{"id":"https://openalex.org/W2149665116","doi":"https://doi.org/10.1093/cvr/27.11.1968","title":"Age associated changes in membrane currents in rat ventricular myocytes","display_name":"Age associated changes in membrane currents in rat ventricular myocytes","publication_year":1993,"publication_date":"1993-11-01","ids":{"openalex":"https://openalex.org/W2149665116","doi":"https://doi.org/10.1093/cvr/27.11.1968","mag":"2149665116","pmid":"https://pubmed.ncbi.nlm.nih.gov/8287405"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/27.11.1968","doi":"https://doi.org/10.1093/cvr/27.11.1968","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/27.11.1968","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003033911","display_name":"K E Walker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"K E Walker","raw_affiliation_strings":["Department of Medicine, Medical College of Pennsylvania, Philadelphia","Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker","Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Pennsylvania, Philadelphia","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060742163","display_name":"Edward G. Lakatta","orcid":"https://orcid.org/0000-0002-4772-0035","observed_orcids":["https://orcid.org/0000-0002-4772-0035","https://orcid.org/0000-0002-6663-1556"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E G Lakatta","raw_affiliation_strings":["Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta; Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker","Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta; Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067892109","display_name":"Steven R. Houser","orcid":"https://orcid.org/0000-0001-6359-5425","observed_orcids":["https://orcid.org/0000-0001-6359-5425"]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S R Houser","raw_affiliation_strings":["Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta; Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker","Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker; Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta; Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I84392919"]},{"raw_affiliation_string":"Department of Medicine, Medical College of Pennsylvania, Philadelphia, Pennsylvania, USA: K E Walker","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA: S R Houser. Corre5pondence to Dr Houser","institution_ids":["https://openalex.org/I84392919"]},{"raw_affiliation_string":"Laboratory of Cardiovascular Science, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland, USA: E G Lakatta","institution_ids":["https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003033911"],"corresponding_institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I84392919"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":3.2904,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.9235877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"11","first_page":"1968","last_page":"1977"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-aging","display_name":"cardiac aging","score":0.7440000176429749},{"id":"https://openalex.org/keywords/ventricular-myocytes","display_name":"ventricular myocytes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/l-type-calcium-current","display_name":"L-type calcium current","score":0.9049999713897705},{"id":"https://openalex.org/keywords/transient-outward-potassium-current","display_name":"transient outward potassium current","score":0.9819999933242798},{"id":"https://openalex.org/keywords/inward-rectifier-potassium-current","display_name":"inward rectifier potassium current","score":0.9919999837875366},{"id":"https://openalex.org/keywords/action-potential-duration","display_name":"action potential duration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/calcium-channel-inactivation","display_name":"calcium channel inactivation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/channel-density","display_name":"channel density","score":0.5450000166893005},{"id":"https://openalex.org/keywords/intracellular-calcium-buffering","display_name":"intracellular calcium buffering","score":0.878000020980835},{"id":"https://openalex.org/keywords/action-potential-plateau","display_name":"action potential plateau","score":0.6079999804496765},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6119924187660217},{"id":"https://openalex.org/C101404756","wikidata":"https://www.wikidata.org/wiki/Q5038336","display_name":"Cardiac transient outward potassium current","level":4,"score":0.6001908779144287},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.56940096616745},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.5687252879142761},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5678355097770691},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.5217928886413574},{"id":"https://openalex.org/C2777658833","wikidata":"https://www.wikidata.org/wiki/Q408437","display_name":"EGTA","level":3,"score":0.5000252723693848},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48399853706359863},{"id":"https://openalex.org/C147944092","wikidata":"https://www.wikidata.org/wiki/Q176366","display_name":"Patch clamp","level":3,"score":0.4663870334625244},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45685818791389465},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.4501941502094269},{"id":"https://openalex.org/C47423411","wikidata":"https://www.wikidata.org/wiki/Q7920311","display_name":"Ventricular action