{"id":"https://openalex.org/W2149741986","doi":"https://doi.org/10.3109/0284186x.2014.990110","title":"Constant pattern of relapse in primary central nervous lymphoma patients treated with high-dose methotrexate combinations. A Finnish retrospective study","display_name":"Constant pattern of relapse in primary central nervous lymphoma patients treated with high-dose methotrexate combinations. A Finnish retrospective study","publication_year":2015,"publication_date":"2015-03-11","ids":{"openalex":"https://openalex.org/W2149741986","doi":"https://doi.org/10.3109/0284186x.2014.990110","mag":"2149741986","pmid":"https://pubmed.ncbi.nlm.nih.gov/25761092"},"language":"en","primary_location":{"id":"doi:10.3109/0284186x.2014.990110","doi":"https://doi.org/10.3109/0284186x.2014.990110","is_oa":true,"landing_page_url":"https://doi.org/10.3109/0284186x.2014.990110","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/0284186X.2014.990110?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.tandfonline.com/doi/pdf/10.3109/0284186X.2014.990110?needAccess=true&role=button","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006245646","display_name":"Liisa Harjama","orcid":"https://orcid.org/0000-0003-3623-2359","observed_orcids":["https://orcid.org/0000-0003-3623-2359"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Liisa Harjama","raw_affiliation_strings":["Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082053412","display_name":"Hanne K. Kuitunen","orcid":"https://orcid.org/0000-0001-7328-2043","observed_orcids":["https://orcid.org/0000-0001-7328-2043"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Hanne Kuitunen","raw_affiliation_strings":["Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006535775","display_name":"Taina M. Turpeenniemi-Hujanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Taina Turpeenniemi-Hujanen","raw_affiliation_strings":["Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109104619","display_name":"Kirsi\u2010Maria Haapasaari","orcid":"https://orcid.org/0009-0009-9740-9876","observed_orcids":["https://orcid.org/0009-0009-9740-9876"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kirsi Maria Haapasaari","raw_affiliation_strings":["Oulu University Hospital, Department of Pathology, Oulu University, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Department of Pathology, Oulu University, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051888634","display_name":"Sirpa Lepp\u00e4","orcid":"https://orcid.org/0000-0002-8265-511X","observed_orcids":["https://orcid.org/0000-0002-8265-511X"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sirpa Lepp\u00e4","raw_affiliation_strings":["Helsinki University Hospital, Department of Radiotherapy and Oncology, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital, Department of Radiotherapy and Oncology, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036175948","display_name":"Susanna Mannisto","orcid":"https://orcid.org/0000-0002-4336-2357","observed_orcids":["https://orcid.org/0000-0002-4336-2357"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Susanna Mannisto","raw_affiliation_strings":["Helsinki University Hospital, Department of Radiotherapy and Oncology, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital, Department of Radiotherapy and Oncology, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055183115","display_name":"Marja\u2010Liisa Karjalainen\u2010Lindsberg","orcid":"https://orcid.org/0000-0001-6728-2266","observed_orcids":["https://orcid.org/0000-0001-6728-2266"]},"institutions":[{"id":"https://openalex.org/I2800394112","display_name":"Helsinki University Hospital","ror":"https://ror.org/02e8hzf44","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2800394112","https://openalex.org/I4210166427"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Marja-Liisa Karjalainen-Lindsberg","raw_affiliation_strings":["Helsinki University Hospital, Department of Pathology, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helsinki University Hospital, Department of Pathology, Helsinki, Finland","institution_ids":["https://openalex.org/I2800394112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111561953","display_name":"Tuula Lehtinen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tuula Lehtinen","raw_affiliation_strings":["Tampere University Hospital, Department of Radiotherapy and Oncology, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tampere University Hospital, Department of Radiotherapy and Oncology, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060900975","display_name":"Mine Eray","orcid":"https://orcid.org/0000-0003-1909-277X","observed_orcids":["https://orcid.org/0000-0003-1909-277X"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mine Eray","raw_affiliation_strings":["Tampere University Hospital, Department of Pathology, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tampere University Hospital, Department of Pathology, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049279695","display_name":"Martine Vornanen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Martine Vornanen","raw_affiliation_strings":["Tampere University Hospital, Department of