{"id":"https://openalex.org/W2149896041","doi":null,"title":"Thrombophilic mutations are a main risk factor for placental abruption.","display_name":"Thrombophilic mutations are a main risk factor for placental abruption.","publication_year":2003,"publication_date":"2003-07-01","ids":{"openalex":"https://openalex.org/W2149896041","mag":"2149896041","pmid":"https://pubmed.ncbi.nlm.nih.gov/12857557"},"language":"en","primary_location":{"id":"pmid:12857557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12857557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/740805","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038206846","display_name":"Fabio Facchinetti","orcid":"https://orcid.org/0000-0003-4694-9564","observed_orcids":["https://orcid.org/0000-0003-4694-9564"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabio Facchinetti","raw_affiliation_strings":["Mother-Infant Dept, Univ. of Modena & Reggio Emilia, Italy. Facchi@unimore.it","Mother-Infant Department University of Modena and Reggio Emilia Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mother-Infant Dept, Univ. of Modena & Reggio Emilia, Italy. Facchi@unimore.it","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Mother-Infant Department University of Modena and Reggio Emilia Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079517018","display_name":"Luca Marozio","orcid":"https://orcid.org/0000-0002-9617-5301","observed_orcids":["https://orcid.org/0000-0002-9617-5301"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Marozio","raw_affiliation_strings":["University of Turin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027920606","display_name":"Elvira Grandone","orcid":"https://orcid.org/0000-0002-8980-9783","observed_orcids":["https://orcid.org/0000-0002-8980-9783"]},"institutions":[{"id":"https://openalex.org/I2800188116","display_name":"Casa Sollievo della Sofferenza","ror":"https://ror.org/00md77g41","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2800188116","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elvira Grandone","raw_affiliation_strings":["IRCCS \u2018\u2018Casa Sollievo della Sofferenza\u2019\u2019"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IRCCS \u2018\u2018Casa Sollievo della Sofferenza\u2019\u2019","institution_ids":["https://openalex.org/I2800188116"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033430080","display_name":"C Pizzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Pizzi","raw_affiliation_strings":["Univ. of Modena and Reggio Emilia#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Modena and Reggio Emilia#TAB#","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074676556","display_name":"Annibale Volpe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annibale Volpe","raw_affiliation_strings":["Univ. of Modena and Reggio Emilia#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Modena and Reggio Emilia#TAB#","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045426561","display_name":"Chiara Benedetto","orcid":"https://orcid.org/0000-0003-1514-4771","observed_orcids":["https://orcid.org/0000-0003-1514-4771"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Benedetto","raw_affiliation_strings":["University of Turin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Turin","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.312,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.88577955,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"88","issue":"7","first_page":"785","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9365000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10290","display_name":"Pregnancy and preeclampsia studies","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombophilia","display_name":"thrombophilia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/factor-v-leiden","display_name":"factor V Leiden","score":0.9580000042915344},{"id":"https://openalex.org/keywords/placental-abruption","display_name":"placental abruption","score":0.9110000133514404},{"id":"https://openalex.org/keywords/preeclampsia","display_name":"preeclampsia","score":0.9089999794960022},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7789999842643738},{"id":"https://openalex.org/keywords/pregnancy-complications","display_name":"pregnancy complications","score":0.4449999928474426},{"id":"https://openalex.org/keywords/genetic-screening","display_name":"genetic screening","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C2779225303","wikidata":"https://www.wikidata.org/wiki/Q388113","display_name":"Placental abruption","level":4,"score":0.9052902460098267},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7808490991592407},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.667509913444519},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.6131922006607056},{"id":"https://openalex.org/C2777175894","wikidata":"https://www.wikidata.org/wiki/Q185986","display_name":"Factor V Leiden","level":4,"score":0.6064296960830688},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.5717000365257263},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.529773473739624},{"id":"https://openalex.org/C2780842393","wikidata":"https://www.wikidata.org/wiki/Q1570013","display_name":"Thrombophilia","level":3,"score":0.5230173468589783},{"id":"https://openalex.org/C2776046644","wikidata":"https://www.wikidata.org/wiki/Q422831","display_name":"Factor