{"id":"https://openalex.org/W2149912340","doi":"https://doi.org/10.1002/cm.970030506","title":"F\u2010actin aggregates may activate transformed cell surfaces","display_name":"F\u2010actin aggregates may activate transformed cell surfaces","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W2149912340","doi":"https://doi.org/10.1002/cm.970030506","mag":"2149912340","pmid":"https://pubmed.ncbi.nlm.nih.gov/6661766"},"language":"en","primary_location":{"id":"doi:10.1002/cm.970030506","doi":"https://doi.org/10.1002/cm.970030506","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cm.970030506","pdf_url":null,"source":{"id":"https://openalex.org/S4210187003","display_name":"Cell Motility","issn_l":"0271-6585","issn":["0271-6585","1554-3900"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Motility","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079617493","display_name":"William W. Carley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William W. Carley","raw_affiliation_strings":["School of Applied and Engineering Physics, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Applied and Engineering Physics, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111539887","display_name":"Watt W. Webb","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Watt W. Webb","raw_affiliation_strings":["School of Applied and Engineering Physics, Cornell University, Ithaca, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Applied and Engineering Physics, Cornell University, Ithaca, New York","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111539887"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":0.1685,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.49627991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"3","issue":"5","first_page":"383","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transformed-cells","display_name":"transformed cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/cell-cell-contact","display_name":"cell-cell contact","score":0.546999990940094},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-morphology","display_name":"cell morphology","score":0.6769999861717224},{"id":"https://openalex.org/keywords/tropomyosin","display_name":"tropomyosin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/actin-cytoskeleton","display_name":"actin cytoskeleton","score":0.9369999766349792},{"id":"https://openalex.org/keywords/intercellular-communication","display_name":"intercellular communication","score":0.6660000085830688}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7573187947273254},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.7258488535881042},{"id":"https://openalex.org/C189040839","wikidata":"https://www.wikidata.org/wiki/Q329638","display_name":"Microfilament","level":4,"score":0.7048877477645874},{"id":"https://openalex.org/C125705527","wikidata":"https://www.wikidata.org/wiki/Q185269","display_name":"Actin","level":2,"score":0.677169680595398},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5404518246650696},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5138981342315674},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.4957476556301117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4424525201320648},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4078759551048279},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38675373792648315},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11219009757041931}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002472","descriptor_name":"Cell Transformation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cm.970030506","doi":"https://doi.org/10.1002/cm.970030506","is_oa":false,"landing_page_url":"https://doi.org/10.1002/cm.970030506","pdf_url":null,"source":{"id":"https://openalex.org/S4210187003","display_name":"Cell Motility","issn_l":"0271-6585","issn":["0271-6585","1554-3900"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Motility","raw_type":"journal-article"},{"id":"pmid:6661766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6661766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell motility","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1976574060","https://openalex.org/W1977366331","https://openalex.org/W2002980966","https://openalex.org/W2018190245","https://openalex.org/W2036288037","https://openalex.org/W2042678076","https://openalex.org/W2062145172","https://openalex.org/W2069192165","https://openalex.org/W2090810672","https://openalex.org/W2109618118"],"related_works":["https://openalex.org/W2418767927","https://openalex.org/W1976574060","https://openalex.org/W1977366331","https://openalex.org/W3201483220","https://openalex.org/W2417083005","https://openalex.org/W1972679942","https://openalex.org/W1503008877","https://openalex.org/W2229055286","https://openalex.org/W1537404187","https://openalex.org/W2122382098"],"abstract_inverted_index":{"Observations":[0],"on":[1],"the":[2,54,90,103,121,134,141],"role":[3],"of":[4,29,59,97,107,109,120,127],"transformation-specific":[5],"F-actin":[6,33,91],"aggregates":[7,34],"[Carley":[8],"et":[9],"al,":[10],"1981]":[11],"in":[12,19,41,56,63,66,81,99,133,146],"altering":[13],"morphology,":[14],"adhesion":[15],"and":[16,27,31,36,62,85],"intercellular":[17],"interaction":[18,129],"transformed":[20,60,64,147],"cells":[21,61,65],"are":[22,39],"reported":[23],"here.":[24],"The":[25,95],"appearance":[26],"disappearance":[28],"membrane-":[30],"substrate-associated":[32],"(MAG":[35],"SAG,":[37],"respectively)":[38],"followed":[40],"a":[42],"cell":[43,123],"line":[44],"temperature-sensitive":[45],"for":[46],"transformation.":[47],"Since":[48],"MAG":[49,84],"structures":[50,101],"also":[51],"appear":[52,72],"near":[53,102],"membrane":[55,104],"suspension":[57],"cultures":[58],"coculture":[67],"with":[68,117],"untransformed":[69,82],"cells,":[70,83],"they":[71],"to":[73],"function":[74],"at":[75],"cell-cell":[76,136],"contacts.":[77],"Unlike":[78],"microfilament":[79],"bundles":[80],"SAG":[86],"do":[87],"not":[88],"contain":[89],"regulatory":[92],"protein":[93],"tropomyosin.":[94],"lack":[96],"tropomyosin":[98],"these":[100],"is":[105],"reminiscent":[106],"areas":[108,126],"an":[110],"exceptionally":[111],"active":[112],"actin":[113],"cytoskeleton":[114],"usually":[115],"associated":[116],"motile":[118],"processes":[119],"normal":[122],"membrane.":[124],"Such":[125],"membrane-cytoskeletal":[128],"may":[130],"be":[131],"involved":[132],"aberrant":[135],"communication":[137],"as":[138,140],"well":[139],"aggressive":[142],"behavior":[143],"often":[144],"seen":[145],"cells.":[148]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}