{"id":"https://openalex.org/W2149502003","doi":"https://doi.org/10.1093/jnci/djn241","title":"Anthracycline Cardiotoxicity: One Size Does Not Fit All!","display_name":"Anthracycline Cardiotoxicity: One Size Does Not Fit All!","publication_year":2008,"publication_date":"2008-07-29","ids":{"openalex":"https://openalex.org/W2149502003","doi":"https://doi.org/10.1093/jnci/djn241","mag":"2149502003","pmid":"https://pubmed.ncbi.nlm.nih.gov/18664649"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/djn241","doi":"https://doi.org/10.1093/jnci/djn241","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/djn241","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091772334","display_name":"Dawn L. Hershman","orcid":"https://orcid.org/0000-0001-8807-153X","observed_orcids":["https://orcid.org/0000-0001-8807-153X"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. L. Hershman","raw_affiliation_strings":["Affiliations of authors: Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)","Affiliations of authors : Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliations of authors: Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Affiliations of authors : Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082554584","display_name":"Alfred I. Neugut","orcid":"https://orcid.org/0000-0002-5949-4522","observed_orcids":["https://orcid.org/0000-0002-5949-4522"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I4390039230"]},{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. I. Neugut","raw_affiliation_strings":["Affiliations of authors: Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)","Affiliations of authors : Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliations of authors: Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]},{"raw_affiliation_string":"Affiliations of authors : Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY (DLH, AIN)","institution_ids":["https://openalex.org/I4390039230","https://openalex.org/I78577930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":0.66,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.76624295,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"100","issue":"15","first_page":"1046","last_page":"1047"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9179999828338623},{"id":"https://openalex.org/keywords/early-breast-cancer","display_name":"early breast cancer","score":0.7360000014305115},{"id":"https://openalex.org/keywords/non-hodgkin-lymphoma","display_name":"non-Hodgkin lymphoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/seer-medicare","display_name":"SEER-Medicare","score":0.8240000009536743},{"id":"https://openalex.org/keywords/observational-studies","display_name":"observational studies","score":0.36899998784065247},{"id":"https://openalex.org/keywords/real-world-evidence","display_name":"real-world evidence","score":0.5619999766349792},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5189999938011169},{"id":"https://openalex.org/keywords/cardiovascular-risk-factors","display_name":"cardiovascular risk factors","score":0.6230000257492065},{"id":"https://openalex.org/keywords/long-term-treatment-toxicity","display_name":"long-term treatment toxicity","score":0.3970000147819519},{"id":"https://openalex.org/keywords/risk-prediction-model","display_name":"risk prediction model","score":0.328000009059906},{"id":"https://openalex.org/keywords/heart-failure-risk-stratification","display_name":"heart failure risk stratification","score":0.30799999833106995},{"id":"https://openalex.org/keywords/community-oncology-practice","display_name":"community oncology practice","score":0.3400000035762787}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.8535462021827698},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.8474978804588318},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.823061466217041},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.6177984476089478},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.6166188716888428},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5326046347618103},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5287171006202698},{"id":"https://openalex.org/C107130276","wikidata":"https://www.wikidata.org/wiki/Q133805","display_name":"Epidemiology","level":2,"score":0.46233317255973816},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4100116193294525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40228182077407837},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3298618793487549},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2670813500881195},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21519413590431213}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006278","descriptor_name":"Medicare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006278","descriptor_name":"Medicare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006278","descriptor_name":"Medicare","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015251","descriptor_name":"Epirubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018426","descriptor_name":"SEER