{"id":"https://openalex.org/W2150073686","doi":null,"title":"Effect of Vitamin \u201cE\u201d Supplements in Therapy of Chronic Hepatitis C: A Histological Study","display_name":"Effect of Vitamin \u201cE\u201d Supplements in Therapy of Chronic Hepatitis C: A Histological Study","publication_year":2004,"publication_date":"2004-06-01","ids":{"openalex":"https://openalex.org/W2150073686","mag":"2150073686"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:18c87313692242deb71b84cf9f9d97d4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/18c87313692242deb71b84cf9f9d97d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gomal Journal of Medical Sciences, Vol 6, Iss 2 (2004)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/18c87313692242deb71b84cf9f9d97d4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089154790","display_name":"Ihsan-ullah Wazir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ihsanullah Wazir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111949310","display_name":"Fidaullah Wazir","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fidaullah Wazir","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Muhammad Javed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Javed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Muhammad Saeed","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muhammad Saeed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032285404","display_name":"Najeeb Ul Haq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Najeeb ul Haq","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5065487820","display_name":"Habibullah Khan","orcid":"https://orcid.org/0000-0001-6073-6106","observed_orcids":["https://orcid.org/0000-0001-6073-6106"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Habibullah Khan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.9449999928474426},{"id":"https://openalex.org/keywords/vitamin-e","display_name":"vitamin E","score":0.8880000114440918},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7879999876022339},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/combination-antiviral-therapy","display_name":"combination antiviral therapy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8019999861717224},{"id":"https://openalex.org/keywords/liver-inflammation","display_name":"liver inflammation","score":0.953000009059906},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.5609999895095825},{"id":"https://openalex.org/keywords/antioxidant-therapy","display_name":"antioxidant therapy","score":0.6790000200271606}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9545570611953735},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.9084978103637695},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.7124053239822388},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6494517922401428},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6363802552223206},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5240497589111328},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.47969934344291687},{"id":"https://openalex.org/C102652120","wikidata":"https://www.wikidata.org/wiki/Q2419430","display_name":"Therapeutic effect","level":2,"score":0.45160236954689026},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.4341801404953003},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2728801965713501},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.12712103128433228}],"mesh":[],"locations_count":1,"locations":[{"id":"pmh:oai:doaj.org/article:18c87313692242deb71b84cf9f9d97d4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/18c87313692242deb71b84cf9f9d97d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gomal Journal of Medical Sciences, Vol 6, Iss 2 (2004)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:18c87313692242deb71b84cf9f9d97d4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/18c87313692242deb71b84cf9f9d97d4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Gomal Journal of Medical Sciences, Vol 6, Iss 2 (2004)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W8277583","https://openalex.org/W65224755","https://openalex.org/W113714250","https://openalex.org/W1503393361","https://openalex.org/W1731358335","https://openalex.org/W1980312274","https://openalex.org/W1990667627","https://openalex.org/W1991718040","https://openalex.org/W2003403665","https://openalex.org/W2004360699","https://openalex.org/W2006309458","https://openalex.org/W2020004919","https://openalex.org/W2024123158","https://openalex.org/W2024880904","https://openalex.org/W2036536337","https://openalex.org/W2043976325","https://openalex.org/W2049028404","https://openalex.org/W2063671857","https://openalex.org/W2076517608","https://openalex.org/W2082299629","https://openalex.org/W2087874793","https://openalex.org/W2129712640","https://openalex.org/W2132290252","https://openalex.org/W2158129157","https://openalex.org/W2182184943","https://openalex.org/W2192223169","https://openalex.org/W3147685877"],"related_works":["https://openalex.org/W2413482773","https://openalex.org/W2032286528","https://openalex.org/W2026415957","https://openalex.org/W2001229070","https://openalex.org/W2090192714","https://openalex.org/W2372676497","https://openalex.org/W2043563312","https://openalex.org/W2141137047","https://openalex.org/W2162675370","https://openalex.org/W2146787258"],"abstract_inverted_index":{"Background:":[0],"Chronic":[1],"Hepatitis":[2],"C":[3,82,232],"is":[4],"a":[5],"major":[6],"healthcare":[7],"problem":[8],"worldwide.":[9],"Current":[10],"therapies":[11],"are":[12],"alpha":[13],"interferon":[14,46,91,221],"used":[15],"either":[16],"alone":[17],"or":[18,161],"in":[19,43,49,99,150,199,229],"combination":[20,44,94,218],"with":[21,45,220],"ribavirin.":[22],"Antioxidant":[23],"approaches":[24],"have":[25],"not":[26],"been":[27],"investigated":[28],"sufficiently.":[29],"The":[30,133],"aim":[31],"of":[32,40,139,157,169,183,214,227],"this":[33],"study":[34,60],"was":[35,61,96,104,113,147,159,204],"to":[36,72,125,175,190,217],"evaluate":[37],"the":[38,155,195,225],"efficacy":[39],"vitamin":[41,102,151],"E":[42,103,152,216],"and":[47,53,92,98,107,115,141,201,207,222],"ribavirin":[48,93,223],"reducing":[50],"hepatic":[51],"inflammation":[52],"fibrosis.":[54,144],"Material":[55],"&":[56],"Methods:":[57],"This":[58],"experimental":[59],"conducted":[62],"at":[63],"Khyber":[64],"Teaching":[65],"Hospital":[66],"Peshawar,":[67],"Pakistan,":[68],"from":[69,79,173,187],"October":[70],"2002":[71],"March":[73],"2003.":[74],"Fourteen":[75],"male":[76],"patients":[77,154],"suffering":[78],"chronic":[80,230],"hepatitis":[81,231],"were":[83,122,135],"divided":[84],"into":[85],"two":[86],"groups;":[87],"In":[88,164,178],"group":[89,100,165,179],"A":[90,200],"therapy":[95,219],"given":[97],"B":[101,180],"added.":[105],"Pre":[106],"post":[108],"treatment":[109],"percutaneous":[110],"liver":[111],"biopsy":[112],"taken":[114],"examined":[116],"under":[117],"light":[118],"microscopy.":[119],"Both":[120],"groups":[121],"graded":[123],"according":[124],"Knodell":[126,170,184,197],"Histology":[127],"Activity":[128],"Index":[129],"numerical":[130],"scoring":[131],"system.":[132],"slides":[134],"scored":[136],"for":[137,143],"grades":[138],"necrosis":[140],"stages":[142],"Results:":[145],"It":[146],"observed":[148],"that":[149],"treated":[153],"progression":[156,226],"fibrosis":[158,228],"prevented":[160],"even":[162],"reversed.":[163],"A,":[166],"post-therapeutic":[167,181,196],"mean":[168,182],"score":[171,185],"decreased":[172,186],"11.00\u00b13.74":[174],"6.60\u00b11.50":[176],"(p<0.02).":[177],"10.5\u00b1":[188],"4.24":[189],"4.37\u00b1":[191],"2.06":[192],"(p<0.005).":[193],"Comparing":[194],"scores":[198],"B,":[202],"it":[203],"6.60":[205],"\u00b11.50":[206],"4.37":[208],"\u00b12.06":[209],"respectively":[210],"(p<0.05).":[211],"Conclusion:":[212],"Addition":[213],"Vitamin":[215],"prevents":[224],"patients.":[233]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}