{"id":"https://openalex.org/W2149509906","doi":"https://doi.org/10.1097/aln.0b013e31819daedd","title":"Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats","display_name":"Dexmedetomidine Attenuates Isoflurane-induced Neurocognitive Impairment in Neonatal Rats","publication_year":2009,"publication_date":"2009-05-01","ids":{"openalex":"https://openalex.org/W2149509906","doi":"https://doi.org/10.1097/aln.0b013e31819daedd","mag":"2149509906","pmid":"https://pubmed.ncbi.nlm.nih.gov/19352168"},"language":"en","primary_location":{"id":"doi:10.1097/aln.0b013e31819daedd","doi":"https://doi.org/10.1097/aln.0b013e31819daedd","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31819daedd","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/110/5/1077/532929/0000542-200905000-00023.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://pubs.asahq.org/anesthesiology/article-pdf/110/5/1077/532929/0000542-200905000-00023.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036299315","display_name":"Robert David Sanders","orcid":"https://orcid.org/0000-0003-0113-0328","observed_orcids":["https://orcid.org/0000-0003-0113-0328"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert\u00a0D. Sanders","raw_affiliation_strings":["Academic Clinical Fellow"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academic Clinical Fellow","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023011217","display_name":"Jing Xu","orcid":"https://orcid.org/0000-0002-6004-4713","observed_orcids":["https://orcid.org/0000-0002-6004-4713"]},"institutions":[{"id":"https://openalex.org/I3019813218","display_name":"Abbott (United Kingdom)","ror":"https://ror.org/03wnay029","country_code":"GB","type":"company","lineage":["https://openalex.org/I3019813218","https://openalex.org/I4210088555"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jing Xu","raw_affiliation_strings":["Attending Physician, Department of Anesthesiology, Gongli Hospital, Pudong, Shanghai, China. Professor Maze has been a consultant for Abbott Laboratories, Abbott Park, Illinois, to facilitate registration of dexmedetomidine in the United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Attending Physician, Department of Anesthesiology, Gongli Hospital, Pudong, Shanghai, China. Professor Maze has been a consultant for Abbott Laboratories, Abbott Park, Illinois, to facilitate registration of dexmedetomidine in the United States","institution_ids":["https://openalex.org/I3019813218"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yi Shu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi Shu","raw_affiliation_strings":["Doctoral Student"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Student","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031626485","display_name":"Adam P. Januszewski","orcid":"https://orcid.org/0000-0002-3649-3201","observed_orcids":["https://orcid.org/0000-0002-3649-3201"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam Januszewski","raw_affiliation_strings":["House Officer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"House Officer","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sunil Halder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sunil Halder","raw_affiliation_strings":["Honorary Research Fellow, Imperial College London, and Specialty Trainee, Department of Anaesthetics, Reading General Hospital, Reading, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Honorary Research Fellow, Imperial College London, and Specialty Trainee, Department of Anaesthetics, Reading General Hospital, Reading, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061850333","display_name":"Ant\u00f3nio Rei Fidalgo","orcid":"https://orcid.org/0000-0003-3384-0017","observed_orcids":["https://orcid.org/0000-0003-3384-0017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Fidalgo","raw_affiliation_strings":["Doctoral Student"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Doctoral Student","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110552721","display_name":"Pamela Sun","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pamela Sun","raw_affiliation_strings":["Medical Student"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Student","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103568706","display_name":"Mahmuda Hossain","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mahmuda Hossain","raw_affiliation_strings":["Research Technician"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Technician","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100707338","display_name":"Daqing Ma","orcid":"https://orcid.org/0000-0003-1235-0537","observed_orcids":["https://orcid.org/0000-0003-1235-0537","https://orcid.org/0000-0002-0688-2097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daqing Ma","raw_affiliation_strings":["Senior