{"id":"https://openalex.org/W2150424331","doi":"https://doi.org/10.1146/annurev.micro.57.030502.090709","title":"Archaeal DNA Replication: Eukaryal Proteins in a Bacterial Context","display_name":"Archaeal DNA Replication: Eukaryal Proteins in a Bacterial Context","publication_year":2003,"publication_date":"2003-10-01","ids":{"openalex":"https://openalex.org/W2150424331","doi":"https://doi.org/10.1146/annurev.micro.57.030502.090709","mag":"2150424331","pmid":"https://pubmed.ncbi.nlm.nih.gov/14527289"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.micro.57.030502.090709","doi":"https://doi.org/10.1146/annurev.micro.57.030502.090709","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.micro.57.030502.090709","pdf_url":null,"source":{"id":"https://openalex.org/S82779230","display_name":"Annual Review of Microbiology","issn_l":"0066-4227","issn":["0066-4227","1545-3251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Microbiology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064079179","display_name":"Beatrice Grabowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beatrice Grabowski","raw_affiliation_strings":["University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 20850;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 20850;","institution_ids":["https://openalex.org/I4405261596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026830739","display_name":"Zvi Kelman","orcid":"https://orcid.org/0000-0003-4774-3963","observed_orcids":["https://orcid.org/0000-0003-4774-3963"]},"institutions":[{"id":"https://openalex.org/I4405261596","display_name":"University of Maryland Biotechnology Institute","ror":"https://ror.org/05j636y43","country_code":"US","type":"facility","lineage":["https://openalex.org/I4405261322","https://openalex.org/I4405261596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zvi Kelman","raw_affiliation_strings":["University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 20850;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, Maryland 20850;","institution_ids":["https://openalex.org/I4405261596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405261596"],"apc_list":null,"apc_paid":null,"fwci":1.1258,"has_fulltext":false,"cited_by_count":153,"citation_normalized_percentile":{"value":0.74267551,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"57","issue":"1","first_page":"487","last_page":"516"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.4203999936580658,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.4203999936580658,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.36010000109672546,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.04560000076889992,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/archaeal-dna-replication","display_name":"archaeal DNA replication","score":0.9179999828338623},{"id":"https://openalex.org/keywords/archaea","display_name":"archaea","score":0.902999997138977},{"id":"https://openalex.org/keywords/extremophiles","display_name":"extremophiles","score":0.6169999837875366},{"id":"https://openalex.org/keywords/archaeal-genomes","display_name":"archaeal genomes","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C550995028","wikidata":"https://www.wikidata.org/wiki/Q10872","display_name":"Archaea","level":3,"score":0.9439486265182495},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7101868391036987},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.6375190615653992},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6021310091018677},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5182844996452332},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4845932722091675},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4436348080635071},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.43494194746017456},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4126977324485779},{"id":"https://openalex.org/C188880781","wikidata":"https://www.wikidata.org/wiki/Q2430501","display_name":"Three-domain system","level":4,"score":0.41099315881729126},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2639225423336029},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001105","descriptor_name":"Archaea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004264","descriptor_name":"DNA Topoisomerases, Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018741","descriptor_name":"Replication Origin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019641","descriptor_name":"DNA, Archaeal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019641","descriptor_name":"DNA, Archaeal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019848","descriptor_name":"Gene