{"id":"https://openalex.org/W2149790902","doi":null,"title":"Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.","display_name":"Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.","publication_year":2003,"publication_date":"2003-08-15","ids":{"openalex":"https://openalex.org/W2149790902","mag":"2149790902","pmid":"https://pubmed.ncbi.nlm.nih.gov/12941821"},"language":"en","primary_location":{"id":"pmid:12941821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090456090","display_name":"Vassiliki Kostourou","orcid":"https://orcid.org/0000-0001-7053-6247","observed_orcids":["https://orcid.org/0000-0001-7053-6247"]},"institutions":[{"id":"https://openalex.org/I165862685","display_name":"St George's, University of London","ror":"https://ror.org/040f08y74","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I165862685","https://openalex.org/I4401726869"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vassiliki Kostourou","raw_affiliation_strings":["Department of Basic Medical Sciences, St. George's Hospital Medical School, London SW17 ORE, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Medical Sciences, St. George's Hospital Medical School, London SW17 ORE, United Kingdom","institution_ids":["https://openalex.org/I165862685"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102963210","display_name":"Simon P. Robinson","orcid":"https://orcid.org/0000-0003-4101-7274","observed_orcids":["https://orcid.org/0000-0003-4101-7274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon P Robinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065682089","display_name":"Guy St. J. Whitley","orcid":"https://orcid.org/0000-0002-9670-3004","observed_orcids":["https://orcid.org/0000-0002-9670-3004"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy St J Whitley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5037497459","display_name":"John R. Griffiths","orcid":"https://orcid.org/0000-0001-7369-6836","observed_orcids":["https://orcid.org/0000-0001-7369-6836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R Griffiths","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6028,"has_fulltext":false,"cited_by_count":62,"citation_normalized_percentile":{"value":0.82306797,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"63","issue":"16","first_page":"4960","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.6606000065803528,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.13089999556541443,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.06880000233650208,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimethylarginine-dimethylaminohydrolase","display_name":"dimethylarginine dimethylaminohydrolase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.9789999723434448},{"id":"https://openalex.org/keywords/glioma","display_name":"glioma","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.8180000185966492},{"id":"https://openalex.org/keywords/asymmetric-dimethylarginine","display_name":"asymmetric dimethylarginine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/l-nmma","display_name":"L-NMMA","score":0.9580000042915344},{"id":"https://openalex.org/keywords/r2-relaxation-rate","display_name":"R2* relaxation rate","score":0.7689999938011169},{"id":"https://openalex.org/keywords/tumor-blood-volume","display_name":"tumor blood volume","score":0.7639999985694885},{"id":"https://openalex.org/keywords/hypercapnia","display_name":"hypercapnia","score":0.8330000042915344},{"id":"https://openalex.org/keywords/hyperoxia","display_name":"hyperoxia","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neovascularization","display_name":"neovascularization","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2779877776","wikidata":"https://www.wikidata.org/wiki/Q752685","display_name":"Asymmetric dimethylarginine","level":4,"score":0.7292927503585815},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5611433982849121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5371552109718323},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5351040959358215},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.46689069271087646},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.4499555230140686},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4420973062515259},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3512195944786072},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32738181948661804},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2021387815475464},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.1766473352909088},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11004066467285156},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010087","descriptor_name":"Oxides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052203","descriptor_name":"Ferrosoferric