{"id":"https://openalex.org/W2149970565","doi":"https://doi.org/10.1111/j.1460-9568.2005.03870.x","title":"Pro\u2010apoptotic protein glyceraldehyde\u20103\u2010phosphate dehydrogenase promotes the formation of Lewy body\u2010like inclusions","display_name":"Pro\u2010apoptotic protein glyceraldehyde\u20103\u2010phosphate dehydrogenase promotes the formation of Lewy body\u2010like inclusions","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2149970565","doi":"https://doi.org/10.1111/j.1460-9568.2005.03870.x","mag":"2149970565","pmid":"https://pubmed.ncbi.nlm.nih.gov/15673432"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.2005.03870.x","doi":"https://doi.org/10.1111/j.1460-9568.2005.03870.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2005.03870.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Katsumi Tsuchiya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201389808","display_name":"Josai University","ror":"https://ror.org/021r6aq66","country_code":"JP","type":"education","lineage":["https://openalex.org/I201389808"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsumi Tsuchiya","raw_affiliation_strings":["Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350-0248, Japan","K.T. and H.T. contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350-0248, Japan","institution_ids":["https://openalex.org/I201389808"]},{"raw_affiliation_string":"K.T. and H.T. contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111492535","display_name":"Hisao Tajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hisao Tajima","raw_affiliation_strings":["K.T. and H.T. contributed equally to this work","Minase Research Institute, Ono Pharmaceutical Co., Ltd, Osaka 618\u20138585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"K.T. and H.T. contributed equally to this work","institution_ids":[]},{"raw_affiliation_string":"Minase Research Institute, Ono Pharmaceutical Co., Ltd, Osaka 618\u20138585, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074392987","display_name":"Toyoyasu Kuwae","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201389808","display_name":"Josai University","ror":"https://ror.org/021r6aq66","country_code":"JP","type":"education","lineage":["https://openalex.org/I201389808"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toyoyasu Kuwae","raw_affiliation_strings":["Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350\u20130248, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350\u20130248, Japan","institution_ids":["https://openalex.org/I201389808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037141327","display_name":"Takao Takeshima","orcid":"https://orcid.org/0000-0003-2678-6956","observed_orcids":["https://orcid.org/0000-0003-2678-6956"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Takeshima","raw_affiliation_strings":["Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112637971","display_name":"Toshiya Nakano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiya Nakano","raw_affiliation_strings":["Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059337555","display_name":"Masaharu Tanaka","orcid":"https://orcid.org/0000-0002-6773-7942","observed_orcids":["https://orcid.org/0000-0002-6773-7942"]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Tanaka","raw_affiliation_strings":["Minase Research Institute, Ono Pharmaceutical Co., Ltd, Osaka 618\u20138585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Research Institute, Ono Pharmaceutical Co., Ltd, Osaka 618\u20138585, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110776612","display_name":"Katsuyoshi Sunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201389808","display_name":"Josai University","ror":"https://ror.org/021r6aq66","country_code":"JP","type":"education","lineage":["https://openalex.org/I201389808"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuyoshi Sunaga","raw_affiliation_strings":["Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350\u20130248, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350\u20130248, Japan","institution_ids":["https://openalex.org/I201389808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111709751","display_name":"Y\u014dko Fukuhara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoko Fukuhara","raw_affiliation_strings":["Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101727402","display_name":"Kenji Nakashima","orcid":"https://orcid.org/0000-0003-1816-6482","observed_orcids":["https://orcid.org/0000-0003-1816-6482"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji Nakashima","raw_affiliation_strings":["Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056296430","display_name":"Eisaku Ohama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Eisaku Ohama","raw_affiliation_strings":["Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuropathology, Institute of Neurological Sciences, Tottori University Faculty of Medicine, Yonago 683\u20138504, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044022978","display_name":"Hideki Mochizuki","orcid":"https://orcid.org/0000-0002-0874-7542","observed_orcids":["https://orcid.org/0000-0002-0874-7542"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Mochizuki","raw_affiliation_strings":["Department of Neurology, Juntendo University School of Medicine, Tokyo 