{"id":"https://openalex.org/W2149947600","doi":"https://doi.org/10.1039/c3an36819j","title":"Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis","display_name":"Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2149947600","doi":"https://doi.org/10.1039/c3an36819j","mag":"2149947600","pmid":"https://pubmed.ncbi.nlm.nih.gov/24091439","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165583"},"language":"en","primary_location":{"id":"doi:10.1039/c3an36819j","doi":"https://doi.org/10.1039/c3an36819j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3an36819j","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165583","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109386333","display_name":"Yogesh M. Kulkarni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yogesh M. Kulkarni","raw_affiliation_strings":["Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, USA","Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia 26506, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011019646","display_name":"Changxing Liu","orcid":"https://orcid.org/0000-0001-9900-9862","observed_orcids":["https://orcid.org/0000-0001-9900-9862","https://orcid.org/0009-0009-9051-7807"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changxing Liu","raw_affiliation_strings":["Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100406589","display_name":"Qi Qi","orcid":"https://orcid.org/0000-0003-4460-0713","observed_orcids":["https://orcid.org/0000-0003-4460-0713"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Qi","raw_affiliation_strings":["Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002381328","display_name":"Yanmei Zhu","orcid":"https://orcid.org/0000-0001-5526-7624","observed_orcids":["https://orcid.org/0000-0001-5526-7624"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanmei Zhu","raw_affiliation_strings":["Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001068793","display_name":"David J. Klinke","orcid":"https://orcid.org/0000-0003-3299-4938","observed_orcids":["https://orcid.org/0000-0003-3299-4938"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David J. Klinke II","raw_affiliation_strings":["Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia, USA","Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100362133","display_name":"Jun Liu","orcid":"https://orcid.org/0000-0003-4800-7749","observed_orcids":["https://orcid.org/0000-0003-4800-7749"]},"institutions":[{"id":"https://openalex.org/I12097938","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24","country_code":"US","type":"education","lineage":["https://openalex.org/I12097938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jun Liu","raw_affiliation_strings":["Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA","Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]},{"raw_affiliation_string":"Mary Babb Randolph Cancer Center, West Virginia University, PO Box 9229, Morgantown, West Virginia, USA","institution_ids":["https://openalex.org/I12097938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001068793","https://openalex.org/A5100362133"],"corresponding_institution_ids":["https://openalex.org/I12097938"],"apc_list":null,"apc_paid":null,"fwci":0.1935,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.61060456,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"138","issue":"22","first_page":"6986","last_page":"6986"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":1.0},{"id":"https://openalex.org/keywords/sh2b3","display_name":"SH2B3","score":0.8870000243186951},{"id":"https://openalex.org/keywords/capns1","display_name":"CAPNS1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7440000176429749},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5820000171661377},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8840000033378601},{"id":"https://openalex.org/keywords/differentially-expressed-proteins","display_name":"differentially expressed proteins","score":0.7620000243186951},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7006826400756836},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6343482136726379},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46303993463516235},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.45661279559135437},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44604814052581787},{"id":"https://openalex.org/C2779403975","wikidata":"https://www.wikidata.org/wiki/Q24724230","display_name":"Caveolin","level":4,"score":0.44515523314476013},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.444273978471756},{"id":"https://openalex.org/C53645450","wikidata":"https://www.wikidata.org/wiki/Q907093","display_name":"Scaffold protein","level":3,"score":0.4412137567996979},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3968328535556793},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16418129205703735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1286250650882721},{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.0805254876613617}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002154","descriptor_name":"Calpain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011975","descriptor_name":"Receptors, Mitogen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037181","descriptor_name":"Lectins, C-Type","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051242","descriptor_name":"Caveolin 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1039/c3an36819j","doi":"https://doi.org/10.1039/c3an36819j","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c3an36819j","pdf_url":null,"source":{"id":"https://openalex.org/S105746325","display_name":"The