{"id":"https://openalex.org/W2150022366","doi":"https://doi.org/10.1677/erc-09-0318","title":"Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors","display_name":"Molecular markers for novel therapies in neuroendocrine (carcinoid) tumors","publication_year":2010,"publication_date":"2010-04-12","ids":{"openalex":"https://openalex.org/W2150022366","doi":"https://doi.org/10.1677/erc-09-0318","mag":"2150022366","pmid":"https://pubmed.ncbi.nlm.nih.gov/20385747"},"language":"en","primary_location":{"id":"doi:10.1677/erc-09-0318","doi":"https://doi.org/10.1677/erc-09-0318","is_oa":true,"landing_page_url":"https://doi.org/10.1677/erc-09-0318","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/17/3/623.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/17/3/623.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113439877","display_name":"Judith A Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judith A Gilbert","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA","Department of Molecular Pharmacology and Experimental Therapeutics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078579599","display_name":"Laura Adhikari","orcid":"https://orcid.org/0000-0001-8419-4022","observed_orcids":["https://orcid.org/0000-0001-8419-4022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura J Adhikari","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110331817","display_name":"Ricardo V. Lloyd","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ricardo V Lloyd","raw_affiliation_strings":["Department of Laboratory Medicine and Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine and Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090904568","display_name":"Joseph Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Rubin","raw_affiliation_strings":["Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089153267","display_name":"Paul Haluska","orcid":"https://orcid.org/0000-0003-3283-4512","observed_orcids":["https://orcid.org/0000-0003-3283-4512"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I4390039279","display_name":"Mayo Clinic Comprehensive Cancer Center (Minnesota)","ror":"https://ror.org/012wxv498","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Haluska","raw_affiliation_strings":["Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I4390039279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088565265","display_name":"Joan M. Carboni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joan M Carboni","raw_affiliation_strings":["Oncology Drug Discovery, Bristol-Myers Squibb, Princeton, New Jersey 08543, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Drug Discovery, Bristol-Myers Squibb, Princeton, New Jersey 08543, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040094376","display_name":"Marco M. Gottardis","orcid":"https://orcid.org/0000-0003-2280-8708","observed_orcids":["https://orcid.org/0000-0003-2280-8708"]},"institutions":[{"id":"https://openalex.org/I4210091812","display_name":"Bristol-Myers Squibb (United States)","ror":"https://ror.org/00gtmwv55","country_code":"US","type":"company","lineage":["https://openalex.org/I4210091812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marco M Gottardis","raw_affiliation_strings":["Oncology Drug Discovery, Bristol-Myers Squibb, Princeton, New Jersey 08543, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Drug Discovery, Bristol-Myers Squibb, Princeton, New Jersey 08543, USA","institution_ids":["https://openalex.org/I4210091812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066722006","display_name":"Matthew M. Ames","orcid":"https://orcid.org/0000-0003-3652-209X","observed_orcids":["https://orcid.org/0000-0003-3652-209X"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Matthew M Ames","raw_affiliation_strings":["Department of Molecular Pharmacology and Experimental Therapeutics,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Pharmacology and Experimental Therapeutics,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5066722006"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.353,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.95714437,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"623","last_page":"636"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":0.9110000133514404},{"id":"https://openalex.org/keywords/carcinoid-tumor","display_name":"carcinoid tumor","score":0.9679999947547913},{"id":"https://openalex.org/keywords/molecular-biomarkers","display_name":"molecular