Lecturer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Lecturer","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065301160","display_name":"Mervyn Maze","orcid":"https://orcid.org/0000-0001-9794-2472","observed_orcids":["https://orcid.org/0000-0001-9794-2472"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mervyn Maze","raw_affiliation_strings":["Sir Ivan Magill Professor of Anaesthesia, Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir Ivan Magill Professor of Anaesthesia, Department of Anaesthetics, Pain Medicine and Intensive Care, Imperial College London, United Kingdom","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.1197,"has_fulltext":true,"cited_by_count":434,"citation_normalized_percentile":{"value":0.98015564,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"110","issue":"5","first_page":"1077","last_page":"1085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":1.0},{"id":"https://openalex.org/keywords/isoflurane","display_name":"isoflurane","score":0.9589999914169312},{"id":"https://openalex.org/keywords/anesthetic-neurotoxicity","display_name":"anesthetic neurotoxicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8159999847412109},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":0.9160000085830688},{"id":"https://openalex.org/keywords/atipamezole","display_name":"atipamezole","score":0.9010000228881836},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.8790000081062317},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.7770000100135803},{"id":"https://openalex.org/keywords/long-term-memory-impairment","display_name":"long-term memory impairment","score":0.8119999766349792},{"id":"https://openalex.org/keywords/fear-conditioning","display_name":"fear conditioning","score":0.7680000066757202},{"id":"https://openalex.org/keywords/neonatal-brain-development","display_name":"neonatal brain development","score":0.6790000200271606},{"id":"https://openalex.org/keywords/organotypic-hippocampal-slice-cultures","display_name":"organotypic hippocampal slice cultures","score":0.8859999775886536}],"concepts":[{"id":"https://openalex.org/C2776359302","wikidata":"https://www.wikidata.org/wiki/Q413918","display_name":"Isoflurane","level":2,"score":0.8824553489685059},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.8305684924125671},{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.8273360729217529},{"id":"https://openalex.org/C2776312488","wikidata":"https://www.wikidata.org/wiki/Q413894","display_name":"Atipamezole","level":5,"score":0.811606764793396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7203669548034668},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6348055601119995},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.6285575032234192},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.4755415916442871},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.4689221978187561},{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.4602353572845459},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2063053548336029},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.114601731300354},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.0},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0},{"id":"https://openalex.org/C2779520467","wikidata":"https://www.wikidata.org/wiki/Q427179","display_name":"Medetomidine","level":4,"score":0.0},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007530","descriptor_name":"Isoflurane","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/aln.0b013e31819daedd","doi":"https://doi.org/10.1097/aln.0b013e31819daedd","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31819daedd","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/110/5/1077/532929/0000542-200905000-00023.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},{"id":"pmid:19352168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19352168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1097/aln.0b013e31819daedd","doi":"https://doi.org/10.1097/aln.0b013e31819daedd","is_oa":true,"landing_page_url":"https://doi.org/10.1097/aln.0b013e31819daedd","pdf_url":"https://pubs.asahq.org/anesthesiology/article-pdf/110/5/1077/532929/0000542-200905000-00023.pdf","source":{"id":"https://openalex.org/S124035732","display_name":"Anesthesiology","issn_l":"0003-3022","issn":["0003-3022","1528-1175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesiology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2149509906.pdf","grobid_xml":"https://content.openalex.org/works/W2149509906.