{"id":"https://openalex.org/W2149794024","doi":null,"title":"B Cell Receptor Signaling in Human B Cells","display_name":"B Cell Receptor Signaling in Human B Cells","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2149794024","mag":"2149794024"},"language":"en","primary_location":{"id":"mag:2149794024","doi":null,"is_oa":false,"landing_page_url":"https://epublications.uef.fi/pub/urn_isbn_978-951-27-0744-7/urn_isbn_978-951-27-0744-7.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070766377","display_name":"Mikko M\u00e4tt\u00f6","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Mikko M\u00e4tt\u00f6","raw_affiliation_strings":["University of Eastern Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland","institution_ids":["https://openalex.org/I175532246"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070766377"],"corresponding_institution_ids":["https://openalex.org/I175532246"],"apc_list":null,"apc_paid":null,"fwci":0.2395,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.57009514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.9950000047683716},{"id":"https://openalex.org/keywords/human-b-cells","display_name":"human B cells","score":0.9509999752044678},{"id":"https://openalex.org/keywords/t-independent-antigens","display_name":"T-independent antigens","score":0.7929999828338623},{"id":"https://openalex.org/keywords/macrophage-cytokines","display_name":"macrophage-derived cytokines","score":0.8999999761581421},{"id":"https://openalex.org/keywords/second-signal","display_name":"second signal","score":0.7860000133514404},{"id":"https://openalex.org/keywords/class-switch-recombination","display_name":"class switch recombination","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cd45-isoforms","display_name":"CD45 isoforms","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cd45ra","display_name":"CD45RA","score":0.949999988079071},{"id":"https://openalex.org/keywords/cd45ro","display_name":"CD45RO","score":0.9940000176429749},{"id":"https://openalex.org/keywords/follicular-lymphoma","display_name":"follicular lymphoma","score":0.8610000014305115},{"id":"https://openalex.org/keywords/apoptosis-detection","display_name":"apoptosis detection","score":0.765999972820282},{"id":"https://openalex.org/keywords/adenovirus-mediated-gene-therapy","display_name":"adenoviral gene therapy","score":0.8949999809265137},{"id":"https://openalex.org/keywords/lentiviral-transduction","display_name":"lentiviral transduction","score":0.8320000171661377}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.6576090455055237},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.6408582329750061},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5951796174049377},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.5737978219985962},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.5594308376312256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5194754004478455},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.474619060754776},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3138465881347656},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23399612307548523},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1978074014186859},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05791619420051575}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2149794024","doi":null,"is_oa":false,"landing_page_url":"https://epublications.uef.fi/pub/urn_isbn_978-951-27-0744-7/urn_isbn_978-951-27-0744-7.