Expression Regulation, Archaeal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020745","descriptor_name":"Genome, Archaeal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051818","descriptor_name":"Replication Protein C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.micro.57.030502.090709","doi":"https://doi.org/10.1146/annurev.micro.57.030502.090709","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.micro.57.030502.090709","pdf_url":null,"source":{"id":"https://openalex.org/S82779230","display_name":"Annual Review of Microbiology","issn_l":"0066-4227","issn":["0066-4227","1545-3251"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Microbiology","raw_type":"journal-article"},{"id":"pmid:14527289","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14527289","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of microbiology","raw_type":"Journal Article"},{"id":"mag:2181717153","doi":null,"is_oa":false,"landing_page_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.micro.57.030502.090709","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":166,"referenced_works":["https://openalex.org/W10876090","https://openalex.org/W197326121","https://openalex.org/W1482372532","https://openalex.org/W1488283397","https://openalex.org/W1526567651","https://openalex.org/W1538033054","https://openalex.org/W1542619083","https://openalex.org/W1542719686","https://openalex.org/W1546701310","https://openalex.org/W1555441333","https://openalex.org/W1557642928","https://openalex.org/W1577230381","https://openalex.org/W1604102349","https://openalex.org/W1605313335","https://openalex.org/W1729887059","https://openalex.org/W1767329992","https://openalex.org/W1845595717","https://openalex.org/W1875835053","https://openalex.org/W1923326679","https://openalex.org/W1963854145","https://openalex.org/W1965453151","https://openalex.org/W1968793036","https://openalex.org/W1973711114","https://openalex.org/W1975383049","https://openalex.org/W1976576231","https://openalex.org/W1978521847","https://openalex.org/W1980782471","https://openalex.org/W1981370593","https://openalex.org/W1981459741","https://openalex.org/W1982121118","https://openalex.org/W1982638125","https://openalex.org/W1984197891","https://openalex.org/W1985746590","https://openalex.org/W1989821243","https://openalex.org/W1990520992","https://openalex.org/W1992091600","https://openalex.org/W1993073412","https://openalex.org/W1994245744","https://openalex.org/W1995246974","https://openalex.org/W1995921935","https://openalex.org/W1996791589","https://openalex.org/W2000965988","https://openalex.org/W2006077118","https://openalex.org/W2006379479","https://openalex.org/W2006583619","https://openalex.org/W2007339069","https://openalex.org/W2007711745","https://openalex.org/W2008071983","https://openalex.org/W2009442572","https://openalex.org/W2010925664","https://openalex.org/W2010958487","https://openalex.org/W2011484500","https://openalex.org/W2014523793","https://openalex.org/W2015155762","https://openalex.org/W2016023787","https://openalex.org/W2016496767","https://openalex.org/W2016889496","https://openalex.org/W2018078151","https://openalex.org/W2019774858","https://openalex.org/W2020633581","https://openalex.org/W2023692235","https://openalex.org/W2027918406","https://openalex.org/W2029309152","https://openalex.org/W2029601274","https://openalex.org/W2029964736","https://openalex.org/W2031333036","https://openalex.org/W2031453158","https://openalex.org/W2031542779","https://openalex.org/W2032554048","https://openalex.org/W2036224124","https://openalex.org/W2036848170","https://openalex.org/W2037491280","https://openalex.org/W2037740592","https://openalex.org/W2038599420","https://openalex.org/W2040369455","https://openalex.org/W2041513811","https://openalex.org/W2042668595","https://openalex.org/W2045709976","https://openalex.org/W2050009050","https://openalex.org/W2052596040","https://openalex.org/W2053152019","https://openalex.org/W2054619244","https://openalex.org/W2056002887","https://openalex.org/W2057840174","https://openalex.org/W2058708506","https://openalex.org/W2059206728","https://openalex.org/W2060919343","https://openalex.org/W2061197588","https://openalex.org/W2062149017","https://openalex.org/W2062550534","https://openalex.org/W2063443838","https://openalex.org/W2064660710","https://openalex.org/W2065314821","https://openalex.org/W2065708234","https://openalex.org/W2065999793","https://openalex.org/W2066027024","https://openalex.org/W2066179156","https://openalex.org/W2068943170","https