritional":[391],"applications":[392,434,447],"expanded":[397],"field,":[400],"there":[401],"such":[404],"wealth":[406],"able":[414],"cover":[416],"burgeoning":[418],"areas":[419,453],"metabolomic":[421,436],"research.":[422],"After":[423],"providing":[424],"historical":[426],"perspective,":[427],"focuses":[430],"biomedical":[433],"emphasis":[439],"new":[441],"approaches,":[443],"preclinical,":[444],"clinical":[446],"technology,":[450],"particularly":[451],"relevant":[454],"practicing":[456],"toxicologists.":[457]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}