biomarkers","score":0.8230000138282776},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.671999990940094},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.6179999709129333},{"id":"https://openalex.org/keywords/kit","display_name":"KIT","score":0.8920000195503235},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.7739999890327454},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.875},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta-receptor-1","display_name":"TGFBR1","score":0.8880000114440918},{"id":"https://openalex.org/keywords/somatostatin-receptor-5","display_name":"somatostatin receptor 5","score":0.8989999890327454},{"id":"https://openalex.org/keywords/17-aag","display_name":"17-AAG","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bms-754807","display_name":"BMS-754807","score":0.984000027179718},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.699999988079071},{"id":"https://openalex.org/keywords/lung-neuroendocrine-tumors","display_name":"lung neuroendocrine tumors","score":0.7319999933242798}],"concepts":[{"id":"https://openalex.org/C144174609","wikidata":"https://www.wikidata.org/wiki/Q14901457","display_name":"Insulin-like growth factor 1 receptor","level":4,"score":0.7152485847473145},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.6876475811004639},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6148825883865356},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.6147468686103821},{"id":"https://openalex.org/C26375932","wikidata":"https://www.wikidata.org/wiki/Q118226","display_name":"Growth factor receptor","level":3,"score":0.5662082433700562},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5065861940383911},{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.4751667380332947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45142027735710144},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.3801567554473877},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35993826389312744},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3443062901496887},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.32197797298431396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3161125183105469},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.20860716700553894},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.18569254875183105},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.15292933583259583}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014227","descriptor_name":"Triazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016227","descriptor_name":"Benzoquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018358","descriptor_name":"Neuroendocrine Tumors","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046888","descriptor_name":"Tissue Array Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047029","descriptor_name":"Lactams, Macrocyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1677/erc-09-0318","doi":"https://doi.org/10.1677/erc-09-0318","is_oa":true,"landing_page_url":"https://doi.org/10.1677/erc-09-0318","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/17/3/623.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},{"id":"pmid:20385747","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20385747","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-related cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1677/erc-09-0318","doi":"https://doi.org/10.1677/erc-09-0318","is_oa":true,"landing_page_url":"https://doi.org/10.1677/erc-09-0318","pdf_url":"https://erc.bioscientifica.com/downloadpdf/journals/erc/17/3/623.pdf","source":{"id":"https://openalex.org/S193349529","display_name":"Endocrine Related Cancer","issn_l":"1351-0088","issn":["1351-0088","1479-6821"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319937","host_organization_name":"Bioscientifica","host_organization_lineage":["https://openalex.org/P4310319937"],"host_organization_lineage_names":["Bioscientifica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrine-Related Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2150022366.pdf","grobid_xml":"https://content.openalex.org/works/W2150022366.