{"id":"https://openalex.org/W2149641391","doi":null,"title":"Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.","display_name":"Determination of the levels of urokinase and its receptor in human colon carcinoma cell lines.","publication_year":1988,"publication_date":"1988-06-01","ids":{"openalex":"https://openalex.org/W2149641391","mag":"2149641391","pmid":"https://pubmed.ncbi.nlm.nih.gov/2835152"},"language":"en","primary_location":{"id":"pmid:2835152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2835152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084442354","display_name":"Douglas D. Boyd","orcid":"https://orcid.org/0000-0002-1380-402X","observed_orcids":["https://orcid.org/0000-0002-1380-402X"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Boyd","raw_affiliation_strings":["Department of Pharmacology, Bristol-Baylor Laboratory, Baylor College of Medicine, Houston, Texas 77030"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Bristol-Baylor Laboratory, Baylor College of Medicine, Houston, Texas 77030","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109216259","display_name":"Germaine Florent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G Florent","raw_affiliation_strings":["Baylor college of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor college of Medicine;","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Kim","raw_affiliation_strings":["Baylor college of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor college of Medicine;","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111435477","display_name":"Michael G. Brattain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Brattain","raw_affiliation_strings":["Baylor college of Medicine;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor college of Medicine;","institution_ids":["https://openalex.org/I181547552"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I181547552"],"apc_list":null,"apc_paid":null,"fwci":5.7057,"has_fulltext":false,"cited_by_count":125,"citation_normalized_percentile":{"value":0.97254285,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"48","issue":"11","first_page":"3112","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/urokinase-receptor","display_name":"urokinase receptor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-differentiation-markers","display_name":"tumor differentiation markers","score":0.7250000238418579},{"id":"https://openalex.org/keywords/plasminogen-activator","display_name":"plasminogen activator","score":0.8669999837875366},{"id":"https://openalex.org/keywords/receptor-binding","display_name":"receptor binding","score":0.4449999928474426},{"id":"https://openalex.org/keywords/colon-cancer-cell-lines","display_name":"colon cancer cell lines","score":0.7170000076293945},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6579999923706055},{"id":"https://openalex.org/keywords/protease-secretion","display_name":"protease secretion","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.7978710532188416},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.7172368764877319},{"id":"https://openalex.org/C56219504","wikidata":"https://www.wikidata.org/wiki/Q7900869","display_name":"Urokinase receptor","level":3,"score":0.6635322570800781},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.559772789478302},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.5449011921882629},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5313898324966431},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4774773120880127},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.47238659858703613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45434898138046265},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4527474045753479},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43780896067619324},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42188045382499695},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37696442008018494},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20287591218948364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18314293026924133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055293","descriptor_name":"Receptors, Urokinase Plasminogen