Pathology, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tampere University Hospital, Department of Pathology, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077727552","display_name":"Hannu K. Haapasalo","orcid":"https://orcid.org/0000-0003-4811-6961","observed_orcids":["https://orcid.org/0000-0003-4811-6961","https://orcid.org/0000-0003-4389-7391"]},"institutions":[{"id":"https://openalex.org/I4210126318","display_name":"Tampere University Hospital","ror":"https://ror.org/02hvt5f17","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210126318"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Hannu Haapasalo","raw_affiliation_strings":["Tampere University Hospital, Department of Pathology, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tampere University Hospital, Department of Pathology, Tampere, Finland","institution_ids":["https://openalex.org/I4210126318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113586556","display_name":"Ylermi Soini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ylermi Soini","raw_affiliation_strings":["University of Eastern Finland, Department of Pathology, Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland, Department of Pathology, Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109599036","display_name":"Esa Jantunen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Esa Jantunen","raw_affiliation_strings":["University of Eastern Finland, Department of Medicine Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland, Department of Medicine Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105839579","display_name":"Tapio Nousiainen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I175532246","display_name":"University of Eastern Finland","ror":"https://ror.org/00cyydd11","country_code":"FI","type":"education","lineage":["https://openalex.org/I175532246"]},{"id":"https://openalex.org/I4210092991","display_name":"Kuopio University Hospital","ror":"https://ror.org/00fqdfs68","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210092991","https://openalex.org/I4405278559"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Tapio Nousiainen","raw_affiliation_strings":["University of Eastern Finland, Department of Medicine Kuopio University Hospital, Kuopio, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Eastern Finland, Department of Medicine Kuopio University Hospital, Kuopio, Finland","institution_ids":["https://openalex.org/I175532246","https://openalex.org/I4210092991"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009201853","display_name":"Kaija Vasala","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140036","display_name":"Central Finland Health Care District","ror":"https://ror.org/054h11b04","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I4210140036"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kaija Vasala","raw_affiliation_strings":["Central Hospital of Central Finland, Department of Oncology, Jyv\u00e4skyl\u00e4, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Hospital of Central Finland, Department of Oncology, Jyv\u00e4skyl\u00e4, Finland","institution_ids":["https://openalex.org/I4210140036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019774051","display_name":"Outi M. Kuittinen","orcid":"https://orcid.org/0000-0001-9969-0053","observed_orcids":["https://orcid.org/0000-0001-9969-0053"]},"institutions":[{"id":"https://openalex.org/I2799272722","display_name":"Oulu University Hospital","ror":"https://ror.org/045ney286","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2799272722"]},{"id":"https://openalex.org/I98381234","display_name":"University of Oulu","ror":"https://ror.org/03yj89h83","country_code":"FI","type":"education","lineage":["https://openalex.org/I98381234"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Outi Kuittinen","raw_affiliation_strings":["Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu University, Oulu, Finland","institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5082053412"],"corresponding_institution_ids":["https://openalex.org/I2799272722","https://openalex.org/I98381234"],"apc_list":null,"apc_paid":null,"fwci":1.4046,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.81125214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"54","issue":"6","first_page":"939","last_page":"943"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-central-nervous-system-lymphoma","display_name":"primary central nervous system lymphoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/high-dose-methotrexate","display_name":"high-dose methotrexate","score":0.9850000143051147},{"id":"https://openalex.org/keywords/recurrence-patterns","display_name":"recurrence patterns","score":0.75},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.7310000061988831},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.7919999957084656},{"id":"https://openalex.org/keywords/consolidation-therapy","display_name":"consolidation therapy","score":0.7160000205039978},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/first-line-chemotherapy","display_name":"first-line