{"id":"https://openalex.org/W2149795286","doi":null,"title":"Influence of sex on gene expression in human corneal epithelial cells.","display_name":"Influence of sex on gene expression in human corneal epithelial cells.","publication_year":2009,"publication_date":"2009-12-03","ids":{"openalex":"https://openalex.org/W2149795286","mag":"2149795286","pmid":"https://pubmed.ncbi.nlm.nih.gov/20011627","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2790476"},"language":"en","primary_location":{"id":"pmid:20011627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20011627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2790476/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028208557","display_name":"Tomo Suzuki","orcid":"https://orcid.org/0000-0001-5536-1741","observed_orcids":["https://orcid.org/0000-0001-5536-1741"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomo Suzuki","raw_affiliation_strings":["Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047186456","display_name":"Stephen M. Richards","orcid":"https://orcid.org/0000-0002-7604-2368","observed_orcids":["https://orcid.org/0000-0002-7604-2368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen M Richards","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100445782","display_name":"Shaohui Liu","orcid":"https://orcid.org/0000-0002-9691-9630","observed_orcids":["https://orcid.org/0000-0002-9691-9630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaohui Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109175587","display_name":"Roderick V. Jensen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roderick V Jensen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028478656","display_name":"David A. Sullivan","orcid":"https://orcid.org/0000-0002-3424-3778","observed_orcids":["https://orcid.org/0000-0002-3424-3778"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A Sullivan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2737,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.786224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"15","issue":null,"first_page":"2554","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.4569999873638153,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10997","display_name":"Ocular Surface and Contact Lens","score":0.4569999873638153,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.2257000058889389,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13252","display_name":"Sex and Gender in Healthcare","score":0.10719999670982361,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9860000014305115},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9120000004768372},{"id":"https://openalex.org/keywords/corneal-epithelial-cells","display_name":"corneal epithelial cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/cornea","display_name":"cornea","score":0.6679999828338623},{"id":"https://openalex.org/keywords/corneoscleral-rim","display_name":"corneoscleral rim","score":0.7490000128746033},{"id":"https://openalex.org/keywords/differentially-expressed-mrnas","display_name":"differentially expressed mRNAs","score":0.7620000243186951},{"id":"https://openalex.org/keywords/corneal-disease","display_name":"corneal disease","score":0.5960000157356262},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7626817226409912},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.7044594287872314},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.624860405921936},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.613537073135376},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.543402373790741},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4875023066997528},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.47870731353759766},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.4722292423248291},{"id":"https://openalex.org/C112190416","wikidata":"https://www.wikidata.org/wiki/Q2124450","display_name":"RNA extraction","level":4,"score":0.455496609210968},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4400208592414856},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.42477524280548096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3835619390010834},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3531055152416229},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31720685958862305},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.2989104986190796},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041321","descriptor_name":"Chromosomes, Human, X","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041322","descriptor_name":"Chromosomes, Human, Y","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"pmid:20011627","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20011627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2790476","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2790476/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.356.7243","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.356.7243","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/c4/57/Mol_Vis_2009_Dec_3_15_2554-2569.tar.gz","raw_type":"text"},{"id":"mag:2149795286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20011627","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2790476","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2790476/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1772275783","display_name":"Human Tissue and Organ Research Resource","funder_award_id":"U42RR006042","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1954182389","display_name":"Sex, sex steroids and dry eye