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":188,"referenced_works":["https://openalex.org/W63353745","https://openalex.org/W78776630","https://openalex.org/W87316649","https://openalex.org/W96261946","https://openalex.org/W125106425","https://openalex.org/W212009861","https://openalex.org/W1483907253","https://openalex.org/W1501974073","https://openalex.org/W1506897962","https://openalex.org/W1529773650","https://openalex.org/W1537427513","https://openalex.org/W1541663213","https://openalex.org/W1547450219","https://openalex.org/W1563255069","https://openalex.org/W1572385475","https://openalex.org/W1581650643","https://openalex.org/W1589053023","https://openalex.org/W1595316528","https://openalex.org/W1599013943","https://openalex.org/W1609859996","https://openalex.org/W1631949827","https://openalex.org/W1649576367","https://openalex.org/W1656644461","https://openalex.org/W1680951199","https://openalex.org/W1809188197","https://openalex.org/W1821858011","https://openalex.org/W1896084611","https://openalex.org/W1954051147","https://openalex.org/W1964973658","https://openalex.org/W1965678722","https://openalex.org/W1966384388","https://openalex.org/W1966746821","https://openalex.org/W1967261754","https://openalex.org/W1969218281","https://openalex.org/W1969516098","https://openalex.org/W1972589201","https://openalex.org/W1973904936","https://openalex.org/W1974937501","https://openalex.org/W1975555235","https://openalex.org/W1975602003","https://openalex.org/W1975785759","https://openalex.org/W1977609475","https://openalex.org/W1977630840","https://openalex.org/W1979640049","https://openalex.org/W1980004909","https://openalex.org/W1980852433","https://openalex.org/W1983695293","https://openalex.org/W1985831147","https://openalex.org/W1986636542","https://openalex.org/W1987962683","https://openalex.org/W1988422289","https://openalex.org/W1990145497","https://openalex.org/W1990548031","https://openalex.org/W1991683855","https://openalex.org/W1992187708","https://openalex.org/W1992683698","https://openalex.org/W1993243592","https://openalex.org/W1994954155","https://openalex.org/W1995904895","https://openalex.org/W1997569631","https://openalex.org/W1998184496","https://openalex.org/W1999944301","https://openalex.org/W2000714820","https://openalex.org/W2003387372","https://openalex.org/W2003487528","https://openalex.org/W2005115869","https://openalex.org/W2005776089","https://openalex.org/W2007690138","https://openalex.org/W2008065206","https://openalex.org/W2009761723","https://openalex.org/W2009936338","https://openalex.org/W2015744630","https://openalex.org/W2016416598","https://openalex.org/W2017065556","https://openalex.org/W2017460970","https://openalex.org/W2017624184","https://openalex.org/W2018338402","https://openalex.org/W2020931266","https://openalex.org/W2023941836","https://openalex.org/W2031263707","https://openalex.org/W2031503850","https://openalex.org/W2034427054","https://openalex.org/W2034675561","https://openalex.org/W2035544061","https://openalex.org/W2035680000","https://openalex.org/W2036068614","https://openalex.org/W2036383641","https://openalex.org/W2037176755","https://openalex.org/W2037758170","https://openalex.org/W2038512880","https://openalex.org/W2038746829","https://openalex.org/W2039120803","https://openalex.org/W2040345348","https://openalex.org/W2041179764","https://openalex.org/W2042104836","https://openalex.org/W2045640927","https://openalex.org/W2048172864","https://openalex.org/W2051304739","https://openalex.org/W2051439474","https://openalex.org/W2051774115","https://openalex.org/W2052453105","https://openalex.org/W2053823083","https://openalex.org/W2055111573","https://openalex.org/W2055483105","https://openalex.org/W2055861239","https://openalex.org/W2056616704","https://openalex.org/W2057715263","https://openalex.org/W2057917012","https://openalex.org/W2059399853","https://openalex.org/W2059525875","https://openalex.org/W2060090432","https://openalex.org/W2060127911","https://openalex.org/W2060513583","https://openalex.org/W2060871248","https://openalex.org/W2061378564","https://openalex.org/W2062471925","https://openalex.org/W2063949074","https://openalex.org/W2064888792","https://openalex.org/W2065079479","https://openalex.org/W2065392104","https://openalex.org/W2065405653","https://openalex.org/W2065694999","https://openalex.org/W2065934473","https://openalex.org/W2065973297","https://openalex.org/W2067585786","https://openalex.org/W2072716120","https://openalex.org/W2073632063","https://openalex.org/W2074521753","https://openalex.org/W2074585348","https://openalex.org/W2080961105","https://openalex.org/W2084250362","https://openalex.org/W2086800018","https://openalex.org/W2086906150","https://openalex.org/W2090786449","https://openalex.org/W2091515744","https://openalex.org/W2091622299","https://openalex.org/W2094100869","https://openalex.org/W2095304395","https://openalex.org/W2099115964","https://openalex.org/W2101091483","https://openalex.org/W2102895007","https://openalex.org/W2106877484","https://openalex.org/W2108490772","https://openalex.org/W2109037058","https://openalex.org/W2111062373","https://openalex.org/W2113745867","https://openalex.org/W2114637517","https://openalex.org/W2114653456","https://openalex.org/W2116071714","https://openalex.org/W2119005151","https://openalex.org/W2120514355","https://openalex.org/W2120769965","https://openalex.org/W2120977313","https://openalex.org/W2121087466","https://openalex.org/W2123996670","https://openalex.org/W2127092918","https://openalex.org/W2128475635","https://openalex.org/W2128617425","https://openalex.org/W2131666890","https://openalex.org/W2131723671","https://openalex.org/W2132456274","https://openalex.org/W2133168488","https://openalex.org/W2137954917","https://openalex.org/W2140754506","https://openalex.org/W2145606454","https://openalex.org/W2146098096","https://openalex.org/W2147409434","https://openalex.org/W2148759300","https://openalex.org/W2148911589","https://openalex.org/W2149200346","https://openalex.org/W2151627258","https://openalex.org/W2151777859","https://openalex.org/W2152000177","https://openalex.org/W2152624886","https://openalex.org/W2154888744","https://openalex.org/W2155308169","https://openalex.org/W2160749209","https://openalex.org/W2166002768","https://openalex.org/W2168907586","https://openalex.org/W2172136134","https://openalex.org/W2172937773","https://openalex.org/W2326022215","https://openalex.org/W2330018753","https://openalex.org/W2344679143","https://openalex.org/W2408688530","https://openalex.org/W2417385986","https://openalex.org/W4313342465","https://openalex.org/W4313414129"],"related_works":["https://openalex.org/W3096422680","https://openalex.org/W7096278608","https://openalex.org/W1965329263","https://openalex.org/W2131722579","https://openalex.org/W1479920302","https://openalex.org/W1847270645","https://openalex.org/W1754828840","https://openalex.org/W7098079635","https://openalex.org/W2064998281","https://openalex.org/W7027109662"],"abstract_inverted_index":{"B":[0,21,36,56,79,99,131,139,155,178,183,260,340,364,397],"cells":[1,57,140,156,261,367,387,400],"play":[2,203],"an":[3,94],"important":[4,119,255],"role":[5,50,82,205],"in":[6,15,19,43,54,77,93,130,144,147,161,173,206],"the":[7,11,46,49,69,196,209,237,253,284,329,418],"early":[8,333],"phase":[9],"of":[10,30,51,63,73,83,121,165,208,232,252,286,316,396,408,425],"immune":[12],"response":[13],"particularly":[14],"polysaccharide-encapsulated":[16,104],"bacteria-induced":[17],"responses,":[18],"which":[20],"and":[22,48,71,86,127,141,191,195,214,218,295,307,320,343,421,480],"T":[23,32],"cell":[24,37,100,179,184,341,365],"cooperation":[25,146],"is":[26,250,401,413],"interfered.":[27],"The":[28,61,81,163,267],"mechanisms":[29],"these":[31,290],"cell-independent":[33],"(TI)":[34],"-antigen-induced":[35],"responses":[38,47,101,149],"have":[39,292],"been":[40,272],"studied":[41,172],"mainly":[42],"mice,":[44],"but":[45,405],"BCR-mediated":[52,215],"activation":[53],"human":[55,78,110,174,182,362],"are":[58],"not":[59],"known.":[60],"purpose":[62],"this":[64,326,374],"study":[65],"was":[66,91,107,136,171,200,225,240,318,323,353,356,378],"to":[67,202,227,242,257,297,331,388,416],"analyze":[68],"function":[70,143,243],"regulation":[72,164],"antigen-specific":[74],"BCR":[75