chemotherapy","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9549899101257324},{"id":"https://openalex.org/C2781173314","wikidata":"https://www.wikidata.org/wiki/Q3246818","display_name":"Primary central nervous system lymphoma","level":3,"score":0.8771740198135376},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.7447790503501892},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6095881462097168},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.5291008949279785},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5155301094055176},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4960246980190277},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.46471676230430603}],"mesh":[{"descriptor_ui":"D000069283","descriptor_name":"Rituximab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003561","descriptor_name":"Cytarabine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005387","descriptor_name":"Finland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008223","descriptor_name":"Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018572","descriptor_name":"Disease-Free Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3109/0284186x.2014.990110","doi":"https://doi.org/10.3109/0284186x.2014.990110","is_oa":true,"landing_page_url":"https://doi.org/10.3109/0284186x.2014.990110","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/0284186X.2014.990110?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},{"id":"pmid:25761092","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25761092","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta oncologica (Stockholm, Sweden)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3109/0284186x.2014.990110","doi":"https://doi.org/10.3109/0284186x.2014.990110","is_oa":true,"landing_page_url":"https://doi.org/10.3109/0284186x.2014.990110","pdf_url":"https://www.tandfonline.com/doi/pdf/10.3109/0284186X.2014.990110?needAccess=true&role=button","source":{"id":"https://openalex.org/S1043257","display_name":"Acta Oncologica","issn_l":"0284-186X","issn":["0284-186X","1651-226X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Oncologica","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149741986.pdf","grobid_xml":"https://content.openalex.org/works/W2149741986.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1833666995","https://openalex.org/W1969573932","https://openalex.org/W2008962950","https://openalex.org/W2012351614","https://openalex.org/W2070064504","https://openalex.org/W2091004431","https://openalex.org/W2092261723","https://openalex.org/W2099015738","https://openalex.org/W2107423957","https://openalex.org/W2111322227","https://openalex.org/W2120766517","https://openalex.org/W2126959402","https://openalex.org/W2127684687","https://openalex.org/W2149603266","https://openalex.org/W2151690438","https://openalex.org/W2245514449"],"related_works":["https://openalex.org/W3009934713","https://openalex.org/W2767695910","https://openalex.org/W4213110544","https://openalex.org/W4388589476","https://openalex.org/W2078923325","https://openalex.org/W3089038223","https://openalex.org/W2008338547","https://openalex.org/W2899586286","https://openalex.org/W4296449863","https://openalex.org/W2122782894"],"abstract_inverted_index":{"BACKGROUND:":[0],"Primary":[1],"central":[2],"nervous":[3],"system":[4],"lymphoma":[5,149],"(PCNSL)":[6],"is":[7,40,152],"a":[8,13,47,115,153,162],"rare":[9],"brain":[10],"tumour":[11],"with":[12,20,72,79,103,112,122,166],"dismal":[14],"prognosis.":[15],"Several":[16],"phase":[17],"II":[18],"studies":[19],"high-dose":[21],"methotrexate-based":[22],"regimens":[23],"have":[24],"shown":[25],"promising":[26,89],"early":[27],"results,":[28],"but":[29],"in":[30,64,127,164],"all":[31],"hospital-based":[32,48],"data":[33],"published":[34],"so":[35],"far,":[36],"the":[37,53,57,94],"disease":[38],"outcome":[39],"poor.":[41],"MATERIAL":[42],"AND":[43],"METHODS:":[44],"We":[45,87],"performed":[46],"retrospective":[49],"analysis":[50],"to":[51],"evaluate":[52],"long-term":[54],"results":[55],"of":[56,60,93,118],"Nordic":[58],"type":[59],"Bonn":[61],"chemotherapy":[62,78],"regimen":[63],"PCNSL":[65,75,143],"patients.":[66],"The":[67,134],"study":[68],"included":[69],"54":[70],"patients":[71,95,100,165],"newly":[73],"diagnosed":[74],"who":[76],"received":[77],"curative":[80],"intent":[81],"as":[82],"their":[83],"first-line":[84],"treatment.":[85],"RESULTS:":[86],"found":[88],"response":[90],"rates,":[91],"76%":[92],"achieving":[96,101,161],"CR":[97],"and":[98,108,144,150],"22%":[99],"PR,":[102],"corresponding":[104],"two-year":[105],"EFS":[106],"53%":[107],"OS":[109],"76%.":[110],"However,":[111],"longer":[113],"follow-up":[114],"constant":[116],"pattern":[117],"relapses":[119],"was":[120],"observed":[121],"only":[123],"one":[124],"patient":[125],"remaining":[126],"primary":[128],"remission":[129,163],"after":[130,160],"60":[131],"months.":[132],"DISCUSSION:":[133],"finding":[135],"suggests":[136],"that":[137],"basic":[138],"biological":[139],"differences":[140],"exist":[141],"between":[142],"systemic":[145],"diffuse":[146],"large":[147],"B-cell":[148],"there":[151],"need":[154],"for":[155],"consolidation":[156],"or":[157],"maintenance":[158],"therapy":[159],"PCNSL.":[167]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
