{"id":"https://openalex.org/W2149587161","doi":"https://doi.org/10.1043/0003-3219(2006)076[0830:iatnfl]2.0.co;2","title":"Interleukine-1beta and tumor necrosis factor-alpha levels in the human gingival sulcus during orthodontic treatment.","display_name":"Interleukine-1beta and tumor necrosis factor-alpha levels in the human gingival sulcus during orthodontic treatment.","publication_year":2006,"publication_date":"2006-09-01","ids":{"openalex":"https://openalex.org/W2149587161","doi":"https://doi.org/10.1043/0003-3219(2006)076[0830:iatnfl]2.0.co;2","mag":"2149587161","pmid":"https://pubmed.ncbi.nlm.nih.gov/17029518"},"language":"en","primary_location":{"id":"pmid:17029518","doi":"https://doi.org/10.1043/0003-3219(2006)076[0830:iatnfl]2.0.co;2","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17029518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Angle orthodontist","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065594723","display_name":"\u011e\u00fcven\u00e7 Ba\u015faran","orcid":"https://orcid.org/0000-0002-4119-3940","observed_orcids":["https://orcid.org/0000-0002-4119-3940"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"G\u00fcven\u00e7 Ba\u015faran","raw_affiliation_strings":["Dental Faculty, Dice University, Diyarbakir, Turkey. basaran@dicle.edu.tr"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dental Faculty, Dice University, Diyarbakir, Turkey. basaran@dicle.edu.tr","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081396544","display_name":"T\u00f6r\u00fcn \u00d6zer","orcid":"https://orcid.org/0000-0001-6164-2849","observed_orcids":["https://orcid.org/0000-0001-6164-2849"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"T\u00f6r\u00fcn Ozer","raw_affiliation_strings":["aResearch Assistant, Orthodontics, Dental Faculty, Dicle University, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"aResearch Assistant, Orthodontics, Dental Faculty, Dicle University, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062820545","display_name":"Filiz Acun Kaya","orcid":"https://orcid.org/0000-0001-8334-9301","observed_orcids":["https://orcid.org/0000-0001-8334-9301"]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Filiz Acun Kaya","raw_affiliation_strings":["bResearch Assistant, Periodontology, Dental Faculty, Dicle University, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"bResearch Assistant, Periodontology, Dental Faculty, Dicle University, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112013105","display_name":"Abdurrahman Kaplan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Abdurrahman Kaplan","raw_affiliation_strings":["cProfessor, Biochemistry, Dicle University, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"cProfessor, Biochemistry, Dicle University, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023102709","display_name":"Orhan Hamamc\u0131","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123466251","display_name":"Dicle University","ror":"https://ror.org/0257dtg16","country_code":"TR","type":"education","lineage":["https://openalex.org/I123466251"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Orhan Hamamci","raw_affiliation_strings":["dProfessor and Department Chair, Orthodontics, Dental Faculty, Diyarbak\u0131r, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"dProfessor and Department Chair, Orthodontics, Dental Faculty, Diyarbak\u0131r, Turkey","institution_ids":["https://openalex.org/I123466251"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123466251"],"apc_list":null,"apc_paid":null,"fwci":2.603,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.86006826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"76","issue":"5","first_page":"830","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10356","display_name":"Orthodontics and Dentofacial Orthopedics","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/3505","display_name":"Orthodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.16099999845027924,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13768","display_name":"Oral and gingival health research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9700000286102295},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/gingival-crevicular-fluid","display_name":"gingival crevicular fluid","score":0.9950000047683716},{"id":"https://openalex.org/keywords/orthodontic-treatment","display_name":"orthodontic treatment","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fixed-orthodontic-appliances","display_name":"fixed orthodontic appliances","score":0.7900000214576721},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.6420000195503235},{"id":"https://openalex.org/keywords/gingivitis","display_name":"gingivitis","score":0.4740000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8401679396629333},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.6942563056945801},{"id":"https://openalex.org/C515851188","wikidata":"https://www.wikidata.org/wiki/Q13445028","display_name":"Oral hygiene","level":2,"score":0.6722959280014038},{"id":"https://openalex.org/C93015806","wikidata":"https://www.wikidata.org/wiki/Q5563118","display_name":"Gingival sulcus","level":2,"score":0.49778127670288086},{"id":"https://openalex.org/C3020084786","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor \u03b1","level":3,"score":0.46467217803001404},{"id":"https://openalex.org/C29694066","wikidata":"https://www.wikidata.org/wiki/Q118301","display_name":"Orthodontics","level":1,"score":0.3709592819213867},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3553617000579834},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16191506385803223}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000497","descriptor_name":"Alloys","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003722","descriptor_name":"Dental Alloys","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005881","descriptor_name":"Gingiva","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005883","descriptor_name":"Gingival Crevicular Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009532","descriptor_name":"Nickel","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009910","descriptor_name":"Oral Hygiene","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009969","descriptor_name":"Orthodontic Wires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013193","descriptor_name":"Stainless Steel","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014025","descriptor_name":"Titanium","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014087","descriptor_name":"Tooth Movement Techniques","qualifier_ui":"Q000295","qualifier_name":"instrumentation","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D016910","descriptor_name":"Orthodontic Brackets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:17029518","doi":"https://doi.org/10.1043/0003-3219(2006)076[0830:iatnfl]2.0.co;2","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17029518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Angle orthodontist","raw_type":"Journal Article"},{"id":"mag:2149587161","doi":"https://doi.org/10.1043/0003-3219(2006)076[0830:iatnfl]2.0.co;2","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17029518","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1967502057","https://openalex.org/W1975406338","https://openalex.org/W1978495122","https://openalex.org/W1981323152","https://openalex.org/W1983454644","https://openalex.org/W1986615333","https://openalex.org/W1989080833","https://openalex.org/W1991416677","https://openalex.org/W1993537084","https://openalex.org/W2001691223","https://openalex.org/W2003733256","https://openalex.org/W2013553103","https://openalex.org/W2014881963","https://openalex.org/W2025137697","https://openalex.org/W2028179193","https://openalex.org/W2028281832","https://openalex.org/W2031504111","https://openalex.org/W2053034249","https://openalex.org/W2057782747","https://openalex.org/W2067263174","https://openalex.org/W2072115956","https://openalex.org/W2072364025","https://openalex.org/W2080871180","https://openalex.org/W2084218914","https://openalex.org/W2120998349","https://openalex.org/W2130704435","https://openalex.org/W2142825855","https://openalex.org/W2150895170","https://openalex.org/W2172017373","https://openalex.org/W2188150012","https://openalex.org/W2285202011","https://openalex.org/W2395356500"],"related_works":["https://openalex.org/W2409289926","https://openalex.org/W2369316428","https://openalex.org/W3040942662","https://openalex.org/W1995702056","https://openalex.org/W4223955630","https://openalex.org/W2125017765","https://openalex.org/W3136640017","https://openalex.org/W2373731934","https://openalex.org/W2885302005","https://openalex.org/W4231290170"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"test":[2],"whether":[3],"interleukine":[4],"1beta":[5],"(IL-1beta)":[6],"and":[7,28,52,75,77,81,108,130,136,140,151],"tumor":[8],"necrosis":[9],"factor-alpha":[10],"(TNF-alpha)":[11],"levels":[12,153],"differ":[13],"from":[14],"each":[15],"other":[16],"in":[17,40,122,131,147,158],"different":[18],"treatment":[19,114],"levels.":[20],"MATERIALS":[21],"AND":[22],"METHODS:":[23],"Eighteen":[24],"patients,":[25],"nine":[26,29],"female":[27],"male":[30],"(aged":[31],"16-19":[32],"years;":[33],"mean":[34],"17.4":[35],"+/-":[36],"1.8":[37],"years),":[38],"participated":[39],"this":[41],"study.":[42],"Each":[43],"subject":[44],"underwent":[45],"a":[46,60],"session":[47],"on":[48],"professional":[49],"oral":[50,54],"hygiene":[51,55],"received":[53],"instructions.":[56],"Two":[57],"months":[58,112],"later,":[59],"fixed":[61],"orthodontic":[62],"appliance":[63],"was":[64],"placed.":[65],"The":[66],"patients":[67],"were":[68,100,115,120],"seen":[69],"at":[70,72,78,102],"baseline,":[71],"days":[73],"7":[74,107],"21":[76,109],"the":[79,85,88,93,97,103,123,132,143,149],"3rd":[80],"6th":[82,104],"month":[83],"as":[84],"leveling":[86],"of":[87,92,113,125,134,142],"teeth":[89,144],"occurred.":[90],"Records":[91],"baseline":[94],"scores":[95],"for":[96],"distalization":[98,141],"forces":[99],"taken":[101],"month.":[105],"Days":[106],"after":[110],"6":[111],"also":[116],"recorded.":[117],"RESULTS:":[118],"There":[119],"increases":[121,146],"volume":[124],"gingival":[126],"crevicular":[127],"fluid":[128],"(GCF)":[129],"concentrations":[133],"IL-1beta":[135],"TNF-alpha.":[137],"CONCLUSIONS:":[138],"Leveling":[139],"evoke":[145],"both":[148],"IL-1":[150],"TNF-alpha":[152],"that":[154],"can":[155],"be":[156],"detected":[157],"GCF.":[159]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}