113\u20138421, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Juntendo University School of Medicine, Tokyo 113\u20138421, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082083783","display_name":"Yoshikuni Mizuno","orcid":"https://orcid.org/0000-0002-1588-5134","observed_orcids":["https://orcid.org/0000-0002-1588-5134"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikuni Mizuno","raw_affiliation_strings":["Department of Neurology, Juntendo University School of Medicine, Tokyo 113\u20138421, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Juntendo University School of Medicine, Tokyo 113\u20138421, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060507180","display_name":"Nobuo C. Katsube","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210112155","display_name":"Ono Pharmaceutical (Japan)","ror":"https://ror.org/022jefx64","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210112155"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobuo Katsube","raw_affiliation_strings":["Minase Research Institute, Ono Pharmaceutical Co., Ltd, Osaka 618\u20138585, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Minase Research Institute, Ono Pharmaceutical Co., Ltd, Osaka 618\u20138585, Japan","institution_ids":["https://openalex.org/I4210112155"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108729652","display_name":"Ryoichi Ishitani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201389808","display_name":"Josai University","ror":"https://ror.org/021r6aq66","country_code":"JP","type":"education","lineage":["https://openalex.org/I201389808"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoichi Ishitani","raw_affiliation_strings":["Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350\u20130248, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Group on Cellular Neurobiology, Josai University, Sakado, Saitama 350\u20130248, Japan","institution_ids":["https://openalex.org/I201389808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":3.2079,"has_fulltext":false,"cited_by_count":69,"citation_normalized_percentile":{"value":0.91433595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"21","issue":"2","first_page":"317","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glyceraldehyde-3-phosphate-dehydrogenase","display_name":"glyceraldehyde-3-phosphate dehydrogenase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7710000276565552},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9259999990463257},{"id":"https://openalex.org/keywords/beta-synuclein","display_name":"beta-synuclein","score":0.9900000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5910000205039978},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8949999809265137},{"id":"https://openalex.org/keywords/locus-coeruleus","display_name":"locus coeruleus","score":0.8019999861717224},{"id":"https://openalex.org/keywords/ubiquitin-positive-inclusions","display_name":"ubiquitin-positive inclusions","score":0.75}],"concepts":[{"id":"https://openalex.org/C134792803","wikidata":"https://www.wikidata.org/wiki/Q424886","display_name":"Glyceraldehyde 3-phosphate dehydrogenase","level":4,"score":0.9272276163101196},{"id":"https://openalex.org/C2779097696","wikidata":"https://www.wikidata.org/wiki/Q1822234","display_name":"Lewy body","level":4,"score":0.6235503554344177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6148871183395386},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5048690438270569},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.4604831635951996},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45679712295532227},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4520752429962158},{"id":"https://openalex.org/C203750385","wikidata":"https://www.wikidata.org/wiki/Q1308970","display_name":"Inclusion bodies","level":4,"score":0.41304266452789307},{"id":"https://openalex.org/C36124564","wikidata":"https://www.wikidata.org/wiki/Q1286842","display_name":"Cytoplasmic inclusion","level":3,"score":0.4114651083946228},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.4069337844848633},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.3624553680419922},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.29048195481300354},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22718992829322815},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21401286125183105},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1981872320175171},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.1291012167930603},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09632566571235657},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002449","descriptor_name":"Cell Aggregation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002479","descriptor_name":"Inclusion Bodies","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005987","descriptor_name":"Glyceraldehyde-3-Phosphate Dehydrogenases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016631","descriptor_name":"Lewy Bodies","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D019556","descriptor_name":"COS Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046529","descriptor_name":"Microscopy, Electron, Transmission","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047468","descriptor_name":"Immunoprecipitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051843","descriptor_name":"Synucleins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051844","descriptor_name":"alpha-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051846","descriptor_name":"beta-Synuclein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1460-9568.2005.03870.x","doi":"https://doi.org/10.1111/j.1460-9568.2005.03870.