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1964806629","https://openalex.org/W1972090515","https://openalex.org/W1988442083","https://openalex.org/W2038487138","https://openalex.org/W2043692783","https://openalex.org/W2043696829","https://openalex.org/W2072454269","https://openalex.org/W2073639423","https://openalex.org/W2080232093","https://openalex.org/W2098223440","https://openalex.org/W2102769930","https://openalex.org/W2106789440","https://openalex.org/W2106983577","https://openalex.org/W2118004874","https://openalex.org/W2121389354","https://openalex.org/W2122885616","https://openalex.org/W2124727142","https://openalex.org/W2125332438","https://openalex.org/W2130900820","https://openalex.org/W2142850084","https://openalex.org/W2150501295","https://openalex.org/W2155311724","https://openalex.org/W2158475201","https://openalex.org/W2160866033","https://openalex.org/W2161821474","https://openalex.org/W2164837623","https://openalex.org/W2165119042","https://openalex.org/W2274550965","https://openalex.org/W2288763477","https://openalex.org/W2315455232","https://openalex.org/W2371259918","https://openalex.org/W2398587138","https://openalex.org/W4387993641"],"related_works":["https://openalex.org/W2082798082","https://openalex.org/W3494188","https://openalex.org/W2589767313","https://openalex.org/W2183394570","https://openalex.org/W1980451534","https://openalex.org/W2906975053","https://openalex.org/W41852960","https://openalex.org/W2062549872","https://openalex.org/W2131094814","https://openalex.org/W2411088753"],"abstract_inverted_index":{"Neuroendocrine":[0],"(carcinoid)":[1],"tumors":[2],"(NETs)":[3],"are":[4],"endocrine":[5],"neoplasms":[6],"occurring":[7],"most":[8],"frequently":[9],"in":[10,53,76,88,189,197,254],"gastrointestinal":[11],"and":[12,64,82,103,128,142,144,159,181,214,222,239,252,259,275],"bronchopulmonary":[13],"(BP)":[14],"systems.":[15],"The":[16],"majority":[17],"of":[18,47,80,114,139,149,156,186,193,208,219,234,250],"patients":[19],"present":[20],"with":[21,86,172,216,231],"advanced":[22],"disease":[23],"for":[24,36,44,95,279,284],"which":[25],"few":[26,168],"treatment":[27],"options":[28],"exist.":[29],"We":[30],"assessed":[31,52],"104":[32],"NETs":[33,135],"(74":[34],"cases)":[35,158],"biomarkers":[37],"targeted":[38],"by":[39],"anticancer":[40,200,282],"drugs":[41],"under":[42],"development":[43],"other":[45],"forms":[46],"cancer.":[48],"Activating":[49],"mutations":[50,75,147,170],"were":[51,93,165],"epidermal":[54],"growth":[55,66,108,118,130,230],"factor":[56,61,67,109,119],"receptor":[57,62,68,100,110,121,132],"(EGFR),":[58],"stem":[59],"cell":[60],"(KIT),":[63],"platelet-derived":[65],"alpha":[69],"(PDGFRA),":[70],"as":[71,73,277],"well":[72],"non-response":[74,173],"KRAS.":[77],"Copy":[78],"number":[79,163],"EGFR":[81,153,161,251,276],"HER-2/neu":[83],"was":[84],"quantified":[85],"fluorescence":[87],"situ":[89],"hybridization.":[90],"Immunohistochemical":[91],"analyses":[92],"performed":[94],"EGFR,":[96],"KIT,":[97],"PDGFRA,":[98],"somatostatin":[99],"subtypes":[101],"2A":[102],"5":[104],"(SSTR5),":[105],"vascular":[106],"endothelial":[107],"1,":[111],"mammalian":[112],"target":[113],"rapamycin":[115],"(mTOR),":[116],"insulin-like":[117],"1":[120,133,240],"(IGF1R),":[122],"heat":[123],"shock":[124],"protein":[125],"90":[126],"(Hsp90),":[127],"transforming":[129],"factor-beta":[131],"(TGFBR1).":[134],"lacked":[136],"HER2-overexpression":[137],"predictive":[138],"anti-HER2":[140],"response":[141],"KIT":[143],"PDGFRA":[145],"activating":[146],"indicative":[148],"imatinib":[150],"sensitivity.":[151],"High":[152],"aneusomy":[154],"(20%":[155],"all":[157],"elevated":[160],"copy":[162],"(39%)":[164],"found,":[166],"but":[167],"KRAS":[169],"associated":[171],"to":[174],"anti-EGFR":[175],"therapy":[176],"(3%).":[177],"Hsp90,":[178,273],"TGFBR1,":[179],"IGF1R,":[180,274],"SSTR5":[182],"exhibited":[183],"highest":[184],"levels":[185],"immunohistochemical":[187],"staining":[188],"the":[190,255],"largest":[191],"percents":[192],"tumors.":[194],"In":[195],"subsequent":[196],"vitro":[198],"studies,":[199],"drug":[201],"17-(allylamino)-17-demethoxygeldanamycin":[202],"(17-AAG)":[203],"(targeting":[204,227],"Hsp90)":[205],"inhibited":[206,229,263],"proliferation":[207],"BP":[209],"NET":[210],"lines":[211],"NCI-H727,":[212],"NCI-H720,":[213],"NCI-H835":[215],"IC(50)":[217,232],"values":[218,233],"70.4,":[220],"310,":[221],"788":[223],"nM":[224],"respectively;":[225],"BMS-754807":[226,260],"IGF1R/IR)":[228],"428":[235],"nM,":[236],"2.8":[237],"microM,":[238],"microM.":[241],"At":[242],"growth-inhibiting":[243],"concentrations,":[244],"17-AAG":[245],"(24":[246,261],"h)":[247,262],"induced":[248],"loss":[249],"IGF1R":[253,265],"IGF1R-expressing":[256],"NCI-H727":[257],"line,":[258],"constitutive":[264],"autophosphorylation.":[266],"Our":[267],"results":[268],"support":[269],"further":[270],"research":[271],"into":[272],"targets":[278],"developing":[280],"new":[281],"therapeutics":[283],"some":[285],"NETs.":[286]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":11}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