syndromes","funder_award_id":"R01EY005612","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":88,"referenced_works":["https://openalex.org/W21294603","https://openalex.org/W55869092","https://openalex.org/W120300847","https://openalex.org/W1495734300","https://openalex.org/W1515066435","https://openalex.org/W1675850972","https://openalex.org/W1942765113","https://openalex.org/W1954240270","https://openalex.org/W1963704188","https://openalex.org/W1966439295","https://openalex.org/W1970100743","https://openalex.org/W1970844092","https://openalex.org/W1971578865","https://openalex.org/W1971671883","https://openalex.org/W1979807834","https://openalex.org/W1980522728","https://openalex.org/W1982482411","https://openalex.org/W1982794477","https://openalex.org/W1983801381","https://openalex.org/W1984670858","https://openalex.org/W1985677952","https://openalex.org/W1986853457","https://openalex.org/W1989139641","https://openalex.org/W1989500165","https://openalex.org/W1992794281","https://openalex.org/W1994190687","https://openalex.org/W1999720758","https://openalex.org/W2000264668","https://openalex.org/W2002526474","https://openalex.org/W2007529766","https://openalex.org/W2010637767","https://openalex.org/W2013858190","https://openalex.org/W2014607619","https://openalex.org/W2016496153","https://openalex.org/W2018368842","https://openalex.org/W2020448097","https://openalex.org/W2021714025","https://openalex.org/W2023803012","https://openalex.org/W2028465131","https://openalex.org/W2028634883","https://openalex.org/W2032138235","https://openalex.org/W2033834495","https://openalex.org/W2037999001","https://openalex.org/W2051728279","https://openalex.org/W2055763349","https://openalex.org/W2059215530","https://openalex.org/W2067615333","https://openalex.org/W2069444924","https://openalex.org/W2072443660","https://openalex.org/W2073076749","https://openalex.org/W2074794269","https://openalex.org/W2076296600","https://openalex.org/W2079291800","https://openalex.org/W2080043924","https://openalex.org/W2080367498","https://openalex.org/W2082455932","https://openalex.org/W2089046027","https://openalex.org/W2093043155","https://openalex.org/W2101079108","https://openalex.org/W2103017472","https://openalex.org/W2106559777","https://openalex.org/W2121807202","https://openalex.org/W2128420546","https://openalex.org/W2129412572","https://openalex.org/W2131989143","https://openalex.org/W2132561013","https://openalex.org/W2132979808","https://openalex.org/W2135547050","https://openalex.org/W2138919270","https://openalex.org/W2143263778","https://openalex.org/W2143931642","https://openalex.org/W2156961952","https://openalex.org/W2164092182","https://openalex.org/W2167142975","https://openalex.org/W2168495930","https://openalex.org/W2290313884","https://openalex.org/W2394767094","https://openalex.org/W2397384250","https://openalex.org/W2402252503","https://openalex.org/W2405013429","https://openalex.org/W2410835727","https://openalex.org/W2411336184","https://openalex.org/W2411593666","https://openalex.org/W2411746382","https://openalex.org/W2417262088","https://openalex.org/W2417542156","https://openalex.org/W2419228479","https://openalex.org/W4301343599"],"related_works":["https://openalex.org/W7095848705","https://openalex.org/W4406296497","https://openalex.org/W2079291800","https://openalex.org/W3084331777","https://openalex.org/W2028284319","https://openalex.org/W7154576331","https://openalex.org/W2076454390","https://openalex.org/W3104986262","https://openalex.org/W1573036135","https://openalex.org/W1982482411"],"abstract_inverted_index":{"PURPOSE:":[0],"Sex-associated":[1],"differences":[2,22,41,188,209,228],"have":[3],"been":[4],"identified":[5,163],"in":[6,28,33,43,49,52,81,124,129,135,170,175,189,192,199,211,221,229],"the":[7,13,62,118,212,230],"anatomy,":[8],"physiology":[9],"and":[10,51,67,101,144,159,183],"pathophysiology":[11],"of":[12,20,65,98,120,139,215,232],"human":[14,44,125,171,216],"cornea.":[15],"We":[16,161],"hypothesize":[17],"that":[18,114,207],"many":[19],"these":[21,186],"are":[23,133],"due":[24],"to":[25,37,226],"fundamental":[26],"variations":[27],"gene":[29,168,190,213,222],"expression.":[30],"Our":[31,111,202],"objective":[32],"this":[34],"study":[35],"was":[36],"determine":[38],"whether":[39],"such":[40,147],"exist":[42,210],"corneal":[45,56,126,172,217,234],"epithelial":[46,57,127,173,218],"cells":[47,58,128,174],"both":[48],"vivo":[50],"vitro.":[53,176],"METHODS:":[54],"Human":[55],"were":[59,71,90,105,194],"isolated":[60],"from":[61],"corneoscleral":[63],"rims":[64],"male":[66],"female":[68],"donors.":[69],"Cells":[70],"processed":[72],"either":[73],"directly":[74],"for":[75,92],"RNA":[76,88,155],"extraction,":[77],"or":[78],"first":[79],"cultured":[80],"phenol":[82],"red-free":[83],"keratinocyte":[84],"serum-free":[85],"media.":[86],"The":[87],"samples":[89],"examined":[91],"differentially":[93],"expressed":[94],"mRNAs":[95],"by":[96],"using":[97],"CodeLink":[99],"Bioarrays":[100],"Affymetrix":[102],"GeneChips.":[103],"Data":[104],"analyzed":[106],"with":[107,178],"GeneSifter.Net":[108],"software.":[109],"RESULTS:":[110],"results":[112],"demonstrate":[113],"sex":[115],"significantly":[116],"influences":[117],"expression":[119,169,191,214,223],"over":[121],"600":[122],"genes":[123,132],"vivo.":[130,200],"These":[131],"involved":[134],"a":[136],"broad":[137],"spectrum":[138],"biologic":[140],"processes,":[141,150],"molecular":[142],"functions":[143],"cellular":[145],"components,":[146],"as":[148],"metabolic":[149],"DNA":[151],"replication,":[152],"cell":[153],"migration,":[154],"binding,":[156],"oxidoreductase":[157],"activity":[158],"nucleoli.":[160],"also":[162],"significant,":[164],"sex-related":[165,187,208,227],"effects":[166],"on":[167],"However,":[177],"few":[179],"exceptions":[180],"(e.g.,":[181],"X-":[182],"Y-linked":[184],"genes),":[185],"vitro":[193],"typically":[195],"different":[196],"than":[197],"those":[198],"CONCLUSIONS:":[201],"findings":[203],"support":[204],"our":[205],"hypothesis":[206],"cells.":[219],"Variations":[220],"may":[224],"contribute":[225],"prevalence":[231],"certain":[233],"diseases.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}