{"id":"https://openalex.org/W2149793745","doi":"https://doi.org/10.1016/s1046-2023(02)00235-9","title":"Particle detection, number estimation, and feature measurement in gene transfer studies: optical fractionator stereology integrated with digital image processing and analysis","display_name":"Particle detection, number estimation, and feature measurement in gene transfer studies: optical fractionator stereology integrated with digital image processing and analysis","publication_year":2002,"publication_date":"2002-10-01","ids":{"openalex":"https://openalex.org/W2149793745","doi":"https://doi.org/10.1016/s1046-2023(02)00235-9","mag":"2149793745","pmid":"https://pubmed.ncbi.nlm.nih.gov/12413429"},"language":"en","primary_location":{"id":"doi:10.1016/s1046-2023(02)00235-9","doi":"https://doi.org/10.1016/s1046-2023(02)00235-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1046-2023(02)00235-9","pdf_url":null,"source":{"id":"https://openalex.org/S73539393","display_name":"Methods","issn_l":"1046-2023","issn":["1046-2023","1095-9130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113710492","display_name":"Michael A. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A King","raw_affiliation_strings":["Veterans Administration Medical Center, Research Services 151, University of Florida, Gainesville, FL 32602, USA. making@nersp.nerdc.ufl.edu","Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA","University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA","Veterans Administration Medical Center, Research Services 151, University of Florida, Gainesville, FL 32602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration Medical Center, Research Services 151, University of Florida, Gainesville, FL 32602, USA. making@nersp.nerdc.ufl.edu","institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I33213144"]},{"raw_affiliation_string":"Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]},{"raw_affiliation_string":"Veterans Administration Medical Center, Research Services 151, University of Florida, Gainesville, FL 32602, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029784523","display_name":"Nicole C. Scotty","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Scotty","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA","University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104652507","display_name":"Ronald L. Klein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald L Klein","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA","University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103491448","display_name":"Edwin M. Meyer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800717037","display_name":"University of Florida Health","ror":"https://ror.org/04tk2gy88","country_code":"US","type":"education","lineage":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"id":"https://openalex.org/I33213144","display_name":"University of Florida","ror":"https://ror.org/02y3ad647","country_code":"US","type":"education","lineage":["https://openalex.org/I33213144"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin M Meyer","raw_affiliation_strings":["Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA","University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I2800717037","https://openalex.org/I33213144"]},{"raw_affiliation_string":"University of Florida Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA","institution_ids":["https://openalex.org/I33213144"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5113710492"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2800717037","https://openalex.org/I33213144"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":1.7609,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.84882353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"2","first_page":"293","last_page":"299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11830","display_name":"Point processes and geometric inequalities","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/2604","display_name":"Applied Mathematics"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12923","display_name":"Digital Image Processing Techniques","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optical-fractionator","display_name":"optical fractionator","score":0.9620000123977661},{"id":"https://openalex.org/keywords/stereology","display_name":"stereology","score":0.972000002861023},{"id":"https://openalex.org/keywords/gene-transfer","display_name":"gene transfer","score":0.6759999990463257},{"id":"https://openalex.org/keywords/particle-detection","display_name":"particle detection","score":0.7049999833106995},{"id":"https://openalex.org/keywords/particle-number-estimation","display_name":"particle number estimation","score":0.7110000252723694},{"id":"https://openalex.org/keywords/image-processing","display_name":"image processing","score":0.7509999871253967},{"id":"https://openalex.org/keywords/object-counting","display_name":"object counting","score":0.4740000069141388},{"id":"https://openalex.org/keywords/morphometrics","display_name":"morphometrics","score":0.5730000138282776},{"id":"https://openalex.org/keywords/video-microscopy","display_name":"video microscopy","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C34862184","wikidata":"https://www.wikidata.org/wiki/Q5276114","display_name":"Digital microscope","level":3,"score":0.6963765025138855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6753337979316711},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.6113944053649902},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5910272598266602},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5910069942474365},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.5119363069534302},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.4790676534175873},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.4710305333137512},{"id":"https://openalex.org/C42781572","wikidata":"https://www.wikidata.org/wiki/Q1250322","display_name":"Digital image","level":4,"score":0.4528341293334961},{"id":"https://openalex.org/C2988821698","wikidata":"https://www.wikidata.org/wiki/Q16338","display_name":"Personal computer","level":2,"score":0.4514235854148865},{"id":"https://openalex.org/C2779705975","wikidata":"https://www.wikidata.org/wiki/Q62927","display_name":"Digital camera","level":2,"score":0.4228174090385437},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.338899701833725},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.16710048913955688},{"id":"https://openalex.org/C9390403","wikidata":"https://www.wikidata.org/wiki/Q3966","display_name":"Computer hardware","level":1,"score":0.15825918316841125},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.1524207890033722},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D003201","descriptor_name":"Computers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019044","descriptor_name":"Image Cytometry","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D019044","descriptor_name":"Image Cytometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1046-2023(02)00235-9","doi":"https://doi.org/10.1016/s1046-2023(02)00235-9","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1046-2023(02)00235-9","pdf_url":null,"source":{"id":"https://openalex.org/S73539393","display_name":"Methods","issn_l":"1046-2023","issn":["1046-2023","1095-9130"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods","raw_type":"journal-article"},{"id":"pmid:12413429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12413429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods (San Diego, Calif.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G299029527","display_name":null,"funder_award_id":"AG10485","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8681985893","display_name":"Discovery of Novel Drugs for Alzheimer's Disease","funder_award_id":"P01AG010485","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320310009","display_name":"University of Florida","ror":"https://ror.org/02y3ad647"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1811548175","https://openalex.org/W1973211319","https://openalex.org/W1973946799","https://openalex.org/W1995261715","https://openalex.org/W1996809299","https://openalex.org/W2000029710","https://openalex.org/W2014701460","https://openalex.org/W2028574924","https://openalex.org/W2037367554","https://openalex.org/W2052792775","https://openalex.org/W2054907051","https://openalex.org/W2063471759","https://openalex.org/W2067623598","https://openalex.org/W2067705214","https://openalex.org/W2086881060","https://openalex.org/W2105382539","https://openalex.org/W2107196928","https://openalex.org/W2111405228","https://openalex.org/W2118586791","https://openalex.org/W2151349288","https://openalex.org/W2168092251","https://openalex.org/W2178984859","https://openalex.org/W2321725396","https://openalex.org/W4294730393","https://openalex.org/W4296930794"],"related_works":["https://openalex.org/W2728150996","https://openalex.org/W2566718637","https://openalex.org/W2884883099","https://openalex.org/W2033621731","https://openalex.org/W2086881060","https://openalex.org/W2111405228","https://openalex.org/W7132447673","https://openalex.org/W1997929697","https://openalex.org/W2105382539","https://openalex.org/W2624832084"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}