{"id":"https://openalex.org/W2149598146","doi":"https://doi.org/10.1016/j.biocel.2011.05.007","title":"Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle","display_name":"Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle","publication_year":2011,"publication_date":"2011-05-22","ids":{"openalex":"https://openalex.org/W2149598146","doi":"https://doi.org/10.1016/j.biocel.2011.05.007","mag":"2149598146","pmid":"https://pubmed.ncbi.nlm.nih.gov/21621634","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3146557"},"language":"en","primary_location":{"id":"doi:10.1016/j.biocel.2011.05.007","doi":"https://doi.org/10.1016/j.biocel.2011.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2011.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3146557","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051527512","display_name":"Troy Alan Hornberger","orcid":"https://orcid.org/0000-0002-2349-1899","observed_orcids":["https://orcid.org/0000-0002-2349-1899"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Troy A. Hornberger","raw_affiliation_strings":["Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA. thornb1@svm.vetmed.wisc.edu","Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA. thornb1@svm.vetmed.wisc.edu","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]},{"raw_affiliation_string":"Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA","institution_ids":["https://openalex.org/I135310074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051527512"],"corresponding_institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"],"apc_list":{"value":3840,"currency":"USD","value_usd":3840},"apc_paid":null,"fwci":1.1,"has_fulltext":false,"cited_by_count":179,"citation_normalized_percentile":{"value":0.73352951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"43","issue":"9","first_page":"1267","last_page":"1276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.5806000232696533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition","score":0.21580000221729279,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.17319999635219574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.996999979019165},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.8679999709129333},{"id":"https://openalex.org/keywords/skeletal-muscle-mass","display_name":"skeletal muscle mass","score":0.8809999823570251},{"id":"https://openalex.org/keywords/mechanical-loading","display_name":"mechanical loading","score":0.5849999785423279},{"id":"https://openalex.org/keywords/muscle-hypertrophy","display_name":"muscle hypertrophy","score":0.6480000019073486},{"id":"https://openalex.org/keywords/muscle-atrophy","display_name":"muscle atrophy","score":0.765999972820282}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7702808380126953},{"id":"https://openalex.org/C98490376","wikidata":"https://www.wikidata.org/wiki/Q14876060","display_name":"mTORC1","level":4,"score":0.7668049335479736},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.6959457993507385},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.6370837092399597},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5432475805282593},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5154250860214233},{"id":"https://openalex.org/C2777949483","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"Mechanistic target of rapamycin","level":4,"score":0.5045381784439087},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49911952018737793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4859522581100464},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23237431049346924}],"mesh":[{"descriptor_ui":"D000076222","descriptor_name":"Mechanistic Target of Rapamycin Complex 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009470","descriptor_name":"Muscle Spindles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010712","descriptor_name":"Phosphatidic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010739","descriptor_name":"Phospholipase D","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046912","descriptor_name":"Multiprotein Complexes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.biocel.2011.05.007","doi":"https://doi.org/10.1016/j.biocel.2011.05.007","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biocel.2011.05.007","pdf_url":null,"source":{"id":"https://openalex.org/S183320690","display_name":"The International Journal of Biochemistry & Cell Biology","issn_l":"1357-2725","issn":["1357-2725","1878-5875"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The International Journal of Biochemistry & Cell Biology","raw_type":"journal-article"},{"id":"pmid:21621634","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21621634","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The international journal of biochemistry & cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2433061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3146557","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3146557","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3146557","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Biochem Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2433061","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3146557","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1190825394","display_name":null,"funder_award_id":"AR-057347","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G2529319384","display_name":"Mechanotransduction