Program","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D018943","descriptor_name":"Anthracyclines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/djn241","doi":"https://doi.org/10.1093/jnci/djn241","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/djn241","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:18664649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18664649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Comment"},{"id":"pmh:oai:open-archive.highwire.org:jnci:djn241v1","doi":null,"is_oa":false,"landing_page_url":"http://jnci.oxfordjournals.org/cgi/content/short/djn241v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1492360552","https://openalex.org/W1596051841","https://openalex.org/W1796787464","https://openalex.org/W1828224642","https://openalex.org/W1961026612","https://openalex.org/W2005849136","https://openalex.org/W2005865357","https://openalex.org/W2019934381","https://openalex.org/W2022760931","https://openalex.org/W2045806344","https://openalex.org/W2075284324","https://openalex.org/W2105882193","https://openalex.org/W2113155352","https://openalex.org/W2139283516","https://openalex.org/W2152124377"],"related_works":["https://openalex.org/W2569855433","https://openalex.org/W2157841994","https://openalex.org/W2420051576","https://openalex.org/W4323066430","https://openalex.org/W1992099483","https://openalex.org/W95894433","https://openalex.org/W2730846812","https://openalex.org/W2073041174","https://openalex.org/W2396926985","https://openalex.org/W2053291556"],"abstract_inverted_index":{"The":[0,297],"oncology":[1],"community":[2],"has":[3,68,242,259,264,373,542,590],"known":[4,415,611,676,686,706],"for":[5,79,89,108,176,302,317,334,376,388,524,595,606,709,798,804,836,897,908,993,1047,1062,1076],"more":[6,152,565,789,850],"than":[7,201,409,538,559,790],"30":[8],"years":[9,177,287,459],"that":[10,258,574,609,784,885,907,934,978,1023,1035,1151],"anthracycline-containing":[11],"chemotherapy":[12],"improves":[13],"disease-free":[14],"and":[15,51,99,174,228,238,269,279,288,307,337,387,414,455,475,545,553,604,647,695,758,773,840,867,964,983,1012,1078,1118,1127,1153],"overall":[16],"survival":[17],"in":[18,35,127,159,195,204,233,310,323,357,472,579,630,713,722,770,787,884,904,929,950,967,1099],"patients":[19,74,104,171,284,315,389,506,723,805,886,909,1040,1137],"with":[20,136,172,291,378,390,402,421,507,526,550,563,581,679,720,725,767,854,910],"breast":[21,380,509,583,838,912],"cancer":[22,292,381,510,584,839,933,1166],"(":[23,62,326,382,393,442,498,585,658,667,987,1028,1052],"1":[24],").":[25,328,395,444,989,1030,1054],"Despite":[26],"this,":[27],"physicians":[28],"are":[29,75,87,161,193,198,210,222,610,717,748,869,1015],"often":[30,131,162,199,211,858],"reluctant":[31],"to":[32,44,71,213,225,244,249,340,351,411,432,457,519,556,612,632,814,852,871,956,985,1025,1086,1091,1121,1124,1135,1146,1149,1154,1177,1185],"use":[33,138,245,501],"it":[34,67],"certain":[36],"\u201chigh-risk\u201d":[37],"groups,":[38],"such":[39,345,1064],"as":[40,818,861,999,1021],"the":[41,47,55,91,109,118,128,137,145,165,205,234,251,266,294,330,348,358,362,365,435,473,477,493,527,543,576,591,622,633,636,661,714,740,752,771,778,781,822,829,841,894,930,975,1009,1096,1100,1139,1156,1161],"elderly,":[42],"due":[43],"concerns":[45],"over":[46,515],"risk":[48,56,78,208,227,366,417,423,436,614,688,707,721,759,825,982,992,1075,1116,1126,1141],"of":[49,57,93,113,120,139,144,148,153,167,170,180,230,254,261,314,344,367,398,424,437,453,460,468,479,492,547,593,598,615,625,663,675,704,736,742,760,794,801,806,821,832,844,863,917,932,947,962,991,1039,1050,1056,1095,1102,1142,1158,1160,1165,1170],"short-":[50],"long-term":[52,146,252,308],"cardiotoxicity.":[53],"Although":[54,445],"cardiotoxicity":[58,525,537],"is":[59,300,347,728,764,972,996,1058,1072,1080],"dose":[60,470,624,783],"dependent":[61],"2":[63,817],",":[64,384],"3":[65],"),":[66,386,587,660