{"id":"https://openalex.org/W2149914912","doi":"https://doi.org/10.1093/clinchem/43.10.1862","title":"Prostate-specific antigen in serum during the menstrual cycle","display_name":"Prostate-specific antigen in serum during the menstrual cycle","publication_year":1997,"publication_date":"1997-10-01","ids":{"openalex":"https://openalex.org/W2149914912","doi":"https://doi.org/10.1093/clinchem/43.10.1862","mag":"2149914912","pmid":"https://pubmed.ncbi.nlm.nih.gov/9342005"},"language":"en","primary_location":{"id":"doi:10.1093/clinchem/43.10.1862","doi":"https://doi.org/10.1093/clinchem/43.10.1862","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/43.10.1862","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010690456","display_name":"Nosratollah Zarghami","orcid":"https://orcid.org/0000-0002-4236-4537","observed_orcids":["https://orcid.org/0000-0002-4236-4537"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Nosratollah Zarghami","raw_affiliation_strings":["Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario M5G 1L5, Canada","Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario M5G 1L5, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105525050","display_name":"Linda Grass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Linda Grass","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043556576","display_name":"Edward R. Sauter","orcid":"https://orcid.org/0000-0002-8232-9146","observed_orcids":["https://orcid.org/0000-0002-8232-9146"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward R Sauter","raw_affiliation_strings":["Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084226800","display_name":"Eleftherios P. Diamandis","orcid":"https://orcid.org/0000-0002-1589-820X","observed_orcids":["https://orcid.org/0000-0002-1589-820X","https://orcid.org/0009-0000-8901-2072"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Eleftherios P Diamandis","raw_affiliation_strings":["Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario M5G 1L5, Canada","Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, University of Toronto, Toronto, Ontario M5G 1L5, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave., Toronto, Ontario M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5084226800"],"corresponding_institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750"],"apc_list":{"value":4636,"currency":"USD","value_usd":4636},"apc_paid":null,"fwci":1.4358,"has_fulltext":true,"cited_by_count":53,"citation_normalized_percentile":{"value":0.82917933,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"43","issue":"10","first_page":"1862","last_page":"1867"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.7246000170707703,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.16760000586509705,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-antigen","display_name":"prostate-specific antigen","score":0.9990000128746033},{"id":"https://openalex.org/keywords/menstrual-cycle","display_name":"menstrual cycle","score":0.8640000224113464},{"id":"https://openalex.org/keywords/serum-psa","display_name":"serum PSA","score":0.7649999856948853},{"id":"https://openalex.org/keywords/progesterone","display_name":"progesterone","score":0.7889999747276306},{"id":"https://openalex.org/keywords/follicular-phase","display_name":"follicular phase","score":0.8330000042915344},{"id":"https://openalex.org/keywords/luteal-phase","display_name":"luteal phase","score":1.0},{"id":"https://openalex.org/keywords/steroid-hormone-regulation","display_name":"steroid hormone regulation","score":0.7879999876022339},{"id":"https://openalex.org/keywords/breast-tissue","display_name":"breast tissue","score":0.546999990940094},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.6399999856948853},{"id":"https://openalex.org/keywords/luteinizing-hormone","display_name":"luteinizing hormone","score":0.9380000233650208},{"id":"https://openalex.org/keywords/follicle-stimulating-hormone","display_name":"follicle-stimulating hormone","score":0.9869999885559082}],"concepts":[{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6744664907455444},{"id":"https://openalex.org/C2779058012","wikidata":"https://www.wikidata.org/wiki/Q83864","display_name":"Menstrual cycle","level":3,"score":0.6161051988601685},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4636005461215973},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46117767691612244},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.38741713762283325},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.3277832269668579},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32678836584091187},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32350972294807434},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1258247196674347},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008597","descriptor_name":"Menstrual