and the Regulation of Skeletal Muscle Mass","funder_award_id":"R56AR057347","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G8633861164","display_name":"Mechanotransduction and the Regulation of Skeletal Muscle Mass","funder_award_id":"R01AR057347","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G9000272655","display_name":null,"funder_award_id":"AR057347","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":121,"referenced_works":["https://openalex.org/W86843114","https://openalex.org/W1501966284","https://openalex.org/W1519982502","https://openalex.org/W1530473805","https://openalex.org/W1556893777","https://openalex.org/W1582807345","https://openalex.org/W1586159393","https://openalex.org/W1851452871","https://openalex.org/W1862719569","https://openalex.org/W1906543545","https://openalex.org/W1926614894","https://openalex.org/W1930333778","https://openalex.org/W1964531354","https://openalex.org/W1966938917","https://openalex.org/W1970707895","https://openalex.org/W1972431686","https://openalex.org/W1972880994","https://openalex.org/W1974942240","https://openalex.org/W1977734901","https://openalex.org/W1979850916","https://openalex.org/W1979861893","https://openalex.org/W1981861340","https://openalex.org/W1982501876","https://openalex.org/W1982858761","https://openalex.org/W1984618581","https://openalex.org/W1989964807","https://openalex.org/W1991691392","https://openalex.org/W1992117451","https://openalex.org/W1993431258","https://openalex.org/W1995480133","https://openalex.org/W1995874255","https://openalex.org/W1996021619","https://openalex.org/W1998762942","https://openalex.org/W1998763810","https://openalex.org/W2000731858","https://openalex.org/W2001505809","https://openalex.org/W2002959031","https://openalex.org/W2003778711","https://openalex.org/W2004582874","https://openalex.org/W2008100923","https://openalex.org/W2009041102","https://openalex.org/W2009405868","https://openalex.org/W2009463682","https://openalex.org/W2009971361","https://openalex.org/W2010538519","https://openalex.org/W2013706577","https://openalex.org/W2015445654","https://openalex.org/W2025176940","https://openalex.org/W2027628801","https://openalex.org/W2027785297","https://openalex.org/W2028875959","https://openalex.org/W2030243653","https://openalex.org/W2031918765","https://openalex.org/W2035450414","https://openalex.org/W2035965301","https://openalex.org/W2038894877","https://openalex.org/W2042427864","https://openalex.org/W2044328618","https://openalex.org/W2044467623","https://openalex.org/W2045830695","https://openalex.org/W2048589630","https://openalex.org/W2050481377","https://openalex.org/W2051037257","https://openalex.org/W2056137479","https://openalex.org/W2059086985","https://openalex.org/W2059672480","https://openalex.org/W2062020839","https://openalex.org/W2071117792","https://openalex.org/W2073263758","https://openalex.org/W2078160543","https://openalex.org/W2080365596","https://openalex.org/W2080451230","https://openalex.org/W2081920342","https://openalex.org/W2086914553","https://openalex.org/W2092839170","https://openalex.org/W2093874411","https://openalex.org/W2093882277","https://openalex.org/W2099767283","https://openalex.org/W2100679082","https://openalex.org/W2102888099","https://openalex.org/W2104819829","https://openalex.org/W2105981385","https://openalex.org/W2107033751","https://openalex.org/W2110443482","https://openalex.org/W2110966981","https://openalex.org/W2111986642","https://openalex.org/W2113053818","https://openalex.org/W2115928938","https://openalex.org/W2116738170","https://openalex.org/W2117789591","https://openalex.org/W2118689626","https://openalex.org/W2123429890","https://openalex.org/W2124496590","https://openalex.org/W2131355261","https://openalex.org/W2132806001","https://openalex.org/W2133113184","https://openalex.org/W2145068039","https://openalex.org/W2148321229","https://openalex.org/W2152289580","https://openalex.org/W2153497031","https://openalex.org/W2155511470","https://openalex.org/W2155621047","https://openalex.org/W2159132862","https://openalex.org/W2163560348","https://openalex.org/W2163583831","https://openalex.org/W2164462432","https://openalex.org/W2165370562","https://openalex.org/W2165761157","https://openalex.org/W2166994240","https://openalex.org/W2168107233","https://openalex.org/W2169898991","https://openalex.org/W2170704593","https://openalex.org/W2172067307","https://openalex.org/W2172252111","https://openalex.org/W2276826469","https://openalex.org/W2339005651","https://openalex.org/W2341872159","https://openalex.org/W2396168870","https://openalex.org/W2467068113","https://openalex.org/W4244311005","https://openalex.org/W6719488974"],"related_works":["https://openalex.org/W32359538","https://openalex.org/W2050725210","https://openalex.org/W4308914110","https://openalex.org/W2913322512","https://openalex.org/W2115538617","https://openalex.org/W7097407051","https://openalex.org/W2490615332","https://openalex.org/W2093682537","https://openalex.org/W147437269","https://openalex.org/W2896148958"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":13}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}