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2005.03870.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:15673432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15673432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320312387","display_name":"Temple University","ror":"https://ror.org/00kx1jb78"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W138616876","https://openalex.org/W207007096","https://openalex.org/W1489341550","https://openalex.org/W1514910213","https://openalex.org/W1527671059","https://openalex.org/W1529474377","https://openalex.org/W1856608655","https://openalex.org/W1965575645","https://openalex.org/W1976148085","https://openalex.org/W1976316003","https://openalex.org/W1978989017","https://openalex.org/W1985542518","https://openalex.org/W1986625112","https://openalex.org/W1994214260","https://openalex.org/W1995247791","https://openalex.org/W1998584272","https://openalex.org/W2002506451","https://openalex.org/W2008964882","https://openalex.org/W2009556855","https://openalex.org/W2015631023","https://openalex.org/W2025922492","https://openalex.org/W2027649342","https://openalex.org/W2028652101","https://openalex.org/W2046014998","https://openalex.org/W2053359084","https://openalex.org/W2056365448","https://openalex.org/W2064132534","https://openalex.org/W2075001379","https://openalex.org/W2075997185","https://openalex.org/W2077377590","https://openalex.org/W2091204354","https://openalex.org/W2091214947","https://openalex.org/W2094478098","https://openalex.org/W2096298540","https://openalex.org/W2109658405","https://openalex.org/W2132647801","https://openalex.org/W2143331398","https://openalex.org/W2143959688","https://openalex.org/W2171114341","https://openalex.org/W2418219273"],"related_works":["https://openalex.org/W2011621952","https://openalex.org/W4233515613","https://openalex.org/W2164008826","https://openalex.org/W2383018956","https://openalex.org/W2791223230","https://openalex.org/W1973945485","https://openalex.org/W3176494358","https://openalex.org/W2008641471","https://openalex.org/W2028607996","https://openalex.org/W1965575645"],"abstract_inverted_index":{"Glyceraldehyde-3-phosphate":[0],"dehydrogenase":[1],"(GAPDH)":[2],"has":[3],"long":[4],"been":[5],"recognized":[6],"as":[7],"a":[8,25,44,186],"classical":[9],"glycolytic":[10],"protein;":[11],"however,":[12],"previous":[13],"studies":[14],"by":[15,70],"our":[16],"group":[17],"and":[18,65,93,134],"others":[19],"have":[20,38],"demonstrated":[21],"that":[22,40,190,202],"GAPDH":[23,47,85,117,140,205],"is":[24,48],"general":[26],"mediator":[27],"initiating":[28],"one":[29],"or":[30,89],"more":[31],"apoptotic":[32,122,220],"cascades.":[33],"Our":[34],"most":[35],"recent":[36],"findings":[37],"elucidated":[39],"an":[41],"expression":[42],"of":[43,55,84,127,151,174,193],"pro-apoptotic":[45,203],"protein":[46,204],"critically":[49],"regulated":[50],"at":[51],"the":[52,56,71,114,125,162,171,178,210,219],"promoter":[53],"region":[54],"gene.":[57],"Apoptotic":[58],"signals":[59],"for":[60],"its":[61,77,111],"subsequent":[62],"aggregate":[63],"formation":[64,126,213],"nuclear":[66],"translocation":[67],"are":[68],"controlled":[69],"respective":[72],"functional":[73],"domains":[74],"harboured":[75],"within":[76],"cDNA":[78],"component.":[79],"In":[80],"this":[81,146],"study,":[82],"coexpression":[83],"with":[86,96,142,157,218],"either":[87],"wild-type":[88,143],"mutant":[90,116],"(A53T)":[91],"alpha-synuclein":[92,144],"less":[94],"likely":[95],"beta-synuclein":[97],"in":[98,145,170,209,214],"transfected":[99],"COS-7":[100],"cells":[101],"was":[102],"found":[103],"to":[104],"induce":[105],"Lewy":[106,175,194,211],"body-like":[107],"cytoplasmic":[108],"inclusions.":[109,128],"Unlike":[110],"full-length":[112],"construct,":[113],"deleted":[115],"construct":[118],"(C66)":[119],"abolished":[120],"these":[121,167],"signals,":[123],"disfavouring":[124],"The":[129],"generated":[130],"inclusions":[131],"were":[132],"ubiquitin-":[133],"thioflavin":[135],"S-positive":[136],"appearing":[137],"fibrils.":[138],"Furthermore,":[139],"coimmunoprecipitated":[141],"paradigm.":[147],"Importantly,":[148],"immunohistochemical":[149],"examinations":[150],"post":[152],"mortem":[153],"materials":[154],"from":[155,177],"patients":[156],"sporadic":[158],"Parkinson's":[159],"disease":[160],"revealed":[161],"colocalized":[163],"profiles":[164],"immunoreactive":[165],"against":[166],"two":[168],"proteins":[169],"peripheral":[172],"zone":[173],"bodies":[176,195],"affected":[179],"brain":[180],"regions":[181],"(i.e.":[182],"locus":[183],"coeruleus).":[184],"Moreover,":[185],"quantitative":[187],"assessment":[188],"showed":[189],"about":[191],"20%":[192],"displayed":[196],"both":[197],"antigenicities.":[198],"These":[199],"results":[200],"suggest":[201],"may":[206],"be":[207],"involved":[208],"body":[212],"vivo,":[215],"probably":[216],"associated":[217],"death":[221],"pathway.":[222]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