],"been":[69,243,260,265,321,374],"hard":[70,212],"predict":[72,954,980,1070],"which":[73,275,951],"at":[76,512,1073,1138],"greatest":[77,1074,1140],"developing":[80],"complications":[81,253,1027],"from":[82,503,730,812,874],"treatment.":[83,182,255],"Randomized":[84],"clinical":[85,196,324,335,646,802,1111],"trials":[86,197,325,336],"excellent":[88],"establishing":[90],"efficacy":[92],"new":[94],"therapies":[95,833],"by":[96,450,465,476,644],"comparing":[97],"experimental":[98],"standard":[100,1089],"therapies.":[101],"However,":[102],"many":[103],"do":[105,1041],"not":[106,765,938,1042],"qualify":[107],"rigorous":[110],"entry":[111],"criteria":[112],"most":[114],"trials,":[115],"and,":[116],"thus,":[117],"effectiveness":[119],"these":[121,399,446,705,737,846],"treatments,":[122],"or":[123,744],"how":[124,354],"they":[125,462],"work":[126,356],"\u201creal":[129],"world,\u201d":[130],"needs":[132],"further":[133],"clarification,":[134],"usually":[135,223],"observational":[140,216],"studies.":[141],"Furthermore,":[142,629],"determination":[143],"effects":[147,158,232,306,741,747,995],"treatments":[149,355],"can":[150,953,979,1068],"be":[151,188,557,872,893,902,922,1084],"a":[154,311,466,516,521,532,601,673,791,799,819,889,914,1036,1048,1092],"challenge.":[155],"Long-term":[156],"toxic":[157],"particular":[160,262],"rare,":[163],"necessitating":[164],"evaluation":[166],"large":[168,246,451,830],"numbers":[169,452,552],"observation":[173],"follow-up":[175],"following":[178,371],"completion":[179],"primary":[181],"To":[183],"evaluate":[184,250],"this":[185,490,588,620,731,879,1130],"prospectively":[186],"would":[187,701,785],"prohibitively":[189],"expensive.":[190],"Patients":[191],"who":[192,857,868,887,1071,1079],"enrolled":[194],"healthier":[200],"those":[202,401],"treated":[203,724],"community,":[206],"so":[207],"estimates":[209],"generalize.":[214],"Therefore,":[215],"studies,":[217,549,635],"using":[218],"sophisticated":[219],"epidemiological":[220],"methods,":[221],"used":[224],"characterize":[226],"predictors":[229],"late":[231,994],"community.":[235],"A":[236],"novel":[237],"popular":[239],"recent":[240,653],"approach":[241,1131],"administrative":[247],"databases":[248,346],"One":[256,970],"database":[257,299,474,560,634],"value":[263],"Surveillance,":[267],"Epidemiology,":[268],"End":[270],"Results":[271],"(SEER)\u2013Medicare":[272],"linked":[273],"database,":[274,364],"contains":[276],"clinical,":[277],"demographic,":[278],"medical":[280],"claims":[281],"data":[282,502],"on":[283,332,531,568,655,959,965],"aged":[285],"65":[286],"older":[289],"diagnosed":[290],"since":[293],"early":[295],"1990s.":[296],"SEER\u2013Medicare":[298,363],"invaluable":[301],"studying":[303],"unanticipated":[304],"treatment":[305,931,957,986,1019,1046,1090,1144],"outcomes":[309],"population-based":[312],"sample":[313],"who,":[316],"various":[318],"reasons,":[319],"have":[320,849,927,942,1033],"underrepresented":[322],"4":[327],"Given":[329,828],"constraints":[331],"eligibility":[333],"other":[338,607,652,768],"barriers":[339],"trial":[341],"participation,":[342],"analysis":[343,662,880],"only":[349,485],"way":[350],"find":[352,1147],"out":[353],"real":[359],"world.":[360],"Using":[361],"congestive":[368,425,439,480,616,639,710,761,795,918],"heart":[369,404,426,440,481,617,640,711,762,796,919],"failure":[370,441,482,712,763,797,920],"anthracyclines":[372,860],"characterized":[375],"women":[377,580,853],"early-stage":[379,855,911],"5":[383],"6":[385],"non-Hodgkin":[391],"lymphoma":[392],"7":[394,443],"For":[396,1007],"each":[397,569],"analyses,":[400],"prior":[403,572,683,692,696,755],"disease":[405,1115],"were":[406,419,448,463],"less":[407,536,554],"likely":[408,870],"others":[410],"receive":[412,859,1043],"anthracyclines,":[413],"cardiac":[416,684,687],"factors":[418,608,677,708,738,1022,1120],"associated":[420,678,719],"increased":[422],"failure.":[427,618],"Only":[428],"hypertension":[429],"was":[430,627,642],"found":[431],"actually":[433],"potentiate":[434,739],"anthracycline-induced":[438],"studies":[447,561,573,654,769,1032],"strengthened":[449],"subjects":[454],"up":[456],"10":[458,659],"follow-up,":[461],"limited":[464],"lack":[467],"anthracycline":[469,528,626],"information":[471,567],"diagnosis":[478],"being":[483,1016],"determined":[484],"through":[486],"billing":[487],"claims.":[488],"In":[489,619],"issue":[491],"Journal,":[494],"Ryberg":[495,664],"et":[496,665],"al.":[497,666],"8":[499,668],")":[500,669],"about":[504],"1000":[505],