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W649379","https://openalex.org/W1565010155","https://openalex.org/W1965608505","https://openalex.org/W1967568998","https://openalex.org/W1971151298","https://openalex.org/W1971958909","https://openalex.org/W1978666210","https://openalex.org/W1981842342","https://openalex.org/W1984005657","https://openalex.org/W1991780384","https://openalex.org/W1998025917","https://openalex.org/W1998151383","https://openalex.org/W1999485470","https://openalex.org/W2002932881","https://openalex.org/W2003880271","https://openalex.org/W2013498560","https://openalex.org/W2020322439","https://openalex.org/W2021474822","https://openalex.org/W2024281266","https://openalex.org/W2027060658","https://openalex.org/W2039506251","https://openalex.org/W2039691230","https://openalex.org/W2050853004","https://openalex.org/W2054251296","https://openalex.org/W2058185503","https://openalex.org/W2059988722","https://openalex.org/W2063077682","https://openalex.org/W2063541383","https://openalex.org/W2068065215","https://openalex.org/W2070941196","https://openalex.org/W2073268897","https://openalex.org/W2073772517","https://openalex.org/W2074671627","https://openalex.org/W2079054696","https://openalex.org/W2080131125","https://openalex.org/W2081025398","https://openalex.org/W2087828327","https://openalex.org/W2096356147","https://openalex.org/W2100231995","https://openalex.org/W2100569554","https://openalex.org/W2113048472","https://openalex.org/W2114916142","https://openalex.org/W2146784485","https://openalex.org/W2147965244","https://openalex.org/W2158120859","https://openalex.org/W2162665706","https://openalex.org/W4240460966"],"related_works":["https://openalex.org/W2903811746","https://openalex.org/W1974451632","https://openalex.org/W3169036234","https://openalex.org/W3134557857","https://openalex.org/W2409902128","https://openalex.org/W2048787922","https://openalex.org/W2386847120","https://openalex.org/W1895508641","https://openalex.org/W2745749085","https://openalex.org/W3099629854"],"abstract_inverted_index":{"BACKGROUND:":[0],"Neuroapoptosis":[1],"is":[2,24],"induced":[3],"by":[4,64,151,177],"the":[5,11,32,77,103,109,142,161,207,224],"administration":[6,178,238],"of":[7,29,111,163,179,221,223,239],"anesthetic":[8,156],"agents":[9],"to":[10,68,84,102,218,233,246],"young.":[12],"As":[13],"alpha2":[14,78,90],"adrenoceptor":[15,79,91],"signaling":[16],"plays":[17],"a":[18,65,235],"trophic":[19],"role":[20],"during":[21],"development":[22],"and":[23,145],"neuroprotective":[25],"in":[26,49,54,57,59,108,124,141,187,192,206,215],"several":[27],"settings":[28],"neuronal":[30],"injury,":[31],"authors":[33],"investigated":[34],"whether":[35],"dexmedetomidine":[36,87,136,240],"could":[37],"provide":[38],"functional":[39],"protection":[40],"against":[41],"isoflurane-induced":[42,139,184,204,230,248],"injury.":[43],"METHODS:":[44],"Isoflurane-induced":[45,213],"injury":[46,140,205,214],"was":[47,82,99,114,122,149,175],"provoked":[48],"organotypic":[50,104,188],"hippocampal":[51,105,189],"slice":[52,106,190],"cultures":[53,107,191],"vitro":[55,216],"or":[56,72],"vivo":[58,125,135],"postnatal":[60,127],"day":[61,128],"7":[62],"rats":[63],"6-h":[66],"exposure":[67],"0.75%":[69],"isoflurane":[70,166],"with":[71,153],"without":[73],"dexmedetomidine.":[74],"In":[75,134],"vivo,":[76],"antagonist":[80],"atipamezole":[81],"used":[83],"identify":[85],"if":[86],"neuroprotection":[88,148],"involved":[89],"activation.":[92],"The":[93],"gamma-amino-butyric-acid":[94,225],"type":[95,226],"A":[96,227],"antagonist,":[97],"gabazine,":[98],"also":[100,182],"added":[101],"presence":[110],"isoflurane.":[112],"Apoptosis":[113],"assessed":[115,123],"using":[116,130],"cleaved":[117],"caspase-3":[118,185],"immunohistochemistry.":[119],"Cognitive":[120],"function":[121],"on":[126],"40":[129],"fear":[131],"conditioning.":[132],"RESULTS:":[133],"dose-dependently":[137],"prevented":[138,176],"hippocampus,":[143],"thalamus,":[144],"cortex;":[146],"this":[147,199],"attenuated":[150],"treatment":[152,157],"atipamezole.":[154],"Although":[155],"did":[158,167,196],"not":[159,197],"affect":[160],"acquisition":[162],"short-term":[164],"memory,":[165],"induce":[168],"long-term":[169],"memory":[170],"impairment.":[171],"This":[172],"neurocognitive":[173,211],"deficit":[174],"dexmedetomidine,":[180],"which":[181],"inhibited":[183],"expression":[186],"vitro;":[193],"however,":[194],"gabazine":[195],"modify":[198],"neuroapoptosis.":[200],"CONCLUSION:":[201],"Dexmedetomidine":[202],"attenuates":[203],"developing":[208],"brain,":[209],"providing":[210],"protection.":[212],"appears":[217],"be":[219,234,242],"independent":[220],"activation":[222],"receptor.":[228],"If":[229],"neuroapoptosis":[231],"proves":[232],"clinical":[236],"problem,":[237],"may":[241],"an":[243],"important":[244],"adjunct":[245],"prevent":[247],"neurotoxicity.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":29},{"year":2019,"cited_by_count":27},{"year":2018,"cited_by_count":33},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":41},{"year":2015,"cited_by_count":29},{"year":2014,"cited_by_count":40},{"year":2013,"cited_by_count":36},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