Analyst","issn_l":"0003-2654","issn":["0003-2654","1364-5528"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"journal-article"},{"id":"pmid:24091439","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24091439","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Analyst","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3138885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4165583","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165583","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Analyst","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3138885","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4165583","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5683000087738037}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2196839051","display_name":"Noncanonical signaling and Emergent Trastuzumab Resistance in Breast Cancer","funder_award_id":"R15CA132124","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7936105951","display_name":null,"funder_award_id":"R15CA123123","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856889","display_name":"West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)","funder_award_id":"P20GM103434","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310536","display_name":"University of Virginia","ror":"https://ror.org/0153tk833"},{"id":"https://openalex.org/F4320311274","display_name":"West Virginia University","ror":"https://ror.org/011vxgd24"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1966248877","https://openalex.org/W1966824782","https://openalex.org/W1969657682","https://openalex.org/W1974248631","https://openalex.org/W1977837348","https://openalex.org/W1977966461","https://openalex.org/W1978279440","https://openalex.org/W1978430298","https://openalex.org/W1984719690","https://openalex.org/W1987270140","https://openalex.org/W1991875866","https://openalex.org/W1996439867","https://openalex.org/W2005061481","https://openalex.org/W2011485738","https://openalex.org/W2014716303","https://openalex.org/W2023164440","https://openalex.org/W2027719255","https://openalex.org/W2028027261","https://openalex.org/W2033085629","https://openalex.org/W2045489644","https://openalex.org/W2046726975","https://openalex.org/W2046919271","https://openalex.org/W2055913285","https://openalex.org/W2059595150","https://openalex.org/W2061497413","https://openalex.org/W2068908631","https://openalex.org/W2069855944","https://openalex.org/W2075796682","https://openalex.org/W2078308178","https://openalex.org/W2078965007","https://openalex.org/W2083358105","https://openalex.org/W2083623111","https://openalex.org/W2084646989","https://openalex.org/W2085544097","https://openalex.org/W2087222747","https://openalex.org/W2088921555","https://openalex.org/W2092437783","https://openalex.org/W2095480781","https://openalex.org/W2105004898","https://openalex.org/W2110065044","https://openalex.org/W2117692326","https://openalex.org/W2117971572","https://openalex.org/W2135541516","https://openalex.org/W2143838095","https://openalex.org/W2152285853","https://openalex.org/W2156191104","https://openalex.org/W2156754287","https://openalex.org/W2159413140","https://openalex.org/W2163942900","https://openalex.org/W2253190508","https://openalex.org/W4239908869"],"related_works":["https://openalex.org/W2964212914","https://openalex.org/W2156754287","https://openalex.org/W2024504202","https://openalex.org/W2989240454","https://openalex.org/W1526274664","https://openalex.org/W2132082732","https://openalex.org/W2078167017","https://openalex.org/W2612187390","https://openalex.org/W2966716848","https://openalex.org/W1884779781"],"abstract_inverted_index":{"Caveolin-1":[0],"(Cav1)":[1],"is":[2,154],"a":[3,9,94],"small":[4,151,219],"scaffolding":[5],"protein":[6],"involved":[7],"in":[8,37,83,136,156,173,186],"variety":[10],"of":[11,24,68,111,179,183],"cellular":[12],"functions,":[13],"including":[14],"cell":[15,164],"signaling,":[16],"lipid":[17],"transport":[18],"and":[19,62,77,105,160,181,210,216],"membrane":[20],"traffic.":[21],"The":[22],"objective":[23],"this":[25,125],"study":[26],"was":[27,171],"to":[28,32,54,63,166,194],"use":[29],"comparative":[30],"proteomics":[31],"identify":[33,64],"differentially":[34],"expressed":[35],"proteins":[36,46,73,79],"Cav1":[38,84,128,157,174,187,215],"knockout":[39],"(KO)":[40],"mouse":[41],"embryonic":[42],"fibroblasts.":[43],"These":[44],"deregulated":[45],"were":[47,75,81],"then":[48],"analyzed":[49],"using":[50],"systems":[51],"biology":[52],"tools":[53],"gain":[55],"insight":[56],"into":[57],"the":[58,65,89,119,163,192],"local":[59,90],"network":[60,91,99],"properties":[61],"interaction":[66,98,109],"partners":[67,110],"Cav1.":[69,112],"We":[70,146],"identified":[71],"five":[72],"that":[74,80,88,149,208,217],"up-regulated":[76,155],"ten":[78],"down-regulated":[82],"KO":[85,129,158,175,188],"cells,":[86],"suggesting":[87],"behaves":[92],"as":[93,107,118,197],"complex":[95],"system.":[96],"Protein":[97],"analysis":[100],"revealed":[101],"two":[102],"proteins,":[103],"Sh2b3":[104,209],"Clec12b,":[106],"novel":[108],"Functional":[113],"annotation":[114],"showed":[115,131],"apoptosis":[116],"signaling":[117],"most":[120],"significant":[121],"pathway.":[122],"To":[123],"validate":[124],"functional":[126],"annotation,":[127],"cells":[130,142,159,176,189,193],"more":[132],"than":[133],"1.5-fold":[134],"increase":[135],"caspase-3":[137],"activity":[138],"over":[139],"wild":[140],"type":[141],"upon":[143],"apoptotic":[144,167,195],"stimulation.":[145],"also":[147],"found":[148],"calpain":[150,218],"subunit":[152,220],"1":[153,221],"directly":[161],"influences":[162],"response":[165],"stimuli.":[168],"Moreover,":[169],"Capns1":[170,184],"reduced":[172],"following":[177],"re-expression":[178],"Cav1,":[180],"suppression":[182],"expression":[185],"significantly":[190],"inhibited":[191],"stimuli,":[196],"measured":[198],"by":[199],"caspase":[200],"3":[201],"activity.":[202],"In":[203],"conclusion,":[204],"our":[205],"results":[206],"suggest":[207],"Clec12b":[211],"functionally":[212],"interact":[213],"with":[214],"may":[222],"mediate":[223],"Cav1-induced":[224],"apoptosis.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}