://openalex.org/W2069607114","https://openalex.org/W2070889260","https://openalex.org/W2073074255","https://openalex.org/W2074736583","https://openalex.org/W2075451309","https://openalex.org/W2076415733","https://openalex.org/W2080110076","https://openalex.org/W2082668732","https://openalex.org/W2085547772","https://openalex.org/W2087023953","https://openalex.org/W2087736368","https://openalex.org/W2088569428","https://openalex.org/W2089304809","https://openalex.org/W2092911556","https://openalex.org/W2093072087","https://openalex.org/W2093501684","https://openalex.org/W2093703127","https://openalex.org/W2095017360","https://openalex.org/W2096929609","https://openalex.org/W2096984734","https://openalex.org/W2098386120","https://openalex.org/W2098891503","https://openalex.org/W2099376686","https://openalex.org/W2099770698","https://openalex.org/W2100561498","https://openalex.org/W2105311265","https://openalex.org/W2109494124","https://openalex.org/W2110919730","https://openalex.org/W2112482302","https://openalex.org/W2113769029","https://openalex.org/W2115121941","https://openalex.org/W2117419657","https://openalex.org/W2121518101","https://openalex.org/W2127886165","https://openalex.org/W2131723260","https://openalex.org/W2132600317","https://openalex.org/W2133895575","https://openalex.org/W2135476335","https://openalex.org/W2137026987","https://openalex.org/W2138367998","https://openalex.org/W2139004845","https://openalex.org/W2140784559","https://openalex.org/W2146379743","https://openalex.org/W2146754116","https://openalex.org/W2146830682","https://openalex.org/W2147469984","https://openalex.org/W2149021341","https://openalex.org/W2150868367","https://openalex.org/W2153683785","https://openalex.org/W2154949704","https://openalex.org/W2155980033","https://openalex.org/W2157714710","https://openalex.org/W2158510501","https://openalex.org/W2158661016","https://openalex.org/W2159501858","https://openalex.org/W2166103784","https://openalex.org/W2166121860","https://openalex.org/W2166153420","https://openalex.org/W2166865790","https://openalex.org/W2167059685","https://openalex.org/W2167128189","https://openalex.org/W2168215139","https://openalex.org/W2169345278","https://openalex.org/W2171445712","https://openalex.org/W3104756221","https://openalex.org/W4229608773","https://openalex.org/W4250649783","https://openalex.org/W7098416052"],"related_works":["https://openalex.org/W1992091600","https://openalex.org/W2154480364","https://openalex.org/W1973711114","https://openalex.org/W2104539744","https://openalex.org/W1505496449","https://openalex.org/W2347432016","https://openalex.org/W2563643348","https://openalex.org/W1982539168","https://openalex.org/W1988822278","https://openalex.org/W53824661"],"abstract_inverted_index":{"Genome":[0],"sequences":[1],"of":[2,5,15,27,35,63,99,131,139,149,164,166],"a":[3,97],"number":[4],"archaea":[6,94,156],"have":[7,95],"revealed":[8],"an":[9,24,60],"apparent":[10],"paradox":[11],"in":[12,32,73,79,84,91,121,125,136,155],"the":[13,16,33,100,128,146,150,160],"phylogenies":[14],"bacteria,":[17,44],"archaea,":[18,39],"and":[19,66,108,159,162,168],"eukarya,":[20],"as":[21,23],"well":[22],"intriguing":[25],"set":[26],"problems":[28],"to":[29,42,50,58,81,87,127],"be":[30,43,59],"resolved":[31],"study":[34],"DNA":[36,74,153],"replication.":[37],"The":[38,112],"long":[40],"thought":[41],"are":[45,76,170],"not":[46,119],"only":[47,96],"different":[48],"enough":[49],"merit":[51],"their":[52],"own":[53],"domain":[54,141],"but":[55],"also":[56,116],"appear":[57],"interesting":[61],"mosaic":[62],"bacterial,":[64],"eukaryal,":[65],"unique":[67],"features.":[68],"Most":[69],"archaeal":[70,113],"proteins":[71,90],"participating":[72],"replication":[75,89,102,114,154],"more":[77],"similar":[78],"sequence":[80],"those":[82,165],"found":[83,120],"eukarya":[85,169],"than":[86],"analogous":[88],"bacteria.":[92],"However,":[93],"subset":[98],"eukaryal":[101],"machinery,":[103],"apparently":[104],"needing":[105],"fewer":[106],"polypeptides":[107],"structurally":[109],"simpler":[110],"complexes.":[111],"apparatus":[115],"contains":[117],"features":[118],"other":[122],"organisms":[123],"owing,":[124],"part,":[126],"broad":[129],"range":[130],"environmental":[132],"conditions,":[133],"some":[134],"extreme,":[135],"which":[137],"members":[138],"this":[140,144],"thrive.":[142],"In":[143],"review":[145],"current":[147],"knowledge":[148],"mechanisms":[151],"governing":[152],"is":[157],"summarized":[158],"similarities":[161],"differences":[163],"bacteria":[167],"highlighted.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