potential","level":4,"score":0.44624489545822144},{"id":"https://openalex.org/C517785266","wikidata":"https://www.wikidata.org/wiki/Q703","display_name":"Potassium","level":2,"score":0.42294472455978394},{"id":"https://openalex.org/C100837961","wikidata":"https://www.wikidata.org/wiki/Q10290897","display_name":"Voltage clamp","level":3,"score":0.4114808142185211},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3979838788509369},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38287419080734253},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3809766173362732},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.29924076795578003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21074345707893372},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15267351269721985},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000252","descriptor_name":"Calcium-Transporting ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000254","descriptor_name":"Sodium-Potassium-Exchanging ATPase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006352","descriptor_name":"Heart Ventricles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/cvr/27.11.1968","doi":"https://doi.org/10.1093/cvr/27.11.1968","is_oa":false,"landing_page_url":"https://doi.org/10.1093/cvr/27.11.1968","pdf_url":null,"source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmid:8287405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8287405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1671631418","display_name":null,"funder_award_id":"HL-33648","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1974479170","display_name":"ELECTRICAL AND CONTRACTILE PROPERTIES IN HYPERTROPHY","funder_award_id":"5r01hl033648-06","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4614689426","display_name":null,"funder_award_id":"HL-33921","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2189377589","https://openalex.org/W2435977614","https://openalex.org/W2121595149","https://openalex.org/W2073632869","https://openalex.org/W4235034852","https://openalex.org/W2335586463","https://openalex.org/W1606836022","https://openalex.org/W2322329873","https://openalex.org/W2156668426","https://openalex.org/W2265460001"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Action":[1],"potential":[2,61,196,292,335],"duration":[3,197,293,336],"of":[4,17,48,57,100,116,134,153,155,160,202,244,256,333,337],"senescent":[5,88,345],"rat":[6,59],"ventricular":[7,76],"myocytes":[8,77],"is":[9,278,285,317],"longer":[10],"than":[11],"in":[12,27,45,75,97,123,149,168,194,213,217,240,252,269,280,290,326,343],"young":[13,80,226],"adults.":[14],"The":[15,113,235,322],"aim":[16],"the":[18,46,49,58,98,124,150,157,199,218,225,241,253,270,311,338,344],"study":[19,72],"was":[20,128,140,208,246],"to":[21,71,185,224,306,331],"determine":[22],"whether":[23],"age":[24,103,126,164,191,210,237,323],"related":[25,192,288],"changes":[26,325],"L-type":[28],"calcium":[29],"current":[30,35,41],"(ICa),":[31],"transient":[32],"outward":[33],"potassium":[34,40],"(ITO),":[36],"and":[37,53,87,119,136,294],"inwardly":[38],"rectifying":[39],"(IK1)":[42,55],"are":[43],"involved":[44],"prolongation":[47,332],"early":[50,339],"(ICa,":[51],"ITO)":[52],"late":[54],"portions":[56],"action":[60,195,291,334],"plateau.":[62],"METHODS:":[63],"Whole":[64],"cell":[65,230],"voltage":[66,114],"clamp":[67],"techniques":[68],"were":[69,94,107,205,297],"used":[70],"these":[73,327],"currents":[74,106,328],"isolated":[78],"from":[79],"(2-3":[81],"months),":[82,86],"middle":[83],"aged":[84],"(8-9":[85],"(24-25":[89],"months)":[90],"rats.":[91],"RESULTS:":[92],"There":[93,207],"no":[95,189],"differences":[96,193,289],"magnitude":[99],"ICa":[101,117,203,276,282,295],"among":[102],"groups":[104,127],"once":[105],"normalised":[108],"for":[109],"capacitative":[110],"surface":[111],"area.":[112],"dependence":[115],"activation":[118],"steady":[120],"state":[121],"inactivation":[122,154,161,204,257,296],"three":[125],"also":[129],"similar.":[130],"At":[131],"test":[132,260],"potentials":[133],"0":[135,170,267],"+10":[137,176],"mV,":[138,171,177],"there":[139,316],"a":[141,247,318],"significant":[142,190],"(p":[143,232],"<":[144,233],"or":[145,198],"=":[146,221,228],"0.05)":[147],"slowing":[148,251],"time":[151,158,200,254],"course":[152,201],"ICa;":[156],"constants":[159,255],"increased":[162],"with":[163,263],"[young":[165],"v":[166,173,179],"old":[167,219],"ms(SEM):":[169],"22.2(2.2)":[172],"38.0(5.0)":[174],"(slow);":[175],"8.0(2.0)":[178],"15.6(2.0)":[180],"(fast)].":[181],"With":[182],"internal":[183],"EGTA":[184],"buffer":[186],"intracellular":[187,301],"Ca2+,":[188],"observed.":[206],"an":[209],"associated":[211,238,324],"decrease":[212],"peak":[214],"ITO":[215,245,303],"density":[216,277],"(n":[220,227],"25)":[222,229],"compared":[223],"group":[231],"0.05).":[234],"only":[236],"change":[239],"kinetic":[242],"properties":[243],"small":[248],"but":[249,314],"consistent":[250],"at":[258,266],"most":[259],"voltages":[261],"measured,":[262],"significance":[264],"occurring":[265],"mV":[268],"slow":[271],"(tau":[272],"2)":[273],"component.":[274],"CONCLUSIONS:":[275],"maintained":[279],"senescence;":[281],"inactivation,":[283],"however,":[284],"slowed.":[286],"Age":[287],"reduced":[298,319],"by":[299],"buffering":[300],"Ca2+.":[302],"channels":[304],"appear":[305],"retain":[307],"normal":[308],"function":[309],"through":[310],"aging":[312],"process":[313],"overall":[315],"channel":[320],"density.":[321],"should":[329],"contribute":[330],"plateau":[340],"phase":[341],"seen":[342],"rat.":[346]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}