,84,122,166],"signaling":[76,85,167],"cells.":[80,132,335],"a":[87,115,204,229,245,302,337,348,369,402],"separate":[88],"second":[89,116],"signal":[90],"analyzed":[92],"experimental":[95,375],"model":[96,338,376],"mimicking":[97],"TI":[98,148],"caused":[102],"by":[103,168,274,279],"bacteria.":[105],"It":[106,322,355],"shown":[108,201,226,241,380],"that":[109,138,325,381,392],"macrophage":[111],"(M\u03c6)-derived":[112],"cytokines,":[113],"as":[114,150,244,283],"signal,":[117],"were":[118,193],"enhancers":[120],"stimulation-induced":[123],"class":[124],"switch":[125],"recombination":[126],"cytokine":[128,159,216],"production":[129,160],"In":[133,222,373],"addition,":[134,223],"it":[135,377],"demonstrated":[137],"M\u03c6":[142],"close":[145],"soluble":[151],"mediators":[152],"from":[153],"activated":[154],"significantly":[157],"enhanced":[158],"M\u03c6.":[162],"CD45":[169,188,197],"isoforms":[170,189],"GC-derived":[175],"follicular":[176,363],"lymphoma":[177,366],"lines.":[180],"Novel":[181],"lines":[185],"expressing":[186],"distinct":[187],"(RA":[190],"R0)":[192],"established,":[194],"isoform":[198,239],"expression":[199],"fine-tuning":[207],"basal,":[210],"BCRand":[211],"cytokine-induced":[212],"proliferation,":[213],"production,":[217],"BCR-induced":[219,233,248],"intracellular":[220],"signaling.":[221],"CD45R0":[224],"be":[228],"positive":[230],"regulator":[231],"cellular":[234],"events,":[235],"whereas":[236],"CD45RA":[238],"negative":[246,361],"regulator.":[247],"apoptosis":[249,317],"one":[251],"most":[254],"ways":[256],"eliminate":[258],"self-reactive":[259],"during":[262],"development":[263,407],"or":[264,278],"GC":[265],"reaction.":[266],"apoptotic":[268,299,334],"process":[269],"has":[270],"classically":[271],"measured":[273],"detecting":[275],"morphological":[276],"changes":[277],"biochemical":[280],"methods":[281,291],"such":[282],"detection":[285,315],"DNA":[287],"degradation.":[288],"However,":[289],"limited":[293],"sensitivity":[294,330],"ability":[296],"detect":[298,332],"sub-populations.":[300],"Therefore,":[301],"multi-parametric":[303],"Annexin":[304],"V-FITC,":[305],"PI":[306],"SYTO":[308],"17":[309],"staining":[310],"method":[311],"for":[312,339],"flow":[313],"cytometric":[314],"established":[319],"evaluated.":[321],"found":[324],"assay":[327],"increased":[328],"As":[336],"targeted":[342,410],"specific":[344],"adenoviral":[345,393],"gene":[346,371,394],"therapy,":[347],"novel":[349],"fusion":[350],"gene,":[351],"hCAR-EGFP,":[352],"constructed.":[354],"successfully":[357],"introduced":[358],"into":[359],"hCAR":[360],"with":[368],"lentiviral":[370],"transfer.":[372],"indirectly":[379],"adenovirus":[382,385,411],"retargeting":[383],"made":[384],"resistant":[386],"sensitive":[389],"ones,":[390],"suggesting":[391],"therapy":[395],"cell-specific":[398],"cancers":[399],"feasible":[403],"method,":[404],"further":[406],"appropriately":[409],"vectors":[412],"still":[414],"required":[415],"increase":[417],"cell-type":[419],"specificity":[420],"efficacy.":[422],"National":[423],"Library":[424],"Medicine":[426],"Classification:":[427],"QU":[428],"375,":[429],"QW":[430],"568,":[431],"QY":[432],"95,":[433],"QZ":[434],"52,":[435],"WH":[436],"200":[437],"Medical":[438],"Subject":[439],"Headings:":[440],"Adaptor":[441],"Proteins,":[442],"Signal":[443],"Transducing;":[444],"Adenoviridae/genetics;":[445],"Antigens,":[446,448],"CD45;":[447],"T-Independent;":[449],"Apoptosis;":[450],"Apoptosis":[451],"Regulatory":[452],"Proteins;":[453],"BLymphocytes;":[454],"Cell":[455],"Line;":[456],"Cells,":[457],"Cultured;":[458],"Cytokines;":[459],"Flow":[460],"Cytometry;":[461],"Gene":[462,464],"Therapy;":[463],"Transfer":[465],"Techniques;":[466],"Human;":[467],"Lymphoma,":[468,470],"B-Cell;":[469,474],"Follicular;":[471],"Receptors,":[472,475],"Antigen,":[473],"Virus":[476],"To":[477],"Anna,":[478],"Roosa":[479],"Elsa":[481]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}