{"id":"https://openalex.org/W2149584159","doi":"https://doi.org/10.1111/j.1744-313x.2008.00771.x","title":"The G/G genotype of transforming growth factor beta 1 (TGF\u2010\u03b21) single nucleotide (+915G/C) polymorphism coincident with other host and environmental factors is associated with irreversible bronchoconstriction in asthmatics","display_name":"The G/G genotype of transforming growth factor beta 1 (TGF\u2010\u03b21) single nucleotide (+915G/C) polymorphism coincident with other host and environmental factors is associated with irreversible bronchoconstriction in asthmatics","publication_year":2008,"publication_date":"2008-10-08","ids":{"openalex":"https://openalex.org/W2149584159","doi":"https://doi.org/10.1111/j.1744-313x.2008.00771.x","mag":"2149584159","pmid":"https://pubmed.ncbi.nlm.nih.gov/19046298"},"language":"en","primary_location":{"id":"doi:10.1111/j.1744-313x.2008.00771.x","doi":"https://doi.org/10.1111/j.1744-313x.2008.00771.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1744-313x.2008.00771.x","pdf_url":null,"source":{"id":"https://openalex.org/S44859635","display_name":"International Journal of Immunogenetics","issn_l":"1744-3121","issn":["1744-3121","1744-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunogenetics","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2149584159"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075837682","display_name":"Jerzy Liebhart","orcid":"https://orcid.org/0000-0003-2414-9275","observed_orcids":["https://orcid.org/0000-0003-2414-9275"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Jerzy Liebhart","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland. Jerzy.Liebhart@dilnet.wroc.pl","Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland. Jerzy.Liebhart@dilnet.wroc.pl","institution_ids":["https://openalex.org/I385303915"]},{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029393084","display_name":"Ma\u0142gorzata Polak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malgorzata Polak","raw_affiliation_strings":["Lower Silesian Centre for Cellular Transplantation, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lower Silesian Centre for Cellular Transplantation, Wroclaw, Poland,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033495524","display_name":"A D\u00e2browski","orcid":"https://orcid.org/0000-0002-5996-394X","observed_orcids":["https://orcid.org/0000-0002-5996-394X"]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Dabrowski","raw_affiliation_strings":["Mathematical Institute, University of Wroclaw, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Institute, University of Wroclaw, Wroclaw, Poland,","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048635311","display_name":"Rafa\u0142 Dobek","orcid":"https://orcid.org/0000-0003-1386-7562","observed_orcids":["https://orcid.org/0000-0003-1386-7562"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rafal Dobek","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064124522","display_name":"Ewa Liebhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Liebhart","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102884841","display_name":"Anna Dor\u2010Wojnarowska","orcid":"https://orcid.org/0000-0002-1437-1668","observed_orcids":["https://orcid.org/0000-0002-1437-1668"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anna Dor\u2010Wojnarowska","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071518599","display_name":"Wojciech Barg","orcid":"https://orcid.org/0000-0001-9612-6684","observed_orcids":["https://orcid.org/0000-0001-9612-6684"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech Barg","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086443451","display_name":"Aleksandra Kulczak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Aleksandra Kulczak","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016356292","display_name":"Wojciech M\u0119drala","orcid":"https://orcid.org/0000-0001-8116-4725","observed_orcids":["https://orcid.org/0000-0001-8116-4725"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech Medrala","raw_affiliation_strings":["Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Allergology, Wroclaw Medical University, Wroclaw, Poland,","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071118233","display_name":"Urszula G\u0142adysz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219388962","display_name":"University of Wroc\u0142aw","ror":"https://ror.org/00yae6e25","country_code":"PL","type":"education","lineage":["https://openalex.org/I219388962"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Urszula Gladysz","raw_affiliation_strings":["Institute of Computer Science, University of Wroclaw, Wroclaw, Poland and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computer Science, University of Wroclaw, Wroclaw, Poland and","institution_ids":["https://openalex.org/I219388962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058681080","display_name":"Andrzej Lange","orcid":"https://orcid.org/0000-0003-3544-1853","observed_orcids":["https://orcid.org/0000-0003-3544-1853"]},"institutions":[{"id":"https://openalex.org/I4210163977","display_name":"Ludwik Hirszfeld Institute of Immunology and Experimental Therapy","ror":"https://ror.org/05b7p8k90","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210163977","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Andrzej Lange","raw_affiliation_strings":["L.Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland","Lower Silesian Centre for Cellular Transplantation, Wroclaw, Poland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"L.Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Science, Wroclaw, Poland","institution_ids":["https://openalex.org/I4210163977"]},{"raw_affiliation_string":"Lower Silesian Centre for Cellular Transplantation, Wroclaw, Poland,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5075837682"],"corresponding_institution_ids":["https://openalex.org/I385303915"],"apc_list":{"value":2900,"currency":"USD","value_usd":2900},"apc_paid":null,"fwci":1.1481,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80001795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"35","issue":"6","first_page":"417","last_page":"422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.7059999704360962},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.8420000076293945},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8460000157356262},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7990000247955322},{"id":"https://openalex.org/keywords/airway-remodeling","display_name":"airway remodeling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.7260000109672546},{"id":"https://openalex.org/keywords/disease-duration","display_name":"disease duration","score":0.6830000281333923},{"id":"https://openalex.org/keywords/male-sex","display_name":"male sex","score":0.5830000042915344},{"id":"https://openalex.org/keywords/airflow-obstruction","display_name":"airflow obstruction","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.9273176193237305},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7496700286865234},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6098414063453674},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6084863543510437},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.57254958152771},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.4655044674873352},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4257504940032959},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.41449421644210815},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4076226055622101},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3764225244522095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36171674728393555},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3315342962741852},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2932767868041992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2863960564136505},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26696377992630005}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003251","descriptor_name":"Constriction, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016084","descriptor_name":"Bronchoconstriction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1744-313x.2008.00771.x","doi":"https://doi.org/10.1111/j.1744-313x.2008.00771.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1744-313x.2008.00771.x","pdf_url":null,"source":{"id":"https://openalex.org/S44859635","display_name":"International Journal of Immunogenetics","issn_l":"1744-3121","issn":["1744-3121","1744-313X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Immunogenetics","raw_type":"journal-article"},{"id":"pmid:19046298","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19046298","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of immunogenetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W193266072","https://openalex.org/W1499417605","https://openalex.org/W1886267442","https://openalex.org/W1939090767","https://openalex.org/W1968340154","https://openalex.org/W1980186690","https://openalex.org/W1981472931","https://openalex.org/W1982140654","https://openalex.org/W1983100921","https://openalex.org/W2026125421","https://openalex.org/W2028176043","https://openalex.org/W2034258916","https://openalex.org/W2034508361","https://openalex.org/W2038143120","https://openalex.org/W2048426013","https://openalex.org/W2052052686","https://openalex.org/W2052603731","https://openalex.org/W2061015445","https://openalex.org/W2061319019","https://openalex.org/W2063177246","https://openalex.org/W2064981912","https://openalex.org/W2072025288","https://openalex.org/W2073789795","https://openalex.org/W2081635142","https://openalex.org/W2116379520","https://openalex.org/W2116824990","https://openalex.org/W2117263999","https://openalex.org/W2127828262","https://openalex.org/W2130682878","https://openalex.org/W2130764184","https://openalex.org/W2142249617","https://openalex.org/W2150448842","https://openalex.org/W2197553214","https://openalex.org/W2316067769","https://openalex.org/W2766240094","https://openalex.org/W2994597783"],"related_works":["https://openalex.org/W1657080021","https://openalex.org/W2184667034","https://openalex.org/W4231645321","https://openalex.org/W1936523567","https://openalex.org/W2018925850","https://openalex.org/W1576558047","https://openalex.org/W3037852032","https://openalex.org/W2116824990","https://openalex.org/W2093217210","https://openalex.org/W2545117676"],"abstract_inverted_index":{"Irreversible":[0],"airflow":[1],"obstruction":[2,175],"may":[3,34,193],"develop":[4],"in":[5,11,41,56,80,112,141,190,201],"some":[6],"cases":[7],"of":[8,13,44,92,101,167,184,198,217],"asthma":[9,120],"even":[10],"absence":[12],"known":[14],"risk":[15],"factors":[16,33],"such":[17],"as":[18],"smoking":[19,163,213],"and":[20,23,62,98,121,162,214],"environmental":[21],"insults":[22],"despite":[24,74],"implementing":[25],"apparently":[26],"appropriate":[27],"therapy.":[28],"This":[29],"implies":[30],"that":[31,77,129,182],"genetic":[32,51],"significantly":[35,136],"contribute":[36],"to":[37,53,195],"determining":[38],"the":[39,42,45,196,209,218],"severity":[40],"course":[43],"disease.":[46,219],"The":[47,165],"published":[48],"reports":[49],"on":[50,172],"predisposition":[52],"irreversible":[54,110,139,173,199],"bronchoconstriction":[55,111,140,200],"asthma,":[57],"however,":[58],"are":[59],"relatively":[60],"scarce,":[61],"disregard":[63],"its":[64],"potential":[65],"association":[66,108],"with":[67,109,119,138,208],"transforming":[68],"growth":[69],"factor":[70],"(TGF)-beta1":[71],"gene":[72,192],"polymorphism":[73],"established":[75],"role":[76],"TGF-beta1":[78,85,191],"plays":[79],"airway":[81,174],"remodelling.":[82],"We":[83],"tested":[84],"single-nucleotide":[86],"polymorphisms":[87],"(SNPs)":[88],"at":[89,132,169,187],"position":[90,99],"+869":[91],"codon":[93,102,133,170,188],"10":[94,171],"(leucine":[95],"or":[96,105],"proline)":[97,106],"+915":[100],"25":[103,134,189],"(arginine":[104],"for":[107,158],"a":[113],"case-control":[114],"study":[115],"involving":[116],"110":[117],"patients":[118],"109":[122],"controls.":[123],"Multivariate":[124],"logistic":[125],"regression":[126],"analysis":[127],"revealed":[128],"genotype":[130],"G/G":[131],"was":[135,176],"associated":[137],"asthmatics":[142],"(odds":[143],"ratio":[144],"=":[145,152],"4.44;":[146],"95%":[147],"confidence":[148],"interval:":[149],"1.00-19.61;":[150],"P":[151],"0.05),":[153],"but":[154,204],"only":[155,205],"after":[156],"adjustment":[157],"gender,":[159,211],"disease":[160],"duration":[161,216],"index.":[164],"influence":[166],"SNPs":[168],"not":[177],"significant.":[178],"Our":[179],"results":[180],"suggest":[181],"presence":[183],"SNP":[185],"(+915G/G)":[186],"predispose":[194],"development":[197],"asthmatic":[202],"patients,":[203],"when":[206],"coincident":[207],"male":[210],"habitual":[212],"relevant":[215]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}