Activator","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2835152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2835152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2149641391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2835152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W587940312","https://openalex.org/W1483408221","https://openalex.org/W1491292227","https://openalex.org/W1497178009","https://openalex.org/W1508161280","https://openalex.org/W1522792094","https://openalex.org/W1906865038","https://openalex.org/W1972167965","https://openalex.org/W1983649348","https://openalex.org/W1999601337","https://openalex.org/W2005246591","https://openalex.org/W2037754267","https://openalex.org/W2039573204","https://openalex.org/W2041283826","https://openalex.org/W2049631846","https://openalex.org/W2054049732","https://openalex.org/W2069358836","https://openalex.org/W2085864855","https://openalex.org/W2101502555","https://openalex.org/W2106519423","https://openalex.org/W2115947409","https://openalex.org/W2119837316","https://openalex.org/W2121141343","https://openalex.org/W2154671319","https://openalex.org/W2430593758"],"related_works":["https://openalex.org/W1853063088","https://openalex.org/W2158123828","https://openalex.org/W7099649443","https://openalex.org/W1672973700","https://openalex.org/W2317224850","https://openalex.org/W1556047524","https://openalex.org/W2126888026","https://openalex.org/W2416006229","https://openalex.org/W2406109196","https://openalex.org/W1994011289"],"abstract_inverted_index":{"At":[0],"present,":[1],"there":[2],"is":[3,43],"a":[4,19,134,145],"lack":[5],"of":[6,8,21,25,38,78,92,112,128,144,150,166,178,215,240,269,280,283,285],"availability":[7],"differentiation":[9,47],"markers":[10],"for":[11,72,207,272],"colon":[12,49,52,96,201,288],"carcinoma.":[13,50,289],"This":[14,30,232],"may,":[15],"in":[16,48,133,176,209,234,250,286],"part,":[17],"be":[18,161],"consequence":[20],"the":[22,26,33,36,79,110,142,155,164,169,184,210,216,228,237,241,251,255,267,273,281],"diversified":[23],"function":[24],"normal":[27],"human":[28],"colon.":[29],"study":[31],"addresses":[32],"possibility":[34],"that":[35,125,154],"expression":[37,268],"urokinase":[39,73,94,208,265],"and":[40,62,76,101,173,189],"its":[41],"receptor":[42,74,89,167,271],"inversely":[44],"related":[45],"to":[46,87,95,220,236,244],"Six":[51],"carcinoma":[53,202],"cell":[54],"lines":[55],"including":[56],"three":[57,63],"well-differentiated":[58],"(CBS,":[59],"GEO,":[60,188],"FET)":[61],"poorly":[64,157],"differentiated":[65,158],"ones":[66],"(HCT116,":[67],"HCT116b,":[68,261],"RKO)":[69],"were":[70,131,204,225],"screened":[71],"display":[75],"secretion":[77],"plasminogen":[80,217,274],"activator.":[81],"A":[82],"radioreceptor":[83],"assay":[84],"was":[85,98,107,233],"used":[86],"determine":[88],"levels.":[90],"Binding":[91],"radioactive":[93,129],"cells":[97,159,203,258],"saturable,":[99],"specific,":[100],"time":[102],"dependent.":[103],"Cell-bound":[104],"125I-labeled":[105],"protease":[106,242],"unaffected":[108],"by":[109],"presence":[111],"epidermal":[113],"growth":[114],"factor,":[115],"low-molecular-weight":[116],"urokinase,":[117],"plasminogen,":[118],"or":[119],"transferrin.":[120],"Time":[121],"course":[122,143],"studies":[123],"revealed":[124],"maximum":[126],"amounts":[127],"tracer":[130],"bound":[132],"30-min":[135],"period":[136],"with":[137,227],"no":[138],"change":[139],"occurring":[140],"over":[141],"90-min":[146],"incubation.":[147],"Scatchard":[148],"analysis":[149],"ligand":[151],"binding":[152],"indicated":[153],"well-and":[156],"could":[160],"separated":[162],"on":[163],"basis":[165],"display;":[168],"aggressive":[170,257],"RKO,":[171],"HCT116,":[172],"HCT116b":[174],"expressed":[175],"excess":[177],"10(5)":[179],"sites":[180],"per":[181,198],"cell,":[182],"while":[183],"more":[185,229,256],"indolent":[186],"CBS,":[187],"FET":[190],"possessed":[191],"less":[192],"than":[193],"1.5":[194],"X":[195],"10(4)":[196],"receptors":[197],"cell.":[199],"The":[200],"also":[205],"analyzed":[206],"conditioned":[211],"medium.":[212],"Low":[213],"levels":[214,239],"activator":[218,275],"(0.8":[219],"1.3":[221],"ng/ml/10(6)":[222,246],"cells/72":[223,247],"h)":[224,248],"associated":[226],"\"mature\"":[230],"cells.":[231],"contrast":[235],"elevated":[238],"(3.9":[243],"11.4":[245],"present":[249],"medium":[252],"derived":[253],"from":[254],"(HCT":[259],"116,":[260],"RKO).":[262],"Thus,":[263],"secreted":[264],"and/or":[266],"cellular":[270],"may":[276],"provide":[277],"useful":[278],"measurements":[279],"degree":[282],"undifferentiation":[284],"vitro":[287]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}