"metastatic":[508,582,837],"seen":[511],"their":[513,746,864,875],"institution":[514],"20-year":[517],"period":[518],"develop":[520],"predictive":[522,656],"assay":[523],"epirubicin,":[529],"which,":[530],"milligram-per-milligram":[533],"basis,":[534],"causes":[535,597,843],"doxorubicin.":[539],"This":[540],"study":[541,589],"pluses":[544],"minuses":[546],"single-institution":[548],"smaller":[551],"ability":[555],"generalized":[558],"but":[562],"much":[564],"detailed":[566],"subject.":[570],"Unlike":[571],"evaluated":[575],"dose\u2013toxicity":[577],"relationship":[578],"9":[586],"advantage":[592],"controlling":[594,605],"competing":[596,842],"mortality,":[599,845],"performing":[600],"time-dependent":[602],"analysis,":[603,621,732],"increase":[613],"total":[623],"available.":[628],"contrast":[631],"outcome":[637],"(ie,":[638],"failure)":[641],"defined":[643],"both":[645,1125],"objective":[648],"criteria.":[649],"Like":[650],"some":[651,703],"models":[657,1106],"takes":[670],"into":[671,944,1018,1109],"account":[672,1110],"number":[674,831,1038,1164],"risk,":[680,1152],"including":[681],"age,":[682],"disease,":[685],"factors,":[689,1112,1117],"thoracic":[690],"radiation,":[691],"hormonal":[693,756],"therapy,":[694],"cyclophosphamide-based":[697],"chemotherapy.":[698],"As":[699],"one":[700,1059],"expect,":[702],"general":[715],"population":[716],"also":[718,1004],"epirubicin.":[726],"It":[727,900],"unclear":[729],"however,":[733,906],"whether":[734,745],"any":[735],"epirubicin":[743],"purely":[749],"additive.":[750],"Futhermore,":[751],"association":[753],"between":[754],"therapy":[757,866],"consistent":[766],"literature":[772],"deserves":[774],"additional":[775],"confirmation.":[776],"Interestingly,":[777],"authors":[779],"calculate":[780],"maximum":[782],"result":[786],"no":[788],"5%":[792,915],"rate":[793,916],"variety":[800,1049],"scenarios":[803],"different":[807],"ages.":[808],"Maximum":[809],"doses":[810],"ranged":[811],"300":[813],"900":[815],"mg/m":[816],"function":[820],"patient\u2019s":[823],"personal":[824],"factor":[826],"profile.":[827],"currently":[834],"available":[835],"results":[847],"may":[848,892,921,1083],"relevance":[851],"cancer,":[856,913],"part":[862],"adjuvant":[865],"cured":[873],"cancer.":[876],"When":[877],"extrapolated,":[878],"provides":[881],"useful":[882],"information,":[883],"fit":[888,939],"high-risk":[890],"profile":[891,977],"best":[895],"candidates":[896],"non\u2013anthracycline-based":[898],"regimens.":[899],"must":[901],"kept":[903],"mind,":[905],"considered":[923],"unacceptably":[924],"high.":[925],"We":[926,941],"learned":[928],"\u201cone":[935],"size":[936],"does":[937],"all.\u201d":[940],"moved":[943],"an":[945,1179],"era":[946,1101],"personalized":[948],"medicine":[949],"we":[952,1067,1082],"response":[955,984],"based":[958],"genetic":[960,1119],"profiles":[961],"tumors":[963],"variation":[966,1003],"drug":[968],"metabolism.":[969],"example":[971],"Oncotype":[973],"DX,":[974],"21-gene":[976],"recurrence":[981],"11":[988],"Prediction":[990],"within":[997],"reach":[998],"well,":[1000],"because":[1001],"individual":[1002],"affects":[1005],"toxicity.":[1006],"example,":[1008],"UGT1A1,":[1010],"CYP2D6,":[1011],"DPD":[1013],"polymorphisms":[1014],"incorporated":[1017],"decisions":[1020],"contribute":[1024],"treatment-related":[1026],"12":[1029],"Numerous":[1031],"shown":[1034],"substantial":[1037],"standard,":[1044],"life-saving":[1045],"cancers":[1051],"13\u201315":[1053],"Fear":[1055],"toxicity":[1057,1077],"major":[1060],"reason":[1061],"avoiding":[1063],"therapy.":[1065],"If":[1066],"better":[1069],"not,":[1081],"able":[1085],"comfortably":[1087],"offer":[1088],"larger":[1093],"percentage":[1094],"population.":[1097],"Ideally,":[1098],"individualized":[1103],"medicine,":[1104],"future":[1105],"will":[1107,1132],"take":[1108],"tumor":[1113],"characteristics,":[1114],"integrate":[1122],"contributions":[1123],"benefit.":[1128],"Ultimately,":[1129],"allow":[1133],"us":[1134],"identify":[1136],"adverse":[1143],"effects,":[1145],"ways":[1148],"reduce":[1150],"improve":[1155],"quality":[1157],"life":[1159],"rapidly":[1162],"growing":[1163],"survivors.":[1167],"American":[1168,1180],"Society":[1169,1182],"Clinical":[1171,1174],"Oncology":[1172],"Advanced":[1173],"Research":[1175],"Award":[1176],"D.L.H.;":[1178],"Cancer":[1181],"grant":[1183],"(RSGT-01-02404-CPHPS)":[1184],"A.I.N.":[1186]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-08T09:06:37.294493","created_date":"2025-10-10T00:00:00"}