Cycle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012739","descriptor_name":"Gonadal Steroid Hormones","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D017430","descriptor_name":"Prostate-Specific Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/clinchem/43.10.1862","doi":"https://doi.org/10.1093/clinchem/43.10.1862","is_oa":false,"landing_page_url":"https://doi.org/10.1093/clinchem/43.10.1862","pdf_url":null,"source":{"id":"https://openalex.org/S139212996","display_name":"Clinical Chemistry","issn_l":"0009-9147","issn":["0009-9147","1530-8561"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320272","host_organization_name":"American Association for Clinical Chemistry","host_organization_lineage":["https://openalex.org/P4310320272"],"host_organization_lineage_names":["American Association for Clinical Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Chemistry","raw_type":"journal-article"},{"id":"pmid:9342005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9342005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1539251532","https://openalex.org/W1586313738","https://openalex.org/W1648484638","https://openalex.org/W1937480514","https://openalex.org/W1967185109","https://openalex.org/W1978158444","https://openalex.org/W1979237696","https://openalex.org/W1979496966","https://openalex.org/W1997492763","https://openalex.org/W1997501760","https://openalex.org/W2017827421","https://openalex.org/W2026558641","https://openalex.org/W2040151918","https://openalex.org/W2059153388","https://openalex.org/W2070492192","https://openalex.org/W2081626609","https://openalex.org/W2091759497","https://openalex.org/W2118247545","https://openalex.org/W2137632843","https://openalex.org/W2153997727","https://openalex.org/W2163324449","https://openalex.org/W2354231589"],"related_works":["https://openalex.org/W2015324585","https://openalex.org/W2184527035","https://openalex.org/W7096295529","https://openalex.org/W2181988704","https://openalex.org/W2084213250","https://openalex.org/W1979237696","https://openalex.org/W2003569879","https://openalex.org/W92237520","https://openalex.org/W2030057173","https://openalex.org/W1979186052"],"abstract_inverted_index":{"We":[0,20,66],"previously":[1],"found":[2,67],"that":[3,68,221],"prostate-specific":[4],"antigen":[5],"(PSA)":[6],"expression":[7],"in":[8,28,53,62,71,115,155,190,213,225],"the":[9,25,32,57,76,91,102,129,162,172,182,214,230],"female":[10],"breast":[11,164],"is":[12,223],"regulated":[13],"by":[14],"steroid":[15],"hormones":[16],"and":[17,95,97,152,185,211],"their":[18,51,146],"receptors.":[19],"have":[21],"now":[22],"examined":[23],"whether":[24],"PSA":[26,45,54,69,108,124,150,153,183,209,222],"concentration":[27,131],"serum":[29,44,72],"changes":[30,52,109,114],"during":[31,56,75,101,171,229],"menstrual":[33,58,231],"cycle":[34,59],"of":[35,87,136,140],"healthy":[36],"women.":[37],"Among":[38],"14":[39],"women":[40],"studied,":[41],"3":[42],"had":[43],">":[46],"or":[47,120,202],"=":[48],"4":[49],"ng/L;":[50],"content":[55],"were":[60,143,178],"studied":[61],"7":[63],"informative":[64],"cycles.":[65],"concentrations":[70],"are":[73],"highest":[74],"mid-":[77,103,173],"to":[78,104,127,148,174,180,207],"late":[79,92,105,175],"follicular":[80,93],"phase,":[81],"drop":[82],"continuously":[83],"with":[84,113,133],"a":[85,99,134,156,226],"half-life":[86],"3-5":[88],"days":[89],"between":[90],"phase":[94,177],"mid-cycle,":[96],"reach":[98],"minimum":[100],"luteal":[106,176],"phase.":[107],"do":[110],"not":[111,194],"correlate":[112],"lutropin":[116],"(LH),":[117],"follitropin":[118],"(FSH),":[119],"estradiol":[121],"concentrations.":[122],"However,":[123],"peaks":[125],"seem":[126],"follow":[128],"progesterone":[130],"peaks,":[132],"delay":[135],"10-12":[137],"days.":[138],"Sera":[139],"some":[141],"volunteers":[142],"tested":[144],"for":[145],"ability":[147],"upregulate":[149,181,208],"protein":[151,212],"mRNA":[154,184,210],"tissue":[157],"culture":[158],"system":[159],"based":[160],"on":[161],"T-47D":[163,215],"carcinoma":[165],"cell":[166,216],"line.":[167,217],"Only":[168],"sera":[169],"obtained":[170],"able":[179,206],"protein.":[186],"In":[187],"stimulation":[188],"experiments":[189],"vitro,":[191],"progesterone,":[192],"but":[193],"LH,":[195],"FSH,":[196],"estradiol,":[197],"human":[198],"chorionic":[199],"gonadotropin,":[200],"prolactin,":[201],"growth":[203],"hormone,":[204],"was":[205],"These":[218],"data":[219],"suggest":[220],"produced":[224],"cyclical":[227],"manner":[228],"cycle.":[232]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}