Oxide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058185","descriptor_name":"Magnetite Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:12941821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.333.6647","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.333.6647","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://cancerres.aacrjournals.org/content/63/16/4960.full.pdf","raw_type":"text"},{"id":"mag:2149790902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12941821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W37002919","https://openalex.org/W1495287184","https://openalex.org/W1573363574","https://openalex.org/W1578283200","https://openalex.org/W1783580437","https://openalex.org/W1851718973","https://openalex.org/W1964908071","https://openalex.org/W1965759929","https://openalex.org/W1966553263","https://openalex.org/W1971611901","https://openalex.org/W1973111775","https://openalex.org/W1988307856","https://openalex.org/W1997757095","https://openalex.org/W2000383220","https://openalex.org/W2011843899","https://openalex.org/W2017441676","https://openalex.org/W2018051866","https://openalex.org/W2019540655","https://openalex.org/W2020638356","https://openalex.org/W2022912277","https://openalex.org/W2029245342","https://openalex.org/W2035003394","https://openalex.org/W2043898070","https://openalex.org/W2052489624","https://openalex.org/W2058884247","https://openalex.org/W2062594348","https://openalex.org/W2078796888","https://openalex.org/W2079051412","https://openalex.org/W2097818582","https://openalex.org/W2099048452","https://openalex.org/W2103681669","https://openalex.org/W2107547469","https://openalex.org/W2107665428","https://openalex.org/W2119308535","https://openalex.org/W2137721013","https://openalex.org/W2141851994","https://openalex.org/W2151554519","https://openalex.org/W2157036804","https://openalex.org/W2162699507","https://openalex.org/W2170709642"],"related_works":["https://openalex.org/W2058884247","https://openalex.org/W2040719346","https://openalex.org/W2799308043","https://openalex.org/W2037872303","https://openalex.org/W2055136499","https://openalex.org/W3000138326","https://openalex.org/W4404419339","https://openalex.org/W2099957438","https://openalex.org/W4407407242","https://openalex.org/W144882635"],"abstract_inverted_index":{"Intracellular":[0],"factors":[1],"that":[2,241],"regulate":[3],"nitric":[4],"oxide":[5],"(NO)":[6],"synthesis":[7,26],"represent":[8],"important":[9],"targets":[10],"in":[11,32,53,65,85,124,193,211,244,271,292,298,305,327],"tumor":[12,50,110,149,184,227,247,268],"progression.":[13],"Overexpression":[14,288],"of":[15,24,47,108,112,146,182,208,237,250,259,276,289,295,302,331],"dimethylarginine":[16,28],"dimethylaminohydrolase":[17],"(DDAH),":[18],"which":[19],"metabolizes":[20],"the":[21,45,58,93,103,109,113,125,144,147,177,194,212,225,230,242,245,257,274,309,315,328],"endogenous":[22,86],"inhibitors":[23],"NO":[25],"asymmetric":[27],"and":[29,63,71,88,100,179,186,270,311,314],"N-monomethyl-L-arginine,":[30],"results":[31,104,291],"C6":[33,72,217,296,310],"gliomas":[34,68,74,297],"with":[35,40,105,129,203,216,322],"enhanced":[36],"growth":[37],"rate":[38],"compared":[39,102,215],"wild":[41],"type.":[42],"To":[43],"investigate":[44],"effects":[46],"DDAH":[48,70,290,326],"on":[49],"vascular":[51,132,161,173],"morphogenesis":[52],"vivo,":[54],"we":[55,101],"have":[56],"measured":[57],"transverse":[59],"relaxation":[60],"rates":[61,181],"R(2)*":[62,120,178],"R(2)":[64,180,233],"clone":[66],"D27":[67,126,195,213,312],"overexpressing":[69],"wild-type":[73,218],"using":[75,92],"intrinsic":[76],"susceptibility":[77,89,260],"magnetic":[78],"resonance":[79],"imaging":[80],"(MRI),":[81],"sensitive":[82],"to":[83,151,265],"changes":[84],"[deoxyhemoglobin],":[87],"contrast-enhanced":[90],"MRI":[91],"intravascular":[94,277],"blood":[95,191,228,278],"pool":[96,279],"contrast":[97,280],"agent":[98],"NC100150,":[99],"fluorescence":[106],"microscopy":[107],"uptake":[111,207],"perfusion":[114],"marker":[115],"Hoechst":[116,209],"33342.":[117],"The":[118,254,300],"baseline":[119],"was":[121,139],"significantly":[122,189,205],"faster":[123],"tumors,":[127],"consistent":[128,321],"a":[130,158,170,188,204,251,323],"greater":[131,206],"development":[133],"(P":[134,197,220],"<":[135,198,221],"0.02,":[136,199,222],"ANOVA).":[137,200,223],"There":[138],"no":[140],"significant":[141,303],"difference":[142,304],"between":[143,308],"response":[145,307],"two":[148,246],"types":[150,185,248],"hypercapnia":[152],"(5%":[153,165],"CO(2)/95%":[154,166],"air),":[155],"used":[156,168],"as":[157,169,283],"probe":[159,171],"for":[160,172,325],"maturation,":[162],"or":[163],"hyperoxia":[164],"O(2)),":[167],"function.":[174],"NC100150":[175,284],"increased":[176,226,293],"both":[183],"demonstrated":[187],"larger":[190],"volume":[192],"tumors":[196,214,219,313],"This":[201],"correlated":[202],"33342":[210],"Despite":[224],"volume,":[229],"Delta":[231],"R(2)*/Delta":[232],"ratio,":[234],"an":[235],"index":[236],"microvessel":[238],"size,":[239],"showed":[240],"capillaries":[243],"were":[249],"similar":[252,316],"caliber.":[253],"data":[255],"highlight":[256],"potential":[258],"MRI-derived":[261],"quantitative":[262],"end":[263],"points":[264],"noninvasively":[266],"assess":[267],"angiogenesis,":[269],"this":[272],"regard,":[273],"use":[275],"agents":[281],"such":[282],"appears":[285],"very":[286],"promising.":[287],"neovascularization":[294],"vivo.":[299],"lack":[301],"hypercapnic/hyperoxic":[306],"vessel":[317],"caliber":[318],"are":[319],"also":[320],"role":[324],"initial":[329],"stages":[330],"vasculogenesis.":[332]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}