V","level":3,"score":0.4743025302886963},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.2790960967540741},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19451388716697693},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.1530064046382904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08383578062057495},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.06277412176132202},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000037","descriptor_name":"Abruptio Placentae","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005165","descriptor_name":"Factor V","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011516","descriptor_name":"Prothrombin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D019851","descriptor_name":"Thrombophilia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:12857557","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12857557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Haematologica","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d17de3fc7a1d4806abdcc995c33e6a06","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d17de3fc7a1d4806abdcc995c33e6a06","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Haematologica, Vol 88, Iss 7 (2003)","raw_type":"article"},{"id":"pmh:oai:iris.unimore.it:11380/740805","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/740805","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"mag:2149896041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12857557","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/740805","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/740805","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W19183810","https://openalex.org/W1531281563","https://openalex.org/W1836479959","https://openalex.org/W1976957654","https://openalex.org/W2018973645","https://openalex.org/W2040706417","https://openalex.org/W2045492889","https://openalex.org/W2058620910","https://openalex.org/W2061920971","https://openalex.org/W2114157341","https://openalex.org/W2147585082","https://openalex.org/W2316834752"],"related_works":["https://openalex.org/W2142666514","https://openalex.org/W1969040779","https://openalex.org/W2101469638","https://openalex.org/W1976645194","https://openalex.org/W1609619858","https://openalex.org/W2422556400","https://openalex.org/W2007422752","https://openalex.org/W656316296","https://openalex.org/W2058620910","https://openalex.org/W1982675314"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,33,225],"OBJECTIVES:":[2],"The":[3,138,227],"aim":[4],"of":[5,27,47,49,78,81,99,140,148,163,186,194,229,231,245,254,257,265,276,279],"the":[6,50,141,181,192,232,243,255,274],"present":[7],"study":[8],"was":[9,206],"to":[10,111,125,208],"evaluate":[11],"inherited":[12],"thrombophilic":[13,235],"factor":[14,18,201,219,241],"V":[15,282],"Leiden":[16,143],"and":[17,116,283],"II":[19,157],"A20210":[20,158],"mutations":[21,195,236,278],"in":[22,210,248],"women":[23,42,106,131,211],"presenting":[24],"with":[25,89,107,132],"abruption":[26,48,247,264],"a":[28,36,90,146,161,184,238,266],"normally":[29,62,267],"implanted":[30,63,268],"placenta.":[31],"DESIGN":[32],"METHODS:":[34],"In":[35,189],"multi-center,":[37],"case-control":[38],"study,":[39],"50":[40],"consecutive":[41],"requiring":[43,59],"immediate":[44,60],"delivery":[45,70],"because":[46],"placenta":[51,269],"were":[52,123,174],"enrolled.":[53],"Inclusion":[54],"criteria":[55,75,182],"were:":[56,76],"abruptio":[57,133],"placentae":[58,134],"delivery,":[61],"placenta,":[64],"Caucasian":[65,105],"ethnic":[66],"background,":[67],"parity":[68,115],"<3,":[69],"performed":[71],"at":[72],"Institutions.":[73],"Exclusion":[74],"history":[77,80],"thromboembolism,":[79],"2":[82],"or":[83,171],"more":[84,128],"spontaneous":[85],"abortions,":[86],"uterine":[87],"leiomyomas":[88],"diameter":[91],">5":[92],"cm,":[93],"illicit":[94],"drug":[95],"abuse,":[96],"premature":[97],"rupture":[98],"membranes,":[100],"multiple":[101],"pregnancy.":[102],"One":[103],"hundred":[104],"uneventful":[108],"pregnancies":[109],"carried":[110],"term,":[112],"matched":[113],"for":[114,183,242,273],"age,":[117],"served":[118],"as":[119],"controls.":[120,137],"RESULTS:":[121],"Heterozygotes":[122],"found":[124],"be":[126],"significantly":[127],"prevalent":[129],"among":[130,136],"than":[135],"carriership":[139],"FV":[142],"mutation":[144,159],"confers":[145],"OR":[147,162],"9.12":[149],"(95%":[150,165],"C.I.:":[151,166],"2.18-31.7;":[152],"p=0.0005).":[153],"Women":[154],"carrying":[155],"F":[156],"have":[160,261],"12.25":[164],"2.36-29.6;":[167],"p=0.0004).":[168],"No":[169],"homozygotes":[170],"double":[172],"heterozygotes":[173],"found.":[175],"Twenty-three":[176],"patients":[177],"(46%)":[178],"also":[179],"met":[180],"diagnosis":[185],"pre-eclampsia":[187,213],"(PE).":[188],"such":[190],"cases":[191],"prevalence":[193],"(factor":[196,214],"V:":[197,215],"6":[198],"cases,":[199,204,217,222],"26.1%;":[200],"II:":[202,220],"5":[203,216,221],"21.7%)":[205],"similar":[207],"that":[209],"without":[212],"18.7%;":[218],"18.5%).":[223],"INTERPRETATION":[224],"CONCLUSIONS:":[226],"presence":[228,275],"either":[230],"above":[233],"reported":[234],"represents":[237],"relevant":[239],"risk":[240,251],"occurrence":[244],"placental":[246],"Caucasians.":[249],"This":[250],"is":[252],"independent":[253],"development":[256],"pre-eclampsia.":[258],"Patients":[259],"who":[260],"had":[262],"dramatic":[263],"should":[270],"undergo":[271],"evaluation":[272],"genetic":[277],"coagulation":[280],"factors":[281],"II.":[284]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}