{"id":"https://openalex.org/W2149841387","doi":null,"title":"Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.","display_name":"Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats.","publication_year":1986,"publication_date":"1986-12-01","ids":{"openalex":"https://openalex.org/W2149841387","mag":"2149841387","pmid":"https://pubmed.ncbi.nlm.nih.gov/3345521"},"language":"en","primary_location":{"id":"pmid:3345521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3345521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087239740","display_name":"Donald J. DiPette","orcid":"https://orcid.org/0000-0002-5762-9104","observed_orcids":["https://orcid.org/0000-0002-5762-9104","https://orcid.org/0009-0008-9446-7942"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D J DiPette","raw_affiliation_strings":["University of Texas Medical Branch, Galveston 77550","University of Kentucky","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Galveston 77550","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110154456","display_name":"Kimberly A. Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K A Ward","raw_affiliation_strings":["University of Kentucky","University of Texas Medical Branch at Galveston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Kentucky","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":null,"display_name":"R K Jain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R K Jain","raw_affiliation_strings":["Carnegie Mellon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108528216","display_name":"Nancy E. Kerr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N E Kerr","raw_affiliation_strings":["Carnegie Mellon University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carnegie Mellon University","institution_ids":["https://openalex.org/I74973139"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005192196","display_name":"Kathy Schwarzenberger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Schwarzenberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5443,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.83624709,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"46","issue":"12 Pt 1","first_page":"1476","last_page":"304"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.47850000858306885,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.04149999842047691,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.027799999341368675,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/galactose","display_name":"galactose","score":1.0},{"id":"https://openalex.org/keywords/systemic-hemodynamics","display_name":"systemic hemodynamics","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tissue-blood-flow","display_name":"tissue blood flow","score":0.7379999756813049},{"id":"https://openalex.org/keywords/walker-256-carcinoma","display_name":"Walker 256 carcinoma","score":0.8270000219345093},{"id":"https://openalex.org/keywords/tumor-perfusion","display_name":"tumor perfusion","score":0.906000018119812},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8830000162124634},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.718999981880188},{"id":"https://openalex.org/keywords/blood-flow-redistribution","display_name":"blood flow redistribution","score":0.7360000014305115},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.3400000035762787},{"id":"https://openalex.org/keywords/hyperthermia","display_name":"hyperthermia","score":0.7770000100135803},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.6815727949142456},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.677435040473938},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6149805784225464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.592607855796814},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5800479650497437},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.5694476962089539},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5108909010887146},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.5058293342590332},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.5038473010063171},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.49682167172431946},{"id":"https://openalex.org/C2780931953","wikidata":"https://www.wikidata.org/wiki/Q9371","display_name":"Spleen","level":2,"score":0.42360401153564453},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4220660924911499},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42019200325012207}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009374","descriptor_name":"Neoplasms, Experimental","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:3345521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3345521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmid:3779648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3779648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2149841387","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3345521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W87238620","https://openalex.org/W1559551921","https://openalex.org/W1954992595","https://openalex.org/W1968844222","https://openalex.org/W1978730527","https://openalex.org/W2046703664","https://openalex.org/W2047690409","https://openalex.org/W2100157038","https://openalex.org/W2149841387","https://openalex.org/W2170966644","https://openalex.org/W2171338194","https://openalex.org/W2263106412","https://openalex.org/W2269919727","https://openalex.org/W2399592794","https://openalex.org/W2404251367"],"related_works":["https://openalex.org/W1883151848","https://openalex.org/W1502099492","https://openalex.org/W1962798562","https://openalex.org/W254761291","https://openalex.org/W1954992595","https://openalex.org/W2041285180","https://openalex.org/W2011977372","https://openalex.org/W2146978876","https://openalex.org/W2252366206","https://openalex.org/W2438092151"],"abstract_inverted_index":{"The":[0],"effect":[1,212],"of":[2,11,19,116,213],"galactose":[3,41,214,260],"on":[4,215],"systemic":[5,216,241],"hemodynamics":[6,217],"and":[7,15,34,37,58,104,133,136,142,153,193,218,242,245],"blood":[8,117,180,197,219,232,249],"flow":[9,160,181,185,198,220,233,250],"rate":[10,50,161,221,234],"Walker":[12],"256":[13],"carcinomas":[14],"several":[16],"normal":[17,123,164,252],"tissues":[18,124,165,253],"unanesthetized,":[20],"unrestrained":[21],"female":[22],"Sprague-Dawley":[23],"rats":[24],"was":[25,125,175,199],"measured,":[26],"using":[27,259],"the":[28,74,88,128,139,148,177,189,202,211],"radioactive":[29],"microsphere":[30],"technique,":[31],"prior":[32],"to":[33,127,147,224,239,251],"at":[35],"30":[36,90],"60":[38],"min":[39,91],"after":[40],"administration":[42],"(6":[43],"g/kg":[44],"body":[45],"weight,":[46],"i.v.).":[47],"Whereas":[48],"heart":[49],"remained":[51,169],"unchanged":[52],"following":[53,92,171],"injection,":[54],"cardiac":[55,59],"output":[56],"(CO)":[57],"index":[60],"decreased":[61,72,97,167,187],"by":[62,98,109,227],"35%":[63],"(P":[64,83,100,111],"less":[65,84,101,112],"than":[66,85,102,113,201],"0.05).":[67,114],"Mean":[68],"arterial":[69],"pressure":[70],"immediately":[71],"during":[73],"injection":[75],"but":[76],"then":[77],"increased":[78,108],"reaching":[79],"a":[80],"value":[81],"10%":[82],"0.05)":[86,103],"above":[87],"baseline":[89],"injection.":[93,172],"Stroke":[94],"volume":[95],"(SV)":[96],"30%":[99],"total":[105],"peripheral":[106],"resistance":[107],"65%":[110],"Redistribution":[115],"flow,":[118],"expressed":[119],"as":[120],"%CO,":[121],"among":[122],"seen":[126],"brain,":[129],"kidneys,":[130],"liver,":[131],"jejunum,":[132],"hindlimb":[134],"muscle":[135],"away":[137],"from":[138],"pancreas,":[140],"stomach,":[141],"skin.":[143],"Changes":[144],"in":[145,162,176,188,196,204,231,235,248,261],"%CO":[146],"spleen,":[149],"colon,":[150],"forelimb":[151],"muscle,":[152],"peritumor":[154],"tissue":[155],"were":[156],"not":[157,255],"significant.":[158],"Blood":[159,184],"most":[163],"either":[166],"or":[168],"constant":[170],"An":[173],"exception":[174],"liver":[178],"where":[179],"significantly":[182,186],"increased.":[183],"tumor":[190],"(approximately":[191],"60%)":[192],"this":[194],"reduction":[195,203,230],"larger":[200],"CO.":[205],"These":[206],"results":[207],"suggest":[208],"that":[209],"(a)":[210],"are":[222],"similar":[223],"those":[225],"produced":[226],"glucose;":[228],"(b)":[229],"tumors":[236],"is":[237],"due":[238],"both":[240],"local":[243],"effects;":[244],"(c)":[246],"changes":[247],"should":[254],"be":[256],"disregarded":[257],"when":[258],"combination":[262],"with":[263],"hyperthermia":[264],"and/or":[265],"chemotherapy":[266],"for":[267],"